This meeting took place in the past. Here is a list of meetings that are related:
Web Desc
Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches
joint with Stromal Cells in Immunity and Disease
Organizer(s): Shannon J. Turley and Thomas A. Wynn
Date: February 19 - 23, 2020
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Sponsored by Akebia Therapeutics, Genentech, Inc., Merck & Co., Inc., Novartis Institutes for BioMedical Research and Novo Nordisk A/S
Summary of Meeting:
Fibrosis is an important cause of morbidity and mortality worldwide. Fibrotic scarring can affect most tissues and organ systems, lead to destruction of organ architecture and loss of function. Fibrosis is a major pathogenic feature of many chronic inflammatory diseases, including interstitial lung disease, nonalcoholic steatohepatitis (NASH), glomerulonephritis, heart disease, Crohn’s disease, and systemic sclerosis. Fibrotic tissue remodeling also influences cancer metastasis and cancer therapy. Recent advances have provided a deeper understanding of the pathogenesis of fibrosis and revealed novel targets for drugs that are now at various stages of clinical development. This will be the 7th Keystone Symposium on Fibrosis, the first of which took place in 2007, and is intended to be the premier international meeting for anyone with an interest in fibrosis. The conference draws a broad swath of researchers from various disciplines, including epithelial biology, vascular biology, cancer, stem and tissue progenitor cell biology, tissue repair and regeneration, as well as those with disease-specific interests. Finally, this conference is being paired with another Keystone Symposia conference on Stromal Cells in Immunity and Disease. Hosting these two conferences in tandem will bring together academic, clinical, and translational researchers to discuss the core mechanisms driving inflammation and fibrosis, compare and contrast fibrotic diseases of different organs, discuss the best preclinical models, and debate emerging therapies.
Scholarship Deadline: October 17 2019
Discounted Abstract Deadline: October 17 2019
Abstract Deadline: November 20 2019
Discounted Registration Deadline: December 18 2019
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Akebia TherapeuticsGenentech, Inc.Merck & Co., Inc.Novartis Institutes for BioMedical ResearchNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
American Society of Gene & Cell Therapy (ASGCT)Charles River
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Pfizer Inc.

Pliant Therapeutics
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK125002-01
Funding for this conference was made possible (in part) by 1 R13 DK125002-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, February 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Palm Court


Wednesday, February 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Palm Court
No registration fees are used to fund alcohol served at this function.

Thursday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Crystal Gardens


Thursday, February 20 | 7:30AM - 8:00AM
Poster Setup
Room: Crystal Gardens


Thursday, February 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Salon A/B

Speaker 4 of 4
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Macrophage-Fibroblast Circuits

Thursday, February 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Salon A/B

Speaker 3 of 4
David A. Brenner, University of California, San Diego, USA
Linking Inflammation and Myofibroblast Activation

Thursday, February 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Salon A/B

Speaker 2 of 4
* Shannon J. Turley, Genentech, Inc., USA

Thursday, February 20 | 8:00AM - 9:30AM
Welcome and Keynote Session (Joint)
Room: Salon A/B

Speaker 1 of 4
* Scott N. Mueller, University of Melbourne, Australia

Thursday, February 20 | 8:00AM - 7:00PM
Poster Viewing
Room: Crystal Gardens


Thursday, February 20 | 9:30AM - 10:00AM
Coffee Break
Room: Prefunction


Thursday, February 20 | 10:00AM - 12:00PM
Tissue Fibroblasts and Pericytes in Fibrosis
Room: Salon A/B

Speaker 4 of 7
Yuval Rinkevich, Helmholtz Zentrum München, GmbH, Germany
Two Succeeding Fibroblastic Lineages Drive Dermal Development and the Transition from Regeneration to Scarring

Thursday, February 20 | 10:00AM - 12:00PM
Tissue Fibroblasts and Pericytes in Fibrosis
Room: Salon A/B

Speaker 3 of 7
Jonathan M. Kurie, University of Texas MD Anderson Cancer Center, USA
The Fibrotic Tumor Stroma

Thursday, February 20 | 10:00AM - 12:00PM
Tissue Fibroblasts and Pericytes in Fibrosis
Room: Salon A/B

Speaker 2 of 7
* Dean Sheppard, University of California, San Francisco, USA

Thursday, February 20 | 10:00AM - 12:00PM
Tissue Fibroblasts and Pericytes in Fibrosis
Room: Salon A/B

Speaker 1 of 7
* Shannon J. Turley, Genentech, Inc., USA

Thursday, February 20 | 10:00AM - 12:00PM
Tissue Fibroblasts and Pericytes in Fibrosis
Room: Salon A/B

Speaker 5 of 7
Scott M. Turner, Pliant Therapeutics, USA
Identification and Evaluation of Small Molecule Integrin Inhibitors: From Cell Systems to Human Trials

Thursday, February 20 | 10:00AM - 12:00PM
Tissue Fibroblasts and Pericytes in Fibrosis
Room: Salon A/B

Speaker 6 of 7
Tatsuya Tsukui, University of California, San Francisco, USA
Short Talk: Collagen-Producing Lung Cell Atlas Identifies Multiple Subsets with Distinct Localization and Relevance to Fibrosis

Thursday, February 20 | 10:00AM - 12:00PM
Tissue Fibroblasts and Pericytes in Fibrosis
Room: Salon A/B

Speaker 7 of 7
Dianhua Jiang, Cedars-Sinai Medical Center, USA
Short Talk: Longitudinal Transcriptomics Identifies Fibroblast Subtypes during Lung Development and Fibrosis

Thursday, February 20 | 10:00AM - 12:00PM
Stromal Cells in Lymphoid Tissue Development
This session is from Stromal Cells
Room: Salon C

Speaker 1 of 6
* Jason G. Cyster, HHMI/University of California, San Francisco, USA


Thursday, February 20 | 10:00AM - 12:00PM
Stromal Cells in Lymphoid Tissue Development
This session is from Stromal Cells
Room: Salon C

Speaker 2 of 6
Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
Fibroblastic Stromal Cells Direct Lymphoid Organ Development and Immune Activation


Thursday, February 20 | 10:00AM - 12:00PM
Stromal Cells in Lymphoid Tissue Development
This session is from Stromal Cells
Room: Salon C

Speaker 3 of 6
Reina E. Mebius, Amsterdam UMC-VUmc, Netherlands
Control of the Adaptive Immunity by Lymph Node Stromal Cells


Thursday, February 20 | 10:00AM - 12:00PM
Stromal Cells in Lymphoid Tissue Development
This session is from Stromal Cells
Room: Salon C

Speaker 4 of 6
Sanjiv A. Luther, University of Lausanne, Switzerland
Fibroblasts of the Intestinal Lamina Propria are Important Niche Cells Regulating IgA+ Plasma Cell Homeostasis and Function


Thursday, February 20 | 10:00AM - 12:00PM
Stromal Cells in Lymphoid Tissue Development
This session is from Stromal Cells
Room: Salon C

Speaker 5 of 6
Mark C. Coles, University of Oxford, UK
Short Talk: B-Cell Zone Reticular Cell Microenvironments Shape Chemotactic Gradient Formation


Thursday, February 20 | 10:00AM - 12:00PM
Stromal Cells in Lymphoid Tissue Development
This session is from Stromal Cells
Room: Salon C

Speaker 6 of 6
Anne Chauveau, Oxford University, UK
Short Talk: Perivascular Pathways Direct One-Way Migration of T Cells into Splenic T Zones


Thursday, February 20 | 12:00PM - 1:00PM
Lunch
Room: Crystal Gardens


Thursday, February 20 | 12:00PM - 2:30PM
Poster Session 1
Room: Crystal Gardens


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 1 of 10
* Thirumalai R. Ramalingam, Genentech, Inc., USA

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 2 of 10
* Karen Piper Hanley, University of Manchester, UK

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 3 of 10
Daniel Abebayehu, University of Virginia, USA
Inflammatory Cytokines Induce Unique Immuno-Fibroblast Subpopulations Prone to Myofibroblastic Differentiation

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 4 of 10
Daryle J. DePianto, Genentech, Inc., USA
Molecular Mapping of Epithelial Cell Senescence in IPF

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 5 of 10
Tien Peng, University of California, San Francisco, USA
Gli1+ Mesenchymal Cells Modulate Epithelial Progenitor Metaplasia in Lung Fibrosis

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 6 of 10
Lynn M. Williams, Kennedy Institute of Rheumatology, UK
CREBBP/EP300 Regulation of Collagen VI is a Key Determinant of the Myofibroblast Phenotype in Human Fibrosis

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 7 of 10
Sonia Chothani, Duke-NUS Medical School, Singapore
RNA-Binding Proteins: Drivers of Translational Regulation in Cardiac Fibrosis

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 8 of 10
Preethi Vijayaraj, University of California, Los Angeles, USA
Fibrotic Lung Disease is Associated with Proliferation and Desquamation of Ciliated Bronchiolar Epithelium

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 9 of 10
Ahmad N. Nabhan, Genentech, Inc., USA
A Molecular Cell Atlas of the Human Lung from Single Cell RNA Sequencing

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators
of Fibrosis
Room: Salon A/B

Speaker 10 of 10
Veronica Larcher, Goethe University, Germany
Parallel Lineage Tracing Studies Establish Fibroblasts as the Prevailing in vivo Adipocyte Progenitor

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 1 of 10
* Mandy J. McGeachy, University of Pittsburgh, USA


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 2 of 10
* Ruth Ganss, Harry Perkins Institute of Medical Research, Australia


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 3 of 10
Catarina Gago da Graca, Amsterdam UMC - VUMC, Netherlands
Characterization of MHC-II Expressing FRCs in Steady State and Inflammatory Conditions


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 4 of 10
Ana Martínez-Riaño, Francis Crick Institute, UK
Cellular Dynamics of Follicular Dendritic Cells Control Antigen Presentation during the Humoral Response


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 5 of 10
Yannick Alexandre, University of Melbourne, Australia
Mesenchymal Stromal Cells Coordinate Protective Adaptive Immune Responses during Viral Infections in the Spleen


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 6 of 10
Joshua D. Brandstadter, University of Pennsylvania, USA
Distinct Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes Express Individual Notch Ligands and Prime Graft-versus-Host Disease after Bone Marrow Transplantation


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 7 of 10
Junko Sawada, Johns Hopkins All Children's Hospital, USA
TNFa Upregulates R-Ras Expression in High Endothelial Venule and Capillary Endothelium in Lymph Node, Facilitating T Cell Recruitment upon Inflammation


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 8 of 10
Jennifer Eom, University of Auckland, New Zealand
Phenotypically Distinct Fibroblastic Populations in Melanoma-Infiltrated Human Lymph Nodes Provide Unique Microenvironment for T Lymphocytes


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 9 of 10
Ian Boothby, University of California, San Francisco, USA
Neonatal Tregs Suppress the Development of a Stromal Niche for Th2 Cells in Skin


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Stromal Orchestration and Immune Responses
This session is from Stromal Cells
Room: Salon C

Speaker 10 of 10
Ari B. Molofsky, University of California, San Francisco, USA
Stromal Crosstalk with Type 2 Immunity at Tissue Adventitial Niches


Thursday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction


Thursday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Immunity in Non-Lymphoid Tissues
This session is from Stromal Cells
Room: Salon C

Speaker 1 of 6
* Ari B. Molofsky, University of California, San Francisco, USA


Thursday, February 20 | 5:00PM - 7:00PM
Myeloid Cells in Fibrosis
Room: Salon A/B

Speaker 7 of 7
Resat Cinar, NIAAA, National Institutes of Health, USA
Short Talk: Cannabinoid 1 Receptors (CB1R) in Myeloid Cells Promote Fibrosis in Lung: Paracrine Control Drives Fibroproliferative Microenvironment via Multiple Mechanisms

Thursday, February 20 | 5:00PM - 7:00PM
Myeloid Cells in Fibrosis
Room: Salon A/B

Speaker 6 of 7
Prakash Ramachandran, University of Edinburgh, UK
Short Talk: Defining a Novel Macrophage Subpopulation Which Promotes Human Liver Fibrosis

Thursday, February 20 | 5:00PM - 7:00PM
Myeloid Cells in Fibrosis
Room: Salon A/B

Speaker 5 of 7
Frank Tacke, Charité Universitätsmedizin Berlin, Germany
Macrophage Heterogeneity in Liver Homeostasis, Inflammation, and Fibrosis

Thursday, February 20 | 5:00PM - 7:00PM
Myeloid Cells in Fibrosis
Room: Salon A/B

Speaker 4 of 7
Harris Perlman, Northwestern University, USA
Monocyte Derived Macrophages in Inflammation and Fibrosis

Thursday, February 20 | 5:00PM - 7:00PM
Myeloid Cells in Fibrosis
Room: Salon A/B

Speaker 3 of 7
Akira Shizuo, Osaka University, Japan
Molecular Mechanism of Bleomycin-Induced Lung Fibrosis

Thursday, February 20 | 5:00PM - 7:00PM
Myeloid Cells in Fibrosis
Room: Salon A/B

Speaker 2 of 7
* Tatiana Kisseleva, University of California, San Diego, USA

Thursday, February 20 | 5:00PM - 7:00PM
Myeloid Cells in Fibrosis
Room: Salon A/B

Speaker 1 of 7
* Neil C. Henderson, University of Edinburgh, Queen's Medical Research Institute, UK

Thursday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Immunity in Non-Lymphoid Tissues
This session is from Stromal Cells
Room: Salon C

Speaker 2 of 6
Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA
Langerhans Cells and Skin Protection in Lupus Photosensitivity


Thursday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Immunity in Non-Lymphoid Tissues
This session is from Stromal Cells
Room: Salon C

Speaker 3 of 6
Shruti Naik, New York University, USA
Inflammatory Tuning of Epithelial Stem Cells


Thursday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Immunity in Non-Lymphoid Tissues
This session is from Stromal Cells
Room: Salon C

Speaker 4 of 6
Jeremiah Bernier-Latmani, University of Lausanne, Switzerland
Blood Vessel / Telocyte Crosstalk at the Small Intestinal Villus Tip


Thursday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Immunity in Non-Lymphoid Tissues
This session is from Stromal Cells
Room: Salon C

Speaker 5 of 6
Matthew B. Buechler, Genentech, Inc., USA
Short Talk: Tissue-Specific Programming Determines Tenor of Fibroblast and Mesothelial Cell Plasticity and Activation


Thursday, February 20 | 5:00PM - 7:00PM
Stromal Cells and Immunity in Non-Lymphoid Tissues
This session is from Stromal Cells
Room: Salon C

Speaker 6 of 6
Bing Su, Shanghai JiaoTong University School of Medicine, China
Short Talk: Map3k2-Regulated Intestinal Stromal Cells Define a Stem Cell Niche via Wnt Agonist R-spondin1


Friday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Crystal Gardens


Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B

Speaker 1 of 9
* Cory M. Hogaboam, Cedars-Sinai Medical Center, USA

Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B

Speaker 2 of 9
* Katalin Susztak, University of Pennsylvania, USA

Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B

Speaker 3 of 9
Ivan O. Rosas, Baylor College of Medicine, USA
Insights into the Complexity and Diversity of Cell Populations in IPF and COPD using Single Cell RNA-seq

Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B

Speaker 4 of 9
Neil C. Henderson, University of Edinburgh, Queen's Medical Research Institute, UK
Using Single Cell Genomics to Decode the Hepatic Fibrotic Niche

Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B


Coffee Break

Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B

Speaker 6 of 9
Katalin Susztak, University of Pennsylvania, USA
Fatty Acid Oxidation in Tubular Epithelial Cells Regulates Kidney Fibrosis

Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B

Speaker 7 of 9
Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, Blade Therapeutics, USA
New Mechanisms and Vulnerabilities of Fibrosis

Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B

Speaker 8 of 9
Ying Wei, University of California, San Francisco, USA
Short Talk: Reversal of TGFbeta1-Driven Pro-Fibrotic State in Pulmonary Fibrosis Patients

Friday, February 21 | 8:00AM - 11:00AM
Advances in Organ Fibrosis
Room: Salon A/B

Speaker 9 of 9
Satish K. Madala, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Transcriptional Regulation of Fibroblast Activation in Severe Fibrotic Lung Disease

Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C

Speaker 1 of 9
* Reina E. Mebius, Amsterdam UMC-VUmc, Netherlands


Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C

Speaker 2 of 9
João Pereira, Yale University School of Medicine, USA
Cell Circuits, B cells, and Systemic Responses to Microbial Infections


Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C

Speaker 3 of 9
Madelon M. E. de Jong, Erasmus MC, Netherlands
Short Talk: A Unique Inflammatory Stromal Cell Population Associated with NFkappaB Signaling in the Multiple Myeloma Bone Marrow


Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C

Speaker 4 of 9
Tomoya Katakai, Niigata University, Japan
Stromal Cell Diversity in Lymph Nodes


Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C


Coffee Break


Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C

Speaker 6 of 9
Beth A. Tamburini, University of Colorado Denver Anchutz Medical Campus, USA
Control of Immune Responses in Lymph Nodes by Lymphatic Endothelial Cells


Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C

Speaker 7 of 9
Dragos Cristian Dasoveanu, Hospital for Special Surgery, USA
Short Talk: Lymph Node Stromal CCL2 Limits Antibody Responses


Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C

Speaker 8 of 9
Natalia Pikor, Kantonsspital St. Gallen, Switzerland
Short Talk: CXCL12-Dependent Remodeling of Light and Dark Zone Follicular Dendritic Cells Governs the Germinal Center Response


Friday, February 21 | 8:00AM - 11:00AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tis
sues
This session is from Stromal Cells

Room: Salon C

Speaker 9 of 9
Lorenz Jahn, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Transcriptional Responses of Thymic Epithelium, Endothelium, and Mesenchyme to Acute Injury on a Single Cell Level


Friday, February 21 | 11:00AM - 5:00PM
On Own for Lunch


Friday, February 21 | 11:00AM - 1:00PM
Poster Setup
Room: Crystal Gardens


Friday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Crystal Gardens


Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 1 of 9
* Lucie Peduto, Institut Pasteur, France

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 2 of 9
* Michael Underhill, University of British Columbia, Canada

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 3 of 9
Lee A. Borthwick, Newcastle University, UK
A Bioreactor Technology for Modelling Fibrosis in Human and Rodent Precision-Cut Liver Slices

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 4 of 9
Michael Jeffrey Podolsky, University of California, San Francisco, USA
Genome-Wide Screens Identify Novel Regulators of Cell-Mediated Collagen Degradation

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 5 of 9
Maha AlSharqi, McGill University, Canada
Development of CD109-Based Molecules as TGF-Beta Antagonists and Antifibrotic Agents in Scleroderma Fibroblasts

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 6 of 9
Laura Elisabeth Kähäri, University of Turku, Finland
Targeted Delivery of Antibodies to the Draining Lymph Node through the Subcapsular Sinus Floor

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 7 of 9
Kristine Lai, Cornell University, USA
ImmuneChip with Stromal-Specific Chemokine Gradient to Capture Germinal Center B Cell Dynamics

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 8 of 9
Heather J. Faust, Brigham and Womens Hospital, USA
Utilization of 3D Organoids to Study Synovial Fibroblast-Immune Cell Interactions

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: Novel Technologies and Models in Stromal Cell Bi
ology and Fibrosis (Joint)
Room: Salon A/B

Speaker 9 of 9
Anastasia Kousa, Memorial Sloan Kettering Sloan Cancer Center, USA
Construction of a Cellular Interactome Across Epithelium, Endothelium, and Mesenchyme During Thymic Regeneration

Friday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction


Friday, February 21 | 5:00PM - 7:00PM
Unique Drivers of Inflammation and Fibrosis
Room: Salon A/B

Speaker 1 of 7
* Boris Hinz, University of Toronto, Canada

Friday, February 21 | 5:00PM - 7:00PM
Unique Drivers of Inflammation and Fibrosis
Room: Salon A/B

Speaker 2 of 7
* Maria Trojanowska, Boston University School of Medicine, USA

Friday, February 21 | 5:00PM - 7:00PM
Unique Drivers of Inflammation and Fibrosis
Room: Salon A/B

Speaker 3 of 7
Anissa A. Widjaja, DUKE-NUS Medical School, Singapore
Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity and Stromal Inflammation

Friday, February 21 | 5:00PM - 7:00PM
Unique Drivers of Inflammation and Fibrosis
Room: Salon A/B

Speaker 4 of 7
Pilar Alcaide, Tufts University School of Medicine, USA
T Cell Regulation of Cardiac Fibrosis

Friday, February 21 | 5:00PM - 7:00PM
Unique Drivers of Inflammation and Fibrosis
Room: Salon A/B

Speaker 5 of 7
Jelena Mann, Newcastle University, UK
Epigenetics and Fibrosis

Friday, February 21 | 5:00PM - 7:00PM
Unique Drivers of Inflammation and Fibrosis
Room: Salon A/B

Speaker 6 of 7
Ning Ding, Genentech, Inc., USA
Short Talk: WISP1 Activates MRTF to Promote the Progression of Established Liver Fibrosis

Friday, February 21 | 5:00PM - 7:00PM
Unique Drivers of Inflammation and Fibrosis
Room: Salon A/B

Speaker 7 of 7
Akiyoshi Uemura, Nagoya City University, Japan
Short Talk: Activated Microglia Promote Fibrosis in Pericyte-Deficient Retina

Friday, February 21 | 5:00PM - 7:00PM
Endothelial Cells in Immunity and Disease
This session is from Stromal Cells
Room: Salon C

Speaker 1 of 6
* Amanda Lund, New York University, USA


Friday, February 21 | 5:00PM - 7:00PM
Endothelial Cells in Immunity and Disease
This session is from Stromal Cells
Room: Salon C

Speaker 2 of 6
Scott N. Mueller, University of Melbourne, Australia
Disentangling the Splenic Stromal Cell Network in Health in Disease


Friday, February 21 | 5:00PM - 7:00PM
Endothelial Cells in Immunity and Disease
This session is from Stromal Cells
Room: Salon C

Speaker 3 of 6
Cornelia Halin, ETH Zürich, Switzerland
Leukocyte Migration through Afferent Lymphatic Vessels


Friday, February 21 | 5:00PM - 7:00PM
Endothelial Cells in Immunity and Disease
This session is from Stromal Cells
Room: Salon C

Speaker 4 of 6
Ulrich H. Von Andrian, Harvard Medical School, USA
Lymphocyte Patrol of Blood Vessel Endothelium


Friday, February 21 | 5:00PM - 7:00PM
Endothelial Cells in Immunity and Disease
This session is from Stromal Cells
Room: Salon C

Speaker 5 of 6
Akira Takeda, University of Turku, Finland
Short Talk: Human Lymphatic Endothelial Heterogeneity in Health and Disease


Friday, February 21 | 5:00PM - 7:00PM
Endothelial Cells in Immunity and Disease
This session is from Stromal Cells
Room: Salon C

Speaker 6 of 6
Madeline Churchill, Oregon Health and Science University, USA
Short Talk: Dermal Lymphatic Capillary ‘Zippering’ Enhances CD8+ T Cell Priming Following Cutaneous Viral Infection


Friday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crystal Gardens
No registration fees are used to fund alcohol served at this function.

Friday, February 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Crystal Gardens


Saturday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Crystal Gardens


Saturday, February 22 | 8:00AM - 11:00AM
Novel Pathways and Strategies to Ameliorate Fibrosis
Room: Salon A/B

Speaker 1 of 8
* Derek A. Mann, Newcastle University, UK

Saturday, February 22 | 8:00AM - 11:00AM
Novel Pathways and Strategies to Ameliorate Fibrosis
Room: Salon A/B

Speaker 2 of 8
Thomas A. Wynn, Pfizer, USA
Targeting Type 1 and Type 2 Fibrosis

Saturday, February 22 | 8:00AM - 11:00AM
Novel Pathways and Strategies to Ameliorate Fibrosis
Room: Salon A/B

Speaker 3 of 8
Tatiana Kisseleva, University of California, San Diego, USA
The Role of Mesothelin in the Pathogenesis of Parenchymal Organs

Saturday, February 22 | 8:00AM - 11:00AM
Novel Pathways and Strategies to Ameliorate Fibrosis
Room: Salon A/B


Coffee Break

Saturday, February 22 | 8:00AM - 11:00AM
Novel Pathways and Strategies to Ameliorate Fibrosis
Room: Salon A/B

Speaker 5 of 8
Scott L. Friedman, Icahn School of Medicine at Mount Sinai, USA
Target Selection and Validation for Antifibrotic Therapies in Liver

Saturday, February 22 | 8:00AM - 11:00AM
Novel Pathways and Strategies to Ameliorate Fibrosis
Room: Salon A/B

Speaker 6 of 8
Christine Kim Garcia, Columbia University Medical Center, USA
Pulmonary Fibrosis: Inherited Susceptibilities and Personalized Prognostics

Saturday, February 22 | 8:00AM - 11:00AM
Novel Pathways and Strategies to Ameliorate Fibrosis
Room: Salon A/B

Speaker 7 of 8
Jennifer Y. Chen, University of California, San Francisco, USA
Short Talk: Targeting Acid Ceramidase Inhibits YAP/TAZ Mechanosignaling to Ameliorate Fibrosis

Saturday, February 22 | 8:00AM - 11:00AM
Novel Pathways and Strategies to Ameliorate Fibrosis
Room: Salon A/B

Speaker 8 of 8
Andreas Schlitzer, University of Bonn, Germany
Short Talk: Inflammation Experienced Trem2+ Monocyte-Derived Alveolar Macrophages Control Pulmonal Inflammatory Reactivity and Protect from Lung Fibrosis

Saturday, February 22 | 8:00AM - 11:00AM
Stromal Cells in Cancer and Anti-Tumor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 1 of 8
* Hélène Salmon, Institut Curie and Mount Sinai School of Medicine, France


Saturday, February 22 | 8:00AM - 11:00AM
Stromal Cells in Cancer and Anti-Tumor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 2 of 8
Amanda Lund, New York University, USA
Lymphatic Vessels and the Cancer Immunity Life Cycle


Saturday, February 22 | 8:00AM - 11:00AM
Stromal Cells in Cancer and Anti-Tumor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 3 of 8
Anne Fletcher, Monash University, Australia
Human T Cell Suppression Triggered through Cross-Talk with Cancer-Associated Fibroblasts


Saturday, February 22 | 8:00AM - 11:00AM
Stromal Cells in Cancer and Anti-Tumor Immunity
This session is from Stromal Cells
Room: Salon C


Coffee Break


Saturday, February 22 | 8:00AM - 11:00AM
Stromal Cells in Cancer and Anti-Tumor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 5 of 8
Ruth Ganss, Harry Perkins Institute of Medical Research, Australia
Stromal Remodeling and Targeting in Cancer


Saturday, February 22 | 8:00AM - 11:00AM
Stromal Cells in Cancer and Anti-Tumor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 6 of 8
Jacqui Shields, University of Cambridge, UK
Beyond the Cancer Cell: Exploring the Tumour Stroma as Immune Modulators


Saturday, February 22 | 8:00AM - 11:00AM
Stromal Cells in Cancer and Anti-Tumor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 7 of 8
John Andrew Grout, Mount Sinai School of Medicine, USA
Short Talk: Single Cell Transcriptomic Dissection of the Stromal Cell Compartment in Early-Stage Non-Small Cell Lung Carcinoma (NSCLC)


Saturday, February 22 | 8:00AM - 11:00AM
Stromal Cells in Cancer and Anti-Tumor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 8 of 8
Anthony B. Rodriguez, University of Virginia School of Medicine, USA
Short Talk: Tumor-Associated Fibroblasts Act As Surrogate Lymphoid Tissue Organizer Cells That Orchestrate Tumor-Associated Tertiary Lymphoid Structure Development


Saturday, February 22 | 11:00AM - 5:00PM
On Own for Lunch


Saturday, February 22 | 11:00AM - 1:00PM
Poster Setup
Room: Crystal Gardens


Saturday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Crystal Gardens


Saturday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction


Saturday, February 22 | 5:00PM - 7:00PM
Distinct and Common Mechanisms of Fibrosis Revealed by Diffe
rent Tissues

Room: Salon A/B

Speaker 1 of 7
* Robert V. Martinez, Pfizer Inc., USA

Saturday, February 22 | 5:00PM - 7:00PM
Distinct and Common Mechanisms of Fibrosis Revealed by Diffe
rent Tissues

Room: Salon A/B

Speaker 2 of 7
* Anna Burkart Sadusky, NIDDK, National Institutes of Health, USA

Saturday, February 22 | 5:00PM - 7:00PM
Distinct and Common Mechanisms of Fibrosis Revealed by Diffe
rent Tissues

Room: Salon A/B

Speaker 3 of 7
Florian Rieder, Cleveland Clinic, USA
Mechanisms and Future Clinical Trial Endpoints of Intestinal Fibrosis

Saturday, February 22 | 5:00PM - 7:00PM
Distinct and Common Mechanisms of Fibrosis Revealed by Diffe
rent Tissues

Room: Salon A/B

Speaker 4 of 7
Daniel Tschumperlin, Mayo Clinic, USA
Targeting YAP/TAZ in Lung and Liver Fibrosis

Saturday, February 22 | 5:00PM - 7:00PM
Distinct and Common Mechanisms of Fibrosis Revealed by Diffe
rent Tissues

Room: Salon A/B

Speaker 5 of 7
Valerie M. Weaver, University of California, San Francisco, USA
Tissue Tension Induces Matricellular Fibrosis and Tumor Progression in Pancreas

Saturday, February 22 | 5:00PM - 7:00PM
Distinct and Common Mechanisms of Fibrosis Revealed by Diffe
rent Tissues

Room: Salon A/B

Speaker 6 of 7
Tapas Mukherjee, University of Toronto, Canada
Short Talk: Deciphering the Influence of Crohn's Disease-Associated Genetic Risk Factor, NOD2 in Intestinal Fibrosis

Saturday, February 22 | 5:00PM - 7:00PM
Distinct and Common Mechanisms of Fibrosis Revealed by Diffe
rent Tissues

Room: Salon A/B

Speaker 7 of 7
Ji Zhang, Merck & Co., Inc., USA
Short Talk: Molecular Profiling Reveals A Common Metabolic Signature of Tissue Fibrosis

Saturday, February 22 | 5:00PM - 7:00PM
Stroma Cell Contributions During Infection and Inflammation
This session is from Stromal Cells
Room: Salon C

Speaker 1 of 6
* Sanjiv A. Luther, University of Lausanne, Switzerland


Saturday, February 22 | 5:00PM - 7:00PM
Stroma Cell Contributions During Infection and Inflammation
This session is from Stromal Cells
Room: Salon C

Speaker 2 of 6
Melody A. Swartz, University of Chicago, USA
Role of Lymphatic Endothelial Cells in the Regulation of T Cell Memory


Saturday, February 22 | 5:00PM - 7:00PM
Stroma Cell Contributions During Infection and Inflammation
This session is from Stromal Cells
Room: Salon C

Speaker 3 of 6
Susan R. Schwab, New York University School of Medicine, USA
Exit Strategies: S1P Gradients in Inflammation


Saturday, February 22 | 5:00PM - 7:00PM
Stroma Cell Contributions During Infection and Inflammation
This session is from Stromal Cells
Room: Salon C

Speaker 4 of 6
Marc Bajénoff, Centre d'Immunologie Marseille-Luminy, France
Lymphoid Stromal Cells are Essential Components of Macrophage Niches


Saturday, February 22 | 5:00PM - 7:00PM
Stroma Cell Contributions During Infection and Inflammation
This session is from Stromal Cells
Room: Salon C

Speaker 5 of 6
Mandy J. McGeachy, University of Pittsburgh, USA
Short Talk: IL-17 Signals to Lymphoid Stroma to Support Function during Th17 Autoimmune and Th1/CTL Anti-Viral Responses


Saturday, February 22 | 5:00PM - 7:00PM
Stroma Cell Contributions During Infection and Inflammation
This session is from Stromal Cells
Room: Salon C

Speaker 6 of 6
David F. Boyd, St. Jude Children's Research Hospital, USA
Short Talk: Inflammatory Fibroblasts Determine the Outcome of Severe Respiratory Infection in an ADAMTS4-Dependent Manner


Saturday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crystal Gardens
No registration fees are used to fund alcohol served at this function.

Saturday, February 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Crystal Gardens


Sunday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Crystal Gardens


Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B

Speaker 1 of 9
* Andrew Leask, University of Saskatoon, Canada

Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B

Speaker 2 of 9
Dean Sheppard, University of California, San Francisco, USA
Enhancement of Anti-Tumor Immunity by Inhibition of TGFbeta Activation by the Integrin alphavbeta8

Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B

Speaker 3 of 9
Harold A. Chapman, University of California, San Francisco, USA
Lung Progenitors in Epithelial Renewal Following Injury

Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B


Coffee Break

Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B

Speaker 5 of 9
Joseph R. Arron, Genentech, Inc., USA
Reprogramming Pathogenic Cells to Promote Tissue Repair

Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B

Speaker 6 of 9
Chris Cox, Genentech, Inc., USA
Short Talk: Interleukin 1 Maintains the Intestinal Stem Cell Compartment during C. rodentium Infection through Grem1+ Stromal Derived R-spondin 3

Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B

Speaker 7 of 9
Miriam Hohmann, Cedars-Sinai Medical Center, USA
Short Talk: Role of the C-C Chemokine Receptor (CCR10) in Mesenchymal Progenitor Cells in IPF

Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B

Speaker 8 of 9
Wilder Scott, University of British Columbia, Canada
Short Talk: ScRNA-seq and scATAC-seq Uncover the Fate and Function of Adult Mesenchymal Progenitors at Homeostasis and during Regeneration

Sunday, February 23 | 8:00AM - 11:00AM
Progenitor Cells in Tissue Repair and Organ Regeneration
Room: Salon A/B

Speaker 9 of 9
Farshad Babaeijandaghi, University of British Columbia, Canada
Short Talk: CSF1R-Dependent Tissue-Resident and Infiltrating Macrophages Play Distinct Roles in Muscle Regeneration and are Promising Targets to Treat Muscular Dystrophies

Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C

Speaker 1 of 9
* Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA


Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C

Speaker 2 of 9
Michael B. Brenner, Harvard Medical School, USA
Fibroblast Positional Identity Controlled by Inductive Notch Signaling Underlies Pathologic Damage in Inflammatory Arthritis


Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C

Speaker 3 of 9
Lucie Peduto, Institut Pasteur, France
Mesenchymal Cells in Pathology and Tissue Repair


Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C


Coffee Break


Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C

Speaker 5 of 9
George A. Kollias, Alexander Fleming Biomedical Sciences Research Center, Greece
Mesenchymal Causalities in Inflammation, Immunity and Cancer


Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C

Speaker 6 of 9
Ankur Singh, Cornell University, USA
Immune Organoids to Study Immunity and Epigenetics in Health and Diseases


Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C

Speaker 7 of 9
Manolis Roulis, Yale University, USA
Short Talk: Paracrine Orchestration of Intestinal Tumorigenesis by a Confined Mesenchymal Niche


Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C

Speaker 8 of 9
Viviana Cremasco, Novartis Institutes for BioMedical Research, USA
Short Talk: TGFß-Blockade Uncovers Stromal Plasticity in Tumors by Revealing the Existence of a Novel Subset of Interferon-Licensed Fibroblasts


Sunday, February 23 | 8:00AM - 11:15AM
Interrogating Stromal Functions in Disease
This session is from Stromal Cells
Room: Salon C

Speaker 9 of 9
Guillaume Harlé, University of Geneva, Switzerland
Short Talk: Autophagy in Lymphatic Endothelial Cells Dampens Collagen-Induced Arthritis Severity by Regulating Sphingosine-1-Phosphate Production


Sunday, February 23 | 11:00AM - 5:00PM
On Own for Lunch


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 1 of 9
* Edda Fiebiger, AbbVie, Inc., USA

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 2 of 9
* Paul J. Yaworsky, Mediar Therapeutics, USA

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 3 of 9
Claude Jourdan Le Saux, University of California, San Francisco, USA
Serum Biomarker Responses of Pulmonary Fibrosis Patients after Treatment with the LOXL2/TGFß1 Inhibitor EGCG

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 4 of 9
Guiquan Jia, Genentech, Inc., USA
Modulation of a Plasma Cell Signature by Interleukin 6 in Systemic Sclerosis Skin Tissue

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 5 of 9
Juan Juan Marugan, NCATS, National Institutes of Health, USA
ML290 Ameliorates Fibrosis in Multiple in vivo Models

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 6 of 9
Alex Peidl, Western University, Canada
Therapeutic Peptides Based on CCN3 Treat Systemic Sclerosis in a Mouse Model of the Disease

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 7 of 9
Martin Hausmann, University Hospital Zurich, Switzerland
New Therapeutic Approach to Intestinal Fibrosis by Inhibition of pH-Sensing Receptor GPR4-Induced Rho Activation

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 8 of 9
Martin Leduc, Liminal R&D BioSciences Inc., Canada
Fezagepras (PBI-4050) Reduces Pulmonary Fibroblast Activation, Proliferation, and AKT/mTORC/4E-BP1 Signaling

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to t
he Clinic
Room: Salon A/B

Speaker 9 of 9
Piotr L. Sklepkiewicz, OncoArendi Therapeutics SA, Poland
Chitotriosidase (CHIT1) as a Novel Therapeutic Target in Idiopathic Pulmonary Fibrosis (IPF)

Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 1 of 9
* Viviana Cremasco, Novartis Institutes for BioMedical Research, USA


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 2 of 9
* Anne Fletcher, Monash University, Australia


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 3 of 9
Hung N. Nguyen, Brigham and Women's Hospital, USA
Transcriptional Regulation of Fibroblasts in Inflammation


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 4 of 9
Fumitaka Mizoguchi, Tokyo Medical and Dental University, Japan
Gene Expression Profiling of Synovial Fibroblast Subsets Revealed Novel Transcription Factors Driving Their Pathogenic Functions in Rheumatoid Arthritis


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 5 of 9
Maria Steele, Oregon Health & Science University, USA
Lymphatic-Mediated Egress of Tumor-Specific CD8+ T Cells Limits Anti-Tumor Immunity in Melanoma


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 6 of 9
Hafsa Munir, University of Cambridge, UK
Cancer-Associated Fibroblast-Derived Amyloid ß Drives Neutrophil Extracellular Trap Formation to Promote Tumor Progression


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 7 of 9
Sandra Ring, Kantonsspital St. Gallen, Switzerland
IL-33 Provision by Reprogrammed Tumor Fibroblastic Stromal Cells Promotes Local T Cell Activity and Grants Melanoma Eradication


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 8 of 9
Laura Donlin, Hospital for Special Surgery & Weill Cornell Medicine, USA
Fibroblast Activation by ‘Pro-Invasive’ Macrophages in Human Autoimmunity


Sunday, February 23 | 2:30PM - 4:30PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-T
umor Immunity
This session is from Stromal Cells
Room: Salon C

Speaker 9 of 9
Elisabetta Dondi, INSERM, France
Chronic Lymphocytic Leukemia Nurse-Like Cells are an Alternative Source of CCL21 Homeostatic Chemokine in Disorganized Lymph Nodes


Sunday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction


Sunday, February 23 | 5:00PM - 7:00PM
New Directions in Dissecting Stromal Cell Functions (Joint)
Room: Salon A/B

Speaker 1 of 7
* Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland

Sunday, February 23 | 5:00PM - 7:00PM
New Directions in Dissecting Stromal Cell Functions (Joint)
Room: Salon A/B

Speaker 2 of 7
* Thomas A. Wynn, Pfizer, USA

Sunday, February 23 | 5:00PM - 7:00PM
New Directions in Dissecting Stromal Cell Functions (Joint)
Room: Salon A/B

Speaker 3 of 7
Stuart J. Forbes, University of Edinburgh, UK
Liver Stem Cells and Tissue Regeneration

Sunday, February 23 | 5:00PM - 7:00PM
New Directions in Dissecting Stromal Cell Functions (Joint)
Room: Salon A/B

Speaker 4 of 7
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Stromal Cells as Orchestrators of Humoral Immunity

Sunday, February 23 | 5:00PM - 7:00PM
New Directions in Dissecting Stromal Cell Functions (Joint)
Room: Salon A/B

Speaker 5 of 7
Shannon J. Turley, Genentech, Inc., USA
Stromal Cells in Cancer Immunology and Immunotherapy

Sunday, February 23 | 5:00PM - 7:00PM
New Directions in Dissecting Stromal Cell Functions (Joint)
Room: Salon A/B

Speaker 6 of 7
Lesley A. Hill, University of British Columbia, Canada
Short Talk: Fate and Function of “Mesenchymal” Progenitors in Liver Regeneration and Fibrosis

Sunday, February 23 | 5:00PM - 7:00PM
New Directions in Dissecting Stromal Cell Functions (Joint)
Room: Salon A/B

Speaker 7 of 7
Ruth A. Franklin, Harvard University, USA
Short Talk: Environmental Sensing by Fibroblasts Controls Growth Factor Production

Sunday, February 23 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
Room: Salon A/B


Sunday, February 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Crystal Gardens
No registration fees are used to fund alcohol served at this function.

Sunday, February 23 | 8:00PM - 11:00PM
Entertainment
Room: Crystal Gardens
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Monday, February 24 | 10:24AM - 10:24AM
Departure


*Session Chair.