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Web Desc
Obesity and NAFLD: Mechanisms and Therapeutics
Organizer(s): Rebecca A. Haeusler, Shingo Kajimura and Alexei Kharitonenkov
Date: February 23 - 27, 2020
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by AstraZeneca, Gilead Sciences, Inc., Merck & Co., Inc. and Novo Nordisk A/S
Summary of Meeting:
Energy metabolism underlies all facets of human health. With the rates of obesity and nonalcoholic fatty liver disease (NAFLD) surging, understanding how energy metabolism is governed in healthy and diseased states is of the utmost concern. The focus of this Keystone Symposia is to bring obesity and NAFLD disease researchers together to identify metabolic disease factors and future directions. Halting the progression of NAFLD into nonalcoholic steatohepatitis (NASH) is considered an unmet need in human health. Therefore, the conference program is designed to discuss both the regulatory elements driving the progression of obesity and NAFLD and the metabolic underpinnings of NASH. The program also includes sessions on metabolites, hormones, and cellular signaling pathways and features cutting edge therapeutic approaches for obesity and NASH. This conference will bring together scientists and physicians specializing in basic, translational, and clinical research, as well as industry scientists, to create a robust exchange of ideas on how to move the field forward.
Scholarship Deadline: October 23 2019
Discounted Abstract Deadline: October 23 2019
Abstract Deadline: November 21 2019
Discounted Registration Deadline: December 19 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaGilead Sciences, Inc.Merck & Co., Inc.Novo Nordisk A/S
We gratefully acknowledge additional support from these exhibitors at this conference:
Sable Systems International
We gratefully acknowledge additional support for this conference from:
Cayman Chemical CompanyLipedema FoundationResearch Diets, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

89bio

Novo Nordisk A/S

Pfizer Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK123897-01
Funding for this conference was made possible (in part) by 1R13DK123897-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 23 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Sunday, February 23 | 6:00PM - 8:00PM
Welcome Mixer
Room: Van Horne Foyer
No registration fees are used to fund alcohol served at this function.

Monday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B/C


Monday, February 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Van Horne A

Speaker 1 of 2
* Rebecca A. Haeusler, Columbia University, USA

Monday, February 24 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Van Horne A

Speaker 2 of 2
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
The Fourth Dimension of Obesity and NAFLD

Monday, February 24 | 9:00AM - 11:30AM
New Pathways in Hepatic Metabolism
Room: Van Horne A

Speaker 1 of 7
* Maaike Oosterveer, University Medical Center Groningen, Netherlands

Monday, February 24 | 9:00AM - 11:30AM
New Pathways in Hepatic Metabolism
Room: Van Horne A

Speaker 2 of 7
Kun-Liang Guan, University of California, San Diego, USA
The Hippo Pathway in Metabolism and Organ Growth

Monday, February 24 | 9:00AM - 11:30AM
New Pathways in Hepatic Metabolism
Room: Van Horne A


Coffee Break

Monday, February 24 | 9:00AM - 11:30AM
New Pathways in Hepatic Metabolism
Room: Van Horne A

Speaker 4 of 7
Hannele Yki-Järvinen, University of Helsinki, Finland
Function of the PNPLA3 I148M Gene Variant in the Human Liver

Monday, February 24 | 9:00AM - 11:30AM
New Pathways in Hepatic Metabolism
Room: Van Horne A

Speaker 5 of 7
Mark A. Herman, Duke University Medical Center, USA
Molecular Aspects of Fructose-Induced Metabolic Dysregulation

Monday, February 24 | 9:00AM - 11:30AM
New Pathways in Hepatic Metabolism
Room: Van Horne A

Speaker 6 of 7
Lei Yin, University of Michigan Medical School, USA
Short Talk: DDB1 E3 Ligase Links Dietary Fructose Intake and ChREBP Protein Stabilization and Enhanced De Novo Lipogenesis via CRY1 Degradation

Monday, February 24 | 9:00AM - 11:30AM
New Pathways in Hepatic Metabolism
Room: Van Horne A

Speaker 7 of 7
Jennifer L. Estall, Institut de Recherches Cliniques de Montréal, Canada
Short Talk: Glucagon Enhances Insulin-Mediated Suppression of Gluconeogenesis by Regulating the IRS1:IRS2 Ratio via PGC1A

Monday, February 24 | 11:30AM - 5:00PM
On Own for Lunch


Monday, February 24 | 11:30AM - 1:00PM
Poster Setup
Room: Van Horne B/C


Monday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B/C


Monday, February 24 | 2:30PM - 4:30PM
Career Roundtable
Room: DC Coleman
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 1 of 5
Claudio J. Villanueva, University of California, Los Angeles, USA

Monday, February 24 | 2:30PM - 4:30PM
Career Roundtable
Room: DC Coleman
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 2 of 5
Alan Morris, Nature Reviews Endocrinology, Germany

Monday, February 24 | 2:30PM - 4:30PM
Career Roundtable
Room: DC Coleman
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 3 of 5
Yaron Rotman, NIDDK, National Institutes of Health, USA

Monday, February 24 | 2:30PM - 4:30PM
Career Roundtable
Room: DC Coleman
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 4 of 5
Jun Wu, University of Michigan, USA

Monday, February 24 | 2:30PM - 4:30PM
Career Roundtable
Room: DC Coleman
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 5 of 5
Silvia Corvera, University of Massachusetts Medical School, USA

Monday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, February 24 | 5:00PM - 7:00PM
Mitochondrial Function in Energy Balance and Metabolic Disea
se

Room: Van Horne A

Speaker 1 of 6
* Shingo Kajimura, Harvard Medical School, Beth Israel Deaconess Medical Center, USA

Monday, February 24 | 5:00PM - 7:00PM
Mitochondrial Function in Energy Balance and Metabolic Disea
se

Room: Van Horne A

Speaker 2 of 6
Brian N. Finck, Washington University School of Medicine, USA
Targeting Mitochondrial Intermediary Metabolism to Treat NAFLD

Monday, February 24 | 5:00PM - 7:00PM
Mitochondrial Function in Energy Balance and Metabolic Disea
se

Room: Van Horne A

Speaker 3 of 6
Maren C. Podszun, NIDDK, National Institutes of Health, USA
Short Talk: Vitamin E Treatment in NAFLD Reveals Novel Pathway: Oxidative Stress Drives De-Novo Lipogenesis Through S1P/S2P Proteases

Monday, February 24 | 5:00PM - 7:00PM
Mitochondrial Function in Energy Balance and Metabolic Disea
se

Room: Van Horne A

Speaker 4 of 6
Douglas G. Mashek, University of Minnesota, USA
Lipid Droplet Signaling as a Driver of Mitochondrial Metabolism

Monday, February 24 | 5:00PM - 7:00PM
Mitochondrial Function in Energy Balance and Metabolic Disea
se

Room: Van Horne A

Speaker 5 of 6
Jun Wu, University of Michigan, USA
Nicotinic Acetylcholine Receptors in Energy Metabolism

Monday, February 24 | 5:00PM - 7:00PM
Mitochondrial Function in Energy Balance and Metabolic Disea
se

Room: Van Horne A

Speaker 6 of 6
Lawrence Kazak, McGill University, Canada
Short Talk: Creatine Energetics in Brown Fat Controls Energy Expenditure through Creatine Kinase B-Type

Monday, February 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B/C
No registration fees are used to fund alcohol served at this function.

Monday, February 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Van Horne B/C


Tuesday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B/C


Tuesday, February 25 | 8:00AM - 11:00AM
Metabolites Mediating Tissue Crosstalk
Room: Van Horne A

Speaker 1 of 8
Christopher B. Newgard, Duke University Medical Center, USA
Hepatic Metabolic Regulatory Nodes Linked to Cardiometabolic Diseases

Tuesday, February 25 | 8:00AM - 11:00AM
Metabolites Mediating Tissue Crosstalk
Room: Van Horne A

Speaker 2 of 8
Claudio J. Villanueva, University of California, Los Angeles, USA
Adipose-Liver Crosstalk and Adaptive Thermogenesis

Tuesday, February 25 | 8:00AM - 11:00AM
Metabolites Mediating Tissue Crosstalk
Room: Van Horne A


Coffee Break

Tuesday, February 25 | 8:00AM - 11:00AM
Metabolites Mediating Tissue Crosstalk
Room: Van Horne A

Speaker 4 of 8
Rebecca A. Haeusler, Columbia University, USA
Bile Acid Regulation of Metabolism

Tuesday, February 25 | 8:00AM - 11:00AM
Metabolites Mediating Tissue Crosstalk
Room: Van Horne A

Speaker 5 of 8
Annelise Poss, University of Utah, USA
Short Talk: Ceramides as Lipotoxic Mediators of Non-Alcoholic Fatty Liver Disease and Steatohepatitis

Tuesday, February 25 | 8:00AM - 11:00AM
Metabolites Mediating Tissue Crosstalk
Room: Van Horne A

Speaker 6 of 8
* James C. Lo, Weill Cornell Medicine, USA
Short Talk: An Adipose Regulator of Beta Cell Failure

Tuesday, February 25 | 8:00AM - 11:00AM
Metabolites Mediating Tissue Crosstalk
Room: Van Horne A

Speaker 7 of 8
Maaike Oosterveer, University Medical Center Groningen, Netherlands
Short Talk: Hepatic ChREBP Activation Limits NAFLD Development in a Mouse Model for GSD Ia

Tuesday, February 25 | 8:00AM - 11:00AM
Metabolites Mediating Tissue Crosstalk
Room: Van Horne A

Speaker 8 of 8
Kirk M. Habegger, University of Alabama, Birmingham, USA
Short Talk: Title to be Announced

Tuesday, February 25 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, February 25 | 11:00AM - 1:00PM
Poster Setup
Room: Van Horne B/C


Tuesday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B/C


Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 1 of 9
* Claudio J. Villanueva, University of California, Los Angeles, USA

Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 2 of 9
Andrea Galmozzi, The Scripps Research Institute, USA
Intracellular Heme Trafficking in Adipocytes Regulates Energy Homeostasis

Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 3 of 9
Lucia Korinkova, Czech Academy of Sciences, Czech Republic
Impact of Lipidized Prolactin-Releasing Peptide Treatment on Metabolic Syndrome and Leptin-Related Signaling Pathways in Three Mouse Models

Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 4 of 9
Iichiro Shimomura, Osaka University, Japan
Action Mechanism of High-Molecular Weight Multimer Adiponectin – Possible Role of Stem Cells, T-Cadherin, and Exosomes for Organ Protections

Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 5 of 9
Mohammad Abu Odeh, University of California, San Diego, USA
FGF21 Acts Locally on the Adipose Tissue to Induce Weight Loss

Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 6 of 9
Ludger Scheja, University Medical Center Hamburg-Eppendorf, Germany
The Role of the Alternative Pathway-Derived Bile Acids in NAFLD Progression

Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 7 of 9
Abraham Stijn Meijnikman, Amsterdam University Medical Center, Netherlands
Hyperinsulinemia, a Key Player in Visceral Adipose Tissue and Hepatic Cellular Senescence

Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 8 of 9
Yohei Kanamori, Nagoya University, Japan
Role of Iron in the Emergence of Proinflammatory and Profibrotic Macrophages in a Mouse Model of Nonalcoholic Steatohepatitis

Tuesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Late-Breaking Research in Obesity and NAFLD
Room: Van Horne A

Speaker 9 of 9
WonGun Choi, Korea Advanced Institute of Science and Technology, South Korea
The Role of Serotonin Signaling through HTR2A/2B in Visceral Adipose Tissue

Tuesday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, February 25 | 5:00PM - 7:00PM
Drivers of NAFLD and Dyslipidemia in Obesity
Room: Van Horne A

Speaker 1 of 6
* Masahiro Koseki, Osaka University, Japan

Tuesday, February 25 | 5:00PM - 7:00PM
Drivers of NAFLD and Dyslipidemia in Obesity
Room: Van Horne A

Speaker 2 of 6
Elizabeth J. Parks, University of Missouri, USA
Liver Metabolic Flux in NAFLD and NASH

Tuesday, February 25 | 5:00PM - 7:00PM
Drivers of NAFLD and Dyslipidemia in Obesity
Room: Van Horne A

Speaker 3 of 6
Greg Steinberg, McMaster University, Canada
Cellular Energy Sensing and Metabolism: Implications for Treating NAFLD

Tuesday, February 25 | 5:00PM - 7:00PM
Drivers of NAFLD and Dyslipidemia in Obesity
Room: Van Horne A

Speaker 4 of 6
Lale Ozcan, Columbia University, USA
Glucagon-Mediated Regulation of Cholesterol Metabolism

Tuesday, February 25 | 5:00PM - 7:00PM
Drivers of NAFLD and Dyslipidemia in Obesity
Room: Van Horne A

Speaker 5 of 6
Onno Holleboom, Amsterdam UMC, Netherlands
Short Talk: Deficiency of V-ATPase Assembly Factors TMEM199 and CCDC115 Results in Hepatic Steatosis and Hyperlipidemia and May Affect Fusion of Lipid Droplets and Lysosomes

Tuesday, February 25 | 5:00PM - 7:00PM
Drivers of NAFLD and Dyslipidemia in Obesity
Room: Van Horne A

Speaker 6 of 6
Maria Chondronikola, University of California, Davis, USA
Short Talk: Brown Adipose Tissue is Linked to Very-Low-Density Lipoprotein Triglyceride Metabolism in People

Tuesday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B/C
No registration fees are used to fund alcohol served at this function.

Tuesday, February 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Van Horne B/C


Wednesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B/C


Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 1 of 10
* Raymond E. Soccio, University of Pennsylvania, USA

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 2 of 10
Alexei Kharitonenkov, Novo Nordisk, USA
Novel FGF21 Variants

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 3 of 10
Hank Mansbach, 89bio, USA
BIO89-100, a Long-Acting FG21 Analog, for Treatment of NASH and Cardio-Metabolic Disorders

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A


Coffee Break

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 5 of 10
Timothy Rolph, Akero Therapeutics, Inc., USA
Short Talk: AKR-001, a Long-Acting, Degradation-Resistant FGF21 Analog, Elicits Sustained Improvements in Markers of Glycemic Control and Lipid Metabolism in a 4-Week, Multiple Ascending Dose Study

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 6 of 10
Maria E. Wilson, Genentech, Inc., USA
Short Talk: An Anti-FGFR1/KLB Bispecific Antibody Improves Lipid Profile, Markers of Fibrogenesis, and Liver Health in Patients with Type 2 Diabetes (T2DM) and Decreases Hepatic Fat in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 7 of 10
Lotte Bjerre Knudsen, Novo Nordisk A/S, Denmark
GLP-1 Receptor Agonists: Mechanisms Relevant for the Treatment of Obesity and NASH

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 8 of 10
Asger Bach Lund, University of Copenhagen, Denmark
Short Talk: The Effects of GIP on Food Intake, Energy Expenditure and Plasma Glucose in Patients with Type 2 Diabetes Treated with a Long-acting GLP-1 Receptor Agonist

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 9 of 10
Bruce L. Riser, BLR Bio, USA
Short Talk: CCN3-Based Peptide Inhibits/Reverses Liver Injury in a Mouse Model of Diabetes and Obesity

Wednesday, February 26 | 8:00AM - 11:15AM
Obesity Pathogenesis and New Protein Therapeutic Strategies
Room: Van Horne A

Speaker 10 of 10
Magdalene K. Montgomery, University of Melbourne, Australia
Short Talk: Arylsulfatase A (ARSA) is a Novel NASH-Regulated Hepatokine and Potent Regulator of Glycaemic Control

Wednesday, February 26 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Van Horne B/C


Wednesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne B/C


Wednesday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, February 26 | 5:00PM - 7:00PM
Pathogenesis of NASH and Liver Fibrosis
Room: Van Horne A

Speaker 1 of 5
* Yaron Rotman, NIDDK, National Institutes of Health, USA

Wednesday, February 26 | 5:00PM - 7:00PM
Pathogenesis of NASH and Liver Fibrosis
Room: Van Horne A

Speaker 2 of 5
Bart Staels, Institut Pasteur de Lille, Université Lille, France
Pathways in the Transition of Fatty Liver to Active Disease NASH

Wednesday, February 26 | 5:00PM - 7:00PM
Pathogenesis of NASH and Liver Fibrosis
Room: Van Horne A

Speaker 3 of 5
Utpal B. Pajvani, Columbia University Medical Center, USA
Hepatocyte Jagged-Notch Signaling Induces Fibrosis in NASH

Wednesday, February 26 | 5:00PM - 7:00PM
Pathogenesis of NASH and Liver Fibrosis
Room: Van Horne A

Speaker 4 of 5
Anna Mae Diehl, Duke University, USA
Fixing Fatty Livers

Wednesday, February 26 | 5:00PM - 7:00PM
Pathogenesis of NASH and Liver Fibrosis
Room: Van Horne A

Speaker 5 of 5
Charlotte L. Scott, University of Ghent & VIB, Belgium
Short Talk: Lipid-Associated Stress Results in a Loss of Kupffer Cells from the Liver in NAFLD and Repopulation of the Niche by Fatty Liver Associated Macrophages

Wednesday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B/C
No registration fees are used to fund alcohol served at this function.

Wednesday, February 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Van Horne B/C


Thursday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne B/C


Thursday, February 27 | 8:00AM - 11:00AM
Adipose Tissue and Organismal Energy Balance
Room: Van Horne A

Speaker 1 of 8
* Christian Wolfrum, ETH Zürich, Switzerland

Thursday, February 27 | 8:00AM - 11:00AM
Adipose Tissue and Organismal Energy Balance
Room: Van Horne A

Speaker 2 of 8
Shingo Kajimura, Harvard Medical School, Beth Israel Deaconess Medical Center, USA
The Roles of Brown Adipose Tissue Beyond Thermogenesis

Thursday, February 27 | 8:00AM - 11:00AM
Adipose Tissue and Organismal Energy Balance
Room: Van Horne A

Speaker 3 of 8
Karine Clément, INSERM / Sorbonne Universite, France
Origins of Adipose Tissue Fibrosis

Thursday, February 27 | 8:00AM - 11:00AM
Adipose Tissue and Organismal Energy Balance
Room: Van Horne A


Coffee Break

Thursday, February 27 | 8:00AM - 11:00AM
Adipose Tissue and Organismal Energy Balance
Room: Van Horne A

Speaker 5 of 8
Alexander S. Banks, Harvard Medical School, USA
Obesity-Linked PPARgamma S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

Thursday, February 27 | 8:00AM - 11:00AM
Adipose Tissue and Organismal Energy Balance
Room: Van Horne A

Speaker 6 of 8
Silvia Corvera, University of Massachusetts Medical School, USA
Mechanisms Controlling Number and Type of Adipocytes

Thursday, February 27 | 8:00AM - 11:00AM
Adipose Tissue and Organismal Energy Balance
Room: Van Horne A

Speaker 7 of 8
Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Short Talk: Endothelial Lysosomal Acid Lipase Deficiency Impairs White Adipose Tissue Browning

Thursday, February 27 | 8:00AM - 11:00AM
Adipose Tissue and Organismal Energy Balance
Room: Van Horne A

Speaker 8 of 8
Alexander Paul Sakers, University of Pennsylvania, USA
Short Talk: Lineage Specification of Perivascular Thermogenic Adipocytes

Thursday, February 27 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 1 of 9
* Shirly Pinto, Kallyope, USA

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 2 of 9
Victor Leonard Schuster, Albert Einstein College of Medicine, USA
Inhibiting the Prostaglandin Transporter PGT Induces Non-Canonical Thermogenesis at Thermoneutrality

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 3 of 9
Cecile Vernochet, Bill & Melinda Gates Medical Research Institute, USA
Adipose GI Signaling is Essential for Liver Fat and Whole Body Glucose Homeostasis

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 4 of 9
Shengping Wang, Johnson and Johnson, USA
Weight Loss Via Caloric Restriction Resolves Non-Alcoholic Steatohepatitis (NASH) in Cynomolgus Monkeys

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 5 of 9
Eva C. Thoma, Insphero AG, Switzerland
Establishment of a 3D Human NASH Model for High-Throughput Drug Efficacy Testing

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 6 of 9
Caslin Anne Gilroy, University of California at Berkeley, USA
The Metabolic microRNA miR-128-1 as a Therapeutic Target for the Treatment of NASH

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 7 of 9
Jean-Francois Thibodeau, Liminal R&D BioSciences Inc., Canada
PBI-4050: A Free Fatty Acid Mimetic for the Treatment of NAFLD

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 8 of 9
Jerome Deval, Aligos Therapeutics, USA
Preclinical Development of ALG-055009 as a Potent and Selective Thyroid Hormone Receptor Beta Agonist for the Treatment of NASH

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Drug Targets
Room: Van Horne A

Speaker 9 of 9
Jin Zhou, Duke-nus, Singapore
Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Non-Alcoholic Steatohepatitis (NASH)

Thursday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, February 27 | 5:00PM - 6:45PM
Obesity & NAFLD: Bridging Basic Discoveries and Clinical App
lication

Room: Van Horne A

Speaker 1 of 5
* Rebecca A. Haeusler, Columbia University, USA

Thursday, February 27 | 5:00PM - 6:45PM
Obesity & NAFLD: Bridging Basic Discoveries and Clinical App
lication

Room: Van Horne A

Speaker 2 of 5
Robert K. Semple, University of Edinburgh, UK
Mechanisms Linking Human Adipose Tissue, Insulin Resistance and Fatty Liver: Insights from Human Genetics

Thursday, February 27 | 5:00PM - 6:45PM
Obesity & NAFLD: Bridging Basic Discoveries and Clinical App
lication

Room: Van Horne A

Speaker 3 of 5
Jan Borén, University of Gothenburg, Sweden
Novel Interventions for NAFLD

Thursday, February 27 | 5:00PM - 6:45PM
Obesity & NAFLD: Bridging Basic Discoveries and Clinical App
lication

Room: Van Horne A

Speaker 4 of 5
Brian Finan, Novo Nordisk, USA
Peptide Tri Agonists for the Treatment of Obesity and Diabetes

Thursday, February 27 | 5:00PM - 6:45PM
Obesity & NAFLD: Bridging Basic Discoveries and Clinical App
lication

Room: Van Horne A

Speaker 5 of 5
Emelie Barreby, Karolinska Institutet, Sweden
Short Talk: Characterization of Distinct Populations of Liver Macrophages in Obesity and Insulin Resistance

Thursday, February 27 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Van Horne A


Thursday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne B/C
No registration fees are used to fund alcohol served at this function.

Thursday, February 27 | 8:00PM - 11:00PM
Entertainment
Room: Van Horne B/C
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, February 28 | 10:24AM - 10:24AM
Departure


*Session Chair.