Web Desc
Metabolic Decisions in Development and Disease - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Irene Miguel-Aliaga, Ralph J. DeBerardinis and A.J. Marian Walhout
Date: March 24 - 25, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by Novo Nordisk A/S
For important information on the coronavirus, please click here
Summary of Meeting:
Metabolism was once regarded as a homeostatic, housekeeping process that supported but did not instruct cell signaling, gene expression and other networks. In recent years, it has become apparent that metabolism is intimately intertwined with many other networks that determine cellular fate and tissue function, and that metabolites can transmit signals within and between cells. The impact of metabolic signaling is illustrated by the consequences of its dysregulation and it is now understood that many diseases involve pathologically altered metabolism. Mutations in metabolic enzymes underlie numerous developmental disorders, and metabolic alterations in malignant cells impair cellular differentiation and fuel tumor growth. These observations have rekindled interest in disease-oriented metabolism research, which now benefits from increasingly sophisticated analytical and computational tools to understand metabolism and to localize important activities in space and time. The unifying theme of this conference is that proper development requires exquisite metabolic control, and that perturbed metabolism can result in developmental diseases. The conference will bring together scientists exploring how metabolites impact cellular and developmental decisions in a diverse range of model systems, and mechanisms underlying developmental disorders caused by aberrant metabolism. Topics will include the epigenetic roles of metabolites and their oncogenic potential, signaling roles of metabolites across organs, metabolic control of development, and the impact of microbiota-mediated signaling in ageing and metabolic disease. Collectively, participants attending this conference will foster collaborations across a range of disciplines, provide biological questions for emerging technologies, and ultimately develop a new conceptual framework for the study of the instructive roles of metabolites in biology and disease. This novel conference program is designed to capitalize on both the technological and conceptual momentum of this budding field.
Scholarship Deadline: November 1 2020
Abstract Deadline: February 16 2021
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
AdipoGen Life Sciences
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK128974-01
Funding for this conference was made possible (in part) by 1R13DK128974-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, March 24 | 8:00AM - 8:40AM
Welcoming Remarks (Organizers) and Keynote Address (8am Denv
er/Mountain Time Start)

Speaker 1 of 2
* Irene Miguel-Aliaga, Imperial College London, UK

Wednesday, March 24 | 8:00AM - 8:40AM
Welcoming Remarks (Organizers) and Keynote Address (8am Denv
er/Mountain Time Start)

Speaker 2 of 2
Olivier Pourquié, Harvard Medical School, USA
Role of Warburg-Like Metabolism in Cell Fate Control in Vertebrate Development

Wednesday, March 24 | 8:40AM - 11:00AM
Metabolic Control of Gene Expression and Developmental Decis
ions (8:40am Denver/Mountain Time Start)


Speaker 1 of 8
* Irene Miguel-Aliaga, Imperial College London, UK

Wednesday, March 24 | 8:40AM - 11:00AM
Metabolic Control of Gene Expression and Developmental Decis
ions (8:40am Denver/Mountain Time Start)


Speaker 2 of 8
Kathryn E. Wellen, University of Pennsylvania, USA
Crosstalk between Metabolic Pathways, Signaling Networks and the Epigenome

Wednesday, March 24 | 8:40AM - 11:00AM
Metabolic Control of Gene Expression and Developmental Decis
ions (8:40am Denver/Mountain Time Start)


Speaker 3 of 8
* Lydia Finley, Memorial Sloan Kettering Cancer Center, USA
Metabolic Control of Cell Fate Decisions in Stem Cells and Cancer Cells

Wednesday, March 24 | 8:40AM - 11:00AM
Metabolic Control of Gene Expression and Developmental Decis
ions (8:40am Denver/Mountain Time Start)



Coffee Break

Wednesday, March 24 | 8:40AM - 11:00AM
Metabolic Control of Gene Expression and Developmental Decis
ions (8:40am Denver/Mountain Time Start)


Speaker 5 of 8
Alexander Aulehla, European Molecular Biology Laboratory, Germany
Glycolytic Flux Control of Mouse Embryo Segmentation

Wednesday, March 24 | 8:40AM - 11:00AM
Metabolic Control of Gene Expression and Developmental Decis
ions (8:40am Denver/Mountain Time Start)


Speaker 6 of 8
Alex Gould, Francis Crick Institute, UK
Metabolic Responses to a Stressful Start in Life

Wednesday, March 24 | 8:40AM - 11:00AM
Metabolic Control of Gene Expression and Developmental Decis
ions (8:40am Denver/Mountain Time Start)


Speaker 7 of 8
Aurelio Teleman, Deutsches Krebsforschungszentrum, Germany
Regulation of Growth and Signaling by a Lipid Metabolite

Wednesday, March 24 | 8:40AM - 11:00AM
Metabolic Control of Gene Expression and Developmental Decis
ions (8:40am Denver/Mountain Time Start)


Speaker 8 of 8
William Tu, University of California, Los Angeles, USA
Short Talk: The Role of Tryptophan Metabolism in Cell Fate Decisions and Development

Wednesday, March 24 | 11:30AM - 12:30PM
Poster Session 1 (11:30am Denver/Mountain Time Start)


Wednesday, March 24 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 1 of 5
Angela R. Parrish, Springer Nature, USA

Wednesday, March 24 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 2 of 5
Nestor Saiz, Journal of Experimental Medicine, USA

Wednesday, March 24 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 3 of 5
Sejal K. Vyas, Cell Press, USA

Wednesday, March 24 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 4 of 5
Deniz Senyilmaz Tiebe, EMBO, Germany

Wednesday, March 24 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 5 of 5
Stefan Galander, Company of Biologists, UK

Wednesday, March 24 | 2:00PM - 5:00PM
Metabolic Communication across Cells and Tissues (2pm Denver
/Mountain Time Start)


Speaker 1 of 8
Irene Miguel-Aliaga, Imperial College London, UK
Sex Differences in Inter-Organ Metabolic Coupling

Wednesday, March 24 | 2:00PM - 5:00PM
Metabolic Communication across Cells and Tissues (2pm Denver
/Mountain Time Start)


Speaker 2 of 8
* Norbert Perrimon, Harvard Medical School, USA
Inter-Organ Communication Pathways Involved in Organ Wasting

Wednesday, March 24 | 2:00PM - 5:00PM
Metabolic Communication across Cells and Tissues (2pm Denver
/Mountain Time Start)


Speaker 3 of 8
Wendy S. Garrett, Harvard School of Public Health, USA
[NOT AVAILABLE ON DEMAND] Sulfur Amino Acids and the Gut Microbiota in Chronic Kidney Disease and Colorectal Cancer

Wednesday, March 24 | 2:00PM - 5:00PM
Metabolic Communication across Cells and Tissues (2pm Denver
/Mountain Time Start)



Coffee Break

Wednesday, March 24 | 2:00PM - 5:00PM
Metabolic Communication across Cells and Tissues (2pm Denver
/Mountain Time Start)


Speaker 5 of 8
Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Regulation of Lipid Metabolism by the Microbiome and the Circadian Clock

Wednesday, March 24 | 2:00PM - 5:00PM
Metabolic Communication across Cells and Tissues (2pm Denver
/Mountain Time Start)


Speaker 6 of 8
Tadashi Uemura, Kyoto University, Japan
[NOT AVAILABLE ON DEMAND] Impacts of Nutrition Histories in Juvenile Stages on Growth and Later Life Events

Wednesday, March 24 | 2:00PM - 5:00PM
Metabolic Communication across Cells and Tissues (2pm Denver
/Mountain Time Start)


Speaker 7 of 8
* A.J. Marian Walhout, University of Massachusetts Medical School, USA
Structure, Function and Evolution of Biological Networks

Wednesday, March 24 | 2:00PM - 5:00PM
Metabolic Communication across Cells and Tissues (2pm Denver
/Mountain Time Start)


Speaker 8 of 8
Wei Wei, Stanford University, USA
Short Talk: Cell Type-selective Secretome Profiling In Vivo

Thursday, March 25 | 8:00AM - 11:00AM
Maintenance and Perturbation of Metabolic Networks (8am Denv
er/Mountain Time Start)


Speaker 1 of 8
Theodore Alexandrov, European Molecular Biology Laboratory, Germany
Spatial Metabolomics in Tissues and Single Cells

Thursday, March 25 | 8:00AM - 11:00AM
Maintenance and Perturbation of Metabolic Networks (8am Denv
er/Mountain Time Start)


Speaker 2 of 8
Ayelet Erez, Weizmann Institute of Science, Israel
Amino Acids Metabolic Cross Talks between the Cancer and Its Host

Thursday, March 25 | 8:00AM - 11:00AM
Maintenance and Perturbation of Metabolic Networks (8am Denv
er/Mountain Time Start)


Speaker 3 of 8
* Markus Ralser, Francis Crick Institute, UK
Dynamics in Metabolic Networks

Thursday, March 25 | 8:00AM - 11:00AM
Maintenance and Perturbation of Metabolic Networks (8am Denv
er/Mountain Time Start)



Coffee Break

Thursday, March 25 | 8:00AM - 11:00AM
Maintenance and Perturbation of Metabolic Networks (8am Denv
er/Mountain Time Start)


Speaker 5 of 8
Joshua D. Rabinowitz, Princeton University, USA
Metabolic Remodeling in Cancer and Infection

Thursday, March 25 | 8:00AM - 11:00AM
Maintenance and Perturbation of Metabolic Networks (8am Denv
er/Mountain Time Start)


Speaker 6 of 8
* Sarah-Maria Fendt, VIB-KU Leuven, Belgium
[NOT AVAILABLE ON DEMAND] Metabolic Plasticity in Cancer Metastasis

Thursday, March 25 | 8:00AM - 11:00AM
Maintenance and Perturbation of Metabolic Networks (8am Denv
er/Mountain Time Start)


Speaker 7 of 8
Anupama Hemalatha, Yale University, USA
Short Talk: Metabolic Adaptation to Oncogenic Mutations in Mouse Skin by Live Imaging

Thursday, March 25 | 8:00AM - 11:00AM
Maintenance and Perturbation of Metabolic Networks (8am Denv
er/Mountain Time Start)


Speaker 8 of 8
Paula Gutierrez Perez, Research Institute of Molecular Pathology - IMP, Austria
Short Talk: miR-1 Sustains Muscle Physiology by Controlling V-ATPase Complex Assembly

Thursday, March 25 | 11:00AM - 12:00PM
Networking Lounge (11am Denver/Mountain Time Start)


Thursday, March 25 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 1 of 3
Sarah-Maria Fendt, VIB-KU Leuven, Belgium

Thursday, March 25 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 2 of 3
A.J. Marian Walhout, University of Massachusetts Medical School, USA

Thursday, March 25 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 3 of 3
Paul Barrett, NIA, National Institutes of Health, USA

Thursday, March 25 | 1:00PM - 2:00PM
Poster Session 2 (1pm Denver/Mountain Time Start)


Thursday, March 25 | 2:00PM - 4:50PM
Metabolic Disorders (2pm Denver/Mountain Time Start)

Speaker 1 of 7
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Metabolic Transitions and Anomalies in Development

Thursday, March 25 | 2:00PM - 4:50PM
Metabolic Disorders (2pm Denver/Mountain Time Start)

Speaker 2 of 7
Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Metabolic Signaling in Stem Cell Function and Immunity

Thursday, March 25 | 2:00PM - 4:50PM
Metabolic Disorders (2pm Denver/Mountain Time Start)

Speaker 3 of 7
Juan Landoni, University of Helsinki, Finland
Short Talk: The Consequences of Increased mtDNA Replication Frequency: From Premature Ageing to Neonatal Disease

Thursday, March 25 | 2:00PM - 4:50PM
Metabolic Disorders (2pm Denver/Mountain Time Start)


Coffee Break

Thursday, March 25 | 2:00PM - 4:50PM
Metabolic Disorders (2pm Denver/Mountain Time Start)

Speaker 5 of 7
* Jared Rutter, University of Utah, USA
Mitochondrial Metabolism and Cellular Decisions

Thursday, March 25 | 2:00PM - 4:50PM
Metabolic Disorders (2pm Denver/Mountain Time Start)

Speaker 6 of 7
Jason Locasale, Duke University, USA
The Impact of Cellular Metabolism on Chromatin Dynamics and Epigenetics

Thursday, March 25 | 2:00PM - 4:50PM
Metabolic Disorders (2pm Denver/Mountain Time Start)

Speaker 7 of 7
Heather Christofk, University of California, Los Angeles, USA
[NOT AVAILABLE ON DEMAND] Metabolic Control of Signaling and Cell Fate Decisions

Thursday, March 25 | 4:50PM - 5:00PM
Closing Remarks (4:50pm Denver/Mountain Time Start)


*Session Chair.