Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities

joint with Gene Regulation: From Mechanisms to Disease

Organizer(s): Cigall Kadoch and Christopher Vakoc

Sponsored by Incyte Corporation

Summary of Meeting:

The 2020 Keystone Symposia, Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities, in conjunction with the joint conference, Gene Regulation: From Mechanisms to Disease, co-organized by Karen Adelman and Patrick Cramer, will highlight state-of-the art advances in methods, mechanistic insights, and drug discovery efforts across these interrelated fields. Furthermore, results from exome- and genome-wide sequencing efforts point toward major roles for chromatin regulatory machinery in cancer. These data emphasize the immediate need for mechanistic understanding and, in parallel, the identification of novel strategies toward therapeutic targeting for this class of cancer drivers. This conference will help to foster interactions and new connections between basic biologists focused on chromatin architecture, structure, and function with translational biologists focused on model systems for mechanistic interrogation. Participants will attend sessions that will feature the presentation of new methods and techniques in systems biology, imaging, genomics, and drug discovery approaches. Other topics will explore the roles for enhancer structure, genome organization and topology on DNA accessibility and gene expression. Finally, this conference will expose trainees across a wide range of international, interdisciplinary laboratories to cutting edge science in cancer epigenetics and related fields, hoping to further their interests and commitment to this area of biologic research. The concurrent joint conference on 'Gene Regulation: From Mechanisms to Disease' is another unique, one-of-a-kind aspect of this conference, allowing participants to attend talks in their area of interest across two closely-related disciplines. Our cancer-centered audience will have an opportunity to attend select talks as well as two joint sessions, which all the organizers have carefully considered and designed together.

Scholarship Deadline: October 1 2019

Discounted Abstract Deadline: October 1 2019

Abstract Deadline: October 29 2019

Discounted Registration Deadline: November 26 2019

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support from these exhibitors at this conference:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Agios Pharmaceuticals

GlaxoSmithKline UK

GSK Foundation

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA243574-01
Funding for this conference was made possible (in part) by 1R13CA243574-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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