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Web Desc
Diabetes: Glucose Control and Beyond
joint with Islet Biology: From Gene to Cell to Micro-Organ
Organizer(s): Alan D. Attie and Deborah M. Muoio
Date: January 27 - 31, 2020
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Sponsored by Novo Nordisk A/S
Summary of Meeting:
Modern technology has created a favorable climate for the “perfect metabolic storm”. Triggered by lifestyle habits that promote overnutrition and inactivity, Westernized societies are experiencing epidemic rates of obesity and its attendant co-morbidities. Foremost among these is type 2 diabetes mellitus, which is projected to reach a global prevalence of 10% by the year 2045. This grim epidemiological forecast has inspired intense efforts to unravel the molecular mechanisms that link positive energy balance to glucose intolerance and metabolic decline. This conference will assemble international leaders and rising stars in diverse biomedical disciplines with common interests in understanding and combatting cardiometabolic diseases. The program showcases new insights into the molecular underpinnings of obesity-induced dysfunction of the major peripheral organs that coordinate energy flux and glucose control: skeletal and cardiac muscles, the pancreas, adipose tissue, the liver and gut. Thematic emphasis will center on nutrient sensing and signaling, inter-organ crosstalk, mechanisms of insulin resistance, mitochondrial bioenergetics, islet biology and genetics of diabetes. A major goal of the conference is to provide a forum that encourages interactions between basic and translational scientists at all career levels to critically evaluate recent advances and current controversies. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on Islet Biology: From Gene to Cell to Micro-Organ, which will consider metabolism in relation to islet function, in addition to studies of islet cell plasticity and differentiation.
Scholarship Deadline: October 2 2019
Discounted Abstract Deadline: October 2 2019
Abstract Deadline: October 30 2019
Discounted Registration Deadline: December 3 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novo Nordisk A/S
We gratefully acknowledge additional support from these exhibitors at this conference:
Mercodia, Inc.Sable Systems International
We gratefully acknowledge additional support for this conference from:
ALPCO
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Pfizer Research Technology Center
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK123984-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 27 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sweeney Ballroom Foyer


Monday, January 27 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sweeney F
No registration fees are used to fund alcohol served at this function.

Tuesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F


Tuesday, January 28 | 7:30AM - 8:00AM
Poster Setup
Room: Sweeney F


Tuesday, January 28 | 8:00AM - 7:00PM
Poster Viewing
Room: Sweeney F


Tuesday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 3
* Patrick MacDonald, University of Alberta, Canada

Tuesday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 3
* Alan D. Attie, University of Wisconsin-Madison, USA

Tuesday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 3
Morris J. Birnbaum, Pfizer Inc., USA
The Development of Therapeutics for T2DM and Related Diseases

Tuesday, January 28 | 9:00AM - 11:30AM
All About Insulin: Signaling, Secretion, and Action (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 8
* Patrick MacDonald, University of Alberta, Canada

Tuesday, January 28 | 9:00AM - 11:30AM
All About Insulin: Signaling, Secretion, and Action (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 8
* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Tuesday, January 28 | 9:00AM - 11:30AM
All About Insulin: Signaling, Secretion, and Action (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 8
Michael P. Czech, University of Massachusetts Medical School, USA
Molecular Mechanisms of Insulin Resistance

Tuesday, January 28 | 9:00AM - 11:30AM
All About Insulin: Signaling, Secretion, and Action (Joint)
Room: Sweeney Ballroom A-E


Coffee Break

Tuesday, January 28 | 9:00AM - 11:30AM
All About Insulin: Signaling, Secretion, and Action (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 8
Maureen Anne Gannon, Vanderbilt University Medical Center, USA
Promoting ß-cell Survival and Preserving Functional ß-cell Mass by Targeting PGE2 Receptors

Tuesday, January 28 | 9:00AM - 11:30AM
All About Insulin: Signaling, Secretion, and Action (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 8
Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
The Systemic Integration of Hepatic Insulin Resistance

Tuesday, January 28 | 9:00AM - 11:30AM
All About Insulin: Signaling, Secretion, and Action (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 8
Arya Mani, Yale University, USA
Short Talk: Mutations in the Cela2a Gene Unravel the Function of the Encoded Protein as a Novel Incretin

Tuesday, January 28 | 9:00AM - 11:30AM
All About Insulin: Signaling, Secretion, and Action (Joint)
Room: Sweeney Ballroom A-E

Speaker 8 of 8
Amelia K. Linnemann, Indiana University School of Medicine, USA
Short Talk: IFN-alpha Mediates Heterogenous ROS Accumulation in Human Islet Beta-Cells

Tuesday, January 28 | 11:30AM - 12:15PM
Lunch
Room: Sweeney F


Tuesday, January 28 | 12:00PM - 2:30PM
Poster Session 1
Room: Sweeney F


Tuesday, January 28 | 2:30PM - 3:30PM
Workshop: Therapeutic Strategies for Targeting Insulin Actio
n
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Silvia Corvera, University of Massachusetts Medical School, USA

Tuesday, January 28 | 2:30PM - 3:30PM
Workshop: Therapeutic Strategies for Targeting Insulin Actio
n
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Thiago M. Batista, Joslin Diabetes Center, USA
Dissection of Protein Phosphorylation Networks Underlying Muscle Insulin Resistance in Type 2 Diabetes

Tuesday, January 28 | 2:30PM - 3:30PM
Workshop: Therapeutic Strategies for Targeting Insulin Actio
n
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Jaroslawna Meister, NIDDK, National Institutes of Health, USA
Role of ß2-adrenergic Receptor Signaling in Skeletal Muscle Glucose Metabolism

Tuesday, January 28 | 2:30PM - 3:30PM
Workshop: Therapeutic Strategies for Targeting Insulin Actio
n
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Paul M. Titchenell, University of Pennsylvania, USA
Regulation of Skeletal Muscle Metabolism by Insulin Signaling

Tuesday, January 28 | 2:30PM - 3:30PM
Workshop: Therapeutic Strategies for Targeting Insulin Actio
n
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Jacqueline Stoeckli, University of Sydney, Australia
ABHD15: A Novel Player in Insulin Regulation of Lipolysis in Adipocytes

Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 1 of 9
* Karen L. Mohlke, University of North Carolina at Chapel Hill, USA


Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 2 of 9
* James D. Johnson, University of British Columbia, Canada


Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 3 of 9
Joseph Angleson, University of Denver, USA
Melanocortin Receptor-4 Regulates a-Cell Function and the Counter-Regulatory Response to Insulin-Induced Hypoglycemia in Mice


Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 4 of 9
Malin Fex, Lund University, Sweden
Loss of Melatonin Type 1A Receptor Results in Dysregulated Whole-Body Metabolism Characterised by Hyperglucagonemia, Glucose Intolerance and Enhanced Insulin Secretion


Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 5 of 9
YongKyung Kim, University of Colorado Anschutz Medical Campus, USA
PTPN2 Plays a Novel Role in the Beta Cells to Regulate Mitochondrial Function in Type 1 Diabetes Progression


Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 6 of 9
Taiyi Kuo, Columbia University, USA
Identification of C2CD4A as a Human Diabetes Susceptibility Gene with a Role in ß-Cell Insulin Secretion


Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 7 of 9
Haopeng Lin, Alberta Diabetes Institute, Canada
SENP1 in Compensation and Failure of Insulin Secretion with High-Fat Diet


Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 8 of 9
Dapeng Yang, Memorial Sloan Kettering Cancer Center, USA
Sequential CRISPR Screening Uncovers a Novel Role of HHEX in Specifying Human Pancreatic Differentiation


Tuesday, January 28 | 2:30PM - 4:30PM
Workshop 1: What Do GWAS Genes Do in Islets?
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 9 of 9
Taylor S. Morriseau, University of Manitoba, Canada
New Insights into the HNF-1aG319S Variant in Early-Onset T2D Among Manitoba Indigenous Youth


Tuesday, January 28 | 3:30PM - 4:30PM
Panel Discussion
Room: Sweeney Ballroom C-E

Speaker 1 of 7
* David E. James, University of Sydney, Australia

Tuesday, January 28 | 3:30PM - 4:30PM
Panel Discussion
Room: Sweeney Ballroom C-E

Speaker 2 of 7
* Deborah M. Muoio, Duke University Medical Center, USA

Tuesday, January 28 | 3:30PM - 4:30PM
Panel Discussion
Room: Sweeney Ballroom C-E

Speaker 3 of 7
Morris J. Birnbaum, Pfizer Inc., USA

Tuesday, January 28 | 3:30PM - 4:30PM
Panel Discussion
Room: Sweeney Ballroom C-E

Speaker 4 of 7
Michael P. Czech, University of Massachusetts Medical School, USA

Tuesday, January 28 | 3:30PM - 4:30PM
Panel Discussion
Room: Sweeney Ballroom C-E

Speaker 5 of 7
Peter A. Crawford, University of Minnesota, USA

Tuesday, January 28 | 3:30PM - 4:30PM
Panel Discussion
Room: Sweeney Ballroom C-E

Speaker 6 of 7
Daniel P. Kelly, University of Pennsylvania, USA

Tuesday, January 28 | 3:30PM - 4:30PM
Panel Discussion
Room: Sweeney Ballroom C-E

Speaker 7 of 7
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Tuesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom Foyer


Tuesday, January 28 | 5:00PM - 7:00PM
Novel Approaches for Monitoring Carbon Traffic Control
Room: Sweeney Ballroom C-E

Speaker 1 of 6
* Peter A. Crawford, University of Minnesota, USA

Tuesday, January 28 | 5:00PM - 7:00PM
Novel Approaches for Monitoring Carbon Traffic Control
Room: Sweeney Ballroom C-E

Speaker 2 of 6
Joshua D. Rabinowitz, Princeton University, USA
Isotope Tracing for Deciphering Metabolic Network Usage

Tuesday, January 28 | 5:00PM - 7:00PM
Novel Approaches for Monitoring Carbon Traffic Control
Room: Sweeney Ballroom C-E

Speaker 3 of 6
David H. Wasserman, Vanderbilt University School of Medicine, USA
Extramyocellular Barriers to Insulin-Stimulated Muscle Glucose Uptake

Tuesday, January 28 | 5:00PM - 7:00PM
Novel Approaches for Monitoring Carbon Traffic Control
Room: Sweeney Ballroom C-E

Speaker 4 of 6
Barbara M. Bakker, University Medical Center Groningen, Netherlands
Modeling for Young and Old: Tackling the Complexity of Fatty Acid Oxidation in Metabolic Disease

Tuesday, January 28 | 5:00PM - 7:00PM
Novel Approaches for Monitoring Carbon Traffic Control
Room: Sweeney Ballroom C-E

Speaker 5 of 6
Maciek R. Antoniewicz, University of Delaware, USA
Short Talk: Metabolite Cross-Feeding Interactions in Adipocyte-Hepatocyte Co-Cultures Elucidated with a Novel 13C-Metabolic Flux Analysis Technique


Tuesday, January 28 | 5:00PM - 7:00PM
Novel Approaches for Monitoring Carbon Traffic Control
Room: Sweeney Ballroom C-E

Speaker 6 of 6
Jose M. Orozco, Massachusetts Institute of Technology, USA
Short Talk: Dihydroxyacetone Phosphate Signals Glucose Availability to mTORC1

Tuesday, January 28 | 5:00PM - 7:00PM
Islet Plasticity
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 1 of 7
* Jean Buteau, University of Alberta, Canada


Tuesday, January 28 | 5:00PM - 7:00PM
Islet Plasticity
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 2 of 7
* Bridget Wagner, Broad Institute, USA


Tuesday, January 28 | 5:00PM - 7:00PM
Islet Plasticity
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 3 of 7
George K. Gittes, Children's Hospital of Pittsburgh of UPMC, USA
Beta Cell Neogenesis and Protection


Tuesday, January 28 | 5:00PM - 7:00PM
Islet Plasticity
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 4 of 7
Julie B. Sneddon, University California, San Francisco, USA
Elucidating Human Endocrine Cell Fate Selection


Tuesday, January 28 | 5:00PM - 7:00PM
Islet Plasticity
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 5 of 7
Seung K. Kim, Stanford University, USA
Alternative Systems to Study Pancreatic Islet Development and Function


Tuesday, January 28 | 5:00PM - 7:00PM
Islet Plasticity
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 6 of 7
Christine A. Beamish, Houston Methodist Research Institute, USA
Short Talk: Loss of Endocrine Cell Identity Correlates with Pre-Surgical HOMA-ß in Patients with Chronic Pancreatitis Undergoing Islet Auto-Transplantation


Tuesday, January 28 | 5:00PM - 7:00PM
Islet Plasticity
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 7 of 7
Mathieu Latreille, Imperial College London, UK
Short Talk: Beta-Cell Dedifferentiation Is Associated with Epithelial-Mesenchymal Transition In Diabetes


Tuesday, January 28 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F


Wednesday, January 29 | 8:00AM - 11:00AM
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?
Room: Sweeney Ballroom C-E

Speaker 1 of 7
* Judith A. Simcox, University of Wisconsin - Madison, USA

Wednesday, January 29 | 8:00AM - 11:00AM
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?
Room: Sweeney Ballroom C-E

Speaker 2 of 7
Richard Veech, NIAAA, National Institutes of Health, USA
The Effects of Ketone Body Metabolism on the Great Controlling Nucleotide Couples and their Application to Common Diseases

Wednesday, January 29 | 8:00AM - 11:00AM
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?
Room: Sweeney Ballroom C-E

Speaker 3 of 7
Peter A. Crawford, University of Minnesota, USA
Tracing the Role of Intrahepatic Ketone Turnover in Fatty Liver Disease

Wednesday, January 29 | 8:00AM - 11:00AM
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?
Room: Sweeney Ballroom C-E


Coffee Break

Wednesday, January 29 | 8:00AM - 11:00AM
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?
Room: Sweeney Ballroom C-E

Speaker 5 of 7
Daniel P. Kelly, University of Pennsylvania, USA
Ketones and Heart Failure

Wednesday, January 29 | 8:00AM - 11:00AM
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?
Room: Sweeney Ballroom C-E

Speaker 6 of 7
Justin Lengfeld, University of Minnesota, USA
Short Talk: Chronic Low-Dose Ethanol Intake Exacerbates High-Fat Diet Induced Hepatic Fibrosis

Wednesday, January 29 | 8:00AM - 11:00AM
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?
Room: Sweeney Ballroom C-E

Speaker 7 of 7
Meilian Liu, University of New Mexico Health Sciences Center, USA
Short Talk: Adipocyte COX-2/PGE2 Pathway is Required for Intermittent Fasting-Induced Treg Development and Improvement of Insulin Sensitivity


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 1 of 10
* Amelia K. Linnemann, Indiana University School of Medicine, USA


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 2 of 10
* Wen-hong Li, UTSW Medical Ctr, USA


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 3 of 10
Sebastian Barg, Uppsala University, Sweden
Exocytosis of Insulin and Glucagon Granules in Type-2 Diabetes


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 4 of 10
Joana Almaca, University of Miami, USA
Control of Islet Hormone Secretion by Vascular Pericytes


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B


Coffee Break


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 6 of 10
Robin A. Kimmel, University Innsbruck, Austria
In Vivo Imaging of Pancreatic Islet Morphogenesis in Zebrafish


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 7 of 10
Stephan Speier, Helmholtz Zentrum München, Germany
Imaging Islet Physiology in situ and in vivo


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 8 of 10
Yu Hsuan Carol Yang, Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Innervation Modulates the Functional Connectivity between Pancreatic Endocrine Cells


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 9 of 10
Nicole Hallahan, University of Sydney, Australia
Short Talk: Reconstruction of the Polar Domains of Pancreatic Beta-Cells Affects Synaptic Protein Localisation and GSIS


Wednesday, January 29 | 8:00AM - 11:15AM
Visualizing Islet Function in vitro, in situ, and in vivo
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 10 of 10
Barak Blum, University of Wisconsin, USA
Short Talk: Roundabout Receptors Regulate Three-Dimensional Architecture and Facilitate Synchronized Ca2+ Oscillations In Vivo in the Islet of Langerhans


Wednesday, January 29 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 29 | 11:00AM - 1:00PM
Poster Setup
Room: Sweeney F


Wednesday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F


Wednesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom Foyer


Wednesday, January 29 | 5:00PM - 7:00PM
Supercomplexities of Mitochondrial Dynamics and Bioenergetic
s

Room: Sweeney Ballroom C-E

Speaker 1 of 6
* Dave Pagliarini, Washington University in St. Louis, USA

Wednesday, January 29 | 5:00PM - 7:00PM
Supercomplexities of Mitochondrial Dynamics and Bioenergetic
s

Room: Sweeney Ballroom C-E

Speaker 2 of 6
Jared Rutter, University of Utah, USA
Metabolism and Cellular Decisions

Wednesday, January 29 | 5:00PM - 7:00PM
Supercomplexities of Mitochondrial Dynamics and Bioenergetic
s

Room: Sweeney Ballroom C-E

Speaker 3 of 6
Orian S. Shirihai, University of California, Los Angeles, USA
Mitochondrial Heterogeneity in the Adipocyte

Wednesday, January 29 | 5:00PM - 7:00PM
Supercomplexities of Mitochondrial Dynamics and Bioenergetic
s

Room: Sweeney Ballroom C-E

Speaker 4 of 6
Deborah M. Muoio, Duke University Medical Center, USA
Understanding and Preventing Lipid-Induced Mitochondrial Stress

Wednesday, January 29 | 5:00PM - 7:00PM
Supercomplexities of Mitochondrial Dynamics and Bioenergetic
s

Room: Sweeney Ballroom C-E

Speaker 5 of 6
Ayon Ibrahim, University of Pennsylvania, USA
Short Talk: Mitochondrial ATP Production Drives Endothelial Fatty Acid Uptake and Transport

Wednesday, January 29 | 5:00PM - 7:00PM
Supercomplexities of Mitochondrial Dynamics and Bioenergetic
s

Room: Sweeney Ballroom C-E

Speaker 6 of 6
Heather A. Lawson, Washington University in St. Louis, USA
Short Talk: Natural Brown Adipose Expansion and Remission of Hyperglycemia in Obese SM/J Mice

Wednesday, January 29 | 5:00PM - 7:00PM
Molecular and Functional Analysis of Islet Cell Heterogeneit
y
This session is from Islet Biology

Room: Sweeney Ballroom A-B

Speaker 1 of 7
* Claes B. Wollheim, University of Geneva Medical Centre, Switzerland


Wednesday, January 29 | 5:00PM - 7:00PM
Molecular and Functional Analysis of Islet Cell Heterogeneit
y
This session is from Islet Biology

Room: Sweeney Ballroom A-B

Speaker 2 of 7
* Maureen Anne Gannon, Vanderbilt University Medical Center, USA


Wednesday, January 29 | 5:00PM - 7:00PM
Molecular and Functional Analysis of Islet Cell Heterogeneit
y
This session is from Islet Biology

Room: Sweeney Ballroom A-B

Speaker 3 of 7
Wen-hong Li, UTSW Medical Ctr, USA
Functional Heterogeneity of Islet beta Cells


Wednesday, January 29 | 5:00PM - 7:00PM
Molecular and Functional Analysis of Islet Cell Heterogeneit
y
This session is from Islet Biology

Room: Sweeney Ballroom A-B

Speaker 4 of 7
Richard KP Benninger, University of Colorado, USA
Imaging Islet Heterogeneity and Connectivity


Wednesday, January 29 | 5:00PM - 7:00PM
Molecular and Functional Analysis of Islet Cell Heterogeneit
y
This session is from Islet Biology

Room: Sweeney Ballroom A-B

Speaker 5 of 7
Anna Martinez Casals, Science for Life Laboratories, Sweden
Single Cell Protein Variability in Pancreas by CODEX Highly-Multiplexed Imaging


Wednesday, January 29 | 5:00PM - 7:00PM
Molecular and Functional Analysis of Islet Cell Heterogeneit
y
This session is from Islet Biology

Room: Sweeney Ballroom A-B

Speaker 6 of 7
James C. Lo, Weill Cornell Medicine, USA
Short Talk: Adipsin Blocks Beta Cell Failure in Diabetic Mice and Associates with Protection from Diabetes in Humans


Wednesday, January 29 | 5:00PM - 7:00PM
Molecular and Functional Analysis of Islet Cell Heterogeneit
y
This session is from Islet Biology

Room: Sweeney Ballroom A-B

Speaker 7 of 7
Lydia Amanda Farack, Weizmann Institute of Science, Israel
Short Talk: Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas Reveals Division of Labor between ‘Basal Secretor’ Extreme Beta Cells and ‘Glucose Responder’ Non-Extreme Beta Cells


Wednesday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F
No registration fees are used to fund alcohol served at this function.

Wednesday, January 29 | 7:30PM - 10:00PM
Poster Session 2
Room: Sweeney F


Thursday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F


Thursday, January 30 | 8:00AM - 11:00AM
Molecules Mediating Tissue Crosstalk
Room: Sweeney Ballroom C-E

Speaker 1 of 8
* Mark A. Herman, Duke University Medical Center, USA

Thursday, January 30 | 8:00AM - 11:00AM
Molecules Mediating Tissue Crosstalk
Room: Sweeney Ballroom C-E

Speaker 2 of 8
Joseph A. Baur, University of Pennsylvania, USA
Mitochondrial NAD Transport

Thursday, January 30 | 8:00AM - 11:00AM
Molecules Mediating Tissue Crosstalk
Room: Sweeney Ballroom C-E

Speaker 3 of 8
Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
Extracellular Vesicles Mediating Cross-Talk during Exercise

Thursday, January 30 | 8:00AM - 11:00AM
Molecules Mediating Tissue Crosstalk
Room: Sweeney Ballroom C-E


Coffee Break

Thursday, January 30 | 8:00AM - 11:00AM
Molecules Mediating Tissue Crosstalk
Room: Sweeney Ballroom C-E

Speaker 5 of 8
Judith A. Simcox, University of Wisconsin - Madison, USA
Role of Acylcarnitines as Peripheral Metabolic Signals

Thursday, January 30 | 8:00AM - 11:00AM
Molecules Mediating Tissue Crosstalk
Room: Sweeney Ballroom C-E

Speaker 6 of 8
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Lipokines as Nutrient Sensors and Signals

Thursday, January 30 | 8:00AM - 11:00AM
Molecules Mediating Tissue Crosstalk
Room: Sweeney Ballroom C-E

Speaker 7 of 8
Silvia Corvera, University of Massachusetts Medical School, USA
Short Talk: A Placenta to Adipose Tissues Signaling Axis Controls IGF-1 Availability and Insulin Sensitivity in Pregnancy

Thursday, January 30 | 8:00AM - 11:00AM
Molecules Mediating Tissue Crosstalk
Room: Sweeney Ballroom C-E

Speaker 8 of 8
Peter K. Jackson, Stanford University, USA
Short Talk: Omega-3 Fatty Acids Activate Ciliary FFAR4/GPR120 to Trigger cAMP-Dependent Differentiation of Preadipocytes

Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 1 of 10
* Malin Fex, Lund University, Sweden


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 2 of 10
* Jochen Lang, Université de Bordeaux, France


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 3 of 10
Jennifer E. Bruin, Carleton University, Canada
Environmental Toxins and Embryonic Pancreas Development


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 4 of 10
Burcak Yesildag, InSphero AG, Switzerland
Biomimetic Microtissues: Novel Methods for Studying Islet Biology in Health and Disease


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B


Coffee Break


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 6 of 10
Anne Grapin-Botton, University of Copenhagen, Denmark
Three Dimensional Models of Human Pancreas Organogenesis to Understand Diabetes


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 7 of 10
Mark D. Ungrin, University of Calgary, Canada
Generation and Characterization of Human Pseudoislets


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 8 of 10
Phillip L. Lewis, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Development of a Fluidic Platform to Study Insulin Secretion from Pluripotent Stem Cell-Derived Human Insulin-Secreting Cells


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 9 of 10
Ali Hasan Shilleh, University of Colorado, Anschutz Medical Campus, Barbara Davis Center, USA
Short Talk: Determining the Fate of Stem Cell Derived Pancreatic ß-like Cells (sBCs) Upon Transplantation Using Genetic Lineage Tracing


Thursday, January 30 | 8:00AM - 11:15AM
Stem Cells and Micro-Organs
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 10 of 10
Katharina Scheibner, Helmholtz Zentrum Munich, Germany
Short Talk: New Approaches to Produce Beta Cells from Human Stem Cells


Thursday, January 30 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 30 | 11:00AM - 1:00PM
Poster Setup
Room: Sweeney F


Thursday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F


Thursday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom Foyer


Thursday, January 30 | 5:00PM - 7:00PM
Gut Control of Metabolism
Room: Sweeney Ballroom C-E

Speaker 1 of 6
* Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland

Thursday, January 30 | 5:00PM - 7:00PM
Gut Control of Metabolism
Room: Sweeney Ballroom C-E

Speaker 2 of 6
Darleen A. Sandoval, University of Colorado, USA
Using Bariatric Surgery to Understand the Regulatory Role of the Gut in Metabolism

Thursday, January 30 | 5:00PM - 7:00PM
Gut Control of Metabolism
Room: Sweeney Ballroom C-E

Speaker 3 of 6
Mark A. Herman, Duke University Medical Center, USA
Molecular Aspects of Fructose-Induced Metabolic Dysregulation

Thursday, January 30 | 5:00PM - 7:00PM
Gut Control of Metabolism
Room: Sweeney Ballroom C-E

Speaker 4 of 6
Eric Yen, University of Wisconsin-Madison, USA
Intestinal Lipid Processing and Pancreatic Islet Function: A Gut Reaction?

Thursday, January 30 | 5:00PM - 7:00PM
Gut Control of Metabolism
Room: Sweeney Ballroom C-E

Speaker 5 of 6
Marc Liesa, University of California, Los Angeles, USA
Short Talk: Mitochondrial ABCB10 Increases Bilirubin Actions on the Redox State to Promote Insulin Resistance and Steatosis in Liver

Thursday, January 30 | 5:00PM - 7:00PM
Gut Control of Metabolism
Room: Sweeney Ballroom C-E

Speaker 6 of 6
Sophie L. Lewandowski, University of Wisconsin-Madison, USA
Short Talk: Additive Effects of ß-Cell Pyruvate Kinase Activation and GLP-1 Receptor Signaling on Insulin Secretion

Thursday, January 30 | 5:00PM - 7:00PM
Inflammation, Killing, and Islet Dysfunction
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 1 of 7
* Bruce Verchere, University of British Columbia, Canada


Thursday, January 30 | 5:00PM - 7:00PM
Inflammation, Killing, and Islet Dysfunction
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 2 of 7
* Rebecca Hull, University of Washington, USA


Thursday, January 30 | 5:00PM - 7:00PM
Inflammation, Killing, and Islet Dysfunction
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 3 of 7
Anette-Gabriele Ziegler, Helmholtz Zentrum München, Germany
Islet Autoimmunity


Thursday, January 30 | 5:00PM - 7:00PM
Inflammation, Killing, and Islet Dysfunction
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 4 of 7
Irina Maria Stefana, University of Oxford, UK
Hyperphosphorylated Tau is Expressed in Human Pancreatic Islets and Accumulates in the ß-cell Cytoplasm during Ageing


Thursday, January 30 | 5:00PM - 7:00PM
Inflammation, Killing, and Islet Dysfunction
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 5 of 7
Rebecca Hull, University of Washington, USA
Islet Inflammation in CFRD


Thursday, January 30 | 5:00PM - 7:00PM
Inflammation, Killing, and Islet Dysfunction
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 6 of 7
Mollie Huber, University of Florida, USA
Short Talk: Investigating Type 1 Diabetes Pathogenesis Using Live Pancreas Tissue Slices


Thursday, January 30 | 5:00PM - 7:00PM
Inflammation, Killing, and Islet Dysfunction
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 7 of 7
Diane C. Saunders, Vanderbilt University Medical Center, USA
Short Talk: Macrophages Are a Prominent Immune Cell Population in the Developing Human Pancreas


Thursday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F
No registration fees are used to fund alcohol served at this function.

Thursday, January 30 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney F


Friday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F


Friday, January 31 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 3
* Maureen Anne Gannon, Vanderbilt University Medical Center, USA

Friday, January 31 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 3
* Anna L. Gloyn, Stanford University, USA

Friday, January 31 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 3
Maike Sander, University of California, San Diego, USA
Metabolic Influences on Pancreatic Beta Cells

Friday, January 31 | 9:00AM - 11:30AM
Genetics/Genomics of T2D (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 7
* Maureen Anne Gannon, Vanderbilt University Medical Center, USA

Friday, January 31 | 9:00AM - 11:30AM
Genetics/Genomics of T2D (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 7
* Anna L. Gloyn, Stanford University, USA
Unravelling Mechanisms for Pancreatic Islet Dysfunction from GWAS

Friday, January 31 | 9:00AM - 11:30AM
Genetics/Genomics of T2D (Joint)
Room: Sweeney Ballroom A-E


Coffee Break

Friday, January 31 | 9:00AM - 11:30AM
Genetics/Genomics of T2D (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 7
Karen L. Mohlke, University of North Carolina at Chapel Hill, USA
Adipose Tissue Genomics and Type 2 Diabetes

Friday, January 31 | 9:00AM - 11:30AM
Genetics/Genomics of T2D (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 7
Alan D. Attie, University of Wisconsin-Madison, USA
Genetics of Insulin Secretion

Friday, January 31 | 9:00AM - 11:30AM
Genetics/Genomics of T2D (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 7
Marcus M. Seldin, University of California, Irvine, USA
Short Talk: Systems Genetics Approaches to Dissect Inter-tissue Communication


Friday, January 31 | 9:00AM - 11:30AM
Genetics/Genomics of T2D (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 7
Christopher Emfinger, University of Wisconsin-Madison, USA
Short Talk: Zfp148 Regulates a Transcriptional Network Suppressing Insulin Secretion

Friday, January 31 | 11:30AM - 5:00PM
On Own for Lunch


Friday, January 31 | 2:30PM - 4:30PM
Workshop 2: The Human Islet Research Network - Human Pancrea
s Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 1 of 8
* Marcela Brissova, Vanderbilt University, USA


Friday, January 31 | 2:30PM - 4:30PM
Workshop 2: The Human Islet Research Network - Human Pancrea
s Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 2 of 8
* Nicolai M. Doliba, University of Pennsylvania, USA


Friday, January 31 | 2:30PM - 4:30PM
Workshop 2: The Human Islet Research Network - Human Pancrea
s Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 3 of 8
Catherine Lee May, University of Pennsylvania, USA
The Human Pancreas Analysis Program – Type 1 Diabetes


Friday, January 31 | 2:30PM - 4:30PM
Workshop 2: The Human Islet Research Network - Human Pancrea
s Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 4 of 8
Alvin C. Powers, Vanderbilt University School of Medicine, USA
The Human Pancreas Analysis Program - Type 2 Diabetes


Friday, January 31 | 2:30PM - 4:30PM
Workshop 2: The Human Islet Research Network - Human Pancrea
s Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 5 of 8
Xiaoqing Dai, University of Alberta, Canada
Pancreatic a-cell Function and Identity in Type 1 Diabetes Mellitus


Friday, January 31 | 2:30PM - 4:30PM
Workshop 2: The Human Islet Research Network - Human Pancrea
s Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 6 of 8
Matthew Haemmerle, University of Pennsylvania, USA
The PCBP RNA Binding Proteins as Post-Transcriptional Regulators of ß Cell Identity


Friday, January 31 | 2:30PM - 4:30PM
Workshop 2: The Human Islet Research Network - Human Pancrea
s Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 7 of 8
Tiffany Richardson, Vanderbilt University, USA
Pancreatic Islet and Exocrine Tissue Innervation is Not Altered in Type 1 Diabetes


Friday, January 31 | 2:30PM - 4:30PM
Workshop 2: The Human Islet Research Network - Human Pancrea
s Analysis Programs

This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 8 of 8
Rafael Arrojo e Drigo, The Salk Institute Research Institute, USA
Aging of Human Endocrine Pancreatic Cell Types Is Heterogeneous and Sex-Specific


Friday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom Foyer


Friday, January 31 | 5:00PM - 6:45PM
From Systems Biology to Metabolic Physiology
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Barbara M. Bakker, University Medical Center Groningen, Netherlands

Friday, January 31 | 5:00PM - 6:45PM
From Systems Biology to Metabolic Physiology
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Emerging Roles of Bile Acid Signaling in Metabolism and Stemness

Friday, January 31 | 5:00PM - 6:45PM
From Systems Biology to Metabolic Physiology
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Dave Pagliarini, Washington University in St. Louis, USA
Regulation of Mitochondrial Metabolism by Reversible Phosphorylation

Friday, January 31 | 5:00PM - 6:45PM
From Systems Biology to Metabolic Physiology
Room: Sweeney Ballroom C-E

Speaker 4 of 5
David E. James, University of Sydney, Australia
The Role of Reactive Oxygen Species in Insulin Resistance

Friday, January 31 | 5:00PM - 6:45PM
From Systems Biology to Metabolic Physiology
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Takumi Kitamoto, Columbia University, USA
Short Talk: The Genomic Architecture of the FoxO1 Response to Fasting and Refeeding in Liver


Friday, January 31 | 5:00PM - 6:45PM
Novel Approaches to Single Cell Biology
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Mathieu Latreille, Imperial College London, UK


Friday, January 31 | 5:00PM - 6:45PM
Novel Approaches to Single Cell Biology
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 2 of 6
* Julie B. Sneddon, University California, San Francisco, USA


Friday, January 31 | 5:00PM - 6:45PM
Novel Approaches to Single Cell Biology
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Heiko Lickert, Institute of Diabetes and Regeneration, Germany
Deciphering Mechanisms of ß-Cell Failure and Regeneration by Single Cell RNA Sequencing


Friday, January 31 | 5:00PM - 6:45PM
Novel Approaches to Single Cell Biology
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 4 of 6
Diego Balboa, Centre for Genomic Regulation, Spain
Improving Diabetes Disease Modelling with Single Cell RNA Sequencing of Stem Cell Derived Pancreatic Cells


Friday, January 31 | 5:00PM - 6:45PM
Novel Approaches to Single Cell Biology
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Patrick MacDonald, University of Alberta, Canada
Connecting Single-Cell Function and Transcriptomics


Friday, January 31 | 5:00PM - 6:45PM
Novel Approaches to Single Cell Biology
This session is from Islet Biology
Room: Sweeney Ballroom A-B

Speaker 6 of 6
Rachel E. Jennings, University of Manchester, UK
Short Talk: A Single Cell Atlas of the Developing Human Pancreas


Friday, January 31 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Sweeney Ballroom C-E


Friday, January 31 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Islet Biology
Room: Sweeney Ballroom A-B


Friday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F
No registration fees are used to fund alcohol served at this function.

Friday, January 31 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, February 01 | 10:24AM - 10:24AM
Departure


*Session Chair.