Web Desc
Tuberculosis: Science Aimed at Ending the Epidemic - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Anne G. Kasmar, Bruno B. Andrade, Rodrigo Corrêa-Oliveira and David Alland
Date: December 02 - 04, 2020
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
For important information on the coronavirus, please click here
Summary of Meeting:
The aim of this symposium is to mobilize the rigor, creativity and forward-momentum of scientists worldwide to discover and develop new tools that will end the TB epidemic. A few unique features of this conference include sessions that will explore advances across the ecosystem from early discovery through translation and real-world application, as well as sessions that address scientific bottlenecks to be overcome in the search for new tools to prevent, diagnose and definitively cure TB. Finally, the conference will include sessions dedicated to lessons learned from leprosy. There will be numerous opportunities for scientists to catalyze scientific advances that address the global burden of TB.
Global Health Travel Award Deadline: November 18 2020
Scholarship Deadline: October 26 2020
Abstract Deadline: October 29 2020
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI154982-01
Funding for this conference was made possible (in part) by 1R13AI154982-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, December 02 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)


Speaker 1 of 2
* Anne G. Kasmar, Genentech, USA

Wednesday, December 02 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)


Speaker 2 of 2
Soumya Swaminathan, World Health Organization, Switzerland
Taking Science-Based Solutions to Scale

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)


Speaker 1 of 9
* Bruno B. Andrade, Fundação Oswaldo Cruz, Brazil
Breakthroughs from Brazil and Beyond

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)


Speaker 2 of 9
* Mark Hatherill, University of Cape Town, South Africa
Can Host Blood Transcriptomic Biomarkers of Tuberculosis Inform Therapy?

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)


Speaker 3 of 9
Annemieke Geluk, Leiden University Medical Center, Netherlands
Short Talk: Biomarkers to Predict Leprosy: it takes two…

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)


Speaker 4 of 9
Elisa Nemes, University of Cape Town, South Africa
Short Talk: Immune Correlates of Protection in Humans

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)



Coffee Break

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)


Speaker 6 of 9
Eduardo Pinheiro Amaral, NIAID, National Institutes of Health, USA
Short Talk: GPX4 and BACH1 Regulate Necrotic Cell Death and Host Resistance in Mycobacterium Tuberculosis Infection in vivo

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)


Speaker 7 of 9
Courtney R. Plumlee, Seattle Children's Research Institute, USA
Short Talk: Apparent Sterilizing Immunity in BCG-Immunized Mice Challenged with an Ultra-Low Dose of Mycobacterium tuberculosis

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)


Speaker 8 of 9
William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Short Talk: Host Immune Regulator PARP1 Drives TB Sex Differences

Wednesday, December 02 | 8:40AM - 10:50AM
Breakthroughs in Biomarkers (8:40am Denver/Mountain Time Sta
rt)


Speaker 9 of 9
Yang Luo, Harvard Medical School, USA
Short Talk: Genome-to-Genome Analysis Identifies the Effect of the Host Immune Systems on Mycobacterium Tuberculosis and Its Impact on Clinical Outcomes

Wednesday, December 02 | 10:50AM - 11:20AM
Panel: COVID4TB (10:50am Denver/Mountain Time Start)

Speaker 1 of 4
* Rodrigo Corrêa-Oliveira, FIOCRUZ, Brazil

Wednesday, December 02 | 10:50AM - 11:20AM
Panel: COVID4TB (10:50am Denver/Mountain Time Start)

Speaker 2 of 4
Morten Ruhwald, FIND, Switzerland

Wednesday, December 02 | 10:50AM - 11:20AM
Panel: COVID4TB (10:50am Denver/Mountain Time Start)

Speaker 3 of 4
Annette Vogel, BioNTech, Germany

Wednesday, December 02 | 10:50AM - 11:20AM
Panel: COVID4TB (10:50am Denver/Mountain Time Start)

Speaker 4 of 4
David Alland, Rutgers University, New Jersey Medical School, USA

Wednesday, December 02 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 1 of 3
Bryan D. Bryson, Massachusetts Institute of Technology, USA

Wednesday, December 02 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 2 of 3
Joao Monteiro, Nature Medicine, USA

Wednesday, December 02 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 3 of 3
Lakshmi Ramachandra, NIAID, National Institutes of Health, USA

Wednesday, December 02 | 1:30PM - 3:00PM
Poster Session 1 (1:30pm Denver/Mountain Time Start)


Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 1 of 9
Alan Sher, NIAID, National Institutes of Health, USA
Can Basic Immunology Solve Tuberculosis?

Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 2 of 9
Patricia A. Darrah, NIAID, National Institutes of Health, USA
Mechanisms of Protection in Nonhuman Primates

Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 3 of 9
Robert L. Modlin, University of California, Los Angeles, USA
Tricytotoxic CTLs in Leprosy and TB

Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 4 of 9
* Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
Unexpected Aspects of Granuloma Biology

Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 5 of 9
* Milton Ozório Moraes, Oswaldo Cruz Institute- Fiocruz, Brazil
Short Talk: Autophagy and Host Metabolism in Leprosy

Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 6 of 9
Emily Strong, University of Texas Medical Branch, USA
Short Talk: Identification of Autophagy Inhibiting Factors of Mycobacterium tuberculosis by High Throughput Loss of Function Screening

Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 7 of 9
Kerry Hilligan, NIAID, National Institutes of Health, USA
Short Talk: Intravenous BCG Vaccination Transiently Depletes Alveolar Macrophages and Contributes to Protection against Mtb via Long-Term Remodeling of the Pulmonary Myeloid Compartment

Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 8 of 9
Priyanka Talukdar, University of Pittsburgh, USA
Short Talk: Type III Interferons Are Expressed in Tuberculous Granulomas and Promote Inflammatory Phenotypes in Macrophages that Differ from Type I Interferons

Wednesday, December 02 | 3:00PM - 6:00PM
Highlights from the Host (3pm Denver/Mountain Time Start)

Speaker 9 of 9
Stacey Reanna Bartlett, Translational Research Institute–Mater Research Institute,, Australia
Short Talk: GPR183 Oxysterol Axis Is Dysregulated at the Site of Disease during M. tuberculosis Infection

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 1 of 9
Olivier Neyrolles, IPBS, CNRS-University of Toulouse, France
The Biology of Metals in Mycobacterial Virulence and Antimycobacterial Immunity

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 2 of 9
David R. Sherman, University of Washington, USA
How MTB Sees the Host-Pathogen Interface

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 3 of 9
Cressida Madigan, University of California, San Diego, USA
Short Talk: Live-Imaging M. Leprae

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 4 of 9
Babak Javid, University of California San Francisco, USA
Targeting Adaptive Mycobacterial Translation as Anti-Virulence Strategies

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 5 of 9
* Deborah T. Hung, Broad Institute of MIT & Harvard, USA
Mining PROSPECT for TB Drugs

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 6 of 9
Todd A. Gray, New York State Department of Health, USA
Short Talk: The Abundant Small Proteome of Mycobacterium tuberculosis

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 7 of 9
Naila Cristina Soler Camargo, University of São Paulo, Brazil
Short Talk: Pseudogenization as a Source of Genetic Variability to the Mycobacterium tuberculosis Complex

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 8 of 9
* Oyindamola Adefisayo, Weill Cornell Medicine, USA
Short Talk: Functional Characterization of the Transcriptional Response to DNA Damage in Mycobacteria

Thursday, December 03 | 8:00AM - 11:00AM
Back to Bacterial Basics (8am Denver/Mountain Time Start)

Speaker 9 of 9
Jamie H. Corro, State University of New York at Albany, USA
Short Talk: Visualization of Dormancy Induced by Ribosome Hibernation in Zinc-Starved Mycobacteria

Thursday, December 03 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 1 of 4
Salvatore Fabbiano, Cell Press, USA

Thursday, December 03 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 2 of 4
George Hills, Sage Publications, UK

Thursday, December 03 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 3 of 4
Zeljko Durdevic, EMBO Press, Germany

Thursday, December 03 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 4 of 4
Francesca Dickens, Frontiers, UK

Thursday, December 03 | 3:00PM - 6:00PM
Data to Drive Innovation (3pm Denver/Mountain Time Start)

Speaker 1 of 8
Gabriel D. Victora, Rockefeller University, USA
Clonal Dynamics of the Antibody Response

Thursday, December 03 | 3:00PM - 6:00PM
Data to Drive Innovation (3pm Denver/Mountain Time Start)

Speaker 2 of 8
Sarah M. Fortune, Harvard TH Chan School of Public Health, USA
Multiscale Approaches Decipher the Many Faces of Altered Drug Susceptibility in Mycobacterium Tuberculosis

Thursday, December 03 | 3:00PM - 6:00PM
Data to Drive Innovation (3pm Denver/Mountain Time Start)

Speaker 3 of 8
* Purvesh Khatri, Stanford University, USA
Adventures of a Data Parasite: Using Heterogeneity in 'Dirty Data' to Accelerate Translational Medicine

Thursday, December 03 | 3:00PM - 6:00PM
Data to Drive Innovation (3pm Denver/Mountain Time Start)

Speaker 4 of 8
Christopher M. Sassetti, University of Massachusetts Medical School, USA
Modeling Genetic Diversity in TB Susceptibility

Thursday, December 03 | 3:00PM - 6:00PM
Data to Drive Innovation (3pm Denver/Mountain Time Start)

Speaker 5 of 8
Shabaana Khader, Washington University School of Medicine, USA
Tuberculosis Strain Diversity Drives Immune Response

Thursday, December 03 | 3:00PM - 6:00PM
Data to Drive Innovation (3pm Denver/Mountain Time Start)

Speaker 6 of 8
* Shuyi Ma, University of Washington, USA
Short Talk: Data-Driven Inference of Drug Synergy

Thursday, December 03 | 3:00PM - 6:00PM
Data to Drive Innovation (3pm Denver/Mountain Time Start)

Speaker 7 of 8
Caylin G. Winchell, University of Pittsburgh School of Medicine, USA
Short Talk: Defining the Role of CD8 T Cell Subsets in Tuberculosis in Non-Human Primates

Thursday, December 03 | 3:00PM - 6:00PM
Data to Drive Innovation (3pm Denver/Mountain Time Start)

Speaker 8 of 8
Valdir C. Barth, Boston Children's Hospital, USA
Short Talk: Mycobacterium tuberculosis VapC4 Toxin Engages Small ORFs to Initiate an Integrated Oxidative and Copper Stress Response

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 1 of 9
Neel R. Gandhi, Emory University, USA
Transmission is Driving the TB Epidemic, but Where Is the Majority of Transmission Occurring?

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 2 of 9
* Julio Croda, Oswaldo Cruz Foundation / Federal University of Mato Grosso do Sul / Yale School, Brazil
Tuberculosis in Prisons: Spillover and Impact in the Community

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 3 of 9
Padmini Salgame, Rutgers University, USA
Mtb Transmissibility and Tissue Response

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 4 of 9
Kyu Y. Rhee, Weill Cornell Medical College, USA
A Focus on Bacterial Factors

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 5 of 9
* Sara Suliman, Brigham and Women's Hospital, USA
Short Talk: Integration of Genetic and Transcriptional Profiles of Innate Cells to Decipher Mechanisms of TB Susceptibility

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 6 of 9
Betânia M.F. Nogueira, Universidade Federal da Bahia, Brazil
Short Talk: The Effect of Dysglycemia on Mycobacterium tuberculosis Transmission to Close Contacts of Persons with Pulmonary Tuberculosis

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 7 of 9
Paul J. Converse, Johns Hopkins University, USA
Short Talk: The Next-Generation Diarylquinoline TBAJ-587 has Superior Efficacy Against, and Restricts Selection of, Bedaquiline-Resistant Rv0678 Mutants in a Mouse Model of Tuberculosis

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 8 of 9
Nittu Singh, CSIR-IMTECH, India
Short Talk: MtbEis Mediated Acetylation of RelMtb Regulates Stringent Response in Mycobacterium tuberculosis

Friday, December 04 | 8:00AM - 11:00AM
Rethinking Risk in TB (8am Denver/Mountain Time Start)

Speaker 9 of 9
Damian C. Ekiert, New York University School of Medicine, USA
Short Talk: CryoEM Structure of an Mce/YrbE ABC Transporter Complex Sheds Light on Hydrophobic Transport across the Envelope

Friday, December 04 | 1:30PM - 3:00PM
Poster Session 2 (1:30pm Denver/Mountain Time Start)


Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 1 of 10
* David Alland, Rutgers University, New Jersey Medical School, USA

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 2 of 10
Mihai G. Netea, Radboud University, Netherlands
Short Talk: BCG for COVID

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 3 of 10
Lei Gao, Chinese Academy of Medical Sciences, China
LTBI Management in Mainland China

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 4 of 10
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Taming Tuberculosis: The Path from Pathogen to Commensal

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 5 of 10
Clifton E. Barry III, NIAID, National Institutes of Health, USA
Emerging Results from Next Gen EBA Studies

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 6 of 10
Guy B. Marks, University of New South Wales, Australia
Ending TB in the Next 15 Years: Can We Do It, Using the Tools We Have Now, Better?

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)



Coffee Break

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 8 of 10
* Stefanie Krug, Johns Hopkins University School of Medicine, USA
Short Talk: Pyrazinamide Inhibits the Host Enzyme PARP1 to Reduce Inflammation and Accelerate Bacterial Clearance

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 9 of 10
Sarah Leonard, Immunocore Ltd, UK
Short Talk: A Donor-Unrestricted TCR-Bispecific Redirects T Cell Immunity Against Mycobacterium tuberculosis via HLA-E

Friday, December 04 | 3:00PM - 5:45PM
Directing Discovery to Transform TB (3pm Denver/Mountain Tim
e Start)


Speaker 10 of 10
Tony W. Ng, Albert Einstein College of Medicine, USA
Short Talk: An Anti-Viral Vaccine Regimen that Leverages Mycobacteria Specific Helper T Cells Induced by Prior BCG Vaccination

Friday, December 04 | 5:45PM - 6:15PM
Closing Keynote Address (5:45pm Denver/Mountain Time Start)

Speaker 1 of 1
David Alland, Rutgers University, New Jersey Medical School, USA
Turning Discoveries into Useful Tools