This meeting took place in the past. Here is a list of meetings that are related:
Web Desc
Gene Regulation: From Mechanisms to Disease
joint with Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities
Organizer(s): Karen Adelman and Patrick Cramer
Date: January 26 - 30, 2020
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Moderna
Summary of Meeting:
Organismal development, homeostasis and healthy aging all rely on precise control of gene expression programs. Recent technological advances in structural biology, real-time imaging, and next generation sequencing have shed new light on decades-old questions about gene regulation, and we seek to highlight these advances. This meeting aims to bring together pioneers in cryoEM, single-cell microscopy, single cell sequencing and three-dimensional genome architecture, with leading experts in transcriptional regulation, to seed new collaborations and discoveries. This conference provides an ideal environment to foster interactions between transcriptional biologists and experts in single cell imaging and genomic approaches and spur conversations about how to interweave new techniques for structural biology with our growing appreciation that many critical interactions involve intrinsically disordered domains (which are by definition not well behaved in most structural approaches). Participants will attend sessions that critically evaluate the impact of genome organization on gene expression. The conference will also expose trainees to the best science possible and instill in them the enthusiasm we feel for the future of the field. Finally, pairing of this meeting with Cancer Epigenetics is ideal as the topics are inherently related. This allows our meeting to focus on underlying mechanisms and normal developmental systems, while enabling the audience to attend lectures in gene dysregulation in cancer. We plan two joint sessions to maximize interactions.
Scholarship Deadline: October 1 2019
Discounted Abstract Deadline: October 1 2019
Abstract Deadline: October 29 2019
Discounted Registration Deadline: November 26 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Moderna
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Promega Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Human Genome Research Institute (NHGRI)
Grant No. 1R13HG010828-01
Funding for this conference was made possible (in part) by 1R13HG010828-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, January 26 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, January 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 1 of 3
* Karen Adelman, Harvard Medical School, USA

Monday, January 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 2 of 3
* Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA

Monday, January 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 3 of 3
Shelley L. Berger, University of Pennsylvania, USA
Epigenetic Pathways as Targets in Human Cancer

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Liling Wan, University of Pennsylvania, USA

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
Eva Nogales, University of California, Berkeley, USA
Structural Insights into the Regulation of the Gene Silencer PRC2

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom


Coffee Break

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
Mechanisms of Chromatin Transcription

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Dylan J. Taatjes, University of Colorado Boulder, USA
Selective Inhibition of Human CDK7 Reveals High-Confidence Targets and Suggests a New Model for TFIIH Function in Transcription

Monday, January 27 | 11:00AM - 5:00PM
On Own for Lunch


Monday, January 27 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

Room: Quandary Peak

Speaker 1 of 8
* Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

Room: Quandary Peak

Speaker 2 of 8
Ksenia Finogenova, Max-Planck Institute of Biochemistry, Germany
Structural Basis of Nucleosome Binding by PRC2 and Its Inhibition by H3K36 Methylation

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

Room: Quandary Peak

Speaker 3 of 8
François Robert, Institut de Recherches Cliniques de Montreal, Canada
Transcribed Chromatin, Rather Than RNA Polymerase II Itself, Recruits FACT to Active Genes

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

Room: Quandary Peak

Speaker 4 of 8
Jitendra Thakur, Fred Hutchinson Cancer Research Center, USA
Architectural RNA Is Required for Heterochromatin Organization

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

Room: Quandary Peak

Speaker 5 of 8
Gilad Yaakov, Weizmann Institute of Israel, Israel
A Novel Histone Molecular Timer Reveals Minute-Resolution Nucleosome Turnover

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

Room: Quandary Peak

Speaker 6 of 8
Keda Zhou, University of Colorado Boulder, USA
FACT Caught in the Act of Manipulating the Nucleosome

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

Room: Quandary Peak

Speaker 7 of 8
Giulia Cova, Max Planck Institute for Molecular Genetics, Germany
TAD-Shuffling at the FGF8 Locus Causes Split-Hand/Foot Malformation Type 3

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

Room: Quandary Peak

Speaker 8 of 8
Yuan He, Northwestern University, USA
Cryo-Electron Microscopy Structure of a Nucleosome-Bound SWI/SNF Chromatin Remodeling Complex

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 1 of 8
* Yael David, Memorial Sloan Kettering Cancer Center, USA


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 2 of 8
Alessandro Gardini, Wistar Institute, USA
A Role for Nuclear PP2A in Transcription Regulation


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 3 of 8
Ruhee Dere, Baylor College of Medicine, USA
KDM4A Regulates Microtubule Methylation and Genomic Instability


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 4 of 8
Gerard L. Brien, Smurfit Institute of Genetics, Ireland
Disruption of Development Enhancer and PRC2 Function by H3K27M in DIPG


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 5 of 8
Tharu M. Fernando, Genentech, Inc., USA
Characterization and Therapeutic Implications of SMARCA4 Mutations in Cancer


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 6 of 8
Noa Furth, Weizmann Institute of Science, Israel
The Combinatorial Epigenetic Landscape of High Grade Pediatric Gliomas in Single Molecule Resolution


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 7 of 8
Brian J. Abraham, St. Jude Children's Research Hospital, USA
Predicting Master Transcription Factors from Pan-Cancer Expression Data


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 8 of 8
Elizabeth Allene Martin, University of California San Francisco, USA
OGT, a Nutrient-Sensing Enzyme, Controls DNA Methylation in Mouse Embryonic Stem Cells


Monday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
Room: Quandary Peak

Speaker 1 of 6
* Karla M. Neugebauer, Yale University, USA

Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
Room: Quandary Peak

Speaker 2 of 6
Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Living Mammalian Cells

Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
Room: Quandary Peak

Speaker 3 of 6
Danette L. Daniels, Promega Corporation, USA
Kinetic Monitoring of Protein Interactions and Targeted Degradation in Live Cells

Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
Room: Quandary Peak

Speaker 4 of 6
Jennifer F. Kugel, University of Colorado Boulder, USA
Short Talk: Single-Molecule Studies Resolve Heterogeneity in the Activity of Transcribing Complexes to Reveal Steps in Transcription That Dictate the Activity of Pol II

Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
Room: Quandary Peak

Speaker 5 of 6
Benjamin R. Sabari, University of Texas Southwestern Medical Center, USA
Short Talk: Enhancer Features that Drive Formation of Transcriptional Condensates

Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
Room: Quandary Peak

Speaker 6 of 6
Michael S. Levine, Princeton University, USA
Visualizing Developmental Dynamics in Drosophila Embryos

Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 1 of 7
* Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany


Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 2 of 7
Ashby Morrison, Stanford University, USA
Epigenetic Regulation of Carcinogen Susceptibility


Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 3 of 7
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Gene Dysregulation, Condensates and Drugs


Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 4 of 7
Bin Wu, Agios Pharmaceuticals Inc, USA
Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1-mutant Relapsed or Refractory Acute Myeloid Leukemia


Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 5 of 7
Liling Wan, University of Pennsylvania, USA
Short Talk: Chromatin Reader Dysregulation in Cell Fate Control and Cancer


Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 6 of 7
Lena Afeyan, Massachusetts Institute of Technology, USA
Short Talk: Formation and Regulation of Estrogen Receptor-Mediated Transcriptional Condensates in Breast Cancer


Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 7 of 7
Lukas Chavez, University of California, San Diego, USA
Short Talk: Targeting of Tumors as Informed by Oncogenic 3D Genome Organization


Monday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, January 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 1 of 7
* Ali Shilatifard, Northwestern University, USA

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 2 of 7
Tony Kouzarides, University of Cambridge, UK
Modifications of RNA: Their Function and Role in Cancer

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 3 of 7
Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and lncRNAs

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom


Coffee Break

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 5 of 7
Anne Brunet, Stanford University, USA
Epigenetic Regulation of Stem Cell Aging

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 6 of 7
Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain
Epigenetic Influence of Our (Fatty) Diet on Metastatic-Initiating Cells

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 7 of 7
Peter Hsu, University of Washington, USA
Short Talk: Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS


Tuesday, January 28 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, January 28 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 1 of 6
Bin Wu, Agios Pharmaceuticals Inc, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 2 of 6
Krista Lynn Bledsoe, Cell Press, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 3 of 6
Senthilkumar Cinghu, NIEHS, National Institutes of Health, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 4 of 6
Scott A. Armstrong, Dana-Farber Cancer Institute, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 5 of 6
Yael David, Memorial Sloan Kettering Cancer Center, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 6 of 6
Raphaël Rodriguez, Institut Curie, France

Tuesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
Room: Quandary Peak

Speaker 1 of 6
* Alexander Stark, Research Institute of Molecular Pathology - IMP, Austria

Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
Room: Quandary Peak

Speaker 2 of 6
Yongsheng Shi, University of California, Irvine, USA
Probing 3’ End Formation of Coding and Non Coding RNAs

Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
Room: Quandary Peak

Speaker 3 of 6
Karla M. Neugebauer, Yale University, USA
Dynamics of Co-Transcriptional Splicing

Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
Room: Quandary Peak

Speaker 4 of 6
Daisy Castillo-Guzman, University of California, Davis, USA
Short Talk: Uncovering Novel Roles for Splicing Factor SF3B1 in Transcription Dynamics and R-Loop Metabolism

Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
Room: Quandary Peak

Speaker 5 of 6
Megan Insco, Boston Children's Hospital, USA
Short Talk: CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts


Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
Room: Quandary Peak

Speaker 6 of 6
Torben Heick Jensen, Aarhus University, Denmark
Transcription Termination and Links to RNA Processing/Decay Pathways

Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 1 of 6
* Paola Grandi, Cellzome AG, a GSK Company, Germany


Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 2 of 6
Hao Zhu, University of Texas Southwestern Medical Center, USA
Targeting Chromatin Remodeling Complexes for Tissue Regeneration


Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 3 of 6
Paola Grandi, Cellzome AG, a GSK Company, Germany
Click Chemistry and Preclinical Evaluation of Targeted Epigenetic Therapies


Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 4 of 6
Liis Uuskula-Reimand, SickKids Research Institute, Canada
Short Talk: Enhancer Function and Topoisomerase II beta in Hepatocellular Carcinoma


Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 5 of 6
Nicholas C. Gomez, Rockefeller University, USA
Short Talk: Stem Cell Reprogramming during Oncogenesis


Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 6 of 6
Raphaël Rodriguez, Institut Curie, France
Short Talk: CD44 Regulates Epigenetic Plasticity by Mediating Iron Endocytosis


Tuesday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, January 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak

Speaker 1 of 9
* Torben Heick Jensen, Aarhus University, Denmark

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak

Speaker 2 of 9
Geeta J. Narlikar, University of California, San Francisco, USA
Can Phase-Separation Explain the Biological Properties of Heterochromatin?

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak

Speaker 3 of 9
Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Low Complexity Sequences in Gene Regulation

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak


Coffee Break

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak

Speaker 5 of 9
Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Genome-Wide Maps of Enhancer-Gene Connections Link Immune Disease Risk Variants to Target Genes

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak

Speaker 6 of 9
R. Babak Faryabi, University of Pennsylvania, USA
Short Talk: Notch-Instructed 3D Cancer Genomes

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak

Speaker 7 of 9
Tom Owen-Hughes, University of Dundee, UK
Short Talk: Selective Enhancer Decommissioning Following Acute Depletion of the ARID1A Subunit of Mammalian SWI/SNF Complexes

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak

Speaker 8 of 9
Alexander Stark, Research Institute of Molecular Pathology - IMP, Austria
Decoding Regulation: Global Screens to Uncover How Sequence Dictates Gene Activity

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
Room: Quandary Peak

Speaker 9 of 9
Karen Adelman, Harvard Medical School, USA
Interactions Between Coding and Non-Coding RNA loci

Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 1 of 8
* Adrian P. Bracken, Trinity College Dublin, Ireland


Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 2 of 8
Ali Shilatifard, Northwestern University, USA
Principles of Epigenetics and Chromatin in Development and Human Disease


Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 3 of 8
Scott A. Armstrong, Dana-Farber Cancer Institute, USA
Targeting Chromatin Complexes in Leukemia


Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.

Coffee Break


Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 5 of 8
Christopher Vakoc, Cold Spring Harbor Laboratory, USA
Squamous Trans-Differentiation in Pancreatic Cancer


Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 6 of 8
Tannishtha Reya, University of California, San Diego, USA
Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance


Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 7 of 8
Jeff Magee, Washington University, USA
Short Talk: KMT2C/MLL3 Deletions Convey a Selective Advantage to Multiply-Divided HSCs by Blunting Cytokine- and Stress-Induced Lineage Commitment


Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 8 of 8
Jiangbin Ye, Stanford University, USA
Short Talk: Deciphering Warburg Effect: The Connection between Metabolism, Epigenetics and Tumor Differentiation


Wednesday, January 29 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, January 29 | 11:15AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 29 | 5:00PM - 7:00PM
Defining Regulation in Single-Cell Cells
Room: Quandary Peak

Speaker 1 of 4
* Emma Farley, University of California, San Diego, USA

Wednesday, January 29 | 5:00PM - 7:00PM
Defining Regulation in Single-Cell Cells
Room: Quandary Peak

Speaker 2 of 4
Rickard Sandberg, Karolinska Institutet, Sweden
Decoding Transcriptional Regulation and Kinetics Using Single-Cell Transcriptomics

Wednesday, January 29 | 5:00PM - 7:00PM
Defining Regulation in Single-Cell Cells
Room: Quandary Peak

Speaker 3 of 4
William J. Greenleaf, Stanford University, USA
A Single Cell Framework for Multi-Omic Analysis of Disease Identifies Malignant Regulatory Signatures

Wednesday, January 29 | 5:00PM - 7:00PM
Defining Regulation in Single-Cell Cells
Room: Quandary Peak

Speaker 4 of 4
Sarah Hainer, University of Pittsburgh, USA
Short Talk: Profiling of Pluripotency Factors in Single Cells and Early Embryos


Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 1 of 5
* Alessandro Gardini, Wistar Institute, USA


Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 2 of 5
Adrian P. Bracken, Trinity College Dublin, Ireland
PRC2 Complexes in Development and Disease


Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 3 of 5
Marcus Buschbeck, Josep Carreras Leukaemia Research Institute, Spain
Histone Variants Regulate 3D Chromatin Architecture and the Inflammatory Response of Cancer Cells


Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 4 of 5
Yael David, Memorial Sloan Kettering Cancer Center, USA
Revealing Cancer-Associated Epigenetic Events using Novel Chemical Tools


Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 5 of 5
Siddhant U. Jain, University of Wisconsin-Madison, USA
Short Talk: Inhibition of PRC2 Activity by EZHIP and H3 K27M in High-Grade Pediatric Gliomas


Wednesday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, January 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak

Speaker 1 of 9
* Michael S. Levine, Princeton University, USA

Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak

Speaker 2 of 9
Emma Farley, University of California, San Diego, USA
Regulatory Principles Governing Enhancer Function in Development and Disease

Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak

Speaker 3 of 9
François Fuks, Université Libre de Bruxelles, Belgium
Transcriptome-Wide Distribution and Function of RNA Modifications

Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak


Coffee Break

Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak

Speaker 5 of 9
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Small Non-Coding RNA in Replication and Quiescence

Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak

Speaker 6 of 9
Laura A. Banaszynski, University of Texas Southwestern Medical Center, USA
Short Talk: Mechanisms of Enhancer Activation Using the Histone Variant H3.3

Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak

Speaker 7 of 9
Wenqing Cai, Boston Children's Hospital, USA
Short Talk: Enhancer-Dependence of Cell-Type-Specific Gene Expression Increases with Developmental Age

Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak

Speaker 8 of 9
Raja Jothi, NIEHS, National Institutes of Health, USA
Short Talk: Bivalent Chromatin Does Not Poise Genes for Rapid Activation


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
Room: Quandary Peak

Speaker 9 of 9
Kathrin Plath, University of California, Los Angeles, USA
A New Mode of Xist Action

Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches
This session is from Cancer Epigenetics

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 1 of 8
* Jane A. Skok, New York University School of Medicine, USA


Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches
This session is from Cancer Epigenetics

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 2 of 8
Eric R. Olson, Syros Pharmaceuticals, USA
Therapeutic Applications of Altering Tumor Cell Gene Expression


Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches
This session is from Cancer Epigenetics

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 3 of 8
Rab K. Prinjha, GlaxoSmithKline, UK
Epigenetic Inhibition in Cancer: Emerging Strategies and Approaches


Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches
This session is from Cancer Epigenetics

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.

Coffee Break


Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches
This session is from Cancer Epigenetics

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 5 of 8
Jane A. Skok, New York University School of Medicine, USA
CTCFL and its Impact on Gene Regulation and Interplay with CTCF Function


Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches
This session is from Cancer Epigenetics

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 6 of 8
Daniel De Carvalho, University Health Network, Canada
Epigenetic Regulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer


Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches
This session is from Cancer Epigenetics

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 7 of 8
Allyson M. Freedy, Harvard University, USA
Short Talk: CRISPR-suppressor Scanning Reveals a Nonenzymatic Role of LSD1 in AML


Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches
This session is from Cancer Epigenetics

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 8 of 8
Jacob G. Kirkland, Stanford University, USA
Short Talk: Chromatin Regulators Mediate Anthracycline Sensitivity in Breast Cancer


Thursday, January 30 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

Room: Quandary Peak

Speaker 1 of 7
* Jennifer F. Kugel, University of Colorado Boulder, USA

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

Room: Quandary Peak

Speaker 2 of 7
Alon Goren, University of California, San Diego, USA
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

Room: Quandary Peak

Speaker 3 of 7
Gabriella E. Martyn, University of New South Wales, Australia
Revealing the Mechanism Behind Naturally Occurring Mutations which Elevate Fetal Hemoglobin

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

Room: Quandary Peak

Speaker 4 of 7
Kirstin Meyer, University of California, San Francisco, USA
Optogenetic Dissection of YAP Transcriptional Regulation

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

Room: Quandary Peak

Speaker 5 of 7
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Discovering the MYC Proteome Reveals Novel Mechanisms of Oncogenesis

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

Room: Quandary Peak

Speaker 6 of 7
Xavier J. Rambout, University of Rochester Medical Center, USA
Transcriptional Coactivator PGC-1a Contains a Novel CBP80-Binding Motif That Orchestrates Efficient Target-Gene Expression

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

Room: Quandary Peak

Speaker 7 of 7
Haoze Vincent Yu, University of Southern California, USA
Feed-Forward Pioneer Factor Activity Underlies Mammalian Mechanoreceptor Cell Differentiation

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 1 of 8
* Chao Lu, Columbia University, USA


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 2 of 8
SrinivasVinod Saladi, Harvard Medical School, USA
Revealing Oncogenic Role of ACTL6A, Subunit of SWI/SNF Chromatin Remodeling Complex in Squamous Cancers


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 3 of 8
Riyad N.H. Seervai, Baylor College of Medicine, USA
The Histone Methyltransferase SETD2 Is a Tumor Suppressor with Actin Lysine Methyltransferase Activity


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 4 of 8
Michelle M. Mitchener, Princeton University, USA
Biochemical and Cellular Libraries Reveal Cancer-Associated Histone Mutations that Perturb Nucleosome Structure


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 5 of 8
Adam D. Durbin, Dana-Farber Cancer Institute, USA
EP300 Controls the Oncogenic Enhancer Landscape of High-Risk Neuroblastoma


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 6 of 8
Chao Lu, Columbia University, USA
Combinatorial Targeting of Chromatin and Metabolism for Cancer Therapy


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 7 of 8
Bethany A. Buck-Koehntop, University of Utah, USA
Investigating the Methyl-CpG Binding Protein ZBTB38 in Mediating Epigenetic-Based Transcription in Cancer


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 8 of 8
Jarod Waybright, University of North Carolina at Chapel Hill, USA
Reader's Block: Development of Chemical Tools Targeting the Methyl-Lysine Reader MPP8


Thursday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
Room: Quandary Peak

Speaker 1 of 5
Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany
Enhancer Promoter Communication During Embryonic Development

Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
Room: Quandary Peak

Speaker 2 of 5
Shasha Chong, University of California, Berkeley, USA
Dynamic and Selective Low-Complexity Domain Interactions Control Gene Transcription: A Single-Molecule Study

Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
Room: Quandary Peak

Speaker 3 of 5
Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
Short Talk: L1 RNA Knockdown Averts Heterochromatin Loss and Premature Ageing Phenotypes

Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
Room: Quandary Peak

Speaker 4 of 5
Clodagh C. O'Shea, The Salk Institute for Biological Studies, USA
Cracking the Nuclear Codes: Finding Order in Chaos

Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
Room: Quandary Peak

Speaker 5 of 5
Aaron Johnson, University of Colorado School of Medicine, USA
Short Talk: RNA Matchmaking Remodels LncRNA Structure and Promotes PRC2 Activity

Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 1 of 5
* Christopher Vakoc, Cold Spring Harbor Laboratory, USA


Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 2 of 5
Luciano Di Croce, CRG - Center for Genomic Regulation, Spain
Molecular Mechanisms Governing Cell Identity, Differentiation and Cancer Processes


Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 3 of 5
Jikui Song, University of California, Riverside, USA
Structural Studies in DNA Methylation and Links to Human Cancer


Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 4 of 5
Agata E. Lemiesz, Rockefeller University, USA
Short Talk: Novel H2B “Oncohistones” Impact Cellular Differentiation and Signaling


Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
This session is from Cancer Epigenetics
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 5 of 5
Nazar Mashtalir, Dana-Farber Cancer Institute, USA
Short Talk: Mechanism of Cancer-Specific SWI/SNF Complex Targeting by the SS18-SSX Fusion Oncogene


Thursday, January 30 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Quandary Peak


Thursday, January 30 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
This session is from Cancer Epigenetics
Room: Grays/Longs Peak

Speaker 1 of 1
† Christopher Vakoc, Cold Spring Harbor Laboratory, USA


Thursday, January 30 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, January 30 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, January 31 | 10:24AM - 10:24AM
Departure


*Session Chair.