Web Desc
Diabetes: Many Faces of the Disease - VIRTUAL CONTENT AVAILABLE ON DEMAND
joint with Obesity: From Cell to Patient - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Lori Sussel, Juleen R. Zierath and Laura C. Alonso
Date: February 01 - 03, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by AstraZeneca and Novo Nordisk A/S
For important information on the coronavirus, please click here
Summary of Meeting:
Diabetes continues to be a growing health problem throughout the world; the incidence of both type 1 diabetes (T1D) or type 2 diabetes (T2D) has steadily been rising. However, with the advent of novel technologies, high throughput sequencing, and clinical studies involving diverse human populations, there also has been a growing appreciation for the existence of sub-classifications of both T1D and T2D based on genetics and environmental influences. Understanding and characterizing the different diseases is critical to develop more effective personalized therapies. Therefore, the goal of this conference is to highlight traditional and novel aspects of diabetes research. This program will include lectures on atypical forms of T1D, as well as the emerging premise that beta cell dysfunction contributes to progression of this autoimmune disease. A dedicated session for T2D will highlight disease variations and challenge the current dogma associated with genetic and environmental differences between individuals. This conference is being held jointly with Obesity: From Cell to Patient. The program contains joint sessions, workshops, and even a joint Keynote speaker. The joint sessions will highlight the contribution of obesity to T2D pathogenesis, with an emphasis on novel areas of research, including the role of different types and sources of fat, exosome signaling and the role of the microbiome. Overall, this conference strives to raise awareness in the clinical and basic research communities about the need to sub-stratify diabetes to develop better treatment options.
Scholarship Deadline: November 1 2020
Abstract Deadline: December 17 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
ALPCOSable Systems International
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK127701-01
Funding for this conference was made possible (in part) by 1 R13 DK127701-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, February 01 | 8:00AM - 8:40AM
Welcome Remarks and Keynote Address (Joint) (8am Denver/Moun
tain Time Start)

Speaker 1 of 3
* Kevin L. Grove, Novo Nordisk, USA

Monday, February 01 | 8:00AM - 8:40AM
Welcome Remarks and Keynote Address (Joint) (8am Denver/Moun
tain Time Start)

Speaker 2 of 3
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA

Monday, February 01 | 8:00AM - 8:40AM
Welcome Remarks and Keynote Address (Joint) (8am Denver/Moun
tain Time Start)

Speaker 3 of 3
Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Peripheral and Central Faces of Hepatic Insulin Resistance

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 1 of 6
* Kevin L. Grove, Novo Nordisk, USA

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 2 of 6
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA
Hypoglycemia After Bariatric Surgery: Lessons Learned About Intestinal Control of Glucose Metabolism

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 3 of 6
Max Nieuwdorp, University of Amsterdam, Netherlands
Does the Disease Start with the Gut Microbiome?

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 4 of 6
Roy Taylor, Newcastle University, UK
T2DM: Simple Etiology but Heterogenous Individuals

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 5 of 6
Aneta Stefanidis, Monash University, Australia
Short Talk: The Importance of Brown Fat in Mediating Changes in Glucose Regulation following Vertical Sleeve Gastrectomy

Monday, February 01 | 8:40AM - 11:00AM
Gut Instincts: Influence of the Intestine on Glucose Homeost
asis (Joint) (8:40am Denver/Mountain Time Start)


Speaker 6 of 6
Chisayo Kozuka, RIKEN Center for Integrative Medical Sciences, Japan
Short Talk: Bromodomain-Containing Proteins Regulate Glucose Metabolism vis Gut-Liver FGF15/19 Pathway

Monday, February 01 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 1 of 3
Diego V. Bohórquez, Duke University, USA

Monday, February 01 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 2 of 3
Murielle M. Veniant, Amgen Inc., USA

Monday, February 01 | 12:30PM - 1:30PM
Career Roundtable (Joint) (12:30pm Denver/Mountain Time Star
t)

Speaker 3 of 3
Kristen Jane Nadeau, University of Colorado Denver, USA

Monday, February 01 | 1:30PM - 3:00PM
Poster Session 1 (Joint) (1:30pm Denver/Mountain Time Start)


Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)


Speaker 1 of 8
Juleen R. Zierath, Karolinska Institutet, Sweden
Skeletal Muscle Mediators and Exercise-Induced Adaptations Governing Insulin Sensitivity in Type 2 Diabetes

Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)


Speaker 2 of 8
* Joseph T. Brozinick, Eli Lilly and Company, USA
Therapeutically Targeting Skeletal Muscle to Treat Type II Diabetes: Could Urocortin 2 be Exercise in a Bottle?

Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)


Speaker 3 of 8
* Bret H. Goodpaster, Translational Research Institute for Metabolism and Diabetes, USA
Fat Accumulation in Muscle: Implications for Diabetes

Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)


Speaker 4 of 8
Lena Espelage, German Diabetes Center, Germany
Short Talk: Contraction Response in Skeletal Muscle Glucose Uptake Is Regulated by the Two RabGAPs TBC1D1, TBC1D4 and the Key Components of Exercise Signaling, AMPK and Rac1, in a Cooperative Manner

Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)


Speaker 5 of 8
Taiyi Kuo, Columbia University, USA
Short Talk: Systemic Benefits of Gc Inhibition to Preserve Insulin Sensitivity

Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)


Speaker 6 of 8
Dongyin Guan, University of Pennsylvania, USA
Short Talk: Canonical and Non-Canonical Clock Regulators in Obesity and Diabetes

Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)


Speaker 7 of 8
Adam J. Rose, Monash University, Australia
Short Talk: An Endocrine-Hepato-Muscular Metabolic Cycle Links Skeletal Muscle Atrophy and Hyperglycemia in Type 2 Diabetes

Monday, February 01 | 3:00PM - 6:00PM
Muscling in on Insulin Resistance (3pm Denver/Mountain Time
Start)


Speaker 8 of 8
Christoffer Clemmensen, University of Copenhagen, Denmark
Short Talk: GDF15 as a Regulator of Energy Metabolism: Physiology vs. Pharmacology

Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)
This session is from Obesity


Speaker 1 of 8
* Thomas H. Meek, Novo Nordisk, USA


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)
This session is from Obesity


Speaker 2 of 8
Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Central Effects of Bariatric Surgery


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)
This session is from Obesity


Speaker 3 of 8
* Stephanie E. Fulton, University of Montreal, Canada
Curbing Hedonia: Neurometabolic Adaptations to High-Fat Diet and Obesity


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)
This session is from Obesity


Speaker 4 of 8
Dana M. Small, Yale University School of Medicine, USA
Striatal – Prefrontal Circuit Sensitivity to Insulin Determines Working Memory Ability in Youth with Obesity


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)
This session is from Obesity


Speaker 5 of 8
Murielle M. Veniant, Amgen Inc., USA
GIPR Antagonist Antibodies Conjugated to GLP-1 Peptides Decrease Weight in Obese Preclinical Models


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)
This session is from Obesity


Speaker 6 of 8
Elinor L. Sullivan, Oregon National Primate Research Center, USA
[NOT AVAILABLE ON DEMAND] The Influence of Maternal Nutrition and Metabolic State on Offspring Risk for Psychiatric Disorders


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)
This session is from Obesity


Speaker 7 of 8
Chen Liu, University of Texas Southwestern Medical Center, USA
Short Talk: Atypical Antipsychotics Target Hypothalamic Melanocortin 4 Receptors to Cause Weight Gain


Monday, February 01 | 3:00PM - 6:00PM
Central Adaptations to Body Weight Change (3pm Denver/Mounta
in Time Start)
This session is from Obesity


Speaker 8 of 8
Natasha Gaito, Virginia Tech, USA
Short Talk: In silico Analysis of the POMC and NPY Promoters: The Role of Methylation in Environmental Triggers of Obesity


Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)


Speaker 1 of 8
* Laura C. Alonso, Weill Cornell Medicine, USA

Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)


Speaker 2 of 8
Ellen E. Blaak, Maastricht University, Netherlands
Obesity Metabolic Phenotypes Leading to Type 2 Diabetes Mellitus: Implications for Personalized Prevention

Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)


Speaker 3 of 8
Kristen Jane Nadeau, University of Colorado Denver, USA
Emerging Aspects of T2D in Youth

Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)


Speaker 4 of 8
Matthew B. Johnson, University of Exeter Medical School, UK
Genetic Insights into Autoimmune Diabetes

Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)


Speaker 5 of 8
* Carmella Evans-Molina, Indiana University, USA
Type 1 Diabetes: Taking the Long View

Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)


Speaker 6 of 8
Kevan C. Herold, Yale University, USA
Cancer Immunotherapy and T1D

Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)


Speaker 7 of 8
Alka M. Kanaya, University of California, San Francisco, USA
Heterogeneity of Type 2 Diabetes Subtypes by Ethnicity

Tuesday, February 02 | 8:00AM - 11:00AM
Diabetes – One Name, Many Variations (8am Denver/Mountain Ti
me Start)


Speaker 8 of 8
Debora R. Sobreira, University of Chicago, USA
Short Talk: An Integrative Platform to Uncover the Mechanisms of the Association of TCF7L2 and T2D

Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)
This session is from Obesity


Speaker 1 of 8
* Kevin L. Grove, Novo Nordisk, USA


Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)
This session is from Obesity


Speaker 2 of 8
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Novel Insights into the Endocrine Actions of the Adipocyte


Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)
This session is from Obesity


Speaker 3 of 8
Ana Domingos, University of Oxford, UK
Sympathetic Innervation of Adipose Tissue


Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)
This session is from Obesity


Speaker 4 of 8
Sean M. Hartig, Baylor College of Medicine, USA
Leveraging MicroRNA Targets to Treat Obesity


Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)
This session is from Obesity


Speaker 5 of 8
Camilla Charlotte Schéele, University of Copenhagen, Denmark
Early Differentiation of Human Brown and White Adipocytes at Single Cell Level Reveals Common Subtype with Genetic Association to Body Fat Distribution


Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)
This session is from Obesity


Speaker 6 of 8
Stephanie Wesolowski, University of Colorado, USA
Metabolic Programming in the Fetal Liver- Potentiation of Gluconeogenesis by Hypoxemia


Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)
This session is from Obesity


Speaker 7 of 8
Kai Sun, University of Texas Health Science Center at Houston, USA
Short Talk: Adipose-Derived MMP14 Is a Key Player in Metabolic Health


Tuesday, February 02 | 8:00AM - 11:00AM
Adipose Tissue Communication (8am Denver/Mountain Time Start
)
This session is from Obesity


Speaker 8 of 8
Aimee L. Edinger, University of California, Irvine, USA
Short Talk: A Drug-Like Sphingolipid Opposes Mitochondrial Fragmentation and Corrects the Adiponectin:Leptin Ratio and Obesity


Tuesday, February 02 | 12:30PM - 1:30PM
Meet the Editors (Joint) (12:30pm Denver/Mountain Time Start
)

Speaker 1 of 4
Katherine Samaras, Frontiers in Endocrinology, Australia

Tuesday, February 02 | 12:30PM - 1:30PM
Meet the Editors (Joint) (12:30pm Denver/Mountain Time Start
)

Speaker 2 of 4
Jeff Holly, Frontiers in Endocrinology, UK

Tuesday, February 02 | 12:30PM - 1:30PM
Meet the Editors (Joint) (12:30pm Denver/Mountain Time Start
)

Speaker 3 of 4
Kristan van der Vos, Cell Reports Medicine, Netherlands

Tuesday, February 02 | 12:30PM - 1:30PM
Meet the Editors (Joint) (12:30pm Denver/Mountain Time Start
)

Speaker 4 of 4
Allyson Evans, Cell Press, USA

Tuesday, February 02 | 1:30PM - 3:00PM
Poster Session 2 (Joint) (1:30pm Denver/Mountain Time Start)


Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)


Speaker 1 of 8
Chantal Mathieu, KU Leuven, Belgium
Dialog Between the Immune System and the Beta Cell

Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)


Speaker 2 of 8
Laura C. Alonso, Weill Cornell Medicine, USA
ER Stress: The Good, the Bad and the Ugly

Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)


Speaker 3 of 8
* Marc Prentki, Montreal Diabetes Research Center, Canada
Novel Metabolic Enzyme Glycerol 3-P-Phosphatase: From ß-cell Gluco-detoxification to Healthy Aging

Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)


Speaker 4 of 8
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Beta Cell Dysfunction Contributes to T1D

Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)


Speaker 5 of 8
Feyza Engin, University of Wisconsin-Madison, USA
Short Talk: Targeting Beta Cell Unfolded Protein Response in T1D

Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)


Speaker 6 of 8
Sangeeta Dhawan, City of Hope, USA
Short Talk: DNA Hydroxymethylation and Functional Beta Cell Mass in Health and Diabetes

Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)


Speaker 7 of 8
Joan Mir-Coll, InSphero AG, Switzerland
Short Talk: Human Islet Microtissues as an in vitro and in vivo Model System for Diabetes

Tuesday, February 02 | 3:00PM - 6:00PM
The Failing Beta Cell in T1D and T2D (3pm Denver/Mountain Ti
me Start)


Speaker 8 of 8
Blaise Su Jun Low, National University of Singapore, Singapore
Short Talk: Modeling the Insulin Secretion Defects in MODY3 using Patient hIPSC-derived Beta Cells

Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)
This session is from Obesity


Speaker 1 of 8
* Rachel L. Batterham, University College London, UK
[NOT AVAILABLE ON DEMAND] STEP Amylin Trials


Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)
This session is from Obesity


Speaker 2 of 8
Darleen A. Sandoval, University of Colorado, USA
Lessons From Mouse Models of Bariatric Surgery


Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)
This session is from Obesity


Speaker 3 of 8
Diego V. Bohórquez, Duke University, USA
A Gut Choice for Sugars


Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)
This session is from Obesity


Speaker 4 of 8
* Gary J. Schwartz, Albert Einstein College of Medicine, USA
Bottom Up Control of Appetite


Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)
This session is from Obesity


Speaker 5 of 8
Alison Nicole McRae, Mayo Clinic, USA
Short Talk: Overexpression of Regulator Of G-Protein Signaling (RGS) In Obesity Contributes To Impaired GPCR-Mediated Hormone Secretion In Human Enteroedocrine Cells: A Single-Cell RNA Sequencing Study of Gut Epithelium in Human Obesity


Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)
This session is from Obesity


Speaker 6 of 8
Geke Aline Boer, University of Copenhagen, Biomedical Institute, Denmark
Short Talk: GIP Receptor Deletion in Mice Confers Resistance to Obesity via Alterations in Energy Expenditure and Adipose Tissue Lipid Metabolism


Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)
This session is from Obesity


Speaker 7 of 8
Elizabeth Ann Killion, Amgen, USA
Short Talk: Chronic Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Agonism Desensitizes Adipocyte GIPR Activity Mimicking Functional GIPR Antagonism


Tuesday, February 02 | 3:00PM - 6:00PM
A Gut Feeling: How the Gut Speaks to the Brain (3pm Denver/M
ountain Time Start)
This session is from Obesity


Speaker 8 of 8
Ki-Suk Kim, University of Colorado Anschutz Medical Campus, USA
Short Talk: The Role of Bile Acid Receptor Expressed in Intestinal Stem Cells on Enteroendocrine Cell Differentiation after Bariatric Surgery


Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)


Speaker 1 of 7
* Juleen R. Zierath, Karolinska Institutet, Sweden

Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)


Speaker 2 of 7
* Jose C. Florez, Massachusetts General Hospital, USA
Have GWAS Helped Classify Diabetes?

Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)


Speaker 3 of 7
Emma Ahlqvist, Lund University, Sweden
Subclassifying Diabetes by Combining GWAS and Clinical Phenotyping

Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)


Speaker 4 of 7
Paul W. Franks, Lund University, Sweden
Precision Medicine in Obesity and Diabetes

Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)


Speaker 5 of 7
Rory J. McCrimmon, University of Dundee, UK
Mechanisms of Therapies for T2D and Potential Crossover to T1D

Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)


Speaker 6 of 7
Carla J. Greenbaum, Benaroya Research Institute at Virginia Mason, USA
Therapies to Stop T1D…Determining Risk and Conducting Trials

Wednesday, February 03 | 8:00AM - 11:00AM
Novel Therapeutic Strategies (8am Denver/Mountain Time Start
)


Speaker 7 of 7
Allan Ertmann Karlsen, Novo Nordisk, Denmark
Stem Cell Mediated Treatments for Diabetes

Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)
This session is from Obesity


Speaker 1 of 6
Linda Rinaman, Florida State University, USA
GLP-1 Neural Signaling in Stress and Metabolism


Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)
This session is from Obesity


Speaker 2 of 6
* Lori M. Zeltser, Columbia University, USA
Effects of Social Isolation on Stress-Induced Behavior in Females


Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)
This session is from Obesity


Speaker 3 of 6
* Michael Krashes, NIDDK, National Institutes of Health, USA
High-Fat Food Biases Hypothalamic and Mesolimbic Expression of Consummatory Drives


Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)
This session is from Obesity


Speaker 4 of 6
Lotte Bjerre Knudsen, Novo Nordisk A/S, Denmark
GLP-1 in the Treatment of Obesity, Mechanisms that Translate into Durable Weight Loss in Patients


Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)
This session is from Obesity


Speaker 5 of 6
Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Single-Cell Multi-Tissue Dissection of Obesity-Exercise Circuitry in Human and Mouse


Wednesday, February 03 | 8:00AM - 11:00AM
Feeding Behavior: Top Down or Bottom Up? (8am Denver/Mountai
n Time Start)
This session is from Obesity


Speaker 6 of 6
Katherine Blackmore, George Washington University, USA
Short Talk: An Obligatory Forebrain-Hypothalamic ER Stress Driven Circuit Mediates Hepatic Steatosis during Obesity


Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)

Speaker 1 of 7
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA

Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)

Speaker 2 of 7
Alpana P. Shukla, Weill Cornell Medical College, USA
Interaction between T2D and Obesity and COVID Outcomes

Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)

Speaker 3 of 7
G. Todd Alonso, University of Colorado, USA
COVID and TID

Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)

Speaker 4 of 7
Shuibing Chen, Weill Cornell Medical College, USA
COVID Directly Infects Beta Cells and Affects Beta Cell Function

Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)

Speaker 5 of 7
Katie C. Coate, Vanderbilt University Medical Center, USA
ACE2 is Expressed in the Islet Microvasculature and Ducts of Human Pancreas

Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)

Speaker 6 of 7
Francesco Dotta, University of Siena, Italy
Human Beta Cells Express ACE2

Wednesday, February 03 | 11:30AM - 1:00PM
Workshop and Panel Discussion: COVID and Diabetes (11:30am D
enver/Mountain Time Start)

Speaker 7 of 7
Dirk Homann, Icahn School of Medicine at Mount Sinai, USA
Experimental and Natural SARS-CoV-2 Infection of the Human Pancreas

Wednesday, February 03 | 11:30AM - 12:30PM
Workshop and Panel: Patient Perspective and Stigmas (11:30am
Denver/Mountain Time Start)
This session is from Obesity

Speaker 1 of 4
* Rachel L. Batterham, University College London, UK


Wednesday, February 03 | 11:30AM - 12:30PM
Workshop and Panel: Patient Perspective and Stigmas (11:30am
Denver/Mountain Time Start)
This session is from Obesity

Speaker 2 of 4
Vicki Mooney, ECPO Executive Director & Patient, Spain


Wednesday, February 03 | 11:30AM - 12:30PM
Workshop and Panel: Patient Perspective and Stigmas (11:30am
Denver/Mountain Time Start)
This session is from Obesity

Speaker 3 of 4
Francesco Rubino, King's College London, UK


Wednesday, February 03 | 11:30AM - 12:30PM
Workshop and Panel: Patient Perspective and Stigmas (11:30am
Denver/Mountain Time Start)
This session is from Obesity

Speaker 4 of 4
Joseph Nadglowski, Obesity Action Coalition, USA


Wednesday, February 03 | 1:30PM - 3:00PM
Networking Lounge (Joint) (1:30pm Denver/Mountain Time Start
)



Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 1 of 6
* Shane T. Hentges, Colorado State University, USA
POMC Neurons: Distinct Roles in Food Intake, Metabolism and Glucose Regulation

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 2 of 6
* Michael A. Cowley, Monash University, Australia
Hypothalamic Control of Glucose Homeostasis

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 3 of 6
Martin G. Myers, Jr., University of Michigan, USA
Control of Food Intake and Energy Balance via the NTS and DMH

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 4 of 6
Michael W. Schwartz, University of Washington, USA
Unraveling Diabetes Remission Induced by the Brain

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 5 of 6
Ian Enrique Gonzalez, University of Michigan, USA
Short Talk: Paraventricular Hypothalamic Calcitonin Receptor Expressing Neurons Regulate Energy Balance

Wednesday, February 03 | 3:00PM - 5:50PM
CNS Control of Energy Homeostasis and Blood Glucose (Joint)
(3pm Denver/Mountain Time Start)


Speaker 6 of 6
Juliana Bezerra Medeiros de Lima, Wayne State University, USA
Short Talk: ARC GHR Neurons Control System Glucose Sensitivity via Muscle Glucose Uptake

Wednesday, February 03 | 5:50PM - 6:00PM
Closing Remarks (5:50pm Denver/Mountain Time Start)


Wednesday, February 03 | 5:50PM - 6:00PM
Closing Remarks (5:50pm Denver/Mountain Time Start)
This session is from Obesity


*Session Chair.