Web Desc
Lipidomics of Health and Disease - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Michael J.O. Wakelam (in memoriam), Steffany A.L. Bennett and Jean E. Schaffer
Date: March 24 - 26, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by Merck & Co., Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
Lipid metabolism provides the building blocks for cell growth and replication, signaling molecules that initiate and propagate signals inside and outside of cells, and fuel for cell function and division. The role of these molecular species in human disease has become more apparent with advancements in ability to detect and accurately quantify them. This meeting will integrate information generated through lipidomics studies. Specific areas of focus will include using genetic and proteomic data to identify changes in particular molecular species, the importance of changes in lipid metabolism and signaling and the regulatory enzymes for neurodegeneration, metabolic disorders, cancer and inflammation and immune responses. Featured talks will extend beyond methodologies to integrate the current biological and clinical importance of lipids with lipidomics approaches. This will allow us to focus upon the mechanistic importance of lipids in neurodegeneration and other neurological disorders, cancer, inflammation and metabolic disorders. By identifying enzymes that regulate changes in lipidomics, new targets for therapeutics can also be identified. This approach is inspired by PI3kinase, where the basic biochemistry has led to the development of effective inhibitors. We hope to discover other targets for lipid enzyme therapeutics. By moving towards lipid analysis and the biological and medical importance of lipid regulatory pathways, the goal is to use lipidomic profiling to get to better understand and treat different diseases. The majority of lipid related meetings focus on methodologies. We believe that PI3kinase should be reintegrated into meetings about lipid-related disease because it represents successful implementation of this approach. The PI3Kinase specific meeting is no longer attracting sufficient attendees but it remains an important scientific area for discussion. This meeting will also address the importance of particular lipid molecular as opposed to lipid classes. Modern lipidomic methodologies enabled us to identify more than 20,000 potential lipid species in a cell. There are particular species that regulate enzyme activities and membrane properties and thus functions like signaling and cellular migration. This meeting will include a workshop, led by members of LIPID MAPS, on lipidomics methodologies, data handling and storage to further emphasize the biological and medical importance of lipid diversity.
Scholarship Deadline: November 1 2020
Abstract Deadline: February 17 2021
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Merck & Co., Inc.
We gratefully acknowledge additional support from these exhibitors at this conference:
Avanti Polar Lipids, Inc.
We gratefully acknowledge additional support for this conference from:
Cayman Chemical Company
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, March 24 | 8:00AM - 8:10AM
Welcoming Remarks and Dedication to Michael J.O. Wakelam (Or
ganizers) (8am Denver/Mountain Time Start)


Speaker 1 of 1
Steffany A.L. Bennett, University of Ottawa, Canada

Wednesday, March 24 | 8:10AM - 8:40AM
Keynote Address (8:10am Denver/Mountain Time Start)

Speaker 1 of 2
* Jean E. Schaffer, Joslin Diabetes Center, Harvard Medical School, USA

Wednesday, March 24 | 8:10AM - 8:40AM
Keynote Address (8:10am Denver/Mountain Time Start)

Speaker 2 of 2
Sarah Spiegel, Virginia Commonwealth University, USA
Sphingosine-1-Phosphate: From Bench to Clinic

Wednesday, March 24 | 8:40AM - 11:00AM
Lipid Regulation of Metabolic Disorders I (8:40am Denver/Mou
ntain Time Start)


Speaker 1 of 6
* Jean E. Schaffer, Joslin Diabetes Center, Harvard Medical School, USA
Cardiovascular Lipotoxicity

Wednesday, March 24 | 8:40AM - 11:00AM
Lipid Regulation of Metabolic Disorders I (8:40am Denver/Mou
ntain Time Start)


Speaker 2 of 6
* Scott A. Summers, University of Utah, USA
Ceramides and Metabolic Stress

Wednesday, March 24 | 8:40AM - 11:00AM
Lipid Regulation of Metabolic Disorders I (8:40am Denver/Mou
ntain Time Start)



Coffee Break

Wednesday, March 24 | 8:40AM - 11:00AM
Lipid Regulation of Metabolic Disorders I (8:40am Denver/Mou
ntain Time Start)


Speaker 4 of 6
Julian L. Griffin, Imperial College London, UK
Lipids and Cardiovascular and Steatotic Risk

Wednesday, March 24 | 8:40AM - 11:00AM
Lipid Regulation of Metabolic Disorders I (8:40am Denver/Mou
ntain Time Start)


Speaker 5 of 6
Ilka Pinz, Maine Medical Center, USA
Short Talk: Lipidomic Signature of Atrial Tissue Differentiates Diabetic from Non-Diabetic Coronary Artery Bypass Graft Patients

Wednesday, March 24 | 8:40AM - 11:00AM
Lipid Regulation of Metabolic Disorders I (8:40am Denver/Mou
ntain Time Start)


Speaker 6 of 6
Arieh Moussaieff, Hebrew University of Jerusalem, Israel
Short Talk: Shifts in Lipid Metabolic Networks during Early Development, and Possible Implications for Assisted Reproductive Technologies

Wednesday, March 24 | 1:30PM - 3:00PM
Poster Session (1:30pm Denver/Mountain Time Start)


Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)


Speaker 1 of 9
* Christine Des Rosiers, Montreal Heart Institute (MHI), Canada
Untargeted Lipidomics in Humans with Mitochondrial Disorders and Their Mouse Models for Disease Mechanism and Therapy Discovery

Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)


Speaker 2 of 9
Huiyong Yin, Shanghai Institute of Nutrition and Health, China
Oxidized Lipids Regulating Atherosclerosis and Metabolism

Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)


Speaker 3 of 9
Michelle M. Mielke, Mayo Clinic, USA
Plasma Ceramides Are Associated with Specific Cerebrovascular Pathologies

Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)


Speaker 4 of 9
Gerard Bryan Gonzales, Wageningen University, Netherlands
Short Talk: Longitudinal Plasma Lipidome and Growth Faltering in Rural Gambian Children: Inferring Causal Linkages using Econometric Tools

Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)



Coffee Break

Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)


Speaker 6 of 9
Arina Nikitina, Georgia Institute of Technology, USA
Short Talk: Lipid-based Prediction of Differentiation Stage of Human Induced Pluripotent Stem Cell Colonies via MALDI Mass Spectrometry Imaging

Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)


Speaker 7 of 9
Xunxun Shi, University of Ottawa, Canada
Short Talk: A Machine Learning Algorithm for Predicting Differential Ion Mobility Spectrometry Parameters Validated for Assessment of Glycolipid Stereoisomers

Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)


Speaker 8 of 9
* Justin G. Chitpin, University of Ottawa, Canada
Short Talk: BATL: Bayesian Annotations for Targeted Lipidomics

Wednesday, March 24 | 3:00PM - 6:00PM
Lipid Regulation of Metabolic Disorders II (3pm Denver/Mount
ain Time Start)


Speaker 9 of 9
Anton I. Rosenbaum, AstraZeneca, USA
Short Talk: Phosphatidylinositol as Pharmacodynamic Biomarker for Inhibition of Endothelial Lipase by MEDI5884 in Cynomolgus Macaques and Healthy and Stable Coronary Artery Disease Subjects

Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)

Speaker 1 of 9
* John E. Burke, University of Victoria, Canada
Lipid Protein Interaction in Cancer

Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)

Speaker 2 of 9
* Julie D. Saba, University of California, San Francisco, USA
Sphingosine-1-Phosphate Lyase: The Path from Yeast Gene to Gene Therapy

Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)

Speaker 3 of 9
Phillip T. Hawkins, Babraham Institute, UK
Regulation of the Acyl Chain Composition of Phosphoinositides

Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)


Coffee Break

Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)

Speaker 5 of 9
Simon T. Barry, AstraZeneca, UK
Therapeutic Targeting of PI3K-AKT Signalling in
Cancer


Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)

Speaker 6 of 9
Thao Nguyen-Tran, University of Ottawa, Canada
Short Talk: Quantification And Structural Analysis Of Disialogangliosides In Human Plasma and Serum By Nanobore Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry

Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)

Speaker 7 of 9
Grace H. McGregor, University of California San Diego, USA
[NOT AVAILABLE ON DEMAND] Short Talk: Complex Glycosphingolipids in Macular Telangiectasia and Colon Cancer

Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)

Speaker 8 of 9
Barani Govindarajan, Wayne State University, USA
Short Talk: Role of Phosphatidylinositol 4-Kinase IIIa in Chemokine Signaling

Thursday, March 25 | 8:00AM - 11:00AM
Lipids in Cancer (8am Denver/Mountain Time Start)

Speaker 9 of 9
Rens Peeters, RadboudUMC, Netherlands
Short Talk: Tetraspanin CD37 Inhibits Lipid Metabolism in B-Cell Lymphoma

Thursday, March 25 | 11:00AM - 12:00PM
Networking Lounge (11am Denver/Mountain Time Start)


Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)


Speaker 1 of 9
* Thao Nguyen-Tran, University of Ottawa, Canada

Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)


Speaker 2 of 9
* Valerie B. O'Donnell, Cardiff University, UK
Oxylipin Metabolism is Regulated by Mitochondrial b-Oxidation during Bacterial Inflammation

Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)


Speaker 3 of 9
Gregory D. Fairn, University of Toronto, Canada
Palmitoylation of Coronavirus Spike Proteins and Attenuation by a Fatty Acid Synthase Inhibitor

Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)


Speaker 4 of 9
Bruce D. Levy, Brigham and Women's Hospital, USA
Polyisoprenyl Phosphate Remodeling Regulates Dendritic Cell Antigen Uptake and Lung inflammation

Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)



Coffee Break

Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)


Speaker 6 of 9
Robert V. Stahelin, Purdue University, USA
Lipid-Dependent Assembly and Budding of Emerging Viral Pathogens

Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)


Speaker 7 of 9
* Nihal Altan-Bonnet, NHLBI, National Institutes of Health, USA
Sneaking Out with the Trash: Coronavirus Egress

Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)


Speaker 8 of 9
Benjamin Schwarz, Rocky Mountain Laboratories, National Institutes of Health, USA
Short Talk: Immune Lipid Mediator Dysregulation Provides a Potential Mechanistic Link between Metabolic Comorbidities and Severe SARS-CoV-2 Infection in Humans

Thursday, March 25 | 3:00PM - 6:00PM
Lipids in Inflammation and Infection (3pm Denver/Mountain Ti
me Start)


Speaker 9 of 9
Lydia M. Roberts, NIAID, National Institutes of Health, USA
Short Talk: Pulmonary Infection Results in Scarred Lipidome that Impacts the Response to Secondary Challenge

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)


Speaker 1 of 9
* Steffany A.L. Bennett, University of Ottawa, Canada
Glycerolipids and Neurodegeneration

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)


Speaker 2 of 9
Gilbert Di Paolo, Denali Therapeutics Inc., USA
Lipids and Neuronal Disorders

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)


Speaker 3 of 9
Vytas A. Bankaitis, Texas A&M University, USA
Inositol Lipid Signaling and Development of the Mammalian Brain

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)



Coffee Break

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)


Speaker 5 of 9
Tony Futerman, Weizmann Institute of Science, Israel
Neuronal Pathology in Neuronopathic Forms of Gaucher Disease: A Disease in which a Simple Glycosphingolipid Accumulates

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)


Speaker 6 of 9
Frida Mandik, University of Luebeck, Germany
Short Talk: Mitochondrial and Autophagy Alteration in a Fatty Acid Hydroxylase-Associated Neurodegeneration Fly Model

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)


Speaker 7 of 9
Pavel Gerasimov, Izhevsk State Medical Academy, Russia
Short Talk: FTY 720 Improves the Phospholipid Compound of Brain Tissue and Pulmonary Surfactant in the Rodent Model of Acute Brain Ischemia

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)


Speaker 8 of 9
* Graeme S.V. McDowell, University of Ottawa, Canada
Short Talk: Lipidomics Insights into Mechanistic Differences in Acid Ceramidase Loss of Function in Farber’s Lipoganulomatosis and Spinal Muscular Atrophy with Progressive Myoclonic Epilepsy

Friday, March 26 | 8:00AM - 11:00AM
Lipids in Neurodegeneration I (8am Denver/Mountain Time Star
t)


Speaker 9 of 9
Luis Angel Albarran, University of Ottawa, Canada
Short Talk: Lipogenetics of Acid Ceramidase Disorders: From Metabolism to Preclinical Treatment

Friday, March 26 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 1 of 3
Steffany A.L. Bennett, University of Ottawa, Canada

Friday, March 26 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 2 of 3
Eamonn James Dickson, University of California, Davis, USA

Friday, March 26 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 3 of 3
Gilbert Di Paolo, Denali Therapeutics Inc., USA

Friday, March 26 | 1:30PM - 2:30PM
Meet the Editors (1:30pm Denver/Mountain Time Start)

Speaker 1 of 2
Shawnna Buttery, STAR Protocols - Cell Press, USA

Friday, March 26 | 1:30PM - 2:30PM
Meet the Editors (1:30pm Denver/Mountain Time Start)

Speaker 2 of 2
Elisabetta Argenzio, EMBO Journal, Germany

Friday, March 26 | 3:00PM - 5:50PM
Lipids in Neurodegeneration II (3pm Denver/Mountain Time Sta
rt)


Speaker 1 of 8
Eamonn James Dickson, University of California, Davis, USA
Cholesterol and Phosphoinositides in Neurodegeneration

Friday, March 26 | 3:00PM - 5:50PM
Lipids in Neurodegeneration II (3pm Denver/Mountain Time Sta
rt)


Speaker 2 of 8
* Penelope Hallett, Harvard Medical School, USA
Lipid Dyshomeostasis Alters Alpha-Synucleinopathy

Friday, March 26 | 3:00PM - 5:50PM
Lipids in Neurodegeneration II (3pm Denver/Mountain Time Sta
rt)


Speaker 3 of 8
Rachel Saunders-Pullman, Mount Sinai, USA
Lipidomics in Parkinson Disease

Friday, March 26 | 3:00PM - 5:50PM
Lipids in Neurodegeneration II (3pm Denver/Mountain Time Sta
rt)



Coffee Break

Friday, March 26 | 3:00PM - 5:50PM
Lipids in Neurodegeneration II (3pm Denver/Mountain Time Sta
rt)


Speaker 5 of 8
Daiki Hayashi, University of California San Diego, USA
Short Talk: Lipidomics Coupled with Computational Approaches Reveal Unique Substrate Specificity of Human Phospholipases Toward Omega-3 and Omega-6 Fatty Acids in Phospholipids

Friday, March 26 | 3:00PM - 5:50PM
Lipids in Neurodegeneration II (3pm Denver/Mountain Time Sta
rt)


Speaker 6 of 8
* Irina Alecu, University of Ottawa, Canada
Short Talk: Disruptions in Sphingolipid Metabolism and Associated Motor Impairments in an iPLA2ß Knock-out Mouse Model of Neuroaxonal Dystrophy

Friday, March 26 | 3:00PM - 5:50PM
Lipids in Neurodegeneration II (3pm Denver/Mountain Time Sta
rt)


Speaker 7 of 8
Melissa Vos, University of Lübeck, Germany
Short Talk: Ceramide Accumulates in PINK1-Related Parkinson’s Disease Affecting Mitophagy and ß-oxidation

Friday, March 26 | 3:00PM - 5:50PM
Lipids in Neurodegeneration II (3pm Denver/Mountain Time Sta
rt)


Speaker 8 of 8
Miroslava Cuperlovic-Culf, National Research Council, Canada
Short Talk: Analysis of Changes in Lipid Network in Parkinson’s Disease through Distance Correlation and Graph Analytics

Friday, March 26 | 5:50PM - 6:00PM
Closing Remarks

Speaker 1 of 1
Jean E. Schaffer, Joslin Diabetes Center, Harvard Medical School, USA

*Session Chair.