Web Desc
Obesity: From Cell to Patient - VIRTUAL CONTENT AVAILABLE ON DEMAND
joint with Diabetes: Many Faces of the Disease - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Kevin L. Grove, Rachel L. Batterham and Shane T. Hentges
Date: February 01 - 03, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by AstraZeneca and Novo Nordisk A/S
For important information on the coronavirus, please click here
Summary of Meeting:
Obesity is a chronic disease affecting millions of people world-wide, and is often associated with numerous co-morbidities, including Type II diabetes, liver disease and cardiovascular disease. This conference aims to gather the world leaders in obesity research and discuss numerous topics- from the cell to the patient- as they relate to obesity. Obesity is an annual topic for Keystone Symposia and is considered to be one of the most critical in the field and the previous Keystone Symposia conferences have been heavily focused on basic research. Therefore, this conference program particularly aims to address this gap by providing a greater balance with clinical/translational research on the program. Additionally, there are sessions that have a special focus on the gut/brain axis, including the microbiota, as there is emerging research in this area that has made transformational steps in our understanding of etiology of this disease, as well as in treatment. Moreover, there is strong evidence that the gut/brain axis is important not just for appetitive behavior but also energy homeostasis, blood glucose and even emotional state. Finally, this conference is being held jointly with the annual diabetes conference, Diabetes: Many Faces of the Disease, as there is obvious overlap in these fields. Therefore, the program will contain joint sessions and even a joint Keynote speaker. With this pairing, it is anticipated to draw the leaders in this field from around the world, as well as the next generation of future scientists. Connecting scientists in basic, transitional, clinical and pharmaceutical research will be crucial to moving the field forward.
Scholarship Deadline: November 1 2020
Abstract Deadline: December 17 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
AdipoGen Life SciencesSable Systems International
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK127724-01
Funding for this conference was made possible (in part) by 1 R13 DK127724-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, February 01 | 8:00AM - 8:40AM
Welcome Remarks and Keynote Address (Joint) (8am Denver/Moun
tain Time Start)

Speaker 1 of 3
* Kevin L. Grove, Novo Nordisk, USA

Monday, February 01 | 8:00AM - 8:40AM
Welcome Remarks and Keynote Address (Joint) (8am Denver/Moun
tain Time Start)

Speaker 2 of 3
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA

Monday, February 01 | 8:00AM - 8:40AM
Welcome Remarks and Keynote Address (Joint) (8am Denver/Moun
tain Time Start)

Speaker 3 of 3
Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Peripheral and Central Faces of Hepatic Insulin Resistance

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 1 of 6
* Kevin L. Grove, Novo Nordisk, USA

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 2 of 6
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA
Hypoglycemia After Bariatric Surgery: Lessons Learned About Intestinal Control of Glucose Metabolism

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 3 of 6
Max Nieuwdorp, University of Amsterdam, Netherlands
Does the Disease Start with the Gut Microbiome?

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 4 of 6
Roy Taylor, Newcastle University, UK
T2DM: Simple Etiology but Heterogenous Individuals

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 5 of 6
Aneta Stefanidis, Monash University, Australia
Short Talk: The Importance of Brown Fat in Mediating Changes in Glucose Regulation following Vertical Sleeve Gastrectomy

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 6 of 6
Chisayo Kozuka, RIKEN Center for Integrative Medical Sciences, Japan
Short Talk: Bromodomain-Containing Proteins Regulate Glucose Metabolism vis Gut-Liver FGF15/19 Pathway

Monday, February 01 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 1 of 3
Diego V. Bohórquez, Duke University, USA

Monday, February 01 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 2 of 3
Murielle M. Veniant, Amgen Inc., USA

Monday, February 01 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 3 of 3
Kristen Jane Nadeau, University of Colorado Denver, USA

Monday, February 01 | 1:30PM - 3:00PM
Poster Session 1 (Joint) (1:30pm Denver/Mountain Time Start)


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)


Speaker 1 of 8
* Thomas H. Meek, Novo Nordisk, USA

Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)


Speaker 2 of 8
Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Central Effects of Bariatric Surgery

Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)


Speaker 3 of 8
* Stephanie E. Fulton, University of Montreal, Canada
Curbing Hedonia: Neurometabolic Adaptations to High-Fat Diet and Obesity

Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)


Speaker 4 of 8
Dana M. Small, Yale University School of Medicine, USA
Striatal – Prefrontal Circuit Sensitivity to Insulin Determines Working Memory Ability in Youth with Obesity

Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)


Speaker 5 of 8
Murielle M. Veniant, Amgen Inc., USA
GIPR Antagonist Antibodies Conjugated to GLP-1 Peptides Decrease Weight in Obese Preclinical Models

Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)


Speaker 6 of 8
Elinor L. Sullivan, Oregon National Primate Research Center, USA
[NOT AVAILABLE ON DEMAND] The Influence of Maternal Nutrition and Metabolic State on Offspring Risk for Psychiatric Disorders

Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)


Speaker 7 of 8
Chen Liu, University of Texas Southwestern Medical Center, USA
Short Talk: Atypical Antipsychotics Target Hypothalamic Melanocortin 4 Receptors to Cause Weight Gain


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)


Speaker 8 of 8
Natasha Gaito, Virginia Tech, USA
Short Talk: In silico Analysis of the POMC and NPY Promoters: The Role of Methylation in Environmental Triggers of Obesity

Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)
This session is from Diabetes


Speaker 1 of 8
Juleen R. Zierath, Karolinska Institutet, Sweden
Skeletal Muscle Mediators and Exercise-Induced Adaptations Governing Insulin Sensitivity in Type 2 Diabetes


Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)
This session is from Diabetes


Speaker 2 of 8
* Joseph T. Brozinick, Eli Lilly and Company, USA
Therapeutically Targeting Skeletal Muscle to Treat Type II Diabetes: Could Urocortin 2 be Exercise in a Bottle?


Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)
This session is from Diabetes


Speaker 3 of 8
* Bret H. Goodpaster, Translational Research Institute for Metabolism and Diabetes, USA
Fat Accumulation in Muscle: Implications for Diabetes


Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)
This session is from Diabetes


Speaker 4 of 8
Lena Espelage, German Diabetes Center, Germany
Short Talk: Contraction Response in Skeletal Muscle Glucose Uptake Is Regulated by the Two RabGAPs TBC1D1, TBC1D4 and the Key Components of Exercise Signaling, AMPK and Rac1, in a Cooperative Manner


Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)
This session is from Diabetes


Speaker 5 of 8
Taiyi Kuo, Columbia University, USA
Short Talk: Systemic Benefits of Gc Inhibition to Preserve Insulin Sensitivity


Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)
This session is from Diabetes


Speaker 6 of 8
Dongyin Guan, University of Pennsylvania, USA
Short Talk: Canonical and Non-Canonical Clock Regulators in Obesity and Diabetes


Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)
This session is from Diabetes


Speaker 7 of 8
Adam J. Rose, Monash University, Australia
Short Talk: An Endocrine-Hepato-Muscular Metabolic Cycle Links Skeletal Muscle Atrophy and Hyperglycemia in Type 2 Diabetes


Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)
This session is from Diabetes


Speaker 8 of 8
Christoffer Clemmensen, University of Copenhagen, Denmark
Short Talk: GDF15 as a Regulator of Energy Metabolism: Physiology vs. Pharmacology


Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)


Speaker 1 of 8
* Kevin L. Grove, Novo Nordisk, USA

Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)


Speaker 2 of 8
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Novel Insights into the Endocrine Actions of the Adipocyte

Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)


Speaker 3 of 8
Ana Domingos, University of Oxford, UK
Sympathetic Innervation of Adipose Tissue

Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)


Speaker 4 of 8
Sean M. Hartig, Baylor College of Medicine, USA
Leveraging MicroRNA Targets to Treat Obesity

Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)


Speaker 5 of 8
Camilla Charlotte Schéele, University of Copenhagen, Denmark
Early Differentiation of Human Brown and White Adipocytes at Single Cell Level Reveals Common Subtype with Genetic Association to Body Fat Distribution

Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)


Speaker 6 of 8
Stephanie Wesolowski, University of Colorado, USA
Metabolic Programming in the Fetal Liver- Potentiation of Gluconeogenesis by Hypoxemia

Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)


Speaker 7 of 8
Kai Sun, University of Texas Health Science Center at Houston, USA
Short Talk: Adipose-Derived MMP14 Is a Key Player in Metabolic Health

Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)


Speaker 8 of 8
Aimee L. Edinger, University of California, Irvine, USA
Short Talk: A Drug-Like Sphingolipid Opposes Mitochondrial Fragmentation and Corrects the Adiponectin:Leptin Ratio and Obesity

Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 1 of 8
* Laura C. Alonso, Weill Cornell Medicine, USA


Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 2 of 8
Ellen E. Blaak, Maastricht University, Netherlands
Obesity Metabolic Phenotypes Leading to Type 2 Diabetes Mellitus: Implications for Personalized Prevention


Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 3 of 8
Kristen Jane Nadeau, University of Colorado Denver, USA
Emerging Aspects of T2D in Youth


Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 4 of 8
Matthew B. Johnson, University of Exeter Medical School, UK
Genetic Insights into Autoimmune Diabetes


Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 5 of 8
* Carmella Evans-Molina, Indiana University, USA
Type 1 Diabetes: Taking the Long View


Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 6 of 8
Kevan C. Herold, Yale University, USA
Cancer Immunotherapy and T1D


Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 7 of 8
Alka M. Kanaya, University of California, San Francisco, USA
Heterogeneity of Type 2 Diabetes Subtypes by Ethnicity


Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 8 of 8
Debora R. Sobreira, University of Chicago, USA
Short Talk: An Integrative Platform to Uncover the Mechanisms of the Association of TCF7L2 and T2D


Tuesday, February 02 | 12:30PM - 1:30PM
Meet the Editors (Joint) (12:30pm Denver/Mountain Time Start
)

Speaker 1 of 4
Katherine Samaras, Frontiers in Endocrinology, Australia

Tuesday, February 02 | 12:30PM - 1:30PM
Meet the Editors (Joint) (12:30pm Denver/Mountain Time Start
)

Speaker 2 of 4
Jeff Holly, Frontiers in Endocrinology, UK

Tuesday, February 02 | 12:30PM - 1:30PM
Meet the Editors (Joint) (12:30pm Denver/Mountain Time Start
)

Speaker 3 of 4
Kristan van der Vos, Cell Reports Medicine, Netherlands

Tuesday, February 02 | 12:30PM - 1:30PM
Meet the Editors (Joint) (12:30pm Denver/Mountain Time Start
)

Speaker 4 of 4
Allyson Evans, Cell Press, USA

Tuesday, February 02 | 1:30PM - 3:00PM
Poster Session 2 (Joint) (1:30pm Denver/Mountain Time Start)


Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)


Speaker 1 of 8
* Rachel L. Batterham, University College London, UK
[NOT AVAILABLE ON DEMAND] STEP Amylin Trials

Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)


Speaker 2 of 8
Darleen A. Sandoval, University of Colorado, USA
Lessons From Mouse Models of Bariatric Surgery

Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)


Speaker 3 of 8
Diego V. Bohórquez, Duke University, USA
A Gut Choice for Sugars

Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)


Speaker 4 of 8
* Gary J. Schwartz, Albert Einstein College of Medicine, USA
Bottom Up Control of Appetite

Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)


Speaker 5 of 8
Alison Nicole McRae, Mayo Clinic, USA
Short Talk: Overexpression of Regulator Of G-Protein Signaling (RGS) In Obesity Contributes To Impaired GPCR-Mediated Hormone Secretion In Human Enteroedocrine Cells: A Single-Cell RNA Sequencing Study of Gut Epithelium in Human Obesity

Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)


Speaker 6 of 8
Geke Aline Boer, University of Copenhagen, Biomedical Institute, Denmark
Short Talk: GIP Receptor Deletion in Mice Confers Resistance to Obesity via Alterations in Energy Expenditure and Adipose Tissue Lipid Metabolism

Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)


Speaker 7 of 8
Elizabeth Ann Killion, Amgen, USA
Short Talk: Chronic Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Agonism Desensitizes Adipocyte GIPR Activity Mimicking Functional GIPR Antagonism

Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)


Speaker 8 of 8
Ki-Suk Kim, University of Colorado Anschutz Medical Campus, USA
Short Talk: The Role of Bile Acid Receptor Expressed in Intestinal Stem Cells on Enteroendocrine Cell Differentiation after Bariatric Surgery

Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 1 of 8
Chantal Mathieu, KU Leuven, Belgium
Dialog Between the Immune System and the Beta Cell


Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 2 of 8
Laura C. Alonso, Weill Cornell Medicine, USA
ER Stress: The Good, the Bad and the Ugly


Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 3 of 8
* Marc Prentki, Montreal Diabetes Research Center, Canada
Novel Metabolic Enzyme Glycerol 3-P-Phosphatase: From ß-cell Gluco-detoxification to Healthy Aging


Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 4 of 8
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Beta Cell Dysfunction Contributes to T1D


Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 5 of 8
Feyza Engin, University of Wisconsin-Madison, USA
Short Talk: Targeting Beta Cell Unfolded Protein Response in T1D


Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 6 of 8
Sangeeta Dhawan, City of Hope, USA
Short Talk: DNA Hydroxymethylation and Functional Beta Cell Mass in Health and Diabetes


Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 7 of 8
Joan Mir-Coll, InSphero AG, Switzerland
Short Talk: Human Islet Microtissues as an in vitro and in vivo Model System for Diabetes


Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)
This session is from Diabetes


Speaker 8 of 8
Blaise Su Jun Low, National University of Singapore, Singapore
Short Talk: Modeling the Insulin Secretion Defects in MODY3 using Patient hIPSC-derived Beta Cells


Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)


Speaker 1 of 6
Linda Rinaman, Florida State University, USA
GLP-1 Neural Signaling in Stress and Metabolism

Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)


Speaker 2 of 6
* Lori M. Zeltser, Columbia University, USA
Effects of Social Isolation on Stress-Induced Behavior in Females

Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)


Speaker 3 of 6
* Michael Krashes, NIDDK, National Institutes of Health, USA
High-Fat Food Biases Hypothalamic and Mesolimbic Expression of Consummatory Drives

Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)


Speaker 4 of 6
Lotte Bjerre Knudsen, Novo Nordisk A/S, Denmark
GLP-1 in the Treatment of Obesity, Mechanisms that Translate into Durable Weight Loss in Patients

Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)


Speaker 5 of 6
Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Single-Cell Multi-Tissue Dissection of Obesity-Exercise Circuitry in Human and Mouse

Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)


Speaker 6 of 6
Katherine Blackmore, George Washington University, USA
Short Talk: An Obligatory Forebrain-Hypothalamic ER Stress Driven Circuit Mediates Hepatic Steatosis during Obesity

Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)
This session is from Diabetes


Speaker 1 of 7
* Juleen R. Zierath, Karolinska Institutet, Sweden


Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)
This session is from Diabetes


Speaker 2 of 7
* Jose C. Florez, Massachusetts General Hospital, USA
Have GWAS Helped Classify Diabetes?


Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)
This session is from Diabetes


Speaker 3 of 7
Emma Ahlqvist, Lund University, Sweden
Subclassifying Diabetes by Combining GWAS and Clinical Phenotyping


Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)
This session is from Diabetes


Speaker 4 of 7
Paul W. Franks, Lund University, Sweden
Precision Medicine in Obesity and Diabetes


Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)
This session is from Diabetes


Speaker 5 of 7
Rory J. McCrimmon, University of Dundee, UK
Mechanisms of Therapies for T2D and Potential Crossover to T1D


Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)
This session is from Diabetes


Speaker 6 of 7
Carla J. Greenbaum, Benaroya Research Institute at Virginia Mason, USA
Therapies to Stop T1D…Determining Risk and Conducting Trials


Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)
This session is from Diabetes


Speaker 7 of 7
Allan Ertmann Karlsen, Novo Nordisk, Denmark
Stem Cell Mediated Treatments for Diabetes


Wednesday, February 03 | 11:30AM - 12:30PM
Workshop and Panel: Patient Perspective and Stigmas (11:30am
Denver/Mountain Time Start)

Speaker 1 of 4
* Rachel L. Batterham, University College London, UK

Wednesday, February 03 | 11:30AM - 12:30PM
Workshop and Panel: Patient Perspective and Stigmas (11:30am
Denver/Mountain Time Start)

Speaker 2 of 4
Vicki Mooney, ECPO Executive Director & Patient, Spain

Wednesday, February 03 | 11:30AM - 12:30PM
Workshop and Panel: Patient Perspective and Stigmas (11:30am
Denver/Mountain Time Start)

Speaker 3 of 4
Francesco Rubino, King's College London, UK

Wednesday, February 03 | 11:30AM - 12:30PM
Workshop and Panel: Patient Perspective and Stigmas (11:30am
Denver/Mountain Time Start)

Speaker 4 of 4
Joseph Nadglowski, Obesity Action Coalition, USA

Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)
This session is from Diabetes

Speaker 1 of 7
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA


Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)
This session is from Diabetes

Speaker 2 of 7
Alpana P. Shukla, Weill Cornell Medical College, USA
Interaction between T2D and Obesity and COVID Outcomes


Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)
This session is from Diabetes

Speaker 3 of 7
G. Todd Alonso, University of Colorado, USA
COVID and TID


Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)
This session is from Diabetes

Speaker 4 of 7
Shuibing Chen, Weill Cornell Medical College, USA
COVID Directly Infects Beta Cells and Affects Beta Cell Function


Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)
This session is from Diabetes

Speaker 5 of 7
Katie C. Coate, Vanderbilt University Medical Center, USA
ACE2 is Expressed in the Islet Microvasculature and Ducts of Human Pancreas


Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)
This session is from Diabetes

Speaker 6 of 7
Francesco Dotta, University of Siena, Italy
Human Beta Cells Express ACE2


Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)
This session is from Diabetes

Speaker 7 of 7
Dirk Homann, Icahn School of Medicine at Mount Sinai, USA
Experimental and Natural SARS-CoV-2 Infection of the Human Pancreas


Wednesday, February 03 | 1:30PM - 3:00PM
Networking Lounge (Joint) (1:30pm Denver/Mountain Time Start
)



Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 1 of 6
* Shane T. Hentges, Colorado State University, USA
POMC Neurons: Distinct Roles in Food Intake, Metabolism and Glucose Regulation

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 2 of 6
* Michael A. Cowley, Monash University, Australia
Hypothalamic Control of Glucose Homeostasis

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 3 of 6
Martin G. Myers, Jr., University of Michigan, USA
Control of Food Intake and Energy Balance via the NTS and DMH

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 4 of 6
Michael W. Schwartz, University of Washington, USA
Unraveling Diabetes Remission Induced by the Brain

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 5 of 6
Ian Enrique Gonzalez, University of Michigan, USA
Short Talk: Paraventricular Hypothalamic Calcitonin Receptor Expressing Neurons Regulate Energy Balance

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 6 of 6
Juliana Bezerra Medeiros de Lima, Wayne State University, USA
Short Talk: ARC GHR Neurons Control System Glucose Sensitivity via Muscle Glucose Uptake

Wednesday, February 03 | 5:50PM - 6:00PM
Closing Remarks (5:50pm Denver/Mountain Time Start)


Wednesday, February 03 | 5:50PM - 6:00PM
Closing Remarks (5:50pm Denver/Mountain Time Start)
This session is from Diabetes


*Session Chair.