Web Desc
Frontiers in Cryo-Electron Microscopy - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Sriram Subramaniam, Nenad Ban, Dorit Hanein and Pamela Williams
Date: February 03 - 04, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by Genentech, Inc., Merck & Co., Inc. and Vertex Pharmaceuticals Incorporated
For important information on the coronavirus, please click here
Summary of Meeting:
The transition of cryo-electron microscopy (cryo-EM) from a technology that was previously a useful tool to analyze large macromolecular assemblies, to one that can now successfully tackle structure determination of a wide range of proteins and protein complexes of broad general interest has been transformative. The structures of an impressive number of proteins, small and large, sometimes with extensive conformational spread, have been successfully analyzed by cryo-EM, although the landscape of macromolecular entities that are still intractable to analysis by cryo-EM remains immense. This meeting aims to bring together leaders in this emerging field who are defining the new frontiers of cryo-EM and future leaders who are rapidly beginning to adopt this new discipline and will likely drive future innovations in the coming decades. Speakers selected from academia, government and industry will cover applications of cryo-EM technology to fundamental problems in biology with particular relevance to cancer, neuroscience, microbiology and cell signaling, and discuss advances in method developments that are at the forefront of the field.
Scholarship Deadline: November 1 2020
Abstract Deadline: December 17 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Genentech, Inc.Merck & Co., Inc.Thermo Fisher Scientific Inc.Vertex Pharmaceuticals Incorporated
We gratefully acknowledge additional support for this conference from:
DCVC BioGatan
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, February 03 | 8:00AM - 8:10AM
Welcoming Remarks (Organizers) (8am Denver/Mountain Time Sta
rt)


Speaker 1 of 2
Sriram Subramaniam, University of British Columbia, Canada

Wednesday, February 03 | 8:00AM - 8:10AM
Welcoming Remarks (Organizers) (8am Denver/Mountain Time Sta
rt)


Speaker 2 of 2
Nenad Ban, ETH Zürich, Switzerland

Wednesday, February 03 | 8:10AM - 11:00AM
Large and Dynamic Assemblies (8:10am Denver/Mountain Time St
art)


Speaker 1 of 7
* Nenad Ban, ETH Zürich, Switzerland
[NOT AVAILABLE ON DEMAND] Structural Basis of SARS-CoV-2 Translational Shutdown and Programmed Ribosomal Frameshifting

Wednesday, February 03 | 8:10AM - 11:00AM
Large and Dynamic Assemblies (8:10am Denver/Mountain Time St
art)


Speaker 2 of 7
John Rubinstein, University of Toronto, Canada
ATPase Structure and Dynamics

Wednesday, February 03 | 8:10AM - 11:00AM
Large and Dynamic Assemblies (8:10am Denver/Mountain Time St
art)


Speaker 3 of 7
Sriram Subramaniam, University of British Columbia, Canada
Cryo-EM in Cancer Biology

Wednesday, February 03 | 8:10AM - 11:00AM
Large and Dynamic Assemblies (8:10am Denver/Mountain Time St
art)


Speaker 4 of 7
Natalie Strynadka, University of British Columbia, Canada
CryoEM Analysis of the Dual Membrane Spanning Type III Secretion Injectisome of Pathogenic Bacteria

Wednesday, February 03 | 8:10AM - 11:00AM
Large and Dynamic Assemblies (8:10am Denver/Mountain Time St
art)


Speaker 5 of 7
Steven J. Ludtke, Baylor College of Medicine, USA
A Complete Software Pipeline for in-situ Subnanometer Resolution Subtomogram Averaging

Wednesday, February 03 | 8:10AM - 11:00AM
Large and Dynamic Assemblies (8:10am Denver/Mountain Time St
art)


Speaker 6 of 7
Xinzhe Yu, Baylor College of Medicine, USA
Short Talk: Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes

Wednesday, February 03 | 8:10AM - 11:00AM
Large and Dynamic Assemblies (8:10am Denver/Mountain Time St
art)


Speaker 7 of 7
* Carsten Sachse, Forschungszentrum Jülich, Germany
Short Talk: Cryo-EM Reveals Structures of ESCRT-III Membrane Remodeling Proteins in Eukarya and Bacteria

Wednesday, February 03 | 12:00PM - 1:00PM
Meet the Editors (12:00pm Denver/Mountain Time Start)

Speaker 1 of 3
Achim Breiling, EMBO, Germany

Wednesday, February 03 | 12:00PM - 1:00PM
Meet the Editors (12:00pm Denver/Mountain Time Start)

Speaker 2 of 3
Shawnna Buttery, Cell Press, USA

Wednesday, February 03 | 12:00PM - 1:00PM
Meet the Editors (12:00pm Denver/Mountain Time Start)

Speaker 3 of 3
Mishtu Dey, Cell Press, USA

Wednesday, February 03 | 1:00PM - 2:30PM
Poster Session (1pm Denver/Mountain Time Start)


Wednesday, February 03 | 3:00PM - 6:00PM
Methods Development and Correlative Microscopy (3pm Denver/M
ountain Time Start)


Speaker 1 of 7
Peijun Zhang, University of Oxford, UK
In situ Structure Study of Virus Infection

Wednesday, February 03 | 3:00PM - 6:00PM
Methods Development and Correlative Microscopy (3pm Denver/M
ountain Time Start)


Speaker 2 of 7
Jose Rodriguez, University of California, Los Angeles, USA
New Frontiers in Electron Diffraction

Wednesday, February 03 | 3:00PM - 6:00PM
Methods Development and Correlative Microscopy (3pm Denver/M
ountain Time Start)


Speaker 3 of 7
Bridget Carragher, New York Structural Biology Center, USA
Atomic Resolution CryoEM Is Here! Why Won’t Our Protein Samples Cooperate?

Wednesday, February 03 | 3:00PM - 6:00PM
Methods Development and Correlative Microscopy (3pm Denver/M
ountain Time Start)


Speaker 4 of 7
Paul D. Adams, Lawrence Berkeley Laboratory, USA
New Tools for the Interpretation of Cryo-EM Maps

Wednesday, February 03 | 3:00PM - 6:00PM
Methods Development and Correlative Microscopy (3pm Denver/M
ountain Time Start)


Speaker 5 of 7
* Dorit Hanein, Pasteur Institute, France
Regulation of Actin Cytoskeleton

Wednesday, February 03 | 3:00PM - 6:00PM
Methods Development and Correlative Microscopy (3pm Denver/M
ountain Time Start)


Speaker 6 of 7
Greg Pintilie, Stanford University, USA
Short Talk: Quantifiying Resolvability of Atomic Features in Cryo-EM Maps using Q-Scores

Wednesday, February 03 | 3:00PM - 6:00PM
Methods Development and Correlative Microscopy (3pm Denver/M
ountain Time Start)


Speaker 7 of 7
* Petr Chlanda, Heidelberg University, Germany
Short Talk: Dual-axis Volta Phase Plate Cryo-Electron Tomography of Ebola Virus-Like Particles

Thursday, February 04 | 8:00AM - 8:30AM
Keynote Address (8am Denver/Mountain Time Start)

Speaker 1 of 2
* Sriram Subramaniam, University of British Columbia, Canada

Thursday, February 04 | 8:00AM - 8:30AM
Keynote Address (8am Denver/Mountain Time Start)

Speaker 2 of 2
Werner Kühlbrandt, Max-Planck-Institute of Biophysics, Germany
CryoEM of Membrane Protein Complexes in Biological Energy Conversion

Thursday, February 04 | 8:30AM - 11:00AM
Cellular Ultrastructure and Microbial Complexes (8:30am Denv
er/Mountain Time Start)


Speaker 1 of 5
Daniela Nicastro, University of Texas Southwestern Medical Center, USA
Probing the Molecular Organization of Cells and Organelles Using Cryo-Electron Microscopy

Thursday, February 04 | 8:30AM - 11:00AM
Cellular Ultrastructure and Microbial Complexes (8:30am Denv
er/Mountain Time Start)


Speaker 2 of 5
Ohad Medalia, University of Zurich, Switzerland
Nuclear Lamin Filaments in Health and Disease

Thursday, February 04 | 8:30AM - 11:00AM
Cellular Ultrastructure and Microbial Complexes (8:30am Denv
er/Mountain Time Start)


Speaker 3 of 5
Martin Pilhofer, ETH Zurich, Switzerland
[NOT AVAILABLE ON DEMAND] Multiscale Models of Bacterial Contractile Injection Systems

Thursday, February 04 | 8:30AM - 11:00AM
Cellular Ultrastructure and Microbial Complexes (8:30am Denv
er/Mountain Time Start)


Speaker 4 of 5
* Jun Liu, Yale School of Medicine, USA
Dissecting a Molecular Machine by Cryo-Electron Tomography

Thursday, February 04 | 8:30AM - 11:00AM
Cellular Ultrastructure and Microbial Complexes (8:30am Denv
er/Mountain Time Start)


Speaker 5 of 5
* Elizabeth R. Wright, University of Wisconsin-Madison, USA
Host-Pathogen Interactions

Thursday, February 04 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 1 of 3
Bridget Carragher, New York Structural Biology Center, USA

Thursday, February 04 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 2 of 3
Jose Rodriguez, University of California, Los Angeles, USA

Thursday, February 04 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 3 of 3
Giovanna Scapin, NanoImaging Services, USA
Bringing CryoEM to Industry – Lessons Learned


Thursday, February 04 | 1:30PM - 3:00PM
Networking Lounge (1:30pm Denver/Mountain Time Start)


Thursday, February 04 | 3:00PM - 5:50PM
Drug Discovery (3pm Denver/Mountain Time Start)

Speaker 1 of 7
* Pamela Williams, Astex Pharmaceuticals, UK
[NOT AVAILABLE ON DEMAND] Cryo-EM Applications in Industry

Thursday, February 04 | 3:00PM - 5:50PM
Drug Discovery (3pm Denver/Mountain Time Start)

Speaker 2 of 7
Giovanna Scapin, NanoImaging Services, USA
Bringing Cryo-EM to Drug Discovery: Lessons Learned

Thursday, February 04 | 3:00PM - 5:50PM
Drug Discovery (3pm Denver/Mountain Time Start)

Speaker 3 of 7
Patrick M. Sexton, Monash University, Australia
From Apo to Active to Small Molecule Drug Discovery: GPCR Structure using Cryo-EM

Thursday, February 04 | 3:00PM - 5:50PM
Drug Discovery (3pm Denver/Mountain Time Start)

Speaker 4 of 7
Chuangye Yan, Tsinghua University, China
Structural Basis for the Transport and Inhibition of Human Monocarboxylate Transporters

Thursday, February 04 | 3:00PM - 5:50PM
Drug Discovery (3pm Denver/Mountain Time Start)

Speaker 5 of 7
Georg Wolff, Leiden University Medical Center, Netherlands
Short Talk: Discovering RNA Export Pores in Coronavirus Replication Organelles

Thursday, February 04 | 3:00PM - 5:50PM
Drug Discovery (3pm Denver/Mountain Time Start)

Speaker 6 of 7
* Cathy Spangler, University of North Carolina at Chapel Hill, USA
Short Talk: Cryo-EM Structure of cGAS-Nucleosome Complex Reveals Mechanism of Nucleosome-Dependent cGAS Inhibition

Thursday, February 04 | 3:00PM - 5:50PM
Drug Discovery (3pm Denver/Mountain Time Start)

Speaker 7 of 7
Joseph D. Batchelor, Sanofi, USA
[NOT AVAILABLE ON DEMAND] Short Talk: Molecular Determinants of the Factor VIII/von Willebrand Factor Complex Revealed by BIVV001 Cryo-Electron Microscopy

Thursday, February 04 | 5:50PM - 6:00PM
Closing Remarks (5:50pm Denver/Mountain Time Start)

Speaker 1 of 1
Sriram Subramaniam, University of British Columbia, Canada

*Session Chair.