Web Desc
Charting a New Course for Heart Failure: From Discovery to Data
joint with New Insights into the Biology of Exercise
Organizer(s): Mansoor Husain, Benoit G. Bruneau and Marc Pfeffer
Date: March 01 - 05, 2020
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Merck & Co., Inc. and Novo Nordisk A/S
Summary of Meeting:
Heart failure is a global health problem of increasing prevalence. There have been few impactful therapeutic advances to mitigate the high morbidity, and refractory mortality of heart failure. This unique multidisciplinary conference will bring together leading clinicians and scientists to share their latest insights into the genetic, environmental, iatrogenic and pathophysiological mechanisms of heart failure. The meeting program includes sessions and workshops with a specific focus on advances in cardiac fibrosis, immunology, metabolism, regenerative medicine, biomedical engineering, and analytical approaches to large datasets of relevance to this disease. Each session will address a scientific frontier of potential therapeutic relevance in the biology of heart failure and will be framed as a response to an important, unanswered clinical question. This innovative format is intended to highlight translational opportunities in heart failure and to provide a forum that encourages dialogue between cardiovascular researchers and trainees with distinct perspectives, who share a common goal of making an impact in heart failure. This conference will be paired with “New Insights into the Biology of Exercise.” These two Keystone Symposia conferences will share a joint session examining exercise physiology and how it affects cardiac energetics and hypertrophy, which will be of open to attendees of either conference.
Scholarship Deadline: October 31 2019
Discounted Abstract Deadline: October 31 2019
Abstract Deadline: December 3 2019
Discounted Registration Deadline: January 7 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Merck & Co., Inc.Novo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Cytokinetics, Inc.Ted Rogers Centre for Heart Research
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL151106-01
Funding for this conference was made possible (in part) by 1R13HL151106-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This grant is co-funded by the National Heart, Lung, And Blood Institute (NHLBI) and the National Institute On Aging (NIA).
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 01 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, March 01 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Monday, March 02 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Longs Peak

Speaker 1 of 3
* Mansoor Husain, Ted Rogers Centre for Heart Research, Canada

Monday, March 02 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Longs Peak

Speaker 2 of 3
* Marc A. Pfeffer, Brigham and Women’s Hospital, USA

Monday, March 02 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Longs Peak

Speaker 3 of 3
Deepak Srivastava, Gladstone Institutes, USA
Cardiac Development: Basis for Disease and Regeneration

Monday, March 02 | 9:00AM - 11:30AM
Heart Failure and Fibrosis
Room: Longs Peak

Speaker 1 of 7
* Benoit G. Bruneau, Gladstone Institutes, USA

Monday, March 02 | 9:00AM - 11:30AM
Heart Failure and Fibrosis
Room: Longs Peak

Speaker 2 of 7
Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
New Molecular Mechanisms of Fibrosis in Heart Failure

Monday, March 02 | 9:00AM - 11:30AM
Heart Failure and Fibrosis
Room: Longs Peak


Coffee Break

Monday, March 02 | 9:00AM - 11:30AM
Heart Failure and Fibrosis
Room: Longs Peak

Speaker 4 of 7
Michelle D. Tallquist, University of Hawaii, USA
Cardiac Fibroblast Regulation of Matrix Assembly and Inflammation

Monday, March 02 | 9:00AM - 11:30AM
Heart Failure and Fibrosis
Room: Longs Peak

Speaker 5 of 7
Eva van Rooij, Hubrecht Institute, Netherlands
Important Regulators of Cardiac Fibrosis During Injury


Monday, March 02 | 9:00AM - 11:30AM
Heart Failure and Fibrosis
Room: Longs Peak

Speaker 6 of 7
Nick Quaife, Imperial College London, UK
Short Talk: Novel Small Open Reading Frames Are Regulators of Cardiac Fibrosis

Monday, March 02 | 9:00AM - 11:30AM
Heart Failure and Fibrosis
Room: Longs Peak

Speaker 7 of 7
Zachary Kadow, Baylor College of Medicine, USA
Short Talk: Cardiac Pitx2 Deficiency Results in Non-Cell Autonomous Activation of Cardiac Fibroblasts

Monday, March 02 | 9:00AM - 11:30AM
Translating the Mechanisms Driving Human Exercise Adaptation
s
This session is from Biology of Exercise

Room: Grays Peak

Speaker 1 of 7
* Sue Bodine, University of Iowa, USA


Monday, March 02 | 9:00AM - 11:30AM
Translating the Mechanisms Driving Human Exercise Adaptation
s
This session is from Biology of Exercise

Room: Grays Peak

Speaker 2 of 7
Ruth J.F. Loos, Mount Sinai School of Medicine, USA
Drivers of Physical Activity and Exercise – Insights from Genetic Association Studies


Monday, March 02 | 9:00AM - 11:30AM
Translating the Mechanisms Driving Human Exercise Adaptation
s
This session is from Biology of Exercise

Room: Grays Peak


Coffee Break


Monday, March 02 | 9:00AM - 11:30AM
Translating the Mechanisms Driving Human Exercise Adaptation
s
This session is from Biology of Exercise

Room: Grays Peak

Speaker 4 of 7
Bret H. Goodpaster, Translational Research Institute for Metabolism and Diabetes, USA
Exercise and Calorie Restriction in Humans: Different Means to the Same End?


Monday, March 02 | 9:00AM - 11:30AM
Translating the Mechanisms Driving Human Exercise Adaptation
s
This session is from Biology of Exercise

Room: Grays Peak

Speaker 5 of 7
Stephen Previs, Merck, USA
Integrative Metabolism in the Search for Drug Targets and Candidates


Monday, March 02 | 9:00AM - 11:30AM
Translating the Mechanisms Driving Human Exercise Adaptation
s
This session is from Biology of Exercise

Room: Grays Peak

Speaker 6 of 7
Jon Woodhead, University of Auckland, New Zealand
Short Talk: MOTS-C Is an Exercise Responsive Peptide That Increases Following Acute High Intensity Exercise and Is Modified by Short-Term Training in Healthy Young Men


Monday, March 02 | 9:00AM - 11:30AM
Translating the Mechanisms Driving Human Exercise Adaptation
s
This session is from Biology of Exercise

Room: Grays Peak

Speaker 7 of 7
Stefan Markus Reitzner, Karolinska Institutet, Sweden
Short Talk: Skeletal Muscle Transcriptomics Following Acute Endurance and Resistance Exercise in Life-Long Trained Males


Monday, March 02 | 11:30AM - 5:00PM
On Own for Lunch


Monday, March 02 | 11:30AM - 1:00PM
Poster Setup
Room: Quandary Peak


Monday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Monday, March 02 | 2:30PM - 4:30PM
Career Roundtable
Room: Torreys Peak I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 1 of 6
Sue Bodine, University of Iowa, USA

Monday, March 02 | 2:30PM - 4:30PM
Career Roundtable
Room: Torreys Peak I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 2 of 6
Benoit G. Bruneau, Gladstone Institutes, USA

Monday, March 02 | 2:30PM - 4:30PM
Career Roundtable
Room: Torreys Peak I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 3 of 6
John P. Thyfault, University of Kansas Medical Center, USA

Monday, March 02 | 2:30PM - 4:30PM
Career Roundtable
Room: Torreys Peak I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 4 of 6
Glenn C. Rowe, University of Alabama at Birmingham, USA

Monday, March 02 | 2:30PM - 4:30PM
Career Roundtable
Room: Torreys Peak I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 5 of 6
Maren Laughlin, NIDDK, National Institutes of Health, USA

Monday, March 02 | 2:30PM - 4:30PM
Career Roundtable
Room: Torreys Peak I & II
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 6 of 6
Eliza Bollinger, Pfizer, USA

Monday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 02 | 5:00PM - 7:15PM
Cardiovascular Response to Exercise (Joint)
Room: Longs Peak

Speaker 1 of 7
* Jill N. Barnes, University of Wisconsin-Madison, USA

Monday, March 02 | 5:00PM - 7:15PM
Cardiovascular Response to Exercise (Joint)
Room: Longs Peak

Speaker 2 of 7
Douglas R. Seals, University of Colorado, USA
Exercise, Oxidative Stress, and Optimal Vascular Aging

Monday, March 02 | 5:00PM - 7:15PM
Cardiovascular Response to Exercise (Joint)
Room: Longs Peak

Speaker 3 of 7
Daniel P. Kelly, University of Pennsylvania, USA
Feeding the Failing Heart

Monday, March 02 | 5:00PM - 7:15PM
Cardiovascular Response to Exercise (Joint)
Room: Longs Peak

Speaker 4 of 7
Julie R. McMullen, Baker Heart and Diabetes Institute, Australia
Molecular Mechanisms of Physiological Cardiac Hypertrophy: Implications for New Heart Failure Therapies, Biomarkers, and Predicting Cardiotoxicity

Monday, March 02 | 5:00PM - 7:15PM
Cardiovascular Response to Exercise (Joint)
Room: Longs Peak

Speaker 5 of 7
Eric Small, University of Rochester, USA
Short Talk: Control of Cardiac Fibroblast Accumulation and Fibrosis in Exercise and Heart Failure

Monday, March 02 | 5:00PM - 7:15PM
Cardiovascular Response to Exercise (Joint)
Room: Longs Peak

Speaker 6 of 7
Haobo Li, Massachusetts General Hospital, USA
Short Talk: lncExACT1 Acts as a Pivotal Switch between Physiological and Pathological Cardiac Growth

Monday, March 02 | 5:00PM - 7:15PM
Cardiovascular Response to Exercise (Joint)
Room: Longs Peak

Speaker 7 of 7
Jonathan Herrera, University of Michigan, USA
Short Talk: High Intensity Interval Training Increases Cardiorespiratory Fitness and Acceleration Capacity in a Transgenic Mouse Model of HCM

Monday, March 02 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Quandary Peak
No registration fees are used to fund alcohol served at this function.

Monday, March 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Quandary Peak


Tuesday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Tuesday, March 03 | 8:00AM - 11:00AM
Learning from Past, Looking at Future
Room: Longs Peak

Speaker 1 of 7
* Lisa Mielniczuk, University of Ottawa, Canada

Tuesday, March 03 | 8:00AM - 11:00AM
Learning from Past, Looking at Future
Room: Longs Peak

Speaker 2 of 7
Marc A. Pfeffer, Brigham and Women’s Hospital, USA
Learning from Past, Looking at Future

Tuesday, March 03 | 8:00AM - 11:00AM
Learning from Past, Looking at Future
Room: Longs Peak

Speaker 3 of 7
Heather Ross, University Health Network, Canada
Preventing Heart Failure Hospitalization with Artificial Intelligence

Tuesday, March 03 | 8:00AM - 11:00AM
Learning from Past, Looking at Future
Room: Longs Peak


Coffee Break

Tuesday, March 03 | 8:00AM - 11:00AM
Learning from Past, Looking at Future
Room: Longs Peak

Speaker 5 of 7
Wilson Lek Wen Tan, National University of Singapore, Singapore
Short Talk: Disease and Phenotype Relevant Genetic Variants Identified from Histone Acetylomes in Human Hearts

Tuesday, March 03 | 8:00AM - 11:00AM
Learning from Past, Looking at Future
Room: Longs Peak

Speaker 6 of 7
James J. Hartman, Cytokinetics Inc., USA
Short Talk: The Novel Myotrope, AMG 594, Is a Small-Molecule Cardiac Troponin Activator That Increases Cardiac Contractility In Vitro and In Vivo

Tuesday, March 03 | 8:00AM - 11:00AM
Learning from Past, Looking at Future
Room: Longs Peak

Speaker 7 of 7
Eric Adler, University of California San Diego, USA
Short Talk: Gene Therapy for Male Patients with Danon Disease using RP-A501; AAV9.LAMP2B

Tuesday, March 03 | 8:00AM - 11:15AM
Integrative Metabolic Response to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 1 of 8
* Bret H. Goodpaster, Translational Research Institute for Metabolism and Diabetes, USA


Tuesday, March 03 | 8:00AM - 11:15AM
Integrative Metabolic Response to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 2 of 8
David H. Wasserman, Vanderbilt University School of Medicine, USA
Coupling of Hepatic Glucose Output to Glucose Uptake by Working Muscle


Tuesday, March 03 | 8:00AM - 11:15AM
Integrative Metabolic Response to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 3 of 8
Simon Schenk, University of California, San Diego, USA
Regulation of Skeletal Muscle Function and Physiology via Acetylation


Tuesday, March 03 | 8:00AM - 11:15AM
Integrative Metabolic Response to Exercise
This session is from Biology of Exercise
Room: Grays Peak


Coffee Break


Tuesday, March 03 | 8:00AM - 11:15AM
Integrative Metabolic Response to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 5 of 8
Marcas M. Bamman, University of Alabama at Birmingham, USA
Inter-Individual Response Heterogeneity: A Window into Molecular Transducers of Exercise Adaptation


Tuesday, March 03 | 8:00AM - 11:15AM
Integrative Metabolic Response to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 6 of 8
Timothy D. Allerton, Pennington Biomedical Research Center, USA
Short Talk: An Ethanolic Extract of Artemisia Dracunculus L. Enhances the Metabolic Benefits of Exercise in Diet-Induced Obese Mice


Tuesday, March 03 | 8:00AM - 11:15AM
Integrative Metabolic Response to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 7 of 8
Gianluca Fulgenzi, NCI, National Institutes of Health, USA
Short Talk: Novel Metabolic Role for Skeletal Muscle BDNF in Pancreatic ß-Cell Insulin Secretion


Tuesday, March 03 | 8:00AM - 11:15AM
Integrative Metabolic Response to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 8 of 8
Diego Hernandez-Saavedra, Ohio State University Wexner Medical Center, USA
Short Talk: Chronic Exercise Negates Concurrent High-Fat Diet to Improve Inter-Tissue Acylcarnitine Handling and Enhances Hepatic Metabolism


Tuesday, March 03 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 03 | 11:00AM - 1:00PM
Poster Setup
Room: Quandary Peak


Tuesday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 1 of 9
* Sara Nunes Vasconcelos, University of Toronto, Canada

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 2 of 9
Michael P. Graziano, TARA Biosystems, USA
BiowireTM II Engineered Human Cardiac Tissues: A Platform for Heart Failure Drug Development

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 3 of 9
George Kensah, University Medical Center Goettingen, Germany
iPSC-based In Vitro Model of Noonan Syndrome with Multiple Lentigines Indicates that Proliferation and Dedifferentiation of Cardiomyocytes Significantly Contribute to Dysfunctional Myocardium

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 4 of 9
Uros Kuzmanov, University of Toronto, Canada
Global Phosphoproteomic Profiling of Signaling Pathway Aberrations in Clinical Samples, Animal and Organ-on-a-Chip Models

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 5 of 9
Fotios G. Pitoulis, Imperial College London, UK
Myocardial Slices – a Novel Cardiac Model to Study Mechanical Load In Vitro

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 6 of 9
Andrea Dooley Thompson, University of Michigan, USA
A High-Throughput Screen for Disease Modifying Compounds to Treat Hypertrophic Cardiomyopathy Associated with MYBPC3 Mutations

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 7 of 9
Jason Maynes, Hospital for Sick Children, Canada
Cardio PyRate: Robust Assessment of Cardiac Myocyte Function Using Computer Vision and Machine Learning

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 8 of 9
Barbara G. Gonzalez Teran, University of California, San Francisco, USA
Integration of Protein Interactome Data with Congenital Heart Disease Variants to Identify Novel Disease Genes

Tuesday, March 03 | 2:30PM - 4:30PM
Workshop: In vitro Models of Heart Failure
Room: Longs Peak

Speaker 9 of 9
Robert Zweigerdt, Medizinische Hochschule Hannover, Hannover Medical School, Germany
Recapitulating Early Embryonic Heart Development with Human Pluripotent Stem Cells

Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 1
This session is from Biology of Exercise
Room: Grays Peak

Speaker 1 of 5
* Sean H. Adams, University of Arkansas for Medical Sciences, USA


Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 1
This session is from Biology of Exercise
Room: Grays Peak

Speaker 2 of 5
Sophie Broome, University of Auckland, New Zealand
Effects of Mitochondria-Targeted Antioxidant Supplementation on the Acute Transcriptional Response to Exercise and Adaptations to High Intensity Interval Training in Middle-Aged Men


Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 1
This session is from Biology of Exercise
Room: Grays Peak

Speaker 3 of 5
Linda A. Buss, University of Otago, New Zealand
Cancer Alters Adaptation of Skeletal Muscle Mitochondria to Exercise


Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 1
This session is from Biology of Exercise
Room: Grays Peak

Speaker 4 of 5
J. Matthew Hinkley, AdventHealth Orlando, USA
Transcriptome Signatures of Skeletal Muscle That Define Sarcopenia and Acute Temporal Response to Endurance Exercise in Older Adults


Tuesday, March 03 | 3:30PM - 4:30PM
Workshop 1
This session is from Biology of Exercise
Room: Grays Peak

Speaker 5 of 5
Malene E. Lindholm, Stanford University, USA
Differential Response Trajectories to Acute Exercise in Blood and Muscle


Tuesday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 03 | 5:00PM - 7:00PM
Regenerative Medicine in Heart Failure
Room: Longs Peak

Speaker 1 of 4
Li Qian, University of North Carolina at Chapel Hill, USA
Altering Cardiac Cell Destiny

Tuesday, March 03 | 5:00PM - 7:00PM
Regenerative Medicine in Heart Failure
Room: Longs Peak

Speaker 2 of 4
* Stephanie Iris Protze, University Health Network, Canada
Human Pluripotent Stem Cells as Source for Biological Pacemakers

Tuesday, March 03 | 5:00PM - 7:00PM
Regenerative Medicine in Heart Failure
Room: Longs Peak

Speaker 3 of 4
Michael A. Laflamme, University Health Network, Canada
Pluripotent Stem Cells for Heart Failure

Tuesday, March 03 | 5:00PM - 7:00PM
Regenerative Medicine in Heart Failure
Room: Longs Peak

Speaker 4 of 4
Lay Ping Ong, University of Cambridge, UK
Short Talk: Cellular Therapy for the Chronically Failing Heart?

Tuesday, March 03 | 5:00PM - 7:00PM
Adipose and Liver Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 1 of 6
* John P. Thyfault, University of Kansas Medical Center, USA


Tuesday, March 03 | 5:00PM - 7:00PM
Adipose and Liver Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 2 of 6
Matthew Watt, University of Melbourne, Australia
Exercise, Hepatokines, and Metabolic Homeostasis


Tuesday, March 03 | 5:00PM - 7:00PM
Adipose and Liver Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 3 of 6
Kristin I. Stanford, Ohio State University, USA
Brown Adipose Tissue Mediates Cardiac Function


Tuesday, March 03 | 5:00PM - 7:00PM
Adipose and Liver Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 4 of 6
Lauren M. Sparks, Translational Research Institute, USA
Exercise Treats Metabolic Dysfunction by Improving Adipose Metabolism


Tuesday, March 03 | 5:00PM - 7:00PM
Adipose and Liver Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 5 of 6
Hongji Zhang, Ohio State University, USA
Short Talk: Preoperative Exercise Protects the Liver from Surgical Stress by Altering the Immune Environment


Tuesday, March 03 | 5:00PM - 7:00PM
Adipose and Liver Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 6 of 6
Rory Cunningham, University of Missouri, USA
Short Talk: Deletion of Hepatocellular eNOS Impairs Exercise-Induced Improvements in Hepatic Mitochondrial Function


Tuesday, March 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak
No registration fees are used to fund alcohol served at this function.

Tuesday, March 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Quandary Peak


Wednesday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Wednesday, March 04 | 8:00AM - 8:45AM
Special Session: Behind the Curtain on Industry Decisions
Room: Longs Peak

Speaker 1 of 2
* Mansoor Husain, Ted Rogers Centre for Heart Research, Canada

Wednesday, March 04 | 8:00AM - 8:45AM
Special Session: Behind the Curtain on Industry Decisions
Room: Longs Peak

Speaker 2 of 2
Victor Shi, Novartis Pharmaceuticals Corporation, USA

Wednesday, March 04 | 8:00AM - 11:00AM
Exercise and the Brain
This session is from Biology of Exercise
Room: Grays Peak

Speaker 1 of 8
* Frank W. Booth, University of Missouri, USA


Wednesday, March 04 | 8:00AM - 11:00AM
Exercise and the Brain
This session is from Biology of Exercise
Room: Grays Peak

Speaker 2 of 8
Henriette van Praag, Florida Atlantic University, USA
Exercise-Induced Brain Plasticity


Wednesday, March 04 | 8:00AM - 11:00AM
Exercise and the Brain
This session is from Biology of Exercise
Room: Grays Peak

Speaker 3 of 8
Michelle Voss, University of Iowa, USA
Exercise Effects on the Human Brain and Cognition Across the Lifespan


Wednesday, March 04 | 8:00AM - 11:00AM
Exercise and the Brain
This session is from Biology of Exercise
Room: Grays Peak


Coffee Break


Wednesday, March 04 | 8:00AM - 11:00AM
Exercise and the Brain
This session is from Biology of Exercise
Room: Grays Peak

Speaker 5 of 8
Julie A. Christianson, University of Kansas Medical Center, USA
Early Life Stress, Chronic Pain, and Modulation by Exercise


Wednesday, March 04 | 8:00AM - 11:00AM
Exercise and the Brain
This session is from Biology of Exercise
Room: Grays Peak

Speaker 6 of 8
Jill N. Barnes, University of Wisconsin-Madison, USA
Exercise, Cerebral Perfusion, and Cerebral Vascular Function


Wednesday, March 04 | 8:00AM - 11:00AM
Exercise and the Brain
This session is from Biology of Exercise
Room: Grays Peak

Speaker 7 of 8
Constanza J. Cortes Rodriguez, University of Alabama at Birmingham, USA
Short Talk: Enhanced Skeletal Muscle Proteostasis as a Modulator of CNS Aging and Alzheimer’s Disease


Wednesday, March 04 | 8:00AM - 11:00AM
Exercise and the Brain
This session is from Biology of Exercise
Room: Grays Peak

Speaker 8 of 8
Nathan Kerr, University of Missouri, USA
Short Talk: LPS-Induced Mild Cognitive Impairment Displays an Age-Dependent Effect on Cognition That Is Ameliorated by Resistance-Training Exercise


Wednesday, March 04 | 8:45AM - 11:15AM
Heart Repair and Immunity
Room: Longs Peak

Speaker 1 of 7
* Michelle D. Tallquist, University of Hawaii, USA

Wednesday, March 04 | 8:45AM - 11:15AM
Heart Repair and Immunity
Room: Longs Peak

Speaker 2 of 7
Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Hypoxia Regulated Heart Regeneration

Wednesday, March 04 | 8:45AM - 11:15AM
Heart Repair and Immunity
Room: Longs Peak


Coffee Break

Wednesday, March 04 | 8:45AM - 11:15AM
Heart Repair and Immunity
Room: Longs Peak

Speaker 4 of 7
Kory J. Lavine, Washington University School of Medicine, USA
Understanding Heart Failure through Macrophage Biology

Wednesday, March 04 | 8:45AM - 11:15AM
Heart Repair and Immunity
Room: Longs Peak

Speaker 5 of 7
Benoit G. Bruneau, Gladstone Institutes, USA
Gene Regulatory Networks in Heart Development

Wednesday, March 04 | 8:45AM - 11:15AM
Heart Repair and Immunity
Room: Longs Peak

Speaker 6 of 7
Sarah A. Dick, University Health Network, Canada
Short Talk: Using Single Cell Genomics and Genetic Fate Mapping to Define Cardiac Macrophage Heterogeneity and Cardioprotective Functions

Wednesday, March 04 | 8:45AM - 11:15AM
Heart Repair and Immunity
Room: Longs Peak

Speaker 7 of 7
Andy Yu, Massachusetts General Hospital, USA
Short Talk: Increased Activin-A Signaling Is Associated with Endothelial Senescence and Inflammation

Wednesday, March 04 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, March 04 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Wednesday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: MoTrPAC
This session is from Biology of Exercise
Room: Grays Peak

Speaker 1 of 5
* Scott Trappe, Ball State University, USA


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: MoTrPAC
This session is from Biology of Exercise
Room: Grays Peak

Speaker 2 of 5
Bret H. Goodpaster, Translational Research Institute for Metabolism and Diabetes, USA
Overview of MoTrPAC Clinical Protocol


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: MoTrPAC
This session is from Biology of Exercise
Room: Grays Peak

Speaker 3 of 5
Sue Bodine, University of Iowa, USA
Overview of MoTrPAC Preclinical Animal Study Protocol


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: MoTrPAC
This session is from Biology of Exercise
Room: Grays Peak

Speaker 4 of 5
Nicole R. Gay, Stanford University, USA
Acute Endurance Exercise Induces Widespread Transcriptional Changes across Tissues


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: MoTrPAC
This session is from Biology of Exercise
Room: Grays Peak

Speaker 5 of 5
Weijun Qian, Pacific Northwest National Laboratory, USA
Proteomic and Phosphoproteomic Changes in Rat Skeletal Muscle Induced by Acute Endurance Exercise


Wednesday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 04 | 5:00PM - 7:00PM
Exercise as a Treatment for Heart Failure (Joint)
Room: Longs Peak

Speaker 1 of 6
* Heather Ross, University Health Network, Canada

Wednesday, March 04 | 5:00PM - 7:00PM
Exercise as a Treatment for Heart Failure (Joint)
Room: Longs Peak

Speaker 2 of 6
Anthony Rosenzweig, Massachusetts General Hospital, USA
Can Exercise Teach Us How to Treat Heart Failure?

Wednesday, March 04 | 5:00PM - 7:00PM
Exercise as a Treatment for Heart Failure (Joint)
Room: Longs Peak

Speaker 3 of 6
Craig A. Emter, University of Missouri, USA
Exercise and Heart Failure with Preserved Ejection Fraction

Wednesday, March 04 | 5:00PM - 7:00PM
Exercise as a Treatment for Heart Failure (Joint)
Room: Longs Peak

Speaker 4 of 6
Jane E.B. Reusch, Rocky Mountain Regional VA Medical Center/ University of Colorado, Denver, USA
Diabetes, Exercise Intolerance and Incipient Heart Failure: Systemic Microvascular Dysfunction

Wednesday, March 04 | 5:00PM - 7:00PM
Exercise as a Treatment for Heart Failure (Joint)
Room: Longs Peak

Speaker 5 of 6
Bliss Chang, Harvard University, USA
Short Talk: Exercise Training Reverses Cardiac Aging Phenotypes Associated with Heart Failure with Preserved Ejection Fraction

Wednesday, March 04 | 5:00PM - 7:00PM
Exercise as a Treatment for Heart Failure (Joint)
Room: Longs Peak

Speaker 6 of 6
Isabel Witvrouwen, Antwerp University Hospital, Belgium
Short Talk: Vascular Function and Skeletal Muscle Function Associated miR-23a, a Biomarker of VO2peak Trainability in Patients with Heart Failure with Reduced Ejection Fraction?

Wednesday, March 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak
No registration fees are used to fund alcohol served at this function.

Wednesday, March 04 | 7:30PM - 10:00PM
Poster Session 3
Room: Quandary Peak


Thursday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak

Speaker 1 of 9
* Julie R. McMullen, Baker Heart and Diabetes Institute, Australia

Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak

Speaker 2 of 9
J. Travis Hinson, The Jackson Laboratory, USA
Development of a Human Sarcomere Functional Assay to Enable Precise and Scalable Functional Interrogation and Reclassification of Heart Failure-Associated Genetic Variants?

Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak

Speaker 3 of 9
Lisa Mielniczuk, University of Ottawa, Canada
Right Ventricular Adaptation to Pressure Overload: The Role of Metabolism and Neurohormonal Activation

Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak


Coffee Break

Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak

Speaker 5 of 9
Mansoor Husain, Ted Rogers Centre for Heart Research, Canada
Preventing Heart Failure through Metabolic Modulation of Vascular Cells

Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak

Speaker 6 of 9
Ferhaan Ahmad, University of Iowa, USA
Sodium Glucose Co-Transporter 1 (SGLT1) as a Novel Mediator of Heart Failure

Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak

Speaker 7 of 9
Tsunehisa Yamamoto, University of Pennsylvania, USA
Short Talk: Targeting RIP140 to Modulate Energy Metabolism in the Failing Heart

Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak

Speaker 8 of 9
Maria Papadaki, Loyola University Chicago, USA
Short Talk: Methylglyoxal Modifications on Myofilament Proteins Caused by Diabetes Block Heart Failure Drug Targets through Changing Tropomyosin Position

Thursday, March 05 | 8:00AM - 11:15AM
Targeting Metabolism in Heart Failure
Room: Longs Peak

Speaker 9 of 9
Anna C. Calkin, Baker Heart & Diabetes Institute, Australia
Short Talk: Cardiac-specific Induction of Dominant Active IDOL is Cardioprotective in a setting of Lipotoxicity

Thursday, March 05 | 8:00AM - 11:00AM
Molecular Response of Skeletal Muscle to Exercise and Inacti
vity
This session is from Biology of Exercise

Room: Grays Peak

Speaker 1 of 8
* Simon Schenk, University of California, San Diego, USA


Thursday, March 05 | 8:00AM - 11:00AM
Molecular Response of Skeletal Muscle to Exercise and Inacti
vity
This session is from Biology of Exercise

Room: Grays Peak

Speaker 2 of 8
John P. Thyfault, University of Kansas Medical Center, USA
Lost in Translation: Barriers in Translating Rodent Exercise Models to Human Health


Thursday, March 05 | 8:00AM - 11:00AM
Molecular Response of Skeletal Muscle to Exercise and Inacti
vity
This session is from Biology of Exercise

Room: Grays Peak

Speaker 3 of 8
Scott Trappe, Ball State University, USA
Molecular Transducer Responses to Acute and Chronic Exercise Effects


Thursday, March 05 | 8:00AM - 11:00AM
Molecular Response of Skeletal Muscle to Exercise and Inacti
vity
This session is from Biology of Exercise

Room: Grays Peak


Coffee Break


Thursday, March 05 | 8:00AM - 11:00AM
Molecular Response of Skeletal Muscle to Exercise and Inacti
vity
This session is from Biology of Exercise

Room: Grays Peak

Speaker 5 of 8
Sue Bodine, University of Iowa, USA
Molecular Mechanisms Underlying the Differential Response of Young and Old Skeletal Muscle to Inactivity and Reloading


Thursday, March 05 | 8:00AM - 11:00AM
Molecular Response of Skeletal Muscle to Exercise and Inacti
vity
This session is from Biology of Exercise

Room: Grays Peak

Speaker 6 of 8
Charlotte Suetta, University of Copenhagen, Denmark
Differential Anabolic Response to Loading in Young and Old Muscle following Disuse


Thursday, March 05 | 8:00AM - 11:00AM
Molecular Response of Skeletal Muscle to Exercise and Inacti
vity
This session is from Biology of Exercise

Room: Grays Peak

Speaker 7 of 8
Ola A. Hansson, Lund University, Sweden
Short Talk: Genetic Variation in RAB3GAP2 Promotes Capillary Formation and Athlete Performance via Stimulation of Weibel-Palade Body Release


Thursday, March 05 | 8:00AM - 11:00AM
Molecular Response of Skeletal Muscle to Exercise and Inacti
vity
This session is from Biology of Exercise

Room: Grays Peak

Speaker 8 of 8
Maria J. Torres, Duke University, USA
Short Talk: The Chemotherapeutic Agent Docetaxel Disrupts Mitochondrial and Contractile Function in 3D Human Bioengineered Myobundles


Thursday, March 05 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 05 | 5:00PM - 6:45PM
Emerging Concepts in Heart Failure
Room: Longs Peak

Speaker 1 of 6
* Ferhaan Ahmad, University of Iowa, USA

Thursday, March 05 | 5:00PM - 6:45PM
Emerging Concepts in Heart Failure
Room: Longs Peak

Speaker 2 of 6
Kenneth Walsh, University of Virginia School of Medicine, USA
Clonal Hematopoiesis and the Failing Heart

Thursday, March 05 | 5:00PM - 6:45PM
Emerging Concepts in Heart Failure
Room: Longs Peak

Speaker 3 of 6
Javid Moslehi, Vanderbilt University Medical Center, USA
Immune Checkpoint Inhibitor-Associated Cardiotoxicities: Learning from Mice and Humans

Thursday, March 05 | 5:00PM - 6:45PM
Emerging Concepts in Heart Failure
Room: Longs Peak

Speaker 4 of 6
Michael Alexanian, University of California, San Francisco, USA
Short Talk: Dynamic Epigenetic Shifts in Myofibroblast Cell State Drive Reversibility of Heart Failure

Thursday, March 05 | 5:00PM - 6:45PM
Emerging Concepts in Heart Failure
Room: Longs Peak

Speaker 5 of 6
Kathryn N. Ivey, Tenaya Therapeutics, USA
Short Talk: Developing a Clinical Cardiac Reprogramming Gene Therapy

Thursday, March 05 | 5:00PM - 6:45PM
Emerging Concepts in Heart Failure
Room: Longs Peak

Speaker 6 of 6
Austin Hsu, University of California, San Francisco, USA
Short Talk: Salt-Inducible Kinase 1 Maintains HDAC7 Stability to Promote Pathologic Cardiac Remodeling

Thursday, March 05 | 5:00PM - 6:45PM
Mitochondrial Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 1 of 5
* Lauren M. Sparks, Translational Research Institute, USA


Thursday, March 05 | 5:00PM - 6:45PM
Mitochondrial Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 2 of 5
Andrea L. Hevener, University of California, Los Angeles, USA
Exercise and Mitochondrial Quality Control


Thursday, March 05 | 5:00PM - 6:45PM
Mitochondrial Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 3 of 5
Benjamin F. Miller, Oklahoma Medical Research Foundation, USA
Exercise and Metformin Interactions in Skeletal Muscle


Thursday, March 05 | 5:00PM - 6:45PM
Mitochondrial Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 4 of 5
Makoto Kashiwa, Astellas Pharma, Inc., Japan
Potential Pharmacological and Non-Pharmacological Approaches in Patients Who have Difficulty in Physical Exercise


Thursday, March 05 | 5:00PM - 6:45PM
Mitochondrial Adaptations to Exercise
This session is from Biology of Exercise
Room: Grays Peak

Speaker 5 of 5
Timothy M. Moore, University of California, Los Angeles, USA
Short Talk: Leveraging the Exercise Hybrid Mouse Diversity Panel to Understand Mitochondrial DNA


Thursday, March 05 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Longs Peak

Speaker 1 of 2
* Mansoor Husain, Ted Rogers Centre for Heart Research, Canada

Thursday, March 05 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Longs Peak

Speaker 2 of 2
* Benoit G. Bruneau, Gladstone Institutes, USA

Thursday, March 05 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Biology of Exercise
Room: Grays Peak


Thursday, March 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak
No registration fees are used to fund alcohol served at this function.

Thursday, March 05 | 8:00PM - 11:00PM
Entertainment
Room: Quandary Peak
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, March 06 | 10:24AM - 10:24AM
Departure


*Session Chair.