Web Desc
Integrating Metabolism and Immunity - VIRTUAL CONTENT AVAILABLE ON DEMAND
joint with Tumor Metabolism and the Microenvironment - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Marc Y. Donath, Tom Thuren, Bruce M. Spiegelman and Diane Mathis
Date: January 25 - 28, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by AbbVie Inc., Astellas Pharma Inc., Cell Research, Merck & Co., Inc. and Novo Nordisk A/S
For important information on the coronavirus, please click here
Summary of Meeting:
Traditionally, metabolism and immunity have been perceived as two distinct systems with distinct functions: metabolism regulates the disposal and transformation of nutrients, whereas the immune system is responsible for host defense. However, in a broader sense, these two processes are both an organism’s response to stressors, with the aim of restoring homeostasis. An increasing amount of evidence has demonstrated that the chronic activation of the immune system associated with overnutrition may be deleterious, contributing importantly to diabetes and long-term complications, such as cardiovascular disorders. Such dysregulation of the immune system may reflect the duration and magnitude of the metabolic stress, along with genetic predispositions. Accordingly, anti-inflammatory treatments of metabolic diseases emerge as therapies interfering with the pathogenesis of these illnesses and offer disease-modifying potential. Therefore, it is critical that clinical translation be based on an understanding of the physiology and pathophysiology of the role of the immune system in metabolism. This conference will bring together basic scientists and clinicians from both disciplines in order to spark innovative ways of understanding the interactions between the immune system and metabolism. The conference organizers anticipate that the conference will lead to the development of novel therapeutic concepts based on the pathways underlying the pathogenesis of diseases rather than on the manifestation of symptoms belonging to a specific clinical discipline.
Scholarship Deadline: November 1 2020
Abstract Deadline: December 16 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.Astellas Pharma Inc.Cell ResearchMerck & Co., Inc.Novo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
AdipoGen Life SciencesSable Systems International
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK125009-01
Funding for this conference was made possible (in part) by 1 R13 DK125009-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 25 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)

Speaker 1 of 3
* Diane Mathis, Harvard Medical School, USA

Monday, January 25 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)

Speaker 2 of 3
* Marc Y. Donath, University Hospital Basel, Switzerland

Monday, January 25 | 8:00AM - 8:40AM
Welcoming Remarks and Keynote Address (8am Denver/Mountain T
ime Start)

Speaker 3 of 3
Bruce M. Spiegelman, Harvard Medical School, USA
Adipose Inflammation: Many Players and Many Regulatory Functions

Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)


Speaker 1 of 6
* Janelle S. Ayres, The Salk Institute for Biological Studies, USA

Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)


Speaker 2 of 6
* Diane Mathis, Harvard Medical School, USA
Control of Metabolism by Immune Cells

Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)


Speaker 3 of 6
Vishwa Deep Dixit, Yale University, USA
Immunometabolic Regulation of Aging

Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)


Speaker 4 of 6
Ana Domingos, University of Oxford, UK
Neuroimmunometabolism

Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)


Speaker 5 of 6
Emily Vohralik, UNSW Sydney, Australia
Short Talk: Regulation of Adipose Tissue Beiging by Krüppel-Like Factor 3 (KLF3) and Eosinophils

Monday, January 25 | 8:40AM - 10:10AM
Immunometabolism: The Metabolic View (8:40am Denver/Mountain
Time Start)



Coffee Break

Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)
This session is from Tumor Metabolism


Speaker 1 of 7
* Erik A. Sahai, Francis Crick Institute, UK


Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)
This session is from Tumor Metabolism


Speaker 2 of 7
* M. Celeste Simon, University of Pennsylvania, USA
Metabolic Symbioses in Stressful Tumor Microenvironments


Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)
This session is from Tumor Metabolism


Speaker 3 of 7
Costas A. Lyssiotis, University of Michigan, USA
Metabolic Networks in the Tumor Microenvironment


Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)
This session is from Tumor Metabolism


Speaker 4 of 7
Siva Karthik Varanasi, The Salk Institute for Biological Studies, USA
Short Talk: Tumor Metabolism Shapes Antigen Presentation and Adaptive Immune Responses


Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)
This session is from Tumor Metabolism


Speaker 5 of 7
Hilary A. Coller, University of California, Los Angeles, USA
Short Talk: Cancer-Associated Stroma Requires Autophagy to Promote Tumor Growth by Maintaining Melanoma-Associated Fibroblasts and Suppressing Th1-Type Immune Responses


Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)
This session is from Tumor Metabolism


Speaker 6 of 7
Eline C. Brombacher, LUMC, Netherlands
Short Talk: Activation of Nutrient-Sensor AMPK in Tumor-Associated Dendritic Cells Promotes Tolerogenic Responses and Compromises the Anti-Tumor Immunity


Monday, January 25 | 8:40AM - 10:15AM
Metabolic Effects on the Immune System (8:40am Denver/Mounta
in Time Start)
This session is from Tumor Metabolism



Coffee Break


Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)


Speaker 1 of 6
* Vishwa Deep Dixit, Yale University, USA

Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)


Speaker 2 of 6
Christoph Hess, University Hospital Basel/University of Cambridge, Switzerland
From Patient to Molecular Understanding of Immunometabolism

Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)


Speaker 3 of 6
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Repurposed for Cytokines

Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)


Speaker 4 of 6
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Metabolic Adaptations in Host-Microbe Interactions

Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)


Speaker 5 of 6
* Ruth A. Franklin, Harvard University, USA
Stress Responses and Disease Tolerance

Monday, January 25 | 10:20AM - 12:15PM
Immunometabolism: The Immunologist View (10:20am Denver/Moun
tain Time Start)


Speaker 6 of 6
Katrin Andreasson, Stanford University, USA
Short Talk: Metabolic Reprogramming of Myeloid Cells Reverses Cognitive Decline in Aging

Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)
This session is from Tumor Metabolism


Speaker 1 of 5
* Alec Kimmelman, New York University Langone Medical Center, USA


Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)
This session is from Tumor Metabolism


Speaker 2 of 5
Frank Winkler, University Hospital Heidelberg, Germany
Brain Tumor Cells Interconnect to a Functional and Resistant Network


Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)
This session is from Tumor Metabolism


Speaker 3 of 5
Johanna A. Joyce, University of Lausanne, Switzerland
Charting the Immune Landscape across Diverse Brain Cancers


Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)
This session is from Tumor Metabolism


Speaker 4 of 5
* Michael E. Pacold, New York University Medical Center, USA
Brain Metastasis Adaptation to the Metabolic Niche of the Central Nervous System


Monday, January 25 | 10:45AM - 12:15PM
The CNS Microenvironment (10:45am Denver/Mountain Time Start
)
This session is from Tumor Metabolism


Speaker 5 of 5
Gino Ferraro, Harvard Medical School, Massachusetts General Hospital, USA
Short Talk: Fatty Acid Synthesis is Required for Breast Cancer Brain Metastasis


Monday, January 25 | 2:00PM - 3:00PM
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Speaker 1 of 4
Ubaldo E. Martinez Outschoorn, Thomas Jefferson University/Frontiers, USA

Monday, January 25 | 2:00PM - 3:00PM
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Speaker 2 of 4
Stephanie Ailsa Houston, Journal of Experimental Medicine, USA

Monday, January 25 | 2:00PM - 3:00PM
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Speaker 3 of 4
Lise Roth, European Molecular Biology Organization, Germany

Monday, January 25 | 2:00PM - 3:00PM
Meet the Editors (Joint) (2pm Denver/Mountain Time Start)

Speaker 4 of 4
Catarina Sacristán, Cell Press, USA

Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)


Speaker 1 of 7
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)


Speaker 2 of 7
* Morris J. Birnbaum, Pfizer Inc., USA

Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)


Speaker 3 of 7
Marina Mesquida, F. Hoffmann-La Roche Ltd, Switzerland
Anti-Inflammatory Treatment of Diabetic Eye Complications

Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)


Speaker 4 of 7
Marc Y. Donath, University Hospital Basel, Switzerland
IL-1beta in Physiology and Treatment of Metabolic Diseases

Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)


Speaker 5 of 7
Tom Thuren, Novartis Pharmaceuticals, USA
Requirement to Implement Anti-Inflammatory Treatment of Cardiometabolic Diseases

Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)


Speaker 6 of 7
Elena Carcarino, INSERM, France
Short Talk: Epigenomic Regulation of IL-1B Enhancers in Type 2 Diabetes


Tuesday, January 26 | 8:00AM - 9:30AM
Clinical Translation: Unmet Needs (8am Denver/Mountain Time
Start)



Coffee Break

Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)
This session is from Tumor Metabolism

Speaker 1 of 8
* Johanna A. Joyce, University of Lausanne, Switzerland


Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)
This session is from Tumor Metabolism

Speaker 2 of 8
* Ruth Scherz-Shouval, Weizmann Institute of Science, Israel


Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)
This session is from Tumor Metabolism

Speaker 3 of 8
Sarah-Maria Fendt, VIB Leuven, Belgium
Metabolic Rewiring Boosting Metastasis Formation


Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)
This session is from Tumor Metabolism

Speaker 4 of 8
Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Activating a Collaborative Innate-Adaptive Immune Response to Restrain Metastasis


Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)
This session is from Tumor Metabolism

Speaker 5 of 8
Matthew F. Krummel, University of California, San Francisco, USA
Imaging the Tumor Microenvironment in Five Dimensions


Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)
This session is from Tumor Metabolism

Speaker 6 of 8
Heather Christofk, University of California, Los Angeles, USA
Targeting Cancer Asparagine Dependence


Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)
This session is from Tumor Metabolism

Speaker 7 of 8
Kevin B. Walsh, Genentech, USA
Short Talk: VEGF Blockade Augments CD8+ T Cell Activity by Amplifying Tumor Hypoxia


Tuesday, January 26 | 8:00AM - 9:55AM
Metastatic Colonisation (8am Denver/Mountain Time Start)
This session is from Tumor Metabolism


Coffee Break


Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)


Speaker 1 of 6
* Marc Y. Donath, University Hospital Basel, Switzerland

Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)


Speaker 2 of 6
Alan R. Saltiel, University of California, San Diego, USA
Inflammatory Links Between Obesity and Energy Metabolism

Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)


Speaker 3 of 6
Bruce Verchere, University of British Columbia, Canada
Islet Amyloid Polypeptide and Islet Inflammation

Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)


Speaker 4 of 6
* Elise Dalmas, INSERM, France
Innate Immunity in the Pancreatic Islet Niche

Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)


Speaker 5 of 6
Feyza Engin, University of Wisconsin-Madison, USA
Short Talk: Targeting Beta Cell Unfolded Protein Response in Type 1 Diabetes

Tuesday, January 26 | 10:00AM - 11:45AM
Insulin Production and Action (10:00am Denver/Mountain Time
Start)


Speaker 6 of 6
Katia Monsorno, University of Lausanne, Switzerland
Short Talk: Lactate Metabolism in the Control of Microglial Function

Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)
This session is from Tumor Metabolism


Speaker 1 of 7
* Johanna A. Joyce, University of Lausanne, Switzerland


Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)
This session is from Tumor Metabolism


Speaker 2 of 7
Lewis C. Cantley, Weill Cornell Medicine, USA
Insulin and Cancer


Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)
This session is from Tumor Metabolism


Speaker 3 of 7
* Mara H. Sherman, Oregon Health & Science University, USA
Mechanisms and Consequences of Pancreatic Cancer Stromal Evolution


Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)
This session is from Tumor Metabolism


Speaker 4 of 7
Andrea M. Amitrano, University of Rochester School of Medicine & Dentistry, USA
Short Talk: Regulation of CD8+ T Cell Metabolism and Migration with Optogenetics


Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)
This session is from Tumor Metabolism


Speaker 5 of 7
Patricia Altea Manzano, VIB-KU Leuven Center for Cancer Biology, Belgium
[NOT AVAILABLE ON DEMAND] Short Talk: Environmental Fatty Acids Support Changes in Histone Acetylation that Promote Breast Cancer Metastasis


Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)
This session is from Tumor Metabolism


Speaker 6 of 7
Felix Hartmann, Stanford University, USA
Short Talk: Single-Cell Metabolic Regulome Profiling of Human Immune Cells in the Tumor Microenvironment


Tuesday, January 26 | 10:25AM - 12:15PM
The Pancreatic Tumor Microenvironment (10:25am Denver/Mount
ain Time Start)
This session is from Tumor Metabolism


Speaker 7 of 7
Tanya Schild, Weill Cornell Medicine, USA
Short Talk: NADK Regulation by Oncogenic KRAS Signaling is Essential for PDAC


Tuesday, January 26 | 12:00PM - 1:00PM
Poster Session 1 (12pm Denver/Mountain Time Start)


Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)

Speaker 1 of 3
Donita C. Brady, University of Pennsylvania, USA

Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)

Speaker 2 of 3
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Tuesday, January 26 | 1:00PM - 2:00PM
Career Roundtable (Joint) (1pm Denver/Mountain Time Start)

Speaker 3 of 3
Tom Thuren, Novartis Pharmaceuticals, USA

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)

Speaker 1 of 9
* Elise Dalmas, INSERM, France

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)

Speaker 2 of 9
* Bruce M. Spiegelman, Harvard Medical School, USA

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)

Speaker 3 of 9
Rinke Stienstra, Wageningen University and RadboudUMC, Netherlands
Obesity and Diabetes: An Immunometabolic Perspective

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)

Speaker 4 of 9
Paul Cohen, Rockefeller University, USA
The Adipose Tissue Microenvironment in Health and Disease

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)

Speaker 5 of 9
Jun Wu, University of Michigan, USA
[NOT AVAILABLE ON DEMAND] Immune-Beige Adipocyte Communication

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)

Speaker 6 of 9
Inbar Shteinberg, Tel Aviv University, Israel
Short Talk: Distinctive Effects of Alarmins S100A8 and S100A9 on Adaptive Thermogenesis

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)

Speaker 7 of 9
Katelyn D. Miller, Wistar Institute, USA
Short Talk: Inhibition of Acetate Metabolism Enhances Host Anti-Tumor Immunity

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)

Speaker 8 of 9
Pegah Poursharifi, University of Montreal-CRCHUM, Canada
Short Talk: Suppression of ABHD6 Promotes Healthy Expansion of Adipose Tissue in Obesity

Wednesday, January 27 | 8:00AM - 10:00AM
Adipose Tissues (8am Denver/Mountain Time Start)


Coffee Break

Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 1 of 6
* Erik A. Sahai, Francis Crick Institute, UK


Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 2 of 6
Karen H. Vousden, Francis Crick Institute, UK
[NOT AVAILABLE ON DEMAND] Metabolic Control of Invasion and Metastasis


Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 3 of 6
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Autophagy and Systemic Metabolism


Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 4 of 6
Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Regulation of Cancer


Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 5 of 6
* Donita C. Brady, University of Pennsylvania, USA
New Sides for an Old Coin: Copper as an Intracellular Mediator of Autophagy via ULK1/2 Kinase Signaling


Wednesday, January 27 | 8:00AM - 9:40AM
Identifying the Metabolic Dependencies of Cancer Cells (8am
Denver/Mountain Time Start)
This session is from Tumor Metabolism



Coffee Break


Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 1 of 7
* Erik A. Sahai, Francis Crick Institute, UK


Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 2 of 7
Shannon J. Turley, Genentech, Inc., USA
Evolving Stromal-Immune Axis in Cancer Immunology and Immunotherapy


Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 3 of 7
* Marcia C. Haigis, Harvard Medical School, USA
Dissecting the Tumor-Immune Metabolic Crosstalk in the Tumor Microenvironment


Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 4 of 7
Valerie M. Weaver, University of California, San Francisco, USA
Interplay between Tissue Fibrosis, Metabolic Reprogramming and Inflammation in Tumor Evolution


Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 5 of 7
Natalya N. Pavlova, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Translation in Amino Acid-Poor Environments is Limited by tRNAGln Charging


Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 6 of 7
Thomas Hanigan, The Scripps Research Institute, USA
Short Talk: Small Molecule Inhibition of OXA1L Selectively Kills ZFHX3 Mutant NSCLC from Imbalanced Cytidine Pool Expansion


Wednesday, January 27 | 10:10AM - 12:10PM
Therapeutic Targeting of Metabolism and the TME (10:10am Den
ver/Mountain Time Start)
This session is from Tumor Metabolism


Speaker 7 of 7
Arin Aurora, University of Texas Southwestern Medical Center, USA
Short Talk: Metastasizing Melanoma Cells Exhibit Increased Dependence on the Pentose Phosphate Pathway to Manage Oxidative Stress


Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)

Speaker 1 of 8
* Gwendalyn J. Randolph, Washington University, USA

Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)

Speaker 2 of 8
* Alan R. Saltiel, University of California, San Diego, USA

Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)

Speaker 3 of 8
Michael Karin, University of California, San Diego, USA
Mitochondrial DNA Metabolism and IL-1 Mediated Inflammation

Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)

Speaker 4 of 8
Evanna Mills, Dana-Farber Cancer Institute, USA
Thermogenic Fat as a Modifier of the Immune Response

Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)

Speaker 5 of 8
Morris J. Birnbaum, Pfizer Inc., USA
Therapeutic Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease

Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)

Speaker 6 of 8
Han Wang, Ohio State University, Comprehensive Cancer Center, USA
Short Talk: Neutrophil Extracellular Traps Promote the Differentiation of Tregs through Metabolic Reprogramming to Impair Cancer Immunosurveillance in NASH Liver

Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)

Speaker 7 of 8
Sabine Daemen, Washington University in St. Louis, USA
Short Talk: Recruited Monocyte-Derived Macrophages Regulate Hepatic Crown-Like Structure Formation and Liver Fibrosis in NASH

Wednesday, January 27 | 10:10AM - 12:10PM
Liver (10:10am Denver/Mountain Time Start)

Speaker 8 of 8
Jin Young Huh, Seoul National University, South Korea
Short Talk: Tank-Binding Kinase 1 Regulates the Localization of acyl-CoA synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation

Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)

Speaker 1 of 7
* Ana Domingos, University of Oxford, UK

Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)

Speaker 2 of 7
Helga Ellingsgaard, Centre for Physical Activity Research, Copenhagen, Denmark
IL-6, a Physiological Regulator of Adipose Tissue Mass in Humans

Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)

Speaker 3 of 7
* Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
Treatment of Type 2 Diabetes and Age-Related Sarcopenia with the Designer Cytokine IC7Fc

Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)

Speaker 4 of 7
Amy J. Wagers, Harvard University, USA
Stem Cell Metabolism and Muscle Regeneration

Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)

Speaker 5 of 7
Shuang Zhang, Harvard Medical School/Massachusetts General Hospital, USA
Short Talk: Bone Marrow Adipocytes Fuel Fatty Acid Metabolism Directed Myelopoiesis after Myocardial Infarction

Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)

Speaker 6 of 7
Dina Chokr, INSERM, Centre de Recherche des Cordeliers, France
Short Talk: Impact of Histone Lysine Demethylase 6B on Adipose Tissue Macrophage Plasticity

Thursday, January 28 | 8:00AM - 9:45AM
Muscle/Cardiovascular (8am Denver/Mountain Time Start)


Coffee Break

Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)
This session is from Tumor Metabolism


Speaker 1 of 6
* Karin E. de Visser, Netherlands Cancer Institute, Netherlands
How the Genetic Makeup of Breast Cancer Shapes the Immune Landscape


Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)
This session is from Tumor Metabolism


Speaker 2 of 6
* Erik A. Sahai, Francis Crick Institute, UK
Towards a Holistic Understanding of Tumor Architecture


Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)
This session is from Tumor Metabolism


Speaker 3 of 6
Ruth Scherz-Shouval, Weizmann Institute of Science, Israel
Transcriptional Heterogeneity of Cancer-Associated Fibroblasts in the Tumor Microenvironment


Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)
This session is from Tumor Metabolism


Speaker 4 of 6
Hannah Bell, University of Michigan, USA
Short Talk: Microbiota Metabolic Exchange Is Critical for Colorectal Cancer Redox Homeostasis and Growth


Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)
This session is from Tumor Metabolism


Speaker 5 of 6
Christina Schmidt, University of Cambridge, UK
Short Talk: TRACER, a 3D-Model to Study the Influence of the Microenvironment on the Metabolic Profile of Fumarate Hydratase-Deficient Cells


Thursday, January 28 | 8:00AM - 9:45AM
Intercellular Signaling Networks in the TME (8am Denver/Moun
tain Time Start)
This session is from Tumor Metabolism



Coffee Break


Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)

Speaker 1 of 7
* Paul Cohen, Rockefeller University, USA

Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)

Speaker 2 of 7
* Michael Karin, University of California, San Diego, USA

Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)

Speaker 3 of 7
Eicke Latz, University of Bonn, Germany
Pharmacological Modulation of Cellular Metabolism Controls Macrophage Metabolism

Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)

Speaker 4 of 7
Gwendalyn J. Randolph, Washington University, USA
Immunity and Lipoprotein Trafficking

Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)

Speaker 5 of 7
Matthias Nahrendorf, Massachusetts General Hospital, USA
Post-MI Emergency Hematopoiesis and Metabolism

Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)

Speaker 6 of 7
Jan Van den Bossche, Amsterdam UMC VUmc, Netherlands
Short Talk: Macrophage ATP Citrate Lyase Deficiency Stabilizes Atherosclerotic Plaques

Thursday, January 28 | 10:05AM - 11:50AM
Cardiovascular (10:05am Denver/Mountain Time Start)

Speaker 7 of 7
Enyuan Cao, Monash University, Australia
Short Talk: Mesenteric Lymphatic Dysfunction Promotes Insulin Resistance and Represents a Potential Novel Treatment Target in Obesity

Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)
This session is from Tumor Metabolism


Speaker 1 of 5
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Compartmentalized Metabolism in Physiological States of Growth


Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)
This session is from Tumor Metabolism


Speaker 2 of 5
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Regulation of the Immune Metabolism


Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)
This session is from Tumor Metabolism


Speaker 3 of 5
* Alec Kimmelman, New York University Langone Medical Center, USA
Metabolic Crosstalk in PDAC


Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)
This session is from Tumor Metabolism


Speaker 4 of 5
Fabricio Loayza-Puch, German Cancer Research Center, Germany
Short Talk: Dual Ribosome Profiling Uncovers Metabolic Limitations in Distinct Cellular Populations of the Tumor Microenvironment


Thursday, January 28 | 10:15AM - 12:00PM
Metabolic Compartmentalisation (10:15am Denver/Mountain Time
Start)
This session is from Tumor Metabolism


Speaker 5 of 5
Marina Fukano, Rosalind & Morris Goodman Cancer Research Centre, McGill University, Canada
Short Talk: Investigating Intra-Tumour Metabolic Heterogeneity in Triple-Negative Breast Cancer


Thursday, January 28 | 11:50AM - 12:00PM
Closing Remarks (11:50am Denver/Mountain Time Start)


Thursday, January 28 | 12:00PM - 12:10PM
Closing Remarks (12pm Denver/Mountain Time Start)
This session is from Tumor Metabolism


Thursday, January 28 | 12:00PM - 1:30PM
Networking Lounge (12pm Denver/Mountain Time Start)


*Session Chair.

Thursday, January 28 | 12:10PM - 1:30PM
Networking Lounge (12:10pm Denver/Mountain Time Start)
This session is from Tumor Metabolism