Web Desc
The Global Virome in Health and Disease
Organizer(s): David Wang, Frederic D. Bushman and Mya Breitbart
Date: March 01 - 04, 2020
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
Summary of Meeting:
Viruses are the most abundant biological entities on earth, but only recently has it been possible to define the full virome in humans, animals, plants and global environments. Virome signatures have been associated with diverse conditions such as HIV/AIDS, inflammatory bowel disease, malnutrition, graft versus host disease, organ transplantation, and type 1 diabetes, providing novel insights into mechanisms of pathogenesis. Recently, various beneficial roles of the virome have also been identified, thereby broadening our understanding of the commensal microbiome. However, despite these advances, the vast majority of the virome remains undiscovered, and thus many associations with health and disease have yet to be identified. The goals of this conference are to examine the state-of-the art in virome studies, including efforts to define the virome, establish linkages with health and disease, understand interactions between viral and bacterial components of the microbiome, exploit new model systems, and identify mechanisms of immune control. This will be the first conference dedicated solely to the virome, bringing together experts in eukaryotic virology, phage biology, genomics, informatics, public health, model organisms, and immunology. This conference will bridge the distinct research communities that study bacterial and eukaryotic viruses and unify host-based and environmental research frameworks to allow potent new synergies.
Scholarship Deadline: October 30 2019
Discounted Abstract Deadline: October 30 2019
Abstract Deadline: November 21 2019
Discounted Registration Deadline: December 19 2019
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI149881-01
Funding for this conference was made possible (in part) by 1R13AI149881-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 01 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, March 01 | 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Sunday, March 01 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, March 02 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 1 of 2
* David Wang, Washington University School of Medicine, USA

Monday, March 02 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 2 of 2
Forest Rohwer, San Diego State University, USA
Phage Behaving Badly and Clinical Workarounds

Monday, March 02 | 9:00AM - 11:30AM
The Global Virome and Beyond
Room: Mountain/Lake

Speaker 1 of 7
* Amy Kistler, Chan Zuckerberg Biohub, USA

Monday, March 02 | 9:00AM - 11:30AM
The Global Virome and Beyond
Room: Mountain/Lake

Speaker 2 of 7
Mya Breitbart, University of South Florida, USA
Deciphering the “Dissolved”: Ecological Roles of Aquatic Viruses

Monday, March 02 | 9:00AM - 11:30AM
The Global Virome and Beyond
Room: Mountain/Lake


Coffee Break

Monday, March 02 | 9:00AM - 11:30AM
The Global Virome and Beyond
Room: Mountain/Lake

Speaker 4 of 7
Chantal Abergel, CNRS Aix-Marseille Université, France
The Concept of Virus in the Giant Virus Era

Monday, March 02 | 9:00AM - 11:30AM
The Global Virome and Beyond
Room: Mountain/Lake

Speaker 5 of 7
Edward C. Holmes, University of Sydney, Australia
Exploring the Eukaryotic Virome

Monday, March 02 | 9:00AM - 11:30AM
The Global Virome and Beyond
Room: Mountain/Lake

Speaker 6 of 7
João Trindade Marques, Universidade Federal de Minas Gerais, Brazil
Short Talk: The Global Virome of Vector Mosquitoes

Monday, March 02 | 9:00AM - 11:30AM
The Global Virome and Beyond
Room: Mountain/Lake

Speaker 7 of 7
Adriana Messyasz, Oregon State University, USA
Short Talk: Metagenomic Analysis of Viral Communities in Bleached and Non-Bleached Coral Tissue Uncovers a Novel Coral Megavirus

Monday, March 02 | 11:30AM - 5:00PM
On Own for Lunch


Monday, March 02 | 11:30AM - 1:00PM
Poster Setup
Room: Bay


Monday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, March 02 | 5:00PM - 7:00PM
Beneficial and Commensal Viromes
Room: Mountain/Lake

Speaker 1 of 6
* Evelien M. Adriaenssens, Quadram Institute Bioscience, UK

Monday, March 02 | 5:00PM - 7:00PM
Beneficial and Commensal Viromes
Room: Mountain/Lake

Speaker 2 of 6
Susan M. Lehman, U.S. Food and Drug Administration, USA
Thinking about Phage Therapy as a Microbial Ecology Puzzle

Monday, March 02 | 5:00PM - 7:00PM
Beneficial and Commensal Viromes
Room: Mountain/Lake

Speaker 3 of 6
Robert Edwards, San Diego State University, USA
crAssphage: The Most Abundant Virus in the Human Enteric Virome

Monday, March 02 | 5:00PM - 7:00PM
Beneficial and Commensal Viromes
Room: Mountain/Lake

Speaker 4 of 6
Ken H. Cadwell, New York University School of Medicine, USA
Immunomodulation by the Enteric Virome


Monday, March 02 | 5:00PM - 7:00PM
Beneficial and Commensal Viromes
Room: Mountain/Lake

Speaker 5 of 6
Karthik R. Chamakura, Texas A&M University, USA
Short Talk: The ssRNA Phages as a Source for Peptide Antibiotics

Monday, March 02 | 5:00PM - 7:00PM
Beneficial and Commensal Viromes
Room: Mountain/Lake

Speaker 6 of 6
Cynthia Monaco, University of Rochester Medical Center, USA
Short Talk: Transkingdom Interactions in the Female Reproductive Tract

Monday, March 02 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, March 02 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Monday, March 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Tuesday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 03 | 8:00AM - 11:00AM
The Virome in Disease
Room: Mountain/Lake

Speaker 1 of 6
Frederic D. Bushman, University of Pennsylvania, USA
The Human Virome in Health and Disease

Tuesday, March 03 | 8:00AM - 11:00AM
The Virome in Disease
Room: Mountain/Lake

Speaker 2 of 6
Xavier López, FISABIO - Public Health and University of Valencia, Spain
Diagnosing Infections by Metagenomics and Uncovering Novel Disease Associations by Interrogation of the Eukaryotic Virome

Tuesday, March 03 | 8:00AM - 11:00AM
The Virome in Disease
Room: Mountain/Lake


Coffee Break

Tuesday, March 03 | 8:00AM - 11:00AM
The Virome in Disease
Room: Mountain/Lake

Speaker 4 of 6
Eric L. Delwart, University of California, San Francisco, USA
Koch's Postulates in the Age of Viral Metagenomics

Tuesday, March 03 | 8:00AM - 11:00AM
The Virome in Disease
Room: Mountain/Lake

Speaker 5 of 6
Lori R. Holtz, Washington University, USA
Short Talk: Growth Velocity in Children with Environmental Enteric Dysfunction is Associated with Specific Bacterial and Viral Taxa of the Gastrointestinal Tract in Malawian Children

Tuesday, March 03 | 8:00AM - 11:00AM
The Virome in Disease
Room: Mountain/Lake

Speaker 6 of 6
Efrem S. Lim, Arizona State University, USA
Short Talk: Intestinal and Neuronal Inflammation Associated with Virome Alterations in Experimental Gulf War Illness is Reversed by Ribavirin

Tuesday, March 03 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 03 | 11:00AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, March 03 | 2:30PM - 3:30PM
Workshop 1: Origins of the Human Virome
Room: Mountain/Lake

Speaker 1 of 4
* David Wang, Washington University School of Medicine, USA

Tuesday, March 03 | 2:30PM - 3:30PM
Workshop 1: Origins of the Human Virome
Room: Mountain/Lake

Speaker 2 of 4
Rabia Maqsood, Arizona State University, USA
Discordant Transmission of Bacteria and Viruses from Mothers to Babies at Birth

Tuesday, March 03 | 2:30PM - 3:30PM
Workshop 1: Origins of the Human Virome
Room: Mountain/Lake

Speaker 3 of 4
Guanxiang Liang, University of Pennsylvania, USA
Step-Wise Assembly of the Neonatal Virome Modulated by Breast Feeding

Tuesday, March 03 | 2:30PM - 3:30PM
Workshop 1: Origins of the Human Virome
Room: Mountain/Lake

Speaker 4 of 4
Leen Beller, KU Leuven / REGA Institute, Belgium
Exploring the Diversity and Dynamics of the Gut Microbiome in Infants in Their First Year of Life

Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 2: Computational Viromics
Room: Mountain/Lake

Speaker 1 of 5
* Robert Edwards, San Diego State University, USA

Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 2: Computational Viromics
Room: Mountain/Lake

Speaker 2 of 5
Evelien M. Adriaenssens, Quadram Institute Bioscience, UK
The Importance of Bacteriophage Taxonomy in the Analysis of Gut Virome Data

Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 2: Computational Viromics
Room: Mountain/Lake

Speaker 3 of 5
J. Rodney Brister, NLM, National Institutes of Health, USA
How to Find a Virus – a Public Database Story


Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 2: Computational Viromics
Room: Mountain/Lake

Speaker 4 of 5
Moreno Zolfo, University of Trento, Italy
Detection and Meta-Analysis of Non-Viral Contamination in Viromes with ViromeQC

Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 2: Computational Viromics
Room: Mountain/Lake

Speaker 5 of 5
Michael J. Tisza, NCI, National Institutes of Health, USA
Cenote-Taker2 Democratizes Virus Discovery and Annotation from Metagenomic Data

Tuesday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 03 | 5:00PM - 7:00PM
The Virome in Model Systems
Room: Mountain/Lake

Speaker 1 of 5
* Mya Breitbart, University of South Florida, USA

Tuesday, March 03 | 5:00PM - 7:00PM
The Virome in Model Systems
Room: Mountain/Lake

Speaker 2 of 5
David Wang, Washington University School of Medicine, USA
Novel Lessons from the C. elegans Virome

Tuesday, March 03 | 5:00PM - 7:00PM
The Virome in Model Systems
Room: Mountain/Lake

Speaker 3 of 5
Adrienne M.S. Correa, Rice University, USA
Viral Reefscapes: Microbial Interactions with Threatened Coral Hosts and Reef Ecosystems

Tuesday, March 03 | 5:00PM - 7:00PM
The Virome in Model Systems
Room: Mountain/Lake

Speaker 4 of 5
Keir M. Balla, University of Utah, USA
Short Talk: A Widespread Picornavirus Discovered by Visualizing Zebrafish Immune Responses

Tuesday, March 03 | 5:00PM - 7:00PM
The Virome in Model Systems
Room: Mountain/Lake

Speaker 5 of 5
Ryan A. Langlois, University of Minnesota, USA
Short Talk: Innate Immune Barriers to Inter- and Intra-Species Virus Transmission and Evolution

Tuesday, March 03 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, March 03 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Tuesday, March 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Wednesday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 04 | 8:00AM - 11:00AM
Host-Virus Arms Race
Room: Mountain/Lake

Speaker 1 of 8
* Frederic D. Bushman, University of Pennsylvania, USA

Wednesday, March 04 | 8:00AM - 11:00AM
Host-Virus Arms Race
Room: Mountain/Lake

Speaker 2 of 8
Rotem Sorek, Weizmann Institute of Science, Israel
Remote Presentation: Novel Antiphage Defense Systems

Wednesday, March 04 | 8:00AM - 11:00AM
Host-Virus Arms Race
Room: Mountain/Lake

Speaker 3 of 8
Kimberley Seed, University of California, Berkeley, USA
Bacteriophage-Host Arms Race in Vibrio cholerae

Wednesday, March 04 | 8:00AM - 11:00AM
Host-Virus Arms Race
Room: Mountain/Lake


Coffee Break

Wednesday, March 04 | 8:00AM - 11:00AM
Host-Virus Arms Race
Room: Mountain/Lake

Speaker 5 of 8
Karen L. Maxwell, University of Toronto, Canada
Quorum Sensing Inactivation by a Phage Accessory Protein

Wednesday, March 04 | 8:00AM - 11:00AM
Host-Virus Arms Race
Room: Mountain/Lake

Speaker 6 of 8
Kate L. Jeffrey, Harvard Medical School, USA
Divergent Immunomodulation by Healthy and Inflammatory Bowel Disease Human Enteric Viromes

Wednesday, March 04 | 8:00AM - 11:00AM
Host-Virus Arms Race
Room: Mountain/Lake

Speaker 7 of 8
Moira Dion, Université Laval, Canada
Short Talk: Optimizing Phage Host Predictions from Viral Metagenomics Using CRISPR Spacers

Wednesday, March 04 | 8:00AM - 11:00AM
Host-Virus Arms Race
Room: Mountain/Lake

Speaker 8 of 8
Kevin Forsberg, Fred Hutchinson Cancer Research Center, USA
Short Talk: Functional Metagenomics-Guided Discovery of Potent Cas9 Inhibitors in the Human Microbiome

Wednesday, March 04 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, March 04 | 5:00PM - 6:45PM
Virome-Bacterial Microbiome Interactions
Room: Mountain/Lake

Speaker 1 of 5
* Karen L. Maxwell, University of Toronto, Canada

Wednesday, March 04 | 5:00PM - 6:45PM
Virome-Bacterial Microbiome Interactions
Room: Mountain/Lake

Speaker 2 of 5
Paul E. Turner, Yale University, USA
Remote Presentation: Phage-Bacteria Interactions in the Evolution of Antibacterial Resistance

Wednesday, March 04 | 5:00PM - 6:45PM
Virome-Bacterial Microbiome Interactions
Room: Mountain/Lake

Speaker 3 of 5
Megan T. Baldridge, Washington University School of Medicine, USA
Norovirus Infection, the Gut Microbiota and Interferon Lambda

Wednesday, March 04 | 5:00PM - 6:45PM
Virome-Bacterial Microbiome Interactions
Room: Mountain/Lake

Speaker 4 of 5
Emily F. Wissel, Emory University, USA
Short Talk: The Vaginal Virome in Self-Identified African American Women Associated with Bacterial Community during Pregnancy and Preterm Birth

Wednesday, March 04 | 5:00PM - 6:45PM
Virome-Bacterial Microbiome Interactions
Room: Mountain/Lake

Speaker 5 of 5
Paul Kirchberger, University of Texas, USA
Short Talk: Intraspecific Conflict in Ubiquitous Single-Stranded DNA Phages Is Caused by Hypervariable Genomic Regions

Wednesday, March 04 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mountain/Lake


Wednesday, March 04 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, March 04 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Wednesday, March 04 | 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 05 | 10:24AM - 10:24AM
Departure


*Session Chair.