Web Desc
Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities
joint with Gene Regulation: From Mechanisms to Disease
Organizer(s): Cigall Kadoch and Christopher Vakoc
Date: January 26 - 30, 2020
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Incyte Corporation
Summary of Meeting:
The 2020 Keystone Symposia, Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities, in conjunction with the joint conference, Gene Regulation: From Mechanisms to Disease, co-organized by Karen Adelman and Patrick Cramer, will highlight state-of-the art advances in methods, mechanistic insights, and drug discovery efforts across these interrelated fields. Furthermore, results from exome- and genome-wide sequencing efforts point toward major roles for chromatin regulatory machinery in cancer. These data emphasize the immediate need for mechanistic understanding and, in parallel, the identification of novel strategies toward therapeutic targeting for this class of cancer drivers. This conference will help to foster interactions and new connections between basic biologists focused on chromatin architecture, structure, and function with translational biologists focused on model systems for mechanistic interrogation. Participants will attend sessions that will feature the presentation of new methods and techniques in systems biology, imaging, genomics, and drug discovery approaches. Other topics will explore the roles for enhancer structure, genome organization and topology on DNA accessibility and gene expression. Finally, this conference will expose trainees across a wide range of international, interdisciplinary laboratories to cutting edge science in cancer epigenetics and related fields, hoping to further their interests and commitment to this area of biologic research. The concurrent joint conference on 'Gene Regulation: From Mechanisms to Disease' is another unique, one-of-a-kind aspect of this conference, allowing participants to attend talks in their area of interest across two closely-related disciplines. Our cancer-centered audience will have an opportunity to attend select talks as well as two joint sessions, which all the organizers have carefully considered and designed together.
Scholarship Deadline: October 1 2019
Discounted Abstract Deadline: October 1 2019
Abstract Deadline: October 29 2019
Discounted Registration Deadline: November 26 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Incyte Corporation
We gratefully acknowledge additional support from these exhibitors at this conference:
10x GenomicsArima Genomics, Inc.Dovetail GenomicsEclipse Bioinnovations, Inc.EpiCypher
We gratefully acknowledge additional support for this conference from:
American Society of Gene & Cell Therapy (ASGCT)Zymo Research Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Agios Pharmaceuticals

GlaxoSmithKline UK

GSK Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA243574-01
Funding for this conference was made possible (in part) by 1R13CA243574-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, January 26 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, January 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 1 of 3
* Karen Adelman, Harvard Medical School, USA

Monday, January 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 2 of 3
* Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA

Monday, January 27 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 3 of 3
Shelley L. Berger, University of Pennsylvania, USA
Epigenetic Pathways as Targets in Human Cancer

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Liling Wan, University of Pennsylvania, USA

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
Eva Nogales, University of California, Berkeley, USA
Structural Insights into the Regulation of the Gene Silencer PRC2

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom


Coffee Break

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
Mechanisms of Chromatin Transcription

Monday, January 27 | 9:00AM - 11:00AM
Fundamentals of Gene Regulation (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Dylan J. Taatjes, University of Colorado Boulder, USA
Selective Inhibition of Human CDK7 Reveals High-Confidence Targets and Suggests a New Model for TFIIH Function in Transcription

Monday, January 27 | 11:15AM - 5:00PM
On Own for Lunch


Monday, January 27 | 11:15AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
Room: Grays/Longs Peak

Speaker 1 of 8
* Yael David, Memorial Sloan Kettering Cancer Center, USA

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
Room: Grays/Longs Peak

Speaker 2 of 8
Alessandro Gardini, Wistar Institute, USA
A Role for Nuclear PP2A in Transcription Regulation

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
Room: Grays/Longs Peak

Speaker 3 of 8
Ruhee Dere, Baylor College of Medicine, USA
KDM4A Regulates Microtubule Methylation and Genomic Instability

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
Room: Grays/Longs Peak

Speaker 4 of 8
Gerard L. Brien, Smurfit Institute of Genetics, Ireland
Disruption of Development Enhancer and PRC2 Function by H3K27M in DIPG

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
Room: Grays/Longs Peak

Speaker 5 of 8
Tharu M. Fernando, Genentech, Inc., USA
Characterization and Therapeutic Implications of SMARCA4 Mutations in Cancer

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
Room: Grays/Longs Peak

Speaker 6 of 8
Noa Furth, Weizmann Institute of Science, Israel
The Combinatorial Epigenetic Landscape of High Grade Pediatric Gliomas in Single Molecule Resolution

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
Room: Grays/Longs Peak

Speaker 7 of 8
Brian J. Abraham, St. Jude Children's Research Hospital, USA
Predicting Master Transcription Factors from Pan-Cancer Expression Data

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1
Room: Grays/Longs Peak

Speaker 8 of 8
Elizabeth Allene Martin, University of California San Francisco, USA
OGT, a Nutrient-Sensing Enzyme, Controls DNA Methylation in Mouse Embryonic Stem Cells

Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

This session is from Gene Regulation
Room: Quandary Peak

Speaker 1 of 8
* Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

This session is from Gene Regulation
Room: Quandary Peak

Speaker 2 of 8
Ksenia Finogenova, Max-Planck Institute of Biochemistry, Germany
Structural Basis of Nucleosome Binding by PRC2 and Its Inhibition by H3K36 Methylation


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

This session is from Gene Regulation
Room: Quandary Peak

Speaker 3 of 8
François Robert, Institut de Recherches Cliniques de Montreal, Canada
Transcribed Chromatin, Rather Than RNA Polymerase II Itself, Recruits FACT to Active Genes


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

This session is from Gene Regulation
Room: Quandary Peak

Speaker 4 of 8
Jitendra Thakur, Fred Hutchinson Cancer Research Center, USA
Architectural RNA Is Required for Heterochromatin Organization


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

This session is from Gene Regulation
Room: Quandary Peak

Speaker 5 of 8
Gilad Yaakov, Weizmann Institute of Israel, Israel
A Novel Histone Molecular Timer Reveals Minute-Resolution Nucleosome Turnover


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

This session is from Gene Regulation
Room: Quandary Peak

Speaker 6 of 8
Keda Zhou, University of Colorado Boulder, USA
FACT Caught in the Act of Manipulating the Nucleosome


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

This session is from Gene Regulation
Room: Quandary Peak

Speaker 7 of 8
Giulia Cova, Max Planck Institute for Molecular Genetics, Germany
TAD-Shuffling at the FGF8 Locus Causes Split-Hand/Foot Malformation Type 3


Monday, January 27 | 2:30PM - 4:30PM
Workshop 1: Structure and Function of Chromatin

This session is from Gene Regulation
Room: Quandary Peak

Speaker 8 of 8
Yuan He, Northwestern University, USA
Cryo-Electron Microscopy Structure of a Nucleosome-Bound SWI/SNF Chromatin Remodeling Complex


Monday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 1 of 7
* Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany

Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 2 of 7
Ashby Morrison, Stanford University, USA
Epigenetic Regulation of Carcinogen Susceptibility

Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 3 of 7
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Gene Dysregulation, Condensates and Drugs

Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 4 of 7
Bin Wu, Agios Pharmaceuticals Inc, USA
Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1-mutant Relapsed or Refractory Acute Myeloid Leukemia

Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 5 of 7
Liling Wan, University of Pennsylvania, USA
Short Talk: Chromatin Reader Dysregulation in Cell Fate Control and Cancer

Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 6 of 7
Lena Afeyan, Massachusetts Institute of Technology, USA
Short Talk: Formation and Regulation of Estrogen Receptor-Mediated Transcriptional Condensates in Breast Cancer

Monday, January 27 | 5:00PM - 7:15PM
Enhancer Structure in Cancer
Room: Grays/Longs Peak
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
Speaker 7 of 7
Lukas Chavez, University of California, San Diego, USA
Short Talk: Targeting of Tumors as Informed by Oncogenic 3D Genome Organization

Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
This session is from Gene Regulation
Room: Quandary Peak

Speaker 1 of 6
* Karla M. Neugebauer, Yale University, USA


Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
This session is from Gene Regulation
Room: Quandary Peak

Speaker 2 of 6
Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Living Mammalian Cells


Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
This session is from Gene Regulation
Room: Quandary Peak

Speaker 3 of 6
Danette L. Daniels, Promega Corporation, USA
Kinetic Monitoring of Protein Interactions and Targeted Degradation in Live Cells


Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
This session is from Gene Regulation
Room: Quandary Peak

Speaker 4 of 6
Jennifer F. Kugel, University of Colorado Boulder, USA
Short Talk: Single-Molecule Studies Resolve Heterogeneity in the Activity of Transcribing Complexes to Reveal Steps in Transcription That Dictate the Activity of Pol II


Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
This session is from Gene Regulation
Room: Quandary Peak

Speaker 5 of 6
Benjamin R. Sabari, University of Texas Southwestern Medical Center, USA
Short Talk: Enhancer Features that Drive Formation of Transcriptional Condensates


Monday, January 27 | 5:00PM - 7:00PM
Imaging of Transcriptional Dynamics
This session is from Gene Regulation
Room: Quandary Peak

Speaker 6 of 6
Michael S. Levine, Princeton University, USA
Visualizing Developmental Dynamics in Drosophila Embryos


Monday, January 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, January 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 1 of 7
* Ali Shilatifard, Northwestern University, USA

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 2 of 7
Tony Kouzarides, University of Cambridge, UK
Modifications of RNA: Their Function and Role in Cancer

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 3 of 7
Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and lncRNAs

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom


Coffee Break

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 5 of 7
Anne Brunet, Stanford University, USA
Epigenetic Regulation of Stem Cell Aging

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 6 of 7
Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain
Epigenetic Influence of Our (Fatty) Diet on Metastatic-Initiating Cells

Tuesday, January 28 | 8:00AM - 11:00AM
Epigenetic Modifications of Chromatin and RNA (Joint)
Room: Columbine Ballroom

Speaker 7 of 7
Peter Hsu, University of Washington, USA
Short Talk: Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS


Tuesday, January 28 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, January 28 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 1 of 6
Bin Wu, Agios Pharmaceuticals Inc, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 2 of 6
Krista Lynn Bledsoe, Cell Press, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 3 of 6
Senthilkumar Cinghu, NIEHS, National Institutes of Health, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 4 of 6
Scott A. Armstrong, Dana-Farber Cancer Institute, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 5 of 6
Yael David, Memorial Sloan Kettering Cancer Center, USA

Tuesday, January 28 | 2:30PM - 4:30PM
Career Roundtable
Room: Castle Peaks I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 6 of 6
Raphaël Rodriguez, Institut Curie, France

Tuesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 1 of 6
* Paola Grandi, Cellzome AG, a GSK Company, Germany

Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 2 of 6
Hao Zhu, University of Texas Southwestern Medical Center, USA
Targeting Chromatin Remodeling Complexes for Tissue Regeneration

Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 3 of 6
Paola Grandi, Cellzome AG, a GSK Company, Germany
Click Chemistry and Preclinical Evaluation of Targeted Epigenetic Therapies

Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 4 of 6
Liis Uuskula-Reimand, SickKids Research Institute, Canada
Short Talk: Enhancer Function and Topoisomerase II beta in Hepatocellular Carcinoma

Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 5 of 6
Nicholas C. Gomez, Rockefeller University, USA
Short Talk: Stem Cell Reprogramming during Oncogenesis

Tuesday, January 28 | 5:00PM - 7:00PM
Human Disease Models of Chromatin Regulation
Room: Grays/Longs Peak
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
Speaker 6 of 6
Raphaël Rodriguez, Institut Curie, France
Short Talk: CD44 Regulates Epigenetic Plasticity by Mediating Iron Endocytosis

Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
This session is from Gene Regulation
Room: Quandary Peak

Speaker 1 of 6
* Alexander Stark, Research Institute of Molecular Pathology - IMP, Austria


Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
This session is from Gene Regulation
Room: Quandary Peak

Speaker 2 of 6
Yongsheng Shi, University of California, Irvine, USA
Probing 3’ End Formation of Coding and Non Coding RNAs


Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
This session is from Gene Regulation
Room: Quandary Peak

Speaker 3 of 6
Karla M. Neugebauer, Yale University, USA
Dynamics of Co-Transcriptional Splicing


Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
This session is from Gene Regulation
Room: Quandary Peak

Speaker 4 of 6
Daisy Castillo-Guzman, University of California, Davis, USA
Short Talk: Uncovering Novel Roles for Splicing Factor SF3B1 in Transcription Dynamics and R-Loop Metabolism


Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
This session is from Gene Regulation
Room: Quandary Peak

Speaker 5 of 6
Megan Insco, Boston Children's Hospital, USA
Short Talk: CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts


Tuesday, January 28 | 5:00PM - 7:00PM
Coupling of Transcription and RNA Processing
This session is from Gene Regulation
Room: Quandary Peak

Speaker 6 of 6
Torben Heick Jensen, Aarhus University, Denmark
Transcription Termination and Links to RNA Processing/Decay Pathways


Tuesday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, January 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 1 of 8
* Adrian P. Bracken, Trinity College Dublin, Ireland

Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 2 of 8
Ali Shilatifard, Northwestern University, USA
Principles of Epigenetics and Chromatin in Development and Human Disease

Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 3 of 8
Scott A. Armstrong, Dana-Farber Cancer Institute, USA
Targeting Chromatin Complexes in Leukemia

Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.

Coffee Break

Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 5 of 8
Christopher Vakoc, Cold Spring Harbor Laboratory, USA
Squamous Trans-Differentiation in Pancreatic Cancer

Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 6 of 8
Tannishtha Reya, University of California, San Diego, USA
Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance

Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 7 of 8
Jeff Magee, Washington University, USA
Short Talk: KMT2C/MLL3 Deletions Convey a Selective Advantage to Multiply-Divided HSCs by Blunting Cytokine- and Stress-Induced Lineage Commitment

Wednesday, January 29 | 8:00AM - 11:00AM
Synthetic Lethal Vulnerabilities in Cancer
Room: Grays/Longs Peak
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
Speaker 8 of 8
Jiangbin Ye, Stanford University, USA
Short Talk: Deciphering Warburg Effect: The Connection between Metabolism, Epigenetics and Tumor Differentiation

Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak

Speaker 1 of 9
* Torben Heick Jensen, Aarhus University, Denmark


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak

Speaker 2 of 9
Geeta J. Narlikar, University of California, San Francisco, USA
Can Phase-Separation Explain the Biological Properties of Heterochromatin?


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak

Speaker 3 of 9
Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Low Complexity Sequences in Gene Regulation


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak


Coffee Break


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak

Speaker 5 of 9
Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Genome-Wide Maps of Enhancer-Gene Connections Link Immune Disease Risk Variants to Target Genes


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak

Speaker 6 of 9
R. Babak Faryabi, University of Pennsylvania, USA
Short Talk: Notch-Instructed 3D Cancer Genomes


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak

Speaker 7 of 9
Tom Owen-Hughes, University of Dundee, UK
Short Talk: Selective Enhancer Decommissioning Following Acute Depletion of the ARID1A Subunit of Mammalian SWI/SNF Complexes


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak

Speaker 8 of 9
Alexander Stark, Research Institute of Molecular Pathology - IMP, Austria
Decoding Regulation: Global Screens to Uncover How Sequence Dictates Gene Activity


Wednesday, January 29 | 8:00AM - 11:15AM
Communication between Promoters and Enhancers
This session is from Gene Regulation
Room: Quandary Peak

Speaker 9 of 9
Karen Adelman, Harvard Medical School, USA
Interactions Between Coding and Non-Coding RNA loci


Wednesday, January 29 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 29 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 1 of 5
* Alessandro Gardini, Wistar Institute, USA

Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 2 of 5
Adrian P. Bracken, Trinity College Dublin, Ireland
PRC2 Complexes in Development and Disease

Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 3 of 5
Marcus Buschbeck, Josep Carreras Leukaemia Research Institute, Spain
Histone Variants Regulate 3D Chromatin Architecture and the Inflammatory Response of Cancer Cells

Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 4 of 5
Yael David, Memorial Sloan Kettering Cancer Center, USA
Revealing Cancer-Associated Epigenetic Events using Novel Chemical Tools

Wednesday, January 29 | 5:00PM - 7:00PM
Developmental Epigenetics and Transcription
Room: Grays/Longs Peak
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
Speaker 5 of 5
Siddhant U. Jain, University of Wisconsin-Madison, USA
Short Talk: Inhibition of PRC2 Activity by EZHIP and H3 K27M in High-Grade Pediatric Gliomas

Wednesday, January 29 | 5:00PM - 7:00PM
Defining Regulation in Single-Cell Cells
This session is from Gene Regulation
Room: Quandary Peak

Speaker 1 of 4
* Emma Farley, University of California, San Diego, USA


Wednesday, January 29 | 5:00PM - 7:00PM
Defining Regulation in Single-Cell Cells
This session is from Gene Regulation
Room: Quandary Peak

Speaker 2 of 4
Rickard Sandberg, Karolinska Institutet, Sweden
Decoding Transcriptional Regulation and Kinetics Using Single-Cell Transcriptomics


Wednesday, January 29 | 5:00PM - 7:00PM
Defining Regulation in Single-Cell Cells
This session is from Gene Regulation
Room: Quandary Peak

Speaker 3 of 4
William J. Greenleaf, Stanford University, USA
A Single Cell Framework for Multi-Omic Analysis of Disease Identifies Malignant Regulatory Signatures


Wednesday, January 29 | 5:00PM - 7:00PM
Defining Regulation in Single-Cell Cells
This session is from Gene Regulation
Room: Quandary Peak

Speaker 4 of 4
Sarah Hainer, University of Pittsburgh, USA
Short Talk: Profiling of Pluripotency Factors in Single Cells and Early Embryos


Wednesday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, January 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 1 of 8
* Jane A. Skok, New York University School of Medicine, USA

Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 2 of 8
Eric R. Olson, Syros Pharmaceuticals, USA
Therapeutic Applications of Altering Tumor Cell Gene Expression

Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 3 of 8
Rab K. Prinjha, GlaxoSmithKline, UK
Epigenetic Inhibition in Cancer: Emerging Strategies and Approaches

Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.

Coffee Break

Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 5 of 8
Jane A. Skok, New York University School of Medicine, USA
CTCFL and its Impact on Gene Regulation and Interplay with CTCF Function

Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 6 of 8
Daniel De Carvalho, University Health Network, Canada
Epigenetic Regulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer

Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 7 of 8
Allyson M. Freedy, Harvard University, USA
Short Talk: CRISPR-suppressor Scanning Reveals a Nonenzymatic Role of LSD1 in AML

Thursday, January 30 | 8:00AM - 11:00AM
Chromatin Regulatory Modulation: Novel Small Molecule-Based
Approaches

Room: Grays/Longs Peak
This session will highlight new epigenetic strategies to treat cancers.
Speaker 8 of 8
Jacob G. Kirkland, Stanford University, USA
Short Talk: Chromatin Regulators Mediate Anthracycline Sensitivity in Breast Cancer

Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak

Speaker 1 of 9
* Michael S. Levine, Princeton University, USA


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak

Speaker 2 of 9
Emma Farley, University of California, San Diego, USA
Regulatory Principles Governing Enhancer Function in Development and Disease


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak

Speaker 3 of 9
François Fuks, Université Libre de Bruxelles, Belgium
Transcriptome-Wide Distribution and Function of RNA Modifications


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak


Coffee Break


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak

Speaker 5 of 9
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Small Non-Coding RNA in Replication and Quiescence


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak

Speaker 6 of 9
Laura A. Banaszynski, University of Texas Southwestern Medical Center, USA
Short Talk: Mechanisms of Enhancer Activation Using the Histone Variant H3.3


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak

Speaker 7 of 9
Wenqing Cai, Boston Children's Hospital, USA
Short Talk: Enhancer-Dependence of Cell-Type-Specific Gene Expression Increases with Developmental Age


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak

Speaker 8 of 9
Raja Jothi, NIEHS, National Institutes of Health, USA
Short Talk: Bivalent Chromatin Does Not Poise Genes for Rapid Activation


Thursday, January 30 | 8:00AM - 11:15AM
Gene Control in Development
This session is from Gene Regulation
Room: Quandary Peak

Speaker 9 of 9
Kathrin Plath, University of California, Los Angeles, USA
A New Mode of Xist Action


Thursday, January 30 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
Room: Grays/Longs Peak

Speaker 1 of 8
* Chao Lu, Columbia University, USA

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
Room: Grays/Longs Peak

Speaker 2 of 8
SrinivasVinod Saladi, Harvard Medical School, USA
Revealing Oncogenic Role of ACTL6A, Subunit of SWI/SNF Chromatin Remodeling Complex in Squamous Cancers

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
Room: Grays/Longs Peak

Speaker 3 of 8
Riyad N.H. Seervai, Baylor College of Medicine, USA
The Histone Methyltransferase SETD2 Is a Tumor Suppressor with Actin Lysine Methyltransferase Activity

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
Room: Grays/Longs Peak

Speaker 4 of 8
Michelle M. Mitchener, Princeton University, USA
Biochemical and Cellular Libraries Reveal Cancer-Associated Histone Mutations that Perturb Nucleosome Structure

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
Room: Grays/Longs Peak

Speaker 5 of 8
Adam D. Durbin, Dana-Farber Cancer Institute, USA
EP300 Controls the Oncogenic Enhancer Landscape of High-Risk Neuroblastoma

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
Room: Grays/Longs Peak

Speaker 6 of 8
Chao Lu, Columbia University, USA
Combinatorial Targeting of Chromatin and Metabolism for Cancer Therapy

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
Room: Grays/Longs Peak

Speaker 7 of 8
Bethany A. Buck-Koehntop, University of Utah, USA
Investigating the Methyl-CpG Binding Protein ZBTB38 in Mediating Epigenetic-Based Transcription in Cancer

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2
Room: Grays/Longs Peak

Speaker 8 of 8
Jarod Waybright, University of North Carolina at Chapel Hill, USA
Reader's Block: Development of Chemical Tools Targeting the Methyl-Lysine Reader MPP8

Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

This session is from Gene Regulation
Room: Quandary Peak

Speaker 1 of 7
* Jennifer F. Kugel, University of Colorado Boulder, USA


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

This session is from Gene Regulation
Room: Quandary Peak

Speaker 2 of 7
Alon Goren, University of California, San Diego, USA
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

This session is from Gene Regulation
Room: Quandary Peak

Speaker 3 of 7
Gabriella E. Martyn, University of New South Wales, Australia
Revealing the Mechanism Behind Naturally Occurring Mutations which Elevate Fetal Hemoglobin


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

This session is from Gene Regulation
Room: Quandary Peak

Speaker 4 of 7
Kirstin Meyer, University of California, San Francisco, USA
Optogenetic Dissection of YAP Transcriptional Regulation


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

This session is from Gene Regulation
Room: Quandary Peak

Speaker 5 of 7
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Discovering the MYC Proteome Reveals Novel Mechanisms of Oncogenesis


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

This session is from Gene Regulation
Room: Quandary Peak

Speaker 6 of 7
Xavier J. Rambout, University of Rochester Medical Center, USA
Transcriptional Coactivator PGC-1a Contains a Novel CBP80-Binding Motif That Orchestrates Efficient Target-Gene Expression


Thursday, January 30 | 2:30PM - 4:30PM
Workshop 2: Dynamic Gene Regulation

This session is from Gene Regulation
Room: Quandary Peak

Speaker 7 of 7
Haoze Vincent Yu, University of Southern California, USA
Feed-Forward Pioneer Factor Activity Underlies Mammalian Mechanoreceptor Cell Differentiation


Thursday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 1 of 5
* Christopher Vakoc, Cold Spring Harbor Laboratory, USA

Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 2 of 5
Luciano Di Croce, CRG - Center for Genomic Regulation, Spain
Molecular Mechanisms Governing Cell Identity, Differentiation and Cancer Processes

Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 3 of 5
Jikui Song, University of California, Riverside, USA
Structural Studies in DNA Methylation and Links to Human Cancer

Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 4 of 5
Agata E. Lemiesz, Rockefeller University, USA
Short Talk: Novel H2B “Oncohistones” Impact Cellular Differentiation and Signaling

Thursday, January 30 | 5:00PM - 7:00PM
Chromatin Structure and Function in Cancer
Room: Grays/Longs Peak
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
Speaker 5 of 5
Nazar Mashtalir, Dana-Farber Cancer Institute, USA
Short Talk: Mechanism of Cancer-Specific SWI/SNF Complex Targeting by the SS18-SSX Fusion Oncogene

Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
This session is from Gene Regulation
Room: Quandary Peak

Speaker 1 of 5
Eileen E.M. Furlong, European Molecular Biology Laboratory, Germany
Enhancer Promoter Communication During Embryonic Development


Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
This session is from Gene Regulation
Room: Quandary Peak

Speaker 2 of 5
Shasha Chong, University of California, Berkeley, USA
Dynamic and Selective Low-Complexity Domain Interactions Control Gene Transcription: A Single-Molecule Study


Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
This session is from Gene Regulation
Room: Quandary Peak

Speaker 3 of 5
Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
Short Talk: L1 RNA Knockdown Averts Heterochromatin Loss and Premature Ageing Phenotypes


Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
This session is from Gene Regulation
Room: Quandary Peak

Speaker 4 of 5
Clodagh C. O'Shea, The Salk Institute for Biological Studies, USA
Cracking the Nuclear Codes: Finding Order in Chaos


Thursday, January 30 | 5:00PM - 7:00PM
Higher Order Interactions in Transcription Regulation
This session is from Gene Regulation
Room: Quandary Peak

Speaker 5 of 5
Aaron Johnson, University of Colorado School of Medicine, USA
Short Talk: RNA Matchmaking Remodels LncRNA Structure and Promotes PRC2 Activity


Thursday, January 30 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Grays/Longs Peak

Speaker 1 of 1
† Christopher Vakoc, Cold Spring Harbor Laboratory, USA

Thursday, January 30 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Gene Regulation
Room: Quandary Peak


Thursday, January 30 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, January 30 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, January 31 | 10:24AM - 10:24AM
Departure


*Session Chair.