Web Desc
Harnessing the Microbiome for Disease Prevention and Therapy - VIRTUAL CONTENT AVAILABLE ON DEMAND
joint with The Microbiome: From Mother to Child - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Eric G. Pamer, Laurie E. Comstock and Alan Walker
Date: January 18 - 20, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by AstraZeneca, Cell Research, and Novo Nordisk A/S
For important information on the coronavirus, please click here
Summary of Meeting:
Our understanding of the microbiome is advancing rapidly, and continues to productively move through the discovery phase, with numerous correlations being established between specific commensal microbes or microbiota compositions and a wide range of diseases that includes infections, inflammatory conditions, metabolic disease, autoimmunity and neurologic syndromes. The initial discovery of these potentially important correlations has led many laboratories around the world to probe the molecular mechanisms that form the causal link between specific commensal microbes and disease development, progression and resolution. Although there have been great advances, culturing many of the prevalent and metabolically active obligate anaerobic commensals remains a challenge. Exciting advances, however, are emerging from laboratories developing tools to genetically manipulate key commensal organisms, facilitating experimental studies that are identifying the small, bioactive molecules they produce, some of which have therapeutic potential. Studies of the impact of bacteriophage on the microbiota also suggest that they may have therapeutic potential. This Keystone conference will focus on recent advances that demonstrate, at the cellular and molecular level, the impact of the microbiota and its products on disease susceptibility/resistance, with an emphasis on microbial and host metabolism, inter-microbial interactions and the amelioration of diseases.
Scholarship Deadline: November 1 2020
Abstract Deadline: December 7 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaCell ResearchNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Anaerobe SystemsDCVC Bio
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI154725-01
Funding for this conference was made possible (in part) by 1R13AI154725-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 18 | 8:00AM - 8:40AM
Welcome and Keynote Address (Joint) (8am Denver/Mountain Tim
e Start)

Speaker 1 of 3
* Eric G. Pamer, University of Chicago, USA

Monday, January 18 | 8:00AM - 8:40AM
Welcome and Keynote Address (Joint) (8am Denver/Mountain Tim
e Start)

Speaker 2 of 3
* Jacques Ravel, University of Maryland School of Medicine, USA

Monday, January 18 | 8:00AM - 8:40AM
Welcome and Keynote Address (Joint) (8am Denver/Mountain Tim
e Start)

Speaker 3 of 3
Jeffrey I. Gordon, Washington University School of Medicine, USA
[NOT AVAILABLE ON DEMAND] Developing Microbiota-Directed Complementary Foods for Treating Childhood Undernutrition

Monday, January 18 | 8:40AM - 11:00AM
Chemical Biology of the Microbiome (Joint) (8:40am Denver/Mo
untain Time Start)


Speaker 1 of 7
* Emily P. Balskus, Harvard University, USA
Dissecting and Manipulating Microbial Metabolism in the Vagina and the Gut Microbiota

Monday, January 18 | 8:40AM - 11:00AM
Chemical Biology of the Microbiome (Joint) (8:40am Denver/Mo
untain Time Start)


Speaker 2 of 7
Mohamed S. Donia, Princeton University, USA
Chemical Ecology of the Human Microbiome in Health and Disease

Monday, January 18 | 8:40AM - 11:00AM
Chemical Biology of the Microbiome (Joint) (8:40am Denver/Mo
untain Time Start)


Speaker 3 of 7
Michael A. Fischbach, Stanford University, USA
Small Molecules from the Human Microbiota

Monday, January 18 | 8:40AM - 11:00AM
Chemical Biology of the Microbiome (Joint) (8:40am Denver/Mo
untain Time Start)



Coffee Break

Monday, January 18 | 8:40AM - 11:00AM
Chemical Biology of the Microbiome (Joint) (8:40am Denver/Mo
untain Time Start)


Speaker 5 of 7
* Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Metabolism, the Microbiome, and the Circadian Clock

Monday, January 18 | 8:40AM - 11:00AM
Chemical Biology of the Microbiome (Joint) (8:40am Denver/Mo
untain Time Start)


Speaker 6 of 7
Amrisha Bhosle, Broad Institute of MIT and Harvard, USA
Short Talk: Prioritization and Annotation of Novel Bioactive Small Molecules from the Microbiome

Monday, January 18 | 8:40AM - 11:00AM
Chemical Biology of the Microbiome (Joint) (8:40am Denver/Mo
untain Time Start)


Speaker 7 of 7
Christine Isabella, Massachusetts Institute of Technology, USA
Short Talk: Lectin-Sequencing for Analysis of the Gut Microbiome

Monday, January 18 | 11:00AM - 12:30PM
Poster Session 1 (Joint) (11am Denver/Mountain Time Start)


Monday, January 18 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 1 of 3
Matthew Henn, Seres Therapeutics, USA

Monday, January 18 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 2 of 3
Grace M. Aldrovandi, University of California, Los Angeles, USA

Monday, January 18 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 3 of 3
Melody Smith, Memorial Sloan Kettering Cancer Center, USA

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)


Speaker 1 of 9
* Denise M. Monack, Stanford University, USA
Cholesterol Metabolism by the Gut Microbiota Fuels Salmonella Super Spreaders

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)


Speaker 2 of 9
* Wendy S. Garrett, Harvard School of Public Health, USA
[NOT AVAILABLE ON DEMAND] Commensal Bacteria, Inflammation and Cancer

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)


Speaker 3 of 9
Manuela Raffatellu, University of California, San Diego, USA
Mechanisms of Commensal-Mediated Inhibition of Pathogens

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)



Coffee Break

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)


Speaker 5 of 9
Kimberley Seed, University of California, Berkeley, USA
Phage Dynamics during Intestinal Infection with Vibrio cholerae

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)


Speaker 6 of 9
Brittany Miller, University of California, Davis, USA
Short Talk: Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)


Speaker 7 of 9
Kali M. Pruss, Washington University in St. Louis, USA
Short Talk: Clostridium difficile Exploits a Host Metabolite Produced during Toxin-Mediated Infection

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)


Speaker 8 of 9
Mericien Venzon, NYU School of Medicine, USA
Short Talk: Harnessing Gut Bacteria to Disrupt Helminth Life Cycle Progression

Monday, January 18 | 2:00PM - 5:00PM
Interactions of Phage and Pathogens with the Microbiota (2pm
Denver/Mountain Time Start)


Speaker 9 of 9
Apollo Stacy, National Institutes of Health, USA
Short Talk: Infection Trains the Host for Microbiota-Enhanced Resistance to Pathogens

Monday, January 18 | 2:00PM - 5:00PM
The Vaginal Microbiome in Health and Disease (2pm Denver/Mou
ntain Time Start)
This session is from Microbiome: Mother to Child


Speaker 1 of 8
* Jacques Ravel, University of Maryland School of Medicine, USA
Functional Insight into the Vaginal Microbiome


Monday, January 18 | 2:00PM - 5:00PM
The Vaginal Microbiome in Health and Disease (2pm Denver/Mou
ntain Time Start)
This session is from Microbiome: Mother to Child


Speaker 2 of 8
* Tal Korem, Columbia University, USA
The Vaginal Microbiome and Metabolome in Spontaneous Preterm Birth


Monday, January 18 | 2:00PM - 5:00PM
The Vaginal Microbiome in Health and Disease (2pm Denver/Mou
ntain Time Start)
This session is from Microbiome: Mother to Child


Speaker 3 of 8
Marguerite Indriati Hood-Pishchany, Boston Children's Hospital, USA
Ecological Commodities Driving Composition in the Vaginal Microbiome


Monday, January 18 | 2:00PM - 5:00PM
The Vaginal Microbiome in Health and Disease (2pm Denver/Mou
ntain Time Start)
This session is from Microbiome: Mother to Child


Speaker 4 of 8
Lauren Courtney Martin, Stellenbosch University, South Africa
Short Talk: The Maternal Vaginal Microbiome: An Investigation into Its Influence in the Development of Foetal Alcohol Spectrum Disorders (FASD)


Monday, January 18 | 2:00PM - 5:00PM
The Vaginal Microbiome in Health and Disease (2pm Denver/Mou
ntain Time Start)
This session is from Microbiome: Mother to Child



Coffee Break


Monday, January 18 | 2:00PM - 5:00PM
The Vaginal Microbiome in Health and Disease (2pm Denver/Mou
ntain Time Start)
This session is from Microbiome: Mother to Child


Speaker 6 of 8
Nkechi Odogwu, University of Minnesota, USA
Short Talk: Dynamics of the Vaginal Microbiome with Steroid Hormones: A Longitudinal Study from a Pregnant and Postnatal Nigerian Cohort


Monday, January 18 | 2:00PM - 5:00PM
The Vaginal Microbiome in Health and Disease (2pm Denver/Mou
ntain Time Start)
This session is from Microbiome: Mother to Child


Speaker 7 of 8
Matthew R. Hayward, Ragon Institute, USA
Short Talk: Construction of a Comprehensive Bacterial Genome Catalogue for the Female Genital Tract Identifies Hundreds of New Species


Monday, January 18 | 2:00PM - 5:00PM
The Vaginal Microbiome in Health and Disease (2pm Denver/Mou
ntain Time Start)
This session is from Microbiome: Mother to Child


Speaker 8 of 8
Seth M. Bloom, Massachusetts General Hospital, USA
Short Talk: Characterization of Unique Cysteine Metabolic Requirements in Lactobacillus iners Identifies a Target for Therapeutic Manipulation of the Cervicovaginal Microbiota


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)

Speaker 1 of 9
* Cynthia L. Sears, Johns Hopkins University School of Medicine, USA
Bacterial Biofilms Associated with Colon Cancer

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)

Speaker 2 of 9
Melody Smith, Memorial Sloan Kettering Cancer Center, USA
Intestinal Microbiome Analyses Identify Biomarkers for Patient Response to CAR T Cell Therapy

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)

Speaker 3 of 9
* Laurence Zitvogel, Institut Gustave Roussy, France
Metagenomic Hallmarks of Resistance to Immune Checkpoint Inhibitors in Advanced Lung Cancers

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)


Coffee Break

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)

Speaker 5 of 9
Bärbel Stecher, Ludwig-Maximilians-Universität München, Germany
[NOT AVAILABLE ON DEMAND] Probing Microbial Community Functions Using Synthetic Microbial Communities

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)

Speaker 6 of 9
Matthew E. Griffin, Rockefeller University, USA
Short Talk: Dissecting Chemical Factors from the Gut Microbiota to Improve Cancer Immunotherapy

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)

Speaker 7 of 9
Joon Seok Park, Harvard Medical School, USA
Short Talk: The Gut Microbiota Mediated T-Cell Co-Inhibitory Signaling Regulates Responses to anti-PD-1 Cancer Immunotherapy

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)

Speaker 8 of 9
Joanna Dreux, Second Genome, USA
Short Talk: Microbiome-Based Biomarker Predicts Response to Immune Checkpoint Inhibitor Therapy Independently of Clinical Features in a Melanoma Meta-Cohort

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Cancer (8am Denver/Mountain Time Start)

Speaker 9 of 9
Abigail E. Overacre-Delgoffe, University of Pittsburgh, USA
Short Talk: Microbiome-Specific T Cells Drive Tertiary Lymphoid Structure Development and Anti-Tumor Immunity in Colorectal Cancer

Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child


Speaker 1 of 9
* Michal A. Elovitz, University of Pennsylvania School of Medicine, USA
Microbiota-Immune Interactions in the Cervicovaginal Space and Spontaneous Preterm Birth


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child


Speaker 2 of 9
David MacIntyre, Imperial College London, UK
Glycan Mediated Microbiota-Host Interactions in the Reproductive Tract and Pregnancy Outcomes


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child


Speaker 3 of 9
* David A. Relman, Stanford University, USA
The Post-Partum Microbiome and Predisposition Towards Spontaneous Preterm Birth


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child



Coffee Break


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child


Speaker 5 of 9
Katharina Ribbeck, Massachusetts Institute of Technology, USA
Modulation of the Properties of Cervicovaginal Mucus by the Microbiota: A Role in Spontaneous Preterm Birth?


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child


Speaker 6 of 9
Heleen Schuster, Amsterdam University Medical Center, Netherlands
Short Talk: Vaginal Immunoglobulins and Inflammatory Markers in Preterm Birth; A Cohort and Nested Case-Control Study from the PROPELLOR Cohort


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child


Speaker 7 of 9
Julie Mirpuri, University of Texas Southwestern Medical Center, USA
Short Talk: Exposure to Maternal High Fat Diet Is Associated with Altered Prenatal Offspring Intestinal Innate Immunity that Is Dependent on the Maternal Microbiome


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child


Speaker 8 of 9
Laurence Daoust, Université Laval, Canada
Short Talk: Postnatal Environment Impacts the Development of Sex-Specific Metabolic Outcomes in Offspring when Targeting Dams’ Gut Microbiota


Tuesday, January 19 | 8:00AM - 11:00AM
The Microbiome and Pregnancy Outcomes (8am Denver/Mountain T
ime Start)
This session is from Microbiome: Mother to Child


Speaker 9 of 9
Karen Lithgow, University of Calgary, Canada
Short Talk: Secreted Protease Activities of Vaginal Porphyromonas Species Associated with Preterm Birth


Tuesday, January 19 | 11:00AM - 12:30PM
Poster Session 2 (Joint) (11am Denver/Mountain Time Start)


Tuesday, January 19 | 12:30PM - 1:30PM
Meet the Editors (Joint)

Speaker 1 of 3
Andrew T. Gewirtz, Georgia State University / Frontiers, USA

Tuesday, January 19 | 12:30PM - 1:30PM
Meet the Editors (Joint)

Speaker 2 of 3
Montserrat Cols, Journal of Experimental Medicine, USA

Tuesday, January 19 | 12:30PM - 1:30PM
Meet the Editors (Joint)

Speaker 3 of 3
Kristan van der Vos, Cell Reports Medicine, Netherlands

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)


Speaker 1 of 9
Seth Rakoff-Nahoum, Boston Children's Hospital, USA
Metabolites as Mediators of Gut Microbial Ecology

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)


Speaker 2 of 9
Chun-Jun (CJ) Guo, Weill Cornell Medicine, USA
A Genetic Approach to Investigate Microbe-Host Interaction at the Molecular Level

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)


Speaker 3 of 9
* Laurie E. Comstock, Brigham and Women's Hospital/Harvard Medical School, USA
Antibacterial Toxins of the Gut Bacteroidales and Their Therapeutic Potential

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)



Coffee Break

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)


Speaker 5 of 9
* Andrew L. Goodman, Yale School of Medicine, USA
Survival Strategies in the Gut Microbiome

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)


Speaker 6 of 9
Lucas Osborn, Cleveland Clinic Foundation, USA
Short Talk: Colorful Foods and Fatty Liver Disease: A Gut Microbial Perspective

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)


Speaker 7 of 9
Eric A. Franzosa, Harvard T.H. Chan School of Public Health, USA
Short Talk: Integrating Taxonomic, Functional, and Strain Profiling of Microbial Communities with bioBakery 3

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)


Speaker 8 of 9
Jingyuan Fu, University Medical Center Groningen, Netherlands
Short Talk: The Long-Term Genetic Stability and Individual Specificity of the Human Gut Microbiome

Tuesday, January 19 | 2:00PM - 5:00PM
Genetics of Microbe-Microbe Interactions (2pm Denver/Mountai
n Time Start)


Speaker 9 of 9
Yancong Zhang, Broad Institute of MIT and Harvard, USA
Short Talk: Identifying Novel Bioactive Microbial Gene Products in Inflammatory Bowel Disease

Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 1 of 9
* Moran Yassour, Hebrew University of Jerusalem, Israel
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life


Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 2 of 9
Anita L. Kozyrskyj, University of Alberta, Canada
Evidence for Causal Pathways of the Infant Gut Microbiome to Overweight and Atopic Disease


Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 3 of 9
* Grace M. Aldrovandi, University of California, Los Angeles, USA
When Mom is Sick: Maternal Health and the Infant Microbiome


Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child



Coffee Break


Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 5 of 9
Carole Brosseau, INRAE BIA, France
Short Talk: Prebiotics Supplementation during Pregnancy Leads to the Transmission of Microbial and Immune Factors from Mother to Child, Preventing from Food Allergy


Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 6 of 9
Carolyn Ann Thomson, University of Calgary, Canada
Short Talk: The Shape of Things to Come: How the Maternal Microbiota Shapes Susceptibility to Type 1 Diabetes in the Offspring


Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 7 of 9
Mercedes Gomez de Aguero, University of Würzburg, Germany
Short Talk: Neonatal Skin Barrier Formation Occurs Embryonically and Is Driven by Maternal Microbiota


Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 8 of 9
Sanzhima Garmaeva, University Medical Center Groningen, Netherlands
Short Talk: Early Development of the Gut Bacteriome and Virome and Their Interactions


Tuesday, January 19 | 2:00PM - 5:00PM
Microbiome Transmission from Mother to Infants (2pm Denver/M
ountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 9 of 9
Xin M. Luo, Virginia Tech, USA
Short Talk: Regulation of Neonatal IgA Production by the Maternal Microbiota


Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)


Speaker 1 of 9
Ivaylo I. Ivanov, Columbia University, USA
[NOT AVAILABLE ON DEMAND] Uptake and Presentation of Commensal Antigens

Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)


Speaker 2 of 9
* Bana Jabri, University of Chicago, USA
Microbiota, Bowel Inflammation and Celiac Disease

Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)


Speaker 3 of 9
Ramnik Xavier, Massachusetts General Hospital, USA
[NOT AVAILABLE ON DEMAND] Microbiota Compositions and Inflammatory Bowel Disease

Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)



Coffee Break

Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)


Speaker 5 of 9
* Colin Hill, University College Cork, Ireland
Shining Light on the Viral Dark Matter of the Human Gut Microbiome

Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)


Speaker 6 of 9
Snehal N. Chaudhari, Harvard Medical School, USA
Short Talk: A Microbial Metabolite Remodels the Gut-Liver Axis Following Bariatric Surgery

Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)


Speaker 7 of 9
Zachary C. Holmes, Duke University, USA
Short Talk: Individualized Microbiota Responses Are Conserved across Prebiotics and Associated with Diet History

Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)


Speaker 8 of 9
Jianbo Zhang, Massachusetts Institute of Technology, USA
Short Talk: Harnessing Patient Derived Microphysiological System to Study Host-Microbe Interactions

Wednesday, January 20 | 8:00AM - 11:00AM
Microbiome, Immunity, Phage and Inflammation (8am Denver/Mou
ntain Time Start)


Speaker 9 of 9
Matthew Ostrowski, University of Michigan, USA
Short Talk: Xanthan Gum Digestion by Human Gut Microbiota

Wednesday, January 20 | 8:00AM - 9:30AM
Development of the Infant Gut Microbiota (8am Denver/Mountai
n Time Start)
This session is from Microbiome: Mother to Child


Speaker 1 of 4
* Christopher Stewart, Newcastle University, UK
Temporal Development of the Gut Microbiome in Early Childhood


Wednesday, January 20 | 8:00AM - 9:30AM
Development of the Infant Gut Microbiota (8am Denver/Mountai
n Time Start)
This session is from Microbiome: Mother to Child


Speaker 2 of 4
Marie-Claire Arrieta, University of Calgary, Canada
Bacterial and Fungal Microbiome Maturation in Premature and Term Infants


Wednesday, January 20 | 8:00AM - 9:30AM
Development of the Infant Gut Microbiota (8am Denver/Mountai
n Time Start)
This session is from Microbiome: Mother to Child


Speaker 3 of 4
* Erika C. Claud, University of Chicago, USA
NEC and the Preterm Infant Microbiome


Wednesday, January 20 | 8:00AM - 9:30AM
Development of the Infant Gut Microbiota (8am Denver/Mountai
n Time Start)
This session is from Microbiome: Mother to Child



Coffee Break


Wednesday, January 20 | 9:30AM - 11:00AM
The Influence of Nutrition on Infants' Microbiota and Health
(9:30am Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 1 of 4
Steven D. Townsend, Vanderbilt University, USA
Human Milk Oligosaccharides: Defense Against Pathogens


Wednesday, January 20 | 9:30AM - 11:00AM
The Influence of Nutrition on Infants' Microbiota and Health
(9:30am Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 2 of 4
* David M. Aronoff, Vanderbilt University, USA
Group B Streptococcus: Transmission of a Pathogen from Mother to Infant


Wednesday, January 20 | 9:30AM - 11:00AM
The Influence of Nutrition on Infants' Microbiota and Health
(9:30am Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 3 of 4
* Maria Carmen Collado, Institute of Agrochemistry and Food Technology-Spanish National Research Council, Spain
Impact of Maternal Diet and Environment/Geographical Location on Maternal Breast Milk Neonatal Microbiota


Wednesday, January 20 | 9:30AM - 11:00AM
The Influence of Nutrition on Infants' Microbiota and Health
(9:30am Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 4 of 4
Robert Y. Chen, Washington University School of Medicine, USA
Short Talk: Linking the Duodenal Microbiota of Undernourished Children to Enteropathy, Stunting, and Central Nervous System Dysfunction


Wednesday, January 20 | 11:00AM - 12:15PM
Networking Lounge (11am Denver/Mountain Time Start)


Wednesday, January 20 | 11:00AM - 12:15PM
Networking Lounge (11am Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Wednesday, January 20 | 12:15PM - 1:45PM
Clinical Trials to Optimize Microbiome-Mediated Disease Resi
stance (12:15pm Denver/Mountain Time Start)

Speaker 1 of 5
* Eric G. Pamer, University of Chicago, USA

Wednesday, January 20 | 12:15PM - 1:45PM
Clinical Trials to Optimize Microbiome-Mediated Disease Resi
stance (12:15pm Denver/Mountain Time Start)

Speaker 2 of 5
* Matthew Henn, Seres Therapeutics, USA
Microbiome Therapeutics to Treat Bacterial Infections and Inflammatory Disease

Wednesday, January 20 | 12:15PM - 1:45PM
Clinical Trials to Optimize Microbiome-Mediated Disease Resi
stance (12:15pm Denver/Mountain Time Start)

Speaker 3 of 5
Bernat Olle, Vedanta Biosciences, USA
Medicines Based on Defined Bacterial Consortia

Wednesday, January 20 | 12:15PM - 1:45PM
Clinical Trials to Optimize Microbiome-Mediated Disease Resi
stance (12:15pm Denver/Mountain Time Start)

Speaker 4 of 5
Johan van Hylckama Vlieg, Kaleido Biosciences, USA
Synthetic Glycans to Optimize Microbiome Composition and Function

Wednesday, January 20 | 12:15PM - 1:45PM
Clinical Trials to Optimize Microbiome-Mediated Disease Resi
stance (12:15pm Denver/Mountain Time Start)

Speaker 5 of 5
Mark R. Charbonneau, Synlogic, USA
Short Talk: Development of a Synthetic Biotic for the Treatment of Enteric Hyperoxaluria

Wednesday, January 20 | 1:45PM - 2:00PM
Coffee Break


Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)


Speaker 1 of 9
* Kiran Patil, European Molecular Biology Laboratory, Germany
[NOT AVAILABLE ON DEMAND] Impact of Therapeutic Drugs on Microbiota Metabolism

Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)


Speaker 2 of 9
* Alan Walker, University of Aberdeen, UK
Implications of Gut Microbiota Variability for Dietary and Therapeutic Interventions

Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)


Speaker 3 of 9
Paul L. Bollyky, Stanford University, USA
Pf Bacteriophages and the Pathogenesis of Pseudomonas Infections

Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)



Coffee Break

Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)


Speaker 5 of 9
Kenya Honda, Keio University School of Medicine, Japan
Mining the Microbiota and Identifying Effector Microbes that Causally Affect the Host Physiology

Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)


Speaker 6 of 9
Sun-Ho Lee, Mount Sinai Hospital Toronto, Canada
Short Talk: The GEM PROJECT: Altered Host Sero-Reactivity to Microbial Antigens Is Associated with Future Onset of Crohn’s Disease

Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)


Speaker 7 of 9
Tyler Rice, Yale University, USA
Short Talk: Inter-species Gut Commensal Rivalry Dictates Mucosal and Systemic Immune Responses

Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)


Speaker 8 of 9
Timur Tuganbaev, Keio University, Japan
Short Talk: Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis

Wednesday, January 20 | 2:00PM - 4:50PM
Impact of Microbiota Composition, Metabolism and Phage on th
e Host (2pm Denver/Mountain Time Start)


Speaker 9 of 9
Mihnea Mangalea, CU Denver Anschutz Medical Campus, USA
Short Talk: Characterizing the Intestinal Viromes of Individuals at Risk for Developing Rheumatoid Arthritis

Wednesday, January 20 | 2:00PM - 3:30PM
The Mother and Infant Microbiome and Neurodevelopment (2:00p
m Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 1 of 6
* Tracy L. Bale, University of Maryland School of Medicine, USA
The Transfer of Stress and Trauma via the Maternal Vaginal Microbiome


Wednesday, January 20 | 2:00PM - 3:30PM
The Mother and Infant Microbiome and Neurodevelopment (2:00p
m Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 2 of 6
* Elaine Y. Hsiao, University of California, Los Angeles, USA
Microbiome Interactions with the Nervous System during Early Development


Wednesday, January 20 | 2:00PM - 3:30PM
The Mother and Infant Microbiome and Neurodevelopment (2:00p
m Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 3 of 6
Geoffrey N. Pronovost, UCLA, USA
Short Talk: The Maternal Microbiome Regulates Placental and Fetal Development


Wednesday, January 20 | 2:00PM - 3:30PM
The Mother and Infant Microbiome and Neurodevelopment (2:00p
m Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 4 of 6
Ai Ing Lim, NIAID, National Institutes of Health, USA
Short Talk: Maternal Infection Promotes Offspring Tissue-Specific Immune Fitness


Wednesday, January 20 | 2:00PM - 3:30PM
The Mother and Infant Microbiome and Neurodevelopment (2:00p
m Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


Speaker 5 of 6
Joan Miro-Blanch, CIBERDEM, Spain
Short Talk: Sex and Microbiota Shape Metabolism and Epigenetic Marks in the Host


Wednesday, January 20 | 2:00PM - 3:30PM
The Mother and Infant Microbiome and Neurodevelopment (2:00p
m Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child



Coffee Break


Wednesday, January 20 | 3:45PM - 4:50PM
The Placental and Endometrial Microbiota - A Debate: Technic
al Artifact or Biological Reality? (3:45pm Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child

The goal of the session is to have a healthy debate about the controversy surrounding the placental/endometrial microbiota. We aimed to make this in the format of a debate.

This is what we were thinking of doing:
You both could present for no more than 20 minutes, presenting your points and position in the debate, Example from your work would be great, especially any new evidence, which would go with the spirit of Keystone Symposia to present new data. I would encourage you to be constructive in your arguments. It would be great to be guided by the new special issue we published at Microbiome, which Indira contributed to.

In the second part of the session, Michal and I would like to ask you some questions and have the audience ask some questions (not sure exactly how questions will work during the symposium, but we will get trained on this tonight). I would assume that questions will be written in the chat and Michal and I could pick the best and most appropriate ones.
Speaker 1 of 4
* Jacques Ravel, University of Maryland School of Medicine, USA


Wednesday, January 20 | 3:45PM - 4:50PM
The Placental and Endometrial Microbiota - A Debate: Technic
al Artifact or Biological Reality? (3:45pm Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child

The goal of the session is to have a healthy debate about the controversy surrounding the placental/endometrial microbiota. We aimed to make this in the format of a debate.

This is what we were thinking of doing:
You both could present for no more than 20 minutes, presenting your points and position in the debate, Example from your work would be great, especially any new evidence, which would go with the spirit of Keystone Symposia to present new data. I would encourage you to be constructive in your arguments. It would be great to be guided by the new special issue we published at Microbiome, which Indira contributed to.

In the second part of the session, Michal and I would like to ask you some questions and have the audience ask some questions (not sure exactly how questions will work during the symposium, but we will get trained on this tonight). I would assume that questions will be written in the chat and Michal and I could pick the best and most appropriate ones.
Speaker 2 of 4
* Michal A. Elovitz, University of Pennsylvania School of Medicine, USA


Wednesday, January 20 | 3:45PM - 4:50PM
The Placental and Endometrial Microbiota - A Debate: Technic
al Artifact or Biological Reality? (3:45pm Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child

The goal of the session is to have a healthy debate about the controversy surrounding the placental/endometrial microbiota. We aimed to make this in the format of a debate.

This is what we were thinking of doing:
You both could present for no more than 20 minutes, presenting your points and position in the debate, Example from your work would be great, especially any new evidence, which would go with the spirit of Keystone Symposia to present new data. I would encourage you to be constructive in your arguments. It would be great to be guided by the new special issue we published at Microbiome, which Indira contributed to.

In the second part of the session, Michal and I would like to ask you some questions and have the audience ask some questions (not sure exactly how questions will work during the symposium, but we will get trained on this tonight). I would assume that questions will be written in the chat and Michal and I could pick the best and most appropriate ones.
Speaker 3 of 4
Indira U. Mysorekar, Washington University School of Medicine, USA
Moving from 'Microbiome' to Microbes in the Placenta and Uncovering Microbial-Immune Crosstalk


Wednesday, January 20 | 3:45PM - 4:50PM
The Placental and Endometrial Microbiota - A Debate: Technic
al Artifact or Biological Reality? (3:45pm Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child

The goal of the session is to have a healthy debate about the controversy surrounding the placental/endometrial microbiota. We aimed to make this in the format of a debate.

This is what we were thinking of doing:
You both could present for no more than 20 minutes, presenting your points and position in the debate, Example from your work would be great, especially any new evidence, which would go with the spirit of Keystone Symposia to present new data. I would encourage you to be constructive in your arguments. It would be great to be guided by the new special issue we published at Microbiome, which Indira contributed to.

In the second part of the session, Michal and I would like to ask you some questions and have the audience ask some questions (not sure exactly how questions will work during the symposium, but we will get trained on this tonight). I would assume that questions will be written in the chat and Michal and I could pick the best and most appropriate ones.
Speaker 4 of 4
Frederic D. Bushman, University of Pennsylvania, USA
Establishment of the Microbiome and Virome in Newborn Human Infants


Wednesday, January 20 | 4:50PM - 5:00PM
Closing Remarks (4:50pm Denver/Mountain Time Start)


Wednesday, January 20 | 4:50PM - 5:00PM
Closing Remarks (4:50pm Denver/Mountain Time Start)
This session is from Microbiome: Mother to Child


*Session Chair.