Web Desc
Brain Therapeutics: Disruptive Technologies and Opportunities
joint with Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus
Organizer(s): Maria-Jesus Blanco, Kalpana M. Merchant and Mabel Loza
Date: February 16 - 19, 2020
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
CNS disorders represent a major unmet medical need. The associated societal burden is becoming unsustainable due to changing demographics (e.g., aging population). Despite major investments in basic and translational research by government and non-profit institutions world-wide, pharmaceutical companies and equity investors continue to view brain therapeutics as a relatively risky area of investment. This Keystone Symposia conference will highlight groundbreaking technologies and new approaches to de-risk CNS-targeted therapies and demonstrate how interdisciplinary integration has the potential to overcome the contemporary challenges of CNS drug development. One of the unique features of this conference is that it brings together a diversity of scientists, who rarely participate in the same meetings, in order to create an environment for disruptive innovation. Invited speakers will provide both general and technical presentations to engage participants in topics like disease biology-informed target selection, novel medicinal chemistry approaches, biomarkers, and clinical trial design. Advances in technologies such as genomics, imaging and brain delivery will be highlighted throughout. Our featured speakers hail from around the world and represent both public and private sector and young and established scientists. The aim of this conference is to create a space for collaboration that helps attendees address the unmet medical need of CNS disorders even after it has ended. Finally, this meeting will be paired with the Keystone Symposia conference on Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus. The goal of this paring is to stimulate cross-disciplinary thinking about CSF-based medicinal therapies.
Scholarship Deadline: October 29 2019
Discounted Abstract Deadline: October 29 2019
Abstract Deadline: November 19 2019
Discounted Registration Deadline: December 17 2019
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Biogen

Sage Therapeutics

Vincere Biosciences, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS115402-01
Funding for this conference was made possible (in part) by 1R13NS115402-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This grant is co-funded by the National Institute Of Neurological Disorders And Stroke (NINDS) and the National Center For Advancing Translational Sciences (NCATS).
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 16 | 4:00PM - 8:00PM
Arrival and Registration
Room: Cava Santa Fe


Sunday, February 16 | 6:00PM - 8:00PM
Welcome Mixer
Room: Cava Santa Fe
No registration fees are used to fund alcohol served at this function.

Monday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Monday, February 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado A

Speaker 1 of 2
* Maria-Jesus Blanco, Sage Therapeutics, USA

Monday, February 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado A

Speaker 2 of 2
Darryle D. Schoepp, USA
Neuroscience Therapeutics: Current Pipeline Challenges and Lessons Along the Way

Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation

Room: Eldorado A

Speaker 1 of 8
* Maria-Jesus Blanco, Sage Therapeutics, USA

Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation

Room: Eldorado A

Speaker 2 of 8
Kalpana M. Merchant, Vincere Biosciences, Inc., USA
De-Risking Approaches for Disease-Modifying Therapies for Parkinson’s Disease: Opportunities and Challenges Exemplified by the Parkin Activator Program

Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation

Room: Eldorado A


Coffee Break

Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation

Room: Eldorado A

Speaker 4 of 8
Chas Bountra, University of Oxford, UK
New Technologies, Collaborations and Processes, to Accelerate the De-Risking of Pioneer Drug Targets, for Neuro-Psychiatric Conditions

Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation

Room: Eldorado A

Speaker 5 of 8
Shoichiro Ando, Niigata University, Japan
Short Talk: Gene Therapy for DRPLA Model Mice by AAV-Delivered CRISPR / Cas9

Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation

Room: Eldorado A

Speaker 6 of 8
Trevor John Gonzalez, Duke University, USA
Short Talk: Engineering Synthetic Circular RNAs for AAV Mediated Expression in the Brain


Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation

Room: Eldorado A

Speaker 7 of 8
Chao-Hsien Chen, University of Texas MD Anderson Cancer Center, USA
Short Talk: Reversal of Neurodegeneration through Clearance of pTau by Engineered Monocytes

Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation

Room: Eldorado A

Speaker 8 of 8
Andrea Crotti, Astellas Pharma, USA
Short Talk: BIN1 Favors the Spreading of Tau via Extracellular Vesicles

Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 7
* Edwin S. Monuki, University of California, Irvine, USA


Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 7
Norman Ruthven Saunders, University of Melbourne, Australia
The Choroid Plexus: Mechanisms that Limit Drug Entry into the Developing Brain


Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
This session is from Cerebral Fluid Flow
Room: Eldorado B


Coffee Break


Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 4 of 7
Nanna MacAulay, University of Copenhagen, Denmark
Mechanism of CSF Secretion – Conventional Osmosis versus Active Water Transport


Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 5 of 7
Maria Lehtinen, Harvard Medical School, USA
Illuminating the Choroid Plexus


Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 6 of 7
Neil Dani, Boston Children's Hospital, USA
Short Talk: A Cellular and Spatial Map of the Choroid Plexus across Ventricles and Ages


Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 7 of 7
Annarita Patrizi, German Cancer Research Center, Germany
Short Talk: Rescuing Cortical Features in Rett Syndrome through the Choroid Plexus


Monday, February 17 | 11:30AM - 5:00PM
On Own for Lunch


Monday, February 17 | 11:30AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Monday, February 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Monday, February 17 | 2:30PM - 4:30PM
Roundtable: Collaboration & Knowledge Integration Models for
Successful Brain Therapeutics
Room: Eldorado A

Speaker 1 of 4
* Mabel Loza, BioFarma Research Group, University of Santiago de Compostela, Spain

Monday, February 17 | 2:30PM - 4:30PM
Roundtable: Collaboration & Knowledge Integration Models for
Successful Brain Therapeutics
Room: Eldorado A

Speaker 2 of 4
James E. Audia, Chicago Biomedical Consortium, USA
Drug Discovery in the Academic and Not-For-Profit Community

Monday, February 17 | 2:30PM - 4:30PM
Roundtable: Collaboration & Knowledge Integration Models for
Successful Brain Therapeutics
Room: Eldorado A

Speaker 3 of 4
Chas Bountra, University of Oxford, UK

Monday, February 17 | 2:30PM - 4:30PM
Roundtable: Collaboration & Knowledge Integration Models for
Successful Brain Therapeutics
Room: Eldorado A

Speaker 4 of 4
Sohini Chowdhury, Michael J. Fox Foundation, USA

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 9
* Julie Siegenthaler, University of Colorado Denver, USA


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 9
Alexandra E. Hochstetler, Indiana University Purdue University Indianapolis, USA
Functional Studies of Ion Transport in Choroid Plexus Epithelial Cells


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 3 of 9
Engin Deniz, Yale University, USA
Building Xenopus as a Model System for Hydrocephaly and Ependymal Ciliogenesis


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 4 of 9
Eri Iwasawa, Cincinnati Children's Hospital Medical Center, USA
Neuroinflammation and Impaired Neural Differentiation in a Novel Rat Model of Neonatal Hydrocephalus Lacking Motile Cilia-mediated CSF Flow


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 5 of 9
Huixin Xu, Boston Children's Hospital, USA
Developmental Control of Cerebral Fluid Distribution and CSF-K+ by Choroid Plexus


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 6 of 9
Jo Stratton, McGill University, Canada
Ependymal Cells: Their Transcriptional Landscape and Role in Brain Injury


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 7 of 9
Jessie Newville, University of New Mexico, USA
Disruption and Rescue of Ependymal Motile Cilia Function in a Model of Posthemorrhagic Hydrocephalus of Prematurity


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 8 of 9
Haley Masters, University of California, Irvine, USA
Single Cell Transcriptomic and Cell Biological Analysis of Human Choroid Plexus Epithelial Cells Derived from Pluripotent Stem Cells


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 9 of 9
Michael Neel, University of California, Irvine, USA
Characterization of an Aging-Related Amyloid of the Human Choroid Plexus


Monday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy

Room: Eldorado A

Speaker 1 of 6
* Chas Bountra, University of Oxford, UK

Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy

Room: Eldorado A

Speaker 2 of 6
Edoardo Marcora, Icahn School of Medicine at Mount Sinai, USA
From Human Genetics to Causal Biology in Alzheimer's Disease

Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy

Room: Eldorado A

Speaker 3 of 6
Lena F. Burbulla, Northwestern University, USA
Modeling Pathogenesis of Parkinson's Disease Using iPSC

Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy

Room: Eldorado A

Speaker 4 of 6
Damian G. Wheeler, Translucence Biosystems, Inc, USA
Short Talk: Brain-Wide Cellular Resolution Measurement of Neuronal Activity and Neuroinflammation

Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy

Room: Eldorado A

Speaker 5 of 6
Xiaoqing Li, University of Texas at Dallas, USA
Short Talk: Optical Opening of the Blood-Brain Barrier by Laser Excitation of Vasculature-Targeting Plasmonic Nanoparticles

Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy

Room: Eldorado A

Speaker 6 of 6
Daniela Lecca, NIA, National Institutes of Health, USA
Short Talk: Neuroinflammation as a Therapeutic Target in Neurodegenerative Diseases

Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 6
* Jonathan Kipnis, USA


Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 6
Maiken Nedergaard, University of Rochester, USA
Sleep Regulation and Disease Roles of the Glymphatic System


Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 3 of 6
Jeffrey J. Iliff, University of Washington, USA
Evidence for the Role of Glymphatic Dysfunction in the Development of Alzheimer’s Disease


Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 4 of 6
Helene Benveniste, Yale School of Medicine, USA
Glymphatic Flow, Regulation and Function


Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 5 of 6
Iben Lundgaard, University of Lund, Sweden
Short Talk: Cerebral Blood Flow Drives Efflux of CSF from the Ventricular System


Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 6 of 6
Judith de Vos, Amsterdam University Medical Center, Netherlands
Short Talk: The Imaging Cryomicrotome: A Setup for Large Volume 3D Mesoscopic Visualization


Monday, February 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Anasazi Ballroom


Tuesday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain

Room: Eldorado A

Speaker 1 of 7
* James E. Audia, Chicago Biomedical Consortium, USA

Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain

Room: Eldorado A

Speaker 2 of 7
Anastasia Khvorova, University of Massachusetts Medical School, USA
RNAi-Based Modulation of Gene Expression in Central Nervous System

Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain

Room: Eldorado A

Speaker 3 of 7
Jacob M. Hooker, Harvard Medical School, USA
Integrating PET Tracers into CNS Drug Discovery: Impact on the Discovery of Novel HDAC Ligands

Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain

Room: Eldorado A


Coffee Break

Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain

Room: Eldorado A

Speaker 5 of 7
Maria-Jesus Blanco, Sage Therapeutics, USA
Discovery of Allosteric Modulators of GABAA Receptor for CNS Disorders

Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain

Room: Eldorado A

Speaker 6 of 7
Paula Perez Pardo, Utrecht University, Netherlands
Short Talk: Positive Effects of Small Molecule Tryptophan-2,3-Dioxygense Inhibitors on Motor and Non-Motor Symptoms in a Mouse Model of Parkinson’s Disease

Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain

Room: Eldorado A

Speaker 7 of 7
Xavier Barril, Gain Therapeutics, Spain
Short Talk: Correcting Protein Misfolding with Structurally Targeted Allosteric Regulators (STAR): Applications in Rare Diseases and Brain Therapeutics

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 10
* Maiken Nedergaard, University of Rochester, USA


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 10
Jonathan Kipnis, USA
Lymphatic-Glymphatic Roles in Aging and Disease


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 3 of 10
Erik N.T.P. Bakker, University of Amsterdam, Netherlands
The Impact of High Blood Pressure on the Brain: Studies in Spontaneously Hypertensive Rats


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B


Coffee Break


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 5 of 10
Steffi Dreha-Kulaczewski, University Medical Center Göttingen, Germany
Breathe to Drive CSF Flow


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 6 of 10
Julie Siegenthaler, University of Colorado Denver, USA
Short Talk: Origins, Development and Function of the Arachnoid Barrier Layer, a Key Component of the Blood-CSF Barrier


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 7 of 10
Ji Hoon Ahn, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Meningeal Lymphatic Vessels at the Skull Base Drain Cerebrospinal Fluid


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 8 of 10
Fengfei Ding, University of Rochester Medical Center, USA
Short Talk: Chronic Sleep Fragmentation Alters the Brain Glymphatic Function


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 9 of 10
Humberto Mestre, University of Rochester Medical Center, USA
Short Talk: Cerebrospinal Fluid Influx Drives Acute Ischemic Tissue Swelling


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 10 of 10
John R. Cirrito, Washington University, USA
Short Talk: Using Micro-Immunoelectrodes to Study Rapid Mechanisms of Aß Clearance from the Brain Interstitial Fluid of Mice


Tuesday, February 18 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, February 18 | 11:00AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Tuesday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 1 of 6
Maria-Jesus Blanco, Sage Therapeutics, USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 2 of 6
Kalpana M. Merchant, Vincere Biosciences, Inc., USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 3 of 6
Maria Lehtinen, Harvard Medical School, USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 4 of 6
Edwin S. Monuki, University of California, Irvine, USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 5 of 6
Maiken Nedergaard, University of Rochester, USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 6 of 6
Jacob M. Hooker, Harvard Medical School, USA

Tuesday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
Room: Eldorado A

Speaker 1 of 5
* Darryle D. Schoepp, USA

Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
Room: Eldorado A

Speaker 2 of 5
Steffany A.L. Bennett, University of Ottawa, Canada
Remote Presentation: Lipidomic-Based Insights into Disease Mechanisms: A Targeted Lipidomics Discovery Pipeline for Network and Flux Analysis

Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
Room: Eldorado A

Speaker 3 of 5
Gwenn A. Garden, University of Washington, USA
Emerging Glial Biomarkers of CNS Disease

Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
Room: Eldorado A

Speaker 4 of 5
David Nguyen, Sage Therapeutics, USA
Novel Digital Technologies towards CNS Translational Insights

Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
Room: Eldorado A

Speaker 5 of 5
Jagan A. Pillai, Cleveland Clinic, USA
Short Talk: Pathway Based Analysis to Evaluate Inflammatory Analytes of Significance for Therapeutic Targeting in Alzheimer’s Disease

Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 5
* Maria Lehtinen, Harvard Medical School, USA


Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 5
Fiona Doetsch, University of Basel, Switzerland
Choroid Plexus Regulation of Adult Neural Stem Cells


Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 3 of 5
Claire Wyart, Institut du Cerveau et de la Moelle Epinière, France
Origin and Role of the Cerebrospinal Fluid Bidirectional Flow in the Central Canal


Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 4 of 5
Craig Ferris, Northeastern University, USA
Imaging the Effect of the Circadian Light-Dark Cycle on the Glymphatic System in Awake Rats


Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 5 of 5
Laura Lewis, Boston University, USA

Coordinated Neural, Vascular, and Cerebrospinal Fluid Dynamics in Human Sleep


Tuesday, February 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Anasazi Ballroom


Wednesday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery

Room: Eldorado A

Speaker 1 of 6
* Damian G. Wheeler, Translucence Biosystems, Inc, USA

Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery

Room: Eldorado A

Speaker 2 of 6
Tetsuya Suhara, National Institutes for Quantum and Radiological Science and Technology, Japan
Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development

Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery

Room: Eldorado A

Speaker 3 of 6
Lisa L. Shafer, Cerebral Therapeutics, Inc., USA
Emerging Strategies for Brain Drug Delivery: Case Study Applications

Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery

Room: Eldorado A


Coffee Break

Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery

Room: Eldorado A

Speaker 5 of 6
Robert G. Thorne, Denali Therapeutics, USA
Characterizing Fusion Protein Transport Across CNS Barriers: Leveraging Imaging and Other Novel Methods to Assess Brain Delivery

Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery

Room: Eldorado A

Speaker 6 of 6
Frances G. Ghinger, University of Maryland, Baltimore County, USA
Short Talk: Optical Imaging of Ventromedial Prefrontal Cortex Activity Following Chronic Stress

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 10
* Fiona Doetsch, University of Basel, Switzerland


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 10
Roosmarijn E. Vandenbroucke, VIB-UGent Center for Inflammation Research, Belgium
Choroid Plexus-Derived Extracellular Vesicles as Mediators of Neuroinflammation


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 3 of 10
Jean-François Ghersi-Egea, Lyon Neurosciences Research Center, France
Antioxidant Defence at the Choroid Plexus Influences CSF Inflammation during Systemic Perinatal Injuries


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B


Coffee Break


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 5 of 10
Michal Schwartz, Weizmann Institute of Science, Israel
Choroid Plexus Regulation of the Neuroimmune Response


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 6 of 10
Jan Remsik, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Immunological Determinants of Leptomeningeal Metastasis


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 7 of 10
Frederick B. Shipley, Harvard University, USA
Short Talk: Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 8 of 10
Marcus Stoodley, Macquarie University, Australia
Short Talk: Physiological Drivers of Fluid Flow in the Spinal Subarachnoid Space and Spinal Cord


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 9 of 10
Gabriel Jensen, University of Maine, USA
Short Talk: The Meninges and Choroid Plexus are Prominent Telomerase Reverse Transcriptase-Expressing Adult Stem Cell Niches in the Mouse Brain


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 10 of 10
June Goto, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Impaired Glymphatic Flow and The Delayed Neural Differentiation in CCDC39-Deficient Rat Model of Neonatal Hydrocephalus


Wednesday, February 19 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 11
* Iben Lundgaard, University of Lund, Sweden


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 11
Jin Cui, Boston Children's Hospital, USA
Choroid Plexus as a Site of Immune Activation in a Model of Autism Spectrum Disorders


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 3 of 11
Marco Fanous, Duke University, USA
Aquaporin 4 Regulates Adeno-Associated Viral (AAV) Transport across the Blood Brain Barrier


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 4 of 11
Darshan Sapkota, Washington University, USA
Stop Codon Readthrough of Aqp4 Generates a Novel AQP4 Isoform with Pathophysiological Significance


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 5 of 11
Hannah Elizabeth Jones, University of Colorado Anschutz Medical Campus, USA
Developmental Timing and Origins of Perivascular Brain Fibroblasts


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 6 of 11
Daphne M.P. Naessens, Amsterdam UMC, Netherlands
Elucidating Brain Water Management in Spontaneously Hypertensive Rats


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 7 of 11
Dakota E R DeFreitas, Washington University in St. Louis, USA
Evaluation of CSF Distribution in Post-Hemorrhagic Hydrocephalus Rat Brain using Gold Nanoparticle Enhanced X-ray Nanotomography


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 8 of 11
Cameron Sadegh, Harvard University, USA
Choroid Plexus Epithelia Respond Rapidly to Hemorrhage to Minimize Ventriculomegaly Prior to Global Compensatory Increases in CSF Reabsorption


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 9 of 11
Jordan C. Xu, University of California, Irvine, USA
Dural Lympathic Changes in Normal Pressure Hydrocephalus


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 10 of 11
Andrew T. Hale, Vanderbilt University School of Medicine, USA
Integration of Human Genetics and Mutli-Omics Data Implicates Novel Pathways in Hydrocephalus


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 11 of 11
Arie Horowitz, USA
Cerebrospinal Fluid Signature of Hydrocephalus


Wednesday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
Room: Eldorado A

Speaker 1 of 6
* Kalpana M. Merchant, Vincere Biosciences, Inc., USA

Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
Room: Eldorado A

Speaker 2 of 6
Aletta D. Kraneveld, University of Utrecht, Netherlands
Parkinson’s Disease: No Guts No Glory

Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
Room: Eldorado A

Speaker 3 of 6
Giorgia Quadrato, University of Southern California, USC Stem Cell, USA
Modeling Human Brain Development and Disease at Single Cell Resolution with Organoids

Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
Room: Eldorado A

Speaker 4 of 6
Shun Mitsui, Tokai University School of Medicine, Japan
Short Talk: Neural Cell-Specific SQSTM1 Deficiency Accelerates the Onset of Disease in an ALS Mouse Model

Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
Room: Eldorado A

Speaker 5 of 6
Nicholas T. Hertz, Mitokinin Inc., USA
Short Talk: Small Molecule Activators of PINK1 Activity Rescue Sporadic PD Associated alpha-Synuclein Pathology

Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
Room: Eldorado A

Speaker 6 of 6
Taotao Lao, Massachusetts General Hospital/ Harvard Medical School, USA
Short Talk: TREML2 Regulates Microglia Functions in an Alzheimer’s Disease Model

Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 5
* Jeffrey J. Iliff, University of Washington, USA


Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 5
Christopher Moore, Brown University, USA
Remote Presentation: A Systems Approach to the Choroid Plexus


Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 3 of 5
Edwin S. Monuki, University of California, Irvine, USA
Towards a Choroid Plexus-Based Regenerative Medicine


Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 4 of 5
Kristopher T. Kahle, Yale School of Medicine, USA
A Role for Inflammation: TLR-4-mediated Cerebrospinal Fluid Hypersecretion in Post-hemorrhagic and Post-infectious Hydrocephalus


Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 5 of 5
Patricia I. Dickson, Washington University, USA
CSF Delivery of Therapeutics


Wednesday, February 19 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Eldorado A


Wednesday, February 19 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 1 of 2
Edwin S. Monuki, University of California, Irvine, USA


Wednesday, February 19 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
This session is from Cerebral Fluid Flow
Room: Eldorado B

Speaker 2 of 2
Maria Lehtinen, Harvard Medical School, USA


Wednesday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, February 19 | 8:00PM - 11:00PM
Entertainment
Room: Anasazi Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 20 | 10:24AM - 10:24AM
Departure


*Session Chair
†Invited, not yet responded.