Web Desc
Tumor Metabolism and the Microenvironment - VIRTUAL CONTENT AVAILABLE ON DEMAND
joint with Integrating Metabolism and Immunity - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Erik A. Sahai, Alec Kimmelman and Johanna A. Joyce
Date: January 25 - 28, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by AstraZeneca, Cell Research and Gilead Sciences, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
As we know, cancer is a major cause of mortality worldwide. Furthermore, cancers result from mutations within somatic cells; however, their evolution and phenotype are determined by their environment, both local and systemic. Increased understanding of mechanisms that drive cancer will provide new avenues to reduce incidence and to treat the disease. Therefore, this meeting brings together researchers focusing on how nutrient availability and utilization influences tumors and those thinking about the multitude of inter-cellular interactions occurring within tumors. The inter-connections between these fields are becoming ever more apparent and this meeting unites the fields of tumor metabolism and the tumor microenvironment together, sparking new synergies and connectivity between researchers. With the extensive opportunities for discussion and numerous short talk slots on the program, this conference will help nurture early career scientists, the next generation of talent, and lead to the emergence of collaborative networks. Moreover, there is an afternoon workshop on “Transitioning to Independence” for early career researchers. Finally, a thorough understanding of how tumor systems can adapt and re-wire in response to challenges is needed to ensure that new therapies being developed have the best chance of success as they enter clinical trials. To that end, several speakers have been selected with the expectation that they discuss either clinical trial data. This will strengthen the linkage between cutting-edge mechanistic studies and human disease.
Scholarship Deadline: November 1 2020
Abstract Deadline: December 14 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaCell ResearchGilead Sciences, Inc.
We gratefully acknowledge additional support from these exhibitors at this conference:
Don Whitley Scientific LimitedHypOxygen
We gratefully acknowledge additional support for this conference from:
American Association for Cancer Research (AACR)DCVC BioNanoString Technologies, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA254450-01
Funding for this conference was made possible (in part) by 1R13CA254450-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 25 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)

Speaker 1 of 4
* Erik A. Sahai, Francis Crick Institute, UK

Monday, January 25 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)

Speaker 2 of 4
* Alec Kimmelman, New York University Langone Medical Center, USA

Monday, January 25 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)

Speaker 3 of 4
* Johanna A. Joyce, University of Lausanne, Switzerland

Monday, January 25 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)

Speaker 4 of 4
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Impact of Nutrient Availability on Cancer Metabolic Dependencies

Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)


Speaker 1 of 7
* Erik A. Sahai, Francis Crick Institute, UK

Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)


Speaker 2 of 7
* M. Celeste Simon, University of Pennsylvania, USA
Metabolic Symbioses in Stressful Tumor Microenvironments

Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)


Speaker 3 of 7
Costas A. Lyssiotis, University of Michigan, USA
Metabolic Networks in the Tumor Microenvironment

Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)


Speaker 4 of 7
Siva Karthik Varanasi, The Salk Institute for Biological Studies, USA
Short Talk: Tumor Metabolism Shapes Antigen Presentation and Adaptive Immune Responses

Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)


Speaker 5 of 7
Hilary A. Coller, University of California, Los Angeles, USA
Short Talk: Cancer-Associated Stroma Requires Autophagy to Promote Tumor Growth by Maintaining Melanoma-Associated Fibroblasts and Suppressing Th1-Type Immune Responses

Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)


Speaker 6 of 7
Eline C. Brombacher, LUMC, Netherlands
Short Talk: Activation of Nutrient-Sensor AMPK in Tumor-Associated Dendritic Cells Promotes Tolerogenic Responses and Compromises the Anti-Tumor Immunity

Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)



Coffee Break

Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)
This session is from Metabolism and Immunity


Speaker 1 of 6
* Janelle S. Ayres, The Salk Institute for Biological Studies, USA


Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)
This session is from Metabolism and Immunity


Speaker 2 of 6
* Diane Mathis, Harvard Medical School, USA
Control of Metabolism by Immune Cells


Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)
This session is from Metabolism and Immunity


Speaker 3 of 6
Vishwa Deep Dixit, Yale University, USA
Immunometabolic Regulation of Aging


Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)
This session is from Metabolism and Immunity


Speaker 4 of 6
Ana Domingos, University of Oxford, UK
Neuroimmunometabolism


Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)
This session is from Metabolism and Immunity


Speaker 5 of 6
Emily Vohralik, UNSW Sydney, Australia
Short Talk: Regulation of Adipose Tissue Beiging by Krüppel-Like Factor 3 (KLF3) and Eosinophils


Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)
This session is from Metabolism and Immunity



Coffee Break


Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)
This session is from Metabolism and Immunity


Speaker 1 of 6
* Vishwa Deep Dixit, Yale University, USA


Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)
This session is from Metabolism and Immunity


Speaker 2 of 6
Christoph Hess, University Hospital Basel/University of Cambridge, Switzerland
From Patient to Molecular Understanding of Immunometabolism


Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)
This session is from Metabolism and Immunity


Speaker 3 of 6
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Repurposed for Cytokines


Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)
This session is from Metabolism and Immunity


Speaker 4 of 6
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Metabolic Adaptations in Host-Microbe Interactions


Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)
This session is from Metabolism and Immunity


Speaker 5 of 6
* Ruth A. Franklin, Harvard University, USA
Stress Responses and Disease Tolerance


Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)
This session is from Metabolism and Immunity


Speaker 6 of 6
Katrin Andreasson, Stanford University, USA
Short Talk: Metabolic Reprogramming of Myeloid Cells Reverses Cognitive Decline in Aging


Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)


Speaker 1 of 5
* Alec Kimmelman, New York University Langone Medical Center, USA

Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)


Speaker 2 of 5
Frank Winkler, University Hospital Heidelberg, Germany
Brain Tumor Cells Interconnect to a Functional and Resistant Network

Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)


Speaker 3 of 5
Johanna A. Joyce, University of Lausanne, Switzerland
Charting the Immune Landscape across Diverse Brain Cancers

Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)


Speaker 4 of 5
* Michael E. Pacold, New York University Medical Center, USA
Brain Metastasis Adaptation to the Metabolic Niche of the Central Nervous System

Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)


Speaker 5 of 5
Gino Ferraro, Harvard Medical School, Massachusetts General Hospital, USA
Short Talk: Fatty Acid Synthesis is Required for Breast Cancer Brain Metastasis

Monday, January 25 | 2:00PM - 3:00PM
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Speaker 1 of 4
Ubaldo E. Martinez Outschoorn, Thomas Jefferson University/Frontiers, USA

Monday, January 25 | 2:00PM - 3:00PM
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Speaker 2 of 4
Stephanie Ailsa Houston, Journal of Experimental Medicine, USA

Monday, January 25 | 2:00PM - 3:00PM
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Speaker 3 of 4
Lise Roth, European Molecular Biology Organization, Germany

Monday, January 25 | 2:00PM - 3:00PM
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Speaker 4 of 4
Catarina Sacristán, Cell Press, USA

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)

Speaker 1 of 8
* Johanna A. Joyce, University of Lausanne, Switzerland

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)

Speaker 2 of 8
* Ruth Scherz-Shouval, Weizmann Institute of Science, Israel

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)

Speaker 3 of 8
Sarah-Maria Fendt, VIB Leuven, Belgium
Metabolic Rewiring Boosting Metastasis Formation

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)

Speaker 4 of 8
Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Activating a Collaborative Innate-Adaptive Immune Response to Restrain Metastasis

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)

Speaker 5 of 8
Matthew F. Krummel, University of California, San Francisco, USA
Imaging the Tumor Microenvironment in Five Dimensions

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)

Speaker 6 of 8
Heather Christofk, University of California, Los Angeles, USA
Targeting Cancer Asparagine Dependence

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)

Speaker 7 of 8
Kevin B. Walsh, Genentech, USA
Short Talk: VEGF Blockade Augments CD8+ T Cell Activity by Amplifying Tumor Hypoxia

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)


Coffee Break

Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 1 of 7
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland


Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 2 of 7
* Morris J. Birnbaum, Pfizer Inc., USA


Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 3 of 7
Marina Mesquida, F. Hoffmann-La Roche Ltd, Switzerland
Anti-Inflammatory Treatment of Diabetic Eye Complications


Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 4 of 7
Marc Y. Donath, University Hospital Basel, Switzerland
IL-1beta in Physiology and Treatment of Metabolic Diseases


Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 5 of 7
Tom Thuren, Novartis Pharmaceuticals, USA
Requirement to Implement Anti-Inflammatory Treatment of Cardiometabolic Diseases


Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 6 of 7
Elena Carcarino, INSERM, France
Short Talk: Epigenomic Regulation of IL-1B Enhancers in Type 2 Diabetes


Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity



Coffee Break


Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 1 of 6
* Marc Y. Donath, University Hospital Basel, Switzerland


Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 2 of 6
Alan R. Saltiel, University of California, San Diego, USA
Inflammatory Links Between Obesity and Energy Metabolism


Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 3 of 6
Bruce Verchere, University of British Columbia, Canada
Islet Amyloid Polypeptide and Islet Inflammation


Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 4 of 6
* Elise Dalmas, INSERM, France
Innate Immunity in the Pancreatic Islet Niche


Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 5 of 6
Feyza Engin, University of Wisconsin-Madison, USA
Short Talk: Targeting Beta Cell Unfolded Protein Response in Type 1 Diabetes


Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)
This session is from Metabolism and Immunity


Speaker 6 of 6
Katia Monsorno, University of Lausanne, Switzerland
Short Talk: Lactate Metabolism in the Control of Microglial Function


Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)


Speaker 1 of 7
* Johanna A. Joyce, University of Lausanne, Switzerland

Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)


Speaker 2 of 7
Lewis C. Cantley, Weill Cornell Medicine, USA
Insulin and Cancer

Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)


Speaker 3 of 7
* Mara H. Sherman, Oregon Health & Science University, USA
Mechanisms and Consequences of Pancreatic Cancer Stromal Evolution

Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)


Speaker 4 of 7
Andrea M. Amitrano, University of Rochester School of Medicine & Dentistry, USA
Short Talk: Regulation of CD8+ T Cell Metabolism and Migration with Optogenetics

Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)


Speaker 5 of 7
Patricia Altea Manzano, VIB-KU Leuven Center for Cancer Biology, Belgium
[NOT AVAILABLE ON DEMAND] Short Talk: Environmental Fatty Acids Support Changes in Histone Acetylation that Promote Breast Cancer Metastasis

Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)


Speaker 6 of 7
Felix Hartmann, Stanford University, USA
Short Talk: Single-Cell Metabolic Regulome Profiling of Human Immune Cells in the Tumor Microenvironment

Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)


Speaker 7 of 7
Tanya Schild, Weill Cornell Medicine, USA
Short Talk: NADK Regulation by Oncogenic KRAS Signaling is Essential for PDAC

Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)

Speaker 1 of 3
Donita C. Brady, University of Pennsylvania, USA

Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)

Speaker 2 of 3
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)

Speaker 3 of 3
Tom Thuren, Novartis Pharmaceuticals, USA

Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 1 of 3
Donita C. Brady, University of Pennsylvania, USA


Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 2 of 3
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA


Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 3 of 3
Tom Thuren, Novartis Pharmaceuticals, USA


Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)


Speaker 1 of 6
* Erik A. Sahai, Francis Crick Institute, UK

Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)


Speaker 2 of 6
Karen H. Vousden, Francis Crick Institute, UK
[NOT AVAILABLE ON DEMAND] Metabolic Control of Invasion and Metastasis

Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)


Speaker 3 of 6
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Autophagy and Systemic Metabolism

Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)


Speaker 4 of 6
Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Regulation of Cancer

Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)


Speaker 5 of 6
* Donita C. Brady, University of Pennsylvania, USA
New Sides for an Old Coin: Copper as an Intracellular Mediator of Autophagy via ULK1/2 Kinase Signaling

Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)



Coffee Break

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 1 of 9
* Elise Dalmas, INSERM, France


Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 2 of 9
* Bruce M. Spiegelman, Harvard Medical School, USA


Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 3 of 9
Rinke Stienstra, Wageningen University and RadboudUMC, Netherlands
Obesity and Diabetes: An Immunometabolic Perspective


Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 4 of 9
Paul Cohen, Rockefeller University, USA
The Adipose Tissue Microenvironment in Health and Disease


Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 5 of 9
Jun Wu, University of Michigan, USA
[NOT AVAILABLE ON DEMAND] Immune-Beige Adipocyte Communication


Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 6 of 9
Inbar Shteinberg, Tel Aviv University, Israel
Short Talk: Distinctive Effects of Alarmins S100A8 and S100A9 on Adaptive Thermogenesis


Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 7 of 9
Katelyn D. Miller, Wistar Institute, USA
Short Talk: Inhibition of Acetate Metabolism Enhances Host Anti-Tumor Immunity


Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 8 of 9
Pegah Poursharifi, University of Montreal-CRCHUM, Canada
Short Talk: Suppression of ABHD6 Promotes Healthy Expansion of Adipose Tissue in Obesity


Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity


Coffee Break


Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)


Speaker 1 of 7
* Erik A. Sahai, Francis Crick Institute, UK

Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)


Speaker 2 of 7
Shannon J. Turley, Genentech, Inc., USA
Evolving Stromal-Immune Axis in Cancer Immunology and Immunotherapy

Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)


Speaker 3 of 7
* Marcia C. Haigis, Harvard Medical School, USA
Dissecting the Tumor-Immune Metabolic Crosstalk in the Tumor Microenvironment

Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)


Speaker 4 of 7
Valerie M. Weaver, University of California, San Francisco, USA
Interplay between Tissue Fibrosis, Metabolic Reprogramming and Inflammation in Tumor Evolution

Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)


Speaker 5 of 7
Natalya N. Pavlova, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Translation in Amino Acid-Poor Environments is Limited by tRNAGln Charging

Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)


Speaker 6 of 7
Thomas Hanigan, The Scripps Research Institute, USA
Short Talk: Small Molecule Inhibition of OXA1L Selectively Kills ZFHX3 Mutant NSCLC from Imbalanced Cytidine Pool Expansion

Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)


Speaker 7 of 7
Arin Aurora, University of Texas Southwestern Medical Center, USA
Short Talk: Metastasizing Melanoma Cells Exhibit Increased Dependence on the Pentose Phosphate Pathway to Manage Oxidative Stress

Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 1 of 8
* Gwendalyn J. Randolph, Washington University, USA


Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 2 of 8
* Alan R. Saltiel, University of California, San Diego, USA


Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 3 of 8
Michael Karin, University of California, San Diego, USA
Mitochondrial DNA Metabolism and IL-1 Mediated Inflammation


Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 4 of 8
Evanna Mills, Dana-Farber Cancer Institute, USA
Thermogenic Fat as a Modifier of the Immune Response


Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 5 of 8
Morris J. Birnbaum, Pfizer Inc., USA
Therapeutic Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease


Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 6 of 8
Han Wang, Ohio State University, Comprehensive Cancer Center, USA
Short Talk: Neutrophil Extracellular Traps Promote the Differentiation of Tregs through Metabolic Reprogramming to Impair Cancer Immunosurveillance in NASH Liver


Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 7 of 8
Sabine Daemen, Washington University in St. Louis, USA
Short Talk: Recruited Monocyte-Derived Macrophages Regulate Hepatic Crown-Like Structure Formation and Liver Fibrosis in NASH


Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 8 of 8
Jin Young Huh, Seoul National University, South Korea
Short Talk: Tank-Binding Kinase 1 Regulates the Localization of acyl-CoA synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation


Wednesday, January 27 | 1:00PM - 2:00PM
Poster Session 1 (1pm Denver/Mountain Time Start)


Wednesday, January 27 | 2:00PM - 3:00PM
Poster Session 2 (2pm Denver/Mountain Time Start)


Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)


Speaker 1 of 6
* Karin E. de Visser, Netherlands Cancer Institute, Netherlands
How the Genetic Makeup of Breast Cancer Shapes the Immune Landscape

Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)


Speaker 2 of 6
* Erik A. Sahai, Francis Crick Institute, UK
Towards a Holistic Understanding of Tumor Architecture

Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)


Speaker 3 of 6
Ruth Scherz-Shouval, Weizmann Institute of Science, Israel
Transcriptional Heterogeneity of Cancer-Associated Fibroblasts in the Tumor Microenvironment

Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)


Speaker 4 of 6
Hannah Bell, University of Michigan, USA
Short Talk: Microbiota Metabolic Exchange Is Critical for Colorectal Cancer Redox Homeostasis and Growth

Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)


Speaker 5 of 6
Christina Schmidt, University of Cambridge, UK
Short Talk: TRACER, a 3D-Model to Study the Influence of the Microenvironment on the Metabolic Profile of Fumarate Hydratase-Deficient Cells

Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)



Coffee Break

Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 1 of 7
* Ana Domingos, University of Oxford, UK


Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 2 of 7
Helga Ellingsgaard, Centre for Physical Activity Research, Copenhagen, Denmark
IL-6, a Physiological Regulator of Adipose Tissue Mass in Humans


Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 3 of 7
* Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
Treatment of Type 2 Diabetes and Age-Related Sarcopenia with the Designer Cytokine IC7Fc


Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 4 of 7
Amy J. Wagers, Harvard University, USA
Stem Cell Metabolism and Muscle Regeneration


Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 5 of 7
Shuang Zhang, Harvard Medical School/Massachusetts General Hospital, USA
Short Talk: Bone Marrow Adipocytes Fuel Fatty Acid Metabolism Directed Myelopoiesis after Myocardial Infarction


Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 6 of 7
Dina Chokr, INSERM, Centre de Recherche des Cordeliers, France
Short Talk: Impact of Histone Lysine Demethylase 6B on Adipose Tissue Macrophage Plasticity


Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)
This session is from Metabolism and Immunity


Coffee Break


Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 1 of 7
* Paul Cohen, Rockefeller University, USA


Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 2 of 7
* Michael Karin, University of California, San Diego, USA


Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 3 of 7
Eicke Latz, University of Bonn, Germany
Pharmacological Modulation of Cellular Metabolism Controls Macrophage Metabolism


Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 4 of 7
Gwendalyn J. Randolph, Washington University, USA
Immunity and Lipoprotein Trafficking


Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 5 of 7
Matthias Nahrendorf, Massachusetts General Hospital, USA
Post-MI Emergency Hematopoiesis and Metabolism


Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 6 of 7
Jan Van den Bossche, Amsterdam UMC VUmc, Netherlands
Short Talk: Macrophage ATP Citrate Lyase Deficiency Stabilizes Atherosclerotic Plaques


Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)
This session is from Metabolism and Immunity

Speaker 7 of 7
Enyuan Cao, Monash University, Australia
Short Talk: Mesenteric Lymphatic Dysfunction Promotes Insulin Resistance and Represents a Potential Novel Treatment Target in Obesity


Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)


Speaker 1 of 5
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Compartmentalized Metabolism in Physiological States of Growth

Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)


Speaker 2 of 5
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Regulation of the Immune Metabolism

Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)


Speaker 3 of 5
* Alec Kimmelman, New York University Langone Medical Center, USA
Metabolic Crosstalk in PDAC

Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)


Speaker 4 of 5
Fabricio Loayza-Puch, German Cancer Research Center, Germany
Short Talk: Dual Ribosome Profiling Uncovers Metabolic Limitations in Distinct Cellular Populations of the Tumor Microenvironment

Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)


Speaker 5 of 5
Marina Fukano, Rosalind & Morris Goodman Cancer Research Centre, McGill University, Canada
Short Talk: Investigating Intra-Tumour Metabolic Heterogeneity in Triple-Negative Breast Cancer

Thursday, January 28 | 11:50AM - 12:00PM
Closing Remarks (11:50am Denver/Mountain Time Start)
This session is from Metabolism and Immunity


Thursday, January 28 | 12:00PM - 12:10PM
Closing Remarks (12pm Denver/Mountain Time Start)


Thursday, January 28 | 12:00PM - 1:30PM
Networking Lounge (12pm Denver/Mountain Time Start)
This session is from Metabolism and Immunity


*Session Chair.


Thursday, January 28 | 12:10PM - 1:30PM
Networking Lounge (12:10pm Denver/Mountain Time Start)