Web Desc
Cerebral Fluid Flow and Function: Lymphatics, Glymphatics and the Choroid Plexus
joint with Brain Therapeutics: Disruptive Technologies and Opportunities
Organizer(s): Edwin S. Monuki, Maria Lehtinen and Maiken Nedergaard
Date: February 16 - 19, 2020
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
The cerebrospinal fluid (CSF) has long been a 'missing link' in our understanding of brain form, function, and disease. However, recent work has begun to illuminate how the CSF regulates the brain in ways that extend far beyond its passive historical roles and provides unique opportunities for studying, diagnosing, and potentially treating brain disorders. This Keystone Symposia conference brings together an interdisciplinary group of new and established scientists to discuss this newfound excitement about CSF. Talks will feature discoveries about CSF sources (choroid plexus), routes (glymphatics), drainage (lymphatics) and clinical utilities. This conference aims to coalesce an international community that can propel CSF research forward by fostering new ideas, collaborations, and training opportunities. Held jointly with Keystone Symposia’s ‘Brain Therapeutics: Disruptive Technologies and Opportunities for Drug Development,’ the goal of this paring is to stimulate thinking about CSF-based medicinal therapies. CSF has therapeutic advantages over blood because it is 'behind' the blood-brain barrier and equilibrating with the interstitial fluid surrounding brain cells.
Scholarship Deadline: October 29 2019
Discounted Abstract Deadline: October 29 2019
Abstract Deadline: November 19 2019
Discounted Registration Deadline: December 17 2019
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS115398-01
Funding for this conference was made possible (in part) by 1R13NS115398-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 16 | 4:00PM - 8:00PM
Arrival and Registration
Room: Cava Santa Fe


Sunday, February 16 | 6:00PM - 8:00PM
Welcome Mixer
Room: Cava Santa Fe
No registration fees are used to fund alcohol served at this function.

Monday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Monday, February 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado B

Speaker 1 of 4
* Edwin S. Monuki, University of California, Irvine, USA

Monday, February 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado B

Speaker 2 of 4
* Maiken Nedergaard, University of Rochester, USA

Monday, February 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado B

Speaker 3 of 4
* Maria Lehtinen, Harvard Medical School, USA

Monday, February 17 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Eldorado B

Speaker 4 of 4
Kari K. Alitalo, University of Helsinki, Finland
Role of Lymphangiogenic Factors in Cerebral Fluid Flow and Neuropathological Processes in the CNS

Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
Room: Eldorado B

Speaker 1 of 7
* Edwin S. Monuki, University of California, Irvine, USA

Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
Room: Eldorado B

Speaker 2 of 7
Norman Ruthven Saunders, University of Melbourne, Australia
The Choroid Plexus: Mechanisms that Limit Drug Entry into the Developing Brain

Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
Room: Eldorado B


Coffee Break

Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
Room: Eldorado B

Speaker 4 of 7
Nanna MacAulay, University of Copenhagen, Denmark
Mechanism of CSF Secretion – Conventional Osmosis versus Active Water Transport

Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
Room: Eldorado B

Speaker 5 of 7
Maria Lehtinen, Harvard Medical School, USA
Illuminating the Choroid Plexus

Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
Room: Eldorado B

Speaker 6 of 7
Neil Dani, Boston Children's Hospital, USA
Short Talk: A Cellular and Spatial Map of the Choroid Plexus across Ventricles and Ages

Monday, February 17 | 9:00AM - 11:30AM
Choroid Plexus and CSF Regulation of Stem Cells
Room: Eldorado B

Speaker 7 of 7
Annarita Patrizi, German Cancer Research Center, Germany
Short Talk: Rescuing Cortical Features in Rett Syndrome through the Choroid Plexus

Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 1 of 8
* Maria-Jesus Blanco, Sage Therapeutics, USA


Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 2 of 8
Kalpana M. Merchant, Vincere Biosciences, Inc., USA
De-Risking Approaches for Disease-Modifying Therapies for Parkinson’s Disease: Opportunities and Challenges Exemplified by the Parkin Activator Program


Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation
This session is from Brain Therapeutics

Room: Eldorado A


Coffee Break


Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 4 of 8
Chas Bountra, University of Oxford, UK
New Technologies, Collaborations and Processes, to Accelerate the De-Risking of Pioneer Drug Targets, for Neuro-Psychiatric Conditions


Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 5 of 8
Shoichiro Ando, Niigata University, Japan
Short Talk: Gene Therapy for DRPLA Model Mice by AAV-Delivered CRISPR / Cas9


Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 6 of 8
Trevor John Gonzalez, Duke University, USA
Short Talk: Engineering Synthetic Circular RNAs for AAV Mediated Expression in the Brain


Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 7 of 8
Chao-Hsien Chen, University of Texas MD Anderson Cancer Center, USA
Short Talk: Reversal of Neurodegeneration through Clearance of pTau by Engineered Monocytes


Monday, February 17 | 9:00AM - 11:30AM
Challenges and Opportunities for Brain Therapeutics: Preclin
ical to Clinical Translation
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 8 of 8
Andrea Crotti, Astellas Pharma, USA
Short Talk: BIN1 Favors the Spreading of Tau via Extracellular Vesicles


Monday, February 17 | 11:30AM - 5:00PM
On Own for Lunch


Monday, February 17 | 11:30AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Monday, February 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Monday, February 17 | 2:30PM - 4:30PM
Roundtable: Collaboration & Knowledge Integration Models for
Successful Brain Therapeutics
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 1 of 4
* Mabel Loza, BioFarma Research Group, University of Santiago de Compostela, Spain


Monday, February 17 | 2:30PM - 4:30PM
Roundtable: Collaboration & Knowledge Integration Models for
Successful Brain Therapeutics
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 2 of 4
James E. Audia, Chicago Biomedical Consortium, USA
Drug Discovery in the Academic and Not-For-Profit Community


Monday, February 17 | 2:30PM - 4:30PM
Roundtable: Collaboration & Knowledge Integration Models for
Successful Brain Therapeutics
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 3 of 4
Chas Bountra, University of Oxford, UK


Monday, February 17 | 2:30PM - 4:30PM
Roundtable: Collaboration & Knowledge Integration Models for
Successful Brain Therapeutics
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 4 of 4
Sohini Chowdhury, Michael J. Fox Foundation, USA


Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 1 of 9
* Julie Siegenthaler, University of Colorado Denver, USA

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 2 of 9
Alexandra E. Hochstetler, Indiana University Purdue University Indianapolis, USA
Functional Studies of Ion Transport in Choroid Plexus Epithelial Cells

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 3 of 9
Engin Deniz, Yale University, USA
Building Xenopus as a Model System for Hydrocephaly and Ependymal Ciliogenesis

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 4 of 9
Eri Iwasawa, Cincinnati Children's Hospital Medical Center, USA
Neuroinflammation and Impaired Neural Differentiation in a Novel Rat Model of Neonatal Hydrocephalus Lacking Motile Cilia-mediated CSF Flow

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 5 of 9
Huixin Xu, Boston Children's Hospital, USA
Developmental Control of Cerebral Fluid Distribution and CSF-K+ by Choroid Plexus

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 6 of 9
Jo Stratton, McGill University, Canada
Ependymal Cells: Their Transcriptional Landscape and Role in Brain Injury

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 7 of 9
Jessie Newville, University of New Mexico, USA
Disruption and Rescue of Ependymal Motile Cilia Function in a Model of Posthemorrhagic Hydrocephalus of Prematurity

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 8 of 9
Haley Masters, University of California, Irvine, USA
Single Cell Transcriptomic and Cell Biological Analysis of Human Choroid Plexus Epithelial Cells Derived from Pluripotent Stem Cells

Monday, February 17 | 3:30PM - 4:30PM
Workshop 1
Room: Eldorado B

Speaker 9 of 9
Michael Neel, University of California, Irvine, USA
Characterization of an Aging-Related Amyloid of the Human Choroid Plexus

Monday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
Room: Eldorado B

Speaker 1 of 6
* Jonathan Kipnis, Washington University School of Medicine, USA

Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
Room: Eldorado B

Speaker 2 of 6
Maiken Nedergaard, University of Rochester, USA
Sleep Regulation and Disease Roles of the Glymphatic System

Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
Room: Eldorado B

Speaker 3 of 6
Jeffrey J. Iliff, University of Washington, USA
Evidence for the Role of Glymphatic Dysfunction in the Development of Alzheimer’s Disease

Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
Room: Eldorado B

Speaker 4 of 6
Helene Benveniste, Yale School of Medicine, USA
Glymphatic Flow, Regulation and Function

Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
Room: Eldorado B

Speaker 5 of 6
Iben Lundgaard, University of Lund, Sweden
Short Talk: Cerebral Blood Flow Drives Efflux of CSF from the Ventricular System

Monday, February 17 | 5:00PM - 7:00PM
Glymphatics
Room: Eldorado B

Speaker 6 of 6
Judith de Vos, Amsterdam University Medical Center, Netherlands
Short Talk: The Imaging Cryomicrotome: A Setup for Large Volume 3D Mesoscopic Visualization

Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 1 of 6
* Chas Bountra, University of Oxford, UK


Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 2 of 6
Edoardo Marcora, Icahn School of Medicine at Mount Sinai, USA
From Human Genetics to Causal Biology in Alzheimer's Disease


Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 3 of 6
Lena F. Burbulla, Northwestern University, USA
Modeling Pathogenesis of Parkinson's Disease Using iPSC


Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 4 of 6
Damian G. Wheeler, Translucence Biosystems, Inc, USA
Short Talk: Brain-Wide Cellular Resolution Measurement of Neuronal Activity and Neuroinflammation


Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 5 of 6
Xiaoqing Li, University of Texas at Dallas, USA
Short Talk: Optical Opening of the Blood-Brain Barrier by Laser Excitation of Vasculature-Targeting Plasmonic Nanoparticles


Monday, February 17 | 5:00PM - 7:00PM
Advances in Technologies to Garner Insights into Disease Bio
logy
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 6 of 6
Daniela Lecca, NIA, National Institutes of Health, USA
Short Talk: Neuroinflammation as a Therapeutic Target in Neurodegenerative Diseases


Monday, February 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, February 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Anasazi Ballroom


Tuesday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 1 of 10
* Maiken Nedergaard, University of Rochester, USA

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 2 of 10
Jonathan Kipnis, Washington University School of Medicine, USA
Lymphatic-Glymphatic Roles in Aging and Disease

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 3 of 10
Erik N.T.P. Bakker, University of Amsterdam, Netherlands
The Impact of High Blood Pressure on the Brain: Studies in Spontaneously Hypertensive Rats

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B


Coffee Break

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 5 of 10
Steffi Dreha-Kulaczewski, University Medical Center Göttingen, Germany
Breathe to Drive CSF Flow

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 6 of 10
Julie Siegenthaler, University of Colorado Denver, USA
Short Talk: Origins, Development and Function of the Arachnoid Barrier Layer, a Key Component of the Blood-CSF Barrier

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 7 of 10
Ji Hoon Ahn, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Meningeal Lymphatic Vessels at the Skull Base Drain Cerebrospinal Fluid

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 8 of 10
Fengfei Ding, University of Rochester Medical Center, USA
Short Talk: Chronic Sleep Fragmentation Alters the Brain Glymphatic Function

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 9 of 10
Humberto Mestre, University of Rochester Medical Center, USA
Short Talk: Cerebrospinal Fluid Influx Drives Acute Ischemic Tissue Swelling

Tuesday, February 18 | 8:00AM - 11:15AM
Lymphatics and CSF Dynamics
Room: Eldorado B

Speaker 10 of 10
John R. Cirrito, Washington University, USA
Short Talk: Using Micro-Immunoelectrodes to Study Rapid Mechanisms of Aß Clearance from the Brain Interstitial Fluid of Mice

Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 1 of 7
* James E. Audia, Chicago Biomedical Consortium, USA


Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 2 of 7
Anastasia Khvorova, University of Massachusetts Medical School, USA
RNAi-Based Modulation of Gene Expression in Central Nervous System


Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 3 of 7
Jacob M. Hooker, Harvard Medical School, USA
Integrating PET Tracers into CNS Drug Discovery: Impact on the Discovery of Novel HDAC Ligands


Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain
This session is from Brain Therapeutics

Room: Eldorado A


Coffee Break


Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 5 of 7
Maria-Jesus Blanco, Sage Therapeutics, USA
Discovery of Allosteric Modulators of GABAA Receptor for CNS Disorders


Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 6 of 7
Paula Perez Pardo, Utrecht University, Netherlands
Short Talk: Positive Effects of Small Molecule Tryptophan-2,3-Dioxygense Inhibitors on Motor and Non-Motor Symptoms in a Mouse Model of Parkinson’s Disease


Tuesday, February 18 | 8:00AM - 11:00AM
Integrating Novel Medicinal Chemistry Approaches Targeting t
he Brain
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 7 of 7
Xavier Barril, Gain Therapeutics, Spain
Short Talk: Correcting Protein Misfolding with Structurally Targeted Allosteric Regulators (STAR): Applications in Rare Diseases and Brain Therapeutics


Tuesday, February 18 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, February 18 | 11:15AM - 1:00PM
Poster Setup
Room: Anasazi Ballroom


Tuesday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Anasazi Ballroom


Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 1 of 6
Maria-Jesus Blanco, Sage Therapeutics, USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 2 of 6
Kalpana M. Merchant, Vincere Biosciences, Inc., USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 3 of 6
Maria Lehtinen, Harvard Medical School, USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 4 of 6
Edwin S. Monuki, University of California, Irvine, USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 5 of 6
Maiken Nedergaard, University of Rochester, USA

Tuesday, February 18 | 2:30PM - 4:30PM
Career Roundtable
Room: Zia Ballroom
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 6 of 6
Jacob M. Hooker, Harvard Medical School, USA

Tuesday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
Room: Eldorado B

Speaker 1 of 5
* Maria Lehtinen, Harvard Medical School, USA

Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
Room: Eldorado B

Speaker 2 of 5
Fiona Doetsch, University of Basel, Switzerland
Choroid Plexus Regulation of Adult Neural Stem Cells

Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
Room: Eldorado B

Speaker 3 of 5
Claire Wyart, Institut du Cerveau et de la Moelle Epinière, France
Origin and Role of the Cerebrospinal Fluid Bidirectional Flow in the Central Canal

Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
Room: Eldorado B

Speaker 4 of 5
Craig Ferris, Northeastern University, USA
Imaging the Effect of the Circadian Light-Dark Cycle on the Glymphatic System in Awake Rats

Tuesday, February 18 | 5:00PM - 7:00PM
Integrating Brain-Body Signaling
Room: Eldorado B

Speaker 5 of 5
Laura Lewis, Boston University, USA

Coordinated Neural, Vascular, and Cerebrospinal Fluid Dynamics in Human Sleep


Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 1 of 5
* Darryle D. Schoepp, USA


Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 2 of 5
Steffany A.L. Bennett, University of Ottawa, Canada
Remote Presentation: Lipidomic-Based Insights into Disease Mechanisms: A Targeted Lipidomics Discovery Pipeline for Network and Flux Analysis


Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 3 of 5
Gwenn A. Garden, University of Washington, USA
Emerging Glial Biomarkers of CNS Disease


Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 4 of 5
David Nguyen, Sage Therapeutics, USA
Novel Digital Technologies towards CNS Translational Insights


Tuesday, February 18 | 5:00PM - 7:00PM
Diagnostic and/or Disease-State Biomarkers
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 5 of 5
Jagan A. Pillai, Cleveland Clinic, USA
Short Talk: Pathway Based Analysis to Evaluate Inflammatory Analytes of Significance for Therapeutic Targeting in Alzheimer’s Disease


Tuesday, February 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, February 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Anasazi Ballroom


Wednesday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Anasazi Ballroom


Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 1 of 10
* Fiona Doetsch, University of Basel, Switzerland

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 2 of 10
Roosmarijn E. Vandenbroucke, VIB-UGent Center for Inflammation Research, Belgium
Choroid Plexus-Derived Extracellular Vesicles as Mediators of Neuroinflammation

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 3 of 10
Jean-François Ghersi-Egea, Lyon Neurosciences Research Center, France
Antioxidant Defence at the Choroid Plexus Influences CSF Inflammation during Systemic Perinatal Injuries

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B


Coffee Break

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 5 of 10
Michal Schwartz, Weizmann Institute of Science, Israel
Choroid Plexus Regulation of the Neuroimmune Response

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 6 of 10
Jan Remsik, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Immunological Determinants of Leptomeningeal Metastasis

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 7 of 10
Frederick B. Shipley, Harvard University, USA
Short Talk: Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 8 of 10
Marcus Stoodley, Macquarie University, Australia
Short Talk: Physiological Drivers of Fluid Flow in the Spinal Subarachnoid Space and Spinal Cord

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 9 of 10
Gabriel Jensen, University of Maine, USA
Short Talk: The Meninges and Choroid Plexus are Prominent Telomerase Reverse Transcriptase-Expressing Adult Stem Cell Niches in the Mouse Brain

Wednesday, February 19 | 8:00AM - 11:15AM
Choroid Plexus and CSF Regulation of Neuroimmune Responses
Room: Eldorado B

Speaker 10 of 10
June Goto, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Impaired Glymphatic Flow and The Delayed Neural Differentiation in CCDC39-Deficient Rat Model of Neonatal Hydrocephalus

Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 1 of 6
* Damian G. Wheeler, Translucence Biosystems, Inc, USA


Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 2 of 6
Tetsuya Suhara, National Institutes for Quantum and Radiological Science and Technology, Japan
Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development


Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 3 of 6
Lisa L. Shafer, Cerebral Therapeutics, Inc., USA
Emerging Strategies for Brain Drug Delivery: Case Study Applications


Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery
This session is from Brain Therapeutics

Room: Eldorado A


Coffee Break


Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 5 of 6
Robert G. Thorne, Denali Therapeutics, USA
Characterizing Fusion Protein Transport Across CNS Barriers: Leveraging Imaging and Other Novel Methods to Assess Brain Delivery


Wednesday, February 19 | 8:00AM - 11:00AM
Ensuring Target Engagement: Innovative Approaches Towards Ne
uroimaging and Brain Delivery
This session is from Brain Therapeutics

Room: Eldorado A

Speaker 6 of 6
Frances G. Ghinger, University of Maryland, Baltimore County, USA
Short Talk: Optical Imaging of Ventromedial Prefrontal Cortex Activity Following Chronic Stress


Wednesday, February 19 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 1 of 11
* Iben Lundgaard, University of Lund, Sweden

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 2 of 11
Jin Cui, Boston Children's Hospital, USA
Choroid Plexus as a Site of Immune Activation in a Model of Autism Spectrum Disorders

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 3 of 11
Marco Fanous, Duke University, USA
Aquaporin 4 Regulates Adeno-Associated Viral (AAV) Transport across the Blood Brain Barrier

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 4 of 11
Darshan Sapkota, Washington University, USA
Stop Codon Readthrough of Aqp4 Generates a Novel AQP4 Isoform with Pathophysiological Significance

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 5 of 11
Hannah Elizabeth Jones, University of Colorado Anschutz Medical Campus, USA
Developmental Timing and Origins of Perivascular Brain Fibroblasts

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 6 of 11
Daphne M.P. Naessens, Amsterdam UMC, Netherlands
Elucidating Brain Water Management in Spontaneously Hypertensive Rats

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 7 of 11
Dakota E R DeFreitas, Washington University in St. Louis, USA
Evaluation of CSF Distribution in Post-Hemorrhagic Hydrocephalus Rat Brain using Gold Nanoparticle Enhanced X-ray Nanotomography

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 8 of 11
Cameron Sadegh, Harvard University, USA
Choroid Plexus Epithelia Respond Rapidly to Hemorrhage to Minimize Ventriculomegaly Prior to Global Compensatory Increases in CSF Reabsorption

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 9 of 11
Jordan C. Xu, University of California, Irvine, USA
Dural Lympathic Changes in Normal Pressure Hydrocephalus

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 10 of 11
Andrew T. Hale, Vanderbilt University School of Medicine, USA
Integration of Human Genetics and Mutli-Omics Data Implicates Novel Pathways in Hydrocephalus

Wednesday, February 19 | 3:30PM - 4:30PM
Workshop 2
Room: Eldorado B

Speaker 11 of 11
Arie Horowitz, USA
Cerebrospinal Fluid Signature of Hydrocephalus

Wednesday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
Room: Eldorado B

Speaker 1 of 5
* Jeffrey J. Iliff, University of Washington, USA

Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
Room: Eldorado B

Speaker 2 of 5
Christopher Moore, Brown University, USA
Remote Presentation: A Systems Approach to the Choroid Plexus

Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
Room: Eldorado B

Speaker 3 of 5
Edwin S. Monuki, University of California, Irvine, USA
Towards a Choroid Plexus-Based Regenerative Medicine

Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
Room: Eldorado B

Speaker 4 of 5
Kristopher T. Kahle, Yale School of Medicine, USA
A Role for Inflammation: TLR-4-mediated Cerebrospinal Fluid Hypersecretion in Post-hemorrhagic and Post-infectious Hydrocephalus

Wednesday, February 19 | 5:00PM - 7:00PM
Diagnostics and Therapies
Room: Eldorado B

Speaker 5 of 5
Patricia I. Dickson, Washington University, USA
CSF Delivery of Therapeutics

Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 1 of 6
* Kalpana M. Merchant, Vincere Biosciences, Inc., USA


Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 2 of 6
Aletta D. Kraneveld, University of Utrecht, Netherlands
Parkinson’s Disease: No Guts No Glory


Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 3 of 6
Giorgia Quadrato, University of Southern California, USC Stem Cell, USA
Modeling Human Brain Development and Disease at Single Cell Resolution with Organoids


Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 4 of 6
Shun Mitsui, Tokai University School of Medicine, Japan
Short Talk: Neural Cell-Specific SQSTM1 Deficiency Accelerates the Onset of Disease in an ALS Mouse Model


Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 5 of 6
Nicholas T. Hertz, Mitokinin Inc., USA
Short Talk: Small Molecule Activators of PINK1 Activity Rescue Sporadic PD Associated alpha-Synuclein Pathology


Wednesday, February 19 | 5:00PM - 6:45PM
Innovative Therapeutic Approaches Targeting the Brain
This session is from Brain Therapeutics
Room: Eldorado A

Speaker 6 of 6
Taotao Lao, Massachusetts General Hospital/ Harvard Medical School, USA
Short Talk: TREML2 Regulates Microglia Functions in an Alzheimer’s Disease Model


Wednesday, February 19 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Brain Therapeutics
Room: Eldorado A


Wednesday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Anasazi Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, February 19 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Eldorado B

Speaker 1 of 2
Edwin S. Monuki, University of California, Irvine, USA

Wednesday, February 19 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Eldorado B

Speaker 2 of 2
Maria Lehtinen, Harvard Medical School, USA

Wednesday, February 19 | 8:00PM - 11:00PM
Entertainment
Room: Anasazi Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 20 | 10:24AM - 10:24AM
Departure


*Session Chair.