Web Desc
Hematopoiesis - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Daniel Starczynowski, Ross L. Levine and Hanna K.A. Mikkola
Date: April 21 - 23, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Hematopoiesis is a highly regulated and dynamic developmental process by which hematopoietic stem cells self-renew and differentiate to form all blood lineages. Disruption of hematopoiesis resulting from genetic, epigenetic, transcriptional, and/or post-translational defects or due to environmental stressors can result in benign or malignant hematologic disorders. Advances in model systems, genome-editing tools, single-cell analyses, and imaging technologies have provided insight into the molecular, cellular, and developmental basis of normal and malignant hematopoiesis. This Keystone Symposia conference brings together basic and translational researchers to discuss and debate emerging topics and recent advances on developmental hematopoiesis, adult stem cell self-renewal and stem cell niches, novel hematopoietic regulators, and the pathogenesis of bone marrow failure syndromes and leukemia. Taken together, participants at this conference will gain new insight into the biology of normal and malignant hematopoiesis and cutting-edge technologies, as well as have opportunities to cultivate new ideas and establish collaborations with researchers from disparate disciplines.
We gratefully acknowledge additional support for this conference from:
American Association for Cancer Research (AACR)Mission Bio
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1 R13 HL152473-01
Funding for this conference was made possible (in part) by 1 R13 HL152473-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, April 21 | 8:00AM - 8:40AM
Welcome and Keynote Address (8am Denver/Mountain Time Start)

Speaker 1 of 2
* Daniel Starczynowski, Cincinnati Children's Hospital Medical Center, USA

Wednesday, April 21 | 8:00AM - 8:40AM
Welcome and Keynote Address (8am Denver/Mountain Time Start)

Speaker 2 of 2
Benjamin L. Ebert, Dana-Farber Cancer Institute, USA
Clonal Hematopoiesis in Hematologic Malignancies and Cardiovascular Disease

Wednesday, April 21 | 8:40AM - 11:00AM
Hematopoiesis during Stress and Aging (8:40am Denver/Mountai
n Time Start)


Speaker 1 of 6
Ido Amit, Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics

Wednesday, April 21 | 8:40AM - 11:00AM
Hematopoiesis during Stress and Aging (8:40am Denver/Mountai
n Time Start)


Speaker 2 of 6
* Katherine Y. King, Baylor College of Medicine, USA
Infection Is a Driver of Dnmt3a-Mutant Clonal Hematopoiesis

Wednesday, April 21 | 8:40AM - 11:00AM
Hematopoiesis during Stress and Aging (8:40am Denver/Mountai
n Time Start)


Speaker 3 of 6
* Jennifer Trowbridge, The Jackson Laboratory, USA
Microenvironmental Regulation of HSC Aging

Wednesday, April 21 | 8:40AM - 11:00AM
Hematopoiesis during Stress and Aging (8:40am Denver/Mountai
n Time Start)


Speaker 4 of 6
H. Leighton Grimes, Cincinnati Children's Hospital Medical Center, USA
Transitional States in Hematopoiesis

Wednesday, April 21 | 8:40AM - 11:00AM
Hematopoiesis during Stress and Aging (8:40am Denver/Mountai
n Time Start)


Speaker 5 of 6
Anna E. Beaudin, University of Utah School of Medicine, USA
Short Talk: Prenatal Inflammation Perturbs Fetal Hematopoiesis and Causes Persistent Changes to Postnatal Immunity

Wednesday, April 21 | 8:40AM - 11:00AM
Hematopoiesis during Stress and Aging (8:40am Denver/Mountai
n Time Start)


Speaker 6 of 6
Serine Avagyan, Boston Children’s Hospital Cancer and Blood Disorders Center, USA
Short Talk: Clonal Hematopoiesis Results from the Response of Stem and Progenitor Cells to Inflammatory Cues from Mutant Mature Cells

Wednesday, April 21 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 1 of 3
Fernando D. Camargo, Boston Children's Hospital, USA

Wednesday, April 21 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 2 of 3
Hanna K.A. Mikkola, University of California, Los Angeles, USA

Wednesday, April 21 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 3 of 3
Daniel Starczynowski, Cincinnati Children's Hospital Medical Center, USA

Wednesday, April 21 | 1:30PM - 3:00PM
Poster Session (1:30pm Denver/Mountain Time Start)


Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 1 of 10
* Kateri Ann Moore, Ichan School of Medicine at Mount Sinai, USA

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 2 of 10
* Timm Schroeder, ETH Zürich, Switzerland
Long-Term Single-Cell Quantification: New Tools for Old Questions

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 3 of 10
Cristina Lo Celso, Imperial College London; Sir Francis Crick Institute, UK
Microenvironmental Regulation of HSC Function

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 4 of 10
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Niche Biology: Beyond Growth Factors

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 5 of 10
Sisi Chen, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Altered LZTR1 and RIT1 Signaling Drive Clonal Hematopoietic Transformation

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 6 of 10
Adil Rasheed, University of Ottawa Heart Institute, Canada
Short Talk: Mixed Lineage Kinase Domain-Like Protein (MLKL) Maintains the Splenic Microenvironment to Restrict Hematopoiesis During Atherosclerosis

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 7 of 10
Anthony D. Ho, Heidelberg University, Germany
Short Talk: Hematopoietic Stem Cells with Elevated Central Carbon Metabolism Drive the Aging Process and Harbor Clonal Hematopoiesis

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 8 of 10
Christina Marie Termini, University of California, Los Angeles, USA
Short Talk: Semaphorin 3A Controls Bone Marrow Vascular Regeneration and Hematopoietic Reconstitution

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 9 of 10
Zanshé Thompson, University of South Carolina, USA
Short Talk: Ing4 Suppresses Quiescence and Inflammation in Hematopoietic Stem Cells

Wednesday, April 21 | 3:00PM - 6:00PM
Microenvironment and Signaling (3pm Denver/Mountain Time Sta
rt)


Speaker 10 of 10
Melissa A. Meyer, La Jolla Institute for Immunology, USA
Short Talk: Discovery of a Neutrophil Subset with B Cell Features and the Ability to Modulate CD4+ T Cells

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 1 of 10
* Hanna K.A. Mikkola, University of California, Los Angeles, USA

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 2 of 10
* Fernando D. Camargo, Boston Children's Hospital, USA
Assessing HSC Potential in vivo at the Single Cell Level

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 3 of 10
Shannon L. McKinney-Freeman, St. Jude Children's Research Hospital, USA
Ontogeny of the Hematopoietic Hierarchy

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 4 of 10
E. Camilla Forsberg, University of California, Santa Cruz, USA
Chasing Mavericks: The Quest to Understand Hematopoietic Stem Cell Waves

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 5 of 10
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Embryonic Macrophage-Hematopoietic Stem Cell Interactions Determine Adult

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 6 of 10
Catherine S. Rhee, Harvard University/ MGH, USA
Short Talk: Rigidity of Cell Fate and Function among Monocytes

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 7 of 10
Grant Rowe, Boston Children's Hospital, USA
Short Talk: Hematopoiesis at Single Cell Resolution Spanning Human Development and Maturation

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 8 of 10
YeEun Kim, Stanford, USA
Short Talk: A Highly Multiplexed Single Cell Proteomic Screen Reveals the Phenotypic and Functional Landscape of the Human Lympho-Myeloid Differentiation Axis

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 9 of 10
Bianca A. Ulloa, Albert Einstein College of Medicine, USA
Short Talk: Definitive Hematopoietic Stem Cells Minimally Contribute to Embryonic Hematopoiesis

Thursday, April 22 | 8:00AM - 11:00AM
HSC Biology and Development (8am Denver/Mountain Time Start)

Speaker 10 of 10
Hiromitsu Nakauchi, Stanford University, USA
Short Talk: Selective Expansion of Human HSCs in Cytokine-Free Chemically-Defined Medium

Thursday, April 22 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 1 of 5
Daniel Klimmeck, EMBO Journal, Germany

Thursday, April 22 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 2 of 5
Valerie Kouskoff, University of Manchester, UK

Thursday, April 22 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 3 of 5
Eric T. Sawey, Journal of Experimental Medicine (JEM), USA

Thursday, April 22 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 4 of 5
Swapnika Ramu, Cell Press, USA

Thursday, April 22 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 5 of 5
Tanya Bondar, Blood Cancer Discovery of the American Association for Cancer Research, USA

Thursday, April 22 | 3:00PM - 6:00PM
Hematologic Malignancies (3pm Denver/Mountain Time Start)

Speaker 1 of 8
* Daniel Starczynowski, Cincinnati Children's Hospital Medical Center, USA
Adaptive Response of MDS Cells to the Inflammatory Milieu Contributes to
Sustained Myeloid Expansion and a Competitive Advantage


Thursday, April 22 | 3:00PM - 6:00PM
Hematologic Malignancies (3pm Denver/Mountain Time Start)

Speaker 2 of 8
Michael G. Kharas, Memorial Sloan Kettering Cancer Center, USA
RNA Binding Proteins in Leukemia

Thursday, April 22 | 3:00PM - 6:00PM
Hematologic Malignancies (3pm Denver/Mountain Time Start)

Speaker 3 of 8
Iannis Aifantis, New York University School of Medicine, USA
RNA Binding Proteins as Regulators of Myeloid Leukemia Growth and Self-Renewal

Thursday, April 22 | 3:00PM - 6:00PM
Hematologic Malignancies (3pm Denver/Mountain Time Start)

Speaker 4 of 8
* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Role of Mutations in Epigenetic Regulators in Clonal Hematopoiesis and Evolution to AML

Thursday, April 22 | 3:00PM - 6:00PM
Hematologic Malignancies (3pm Denver/Mountain Time Start)

Speaker 5 of 8
Anna-Katharina Wirth, Helmholtz Zentrum Munich, Germany
Short Talk: Modelling Acquired Treatment Resistance in PDX ALL in vivo Reveals Identical Therapeutic Targets Regardless of Diverse Genomic Alterations

Thursday, April 22 | 3:00PM - 6:00PM
Hematologic Malignancies (3pm Denver/Mountain Time Start)

Speaker 6 of 8
Gaurav S. Choudhary, Albert Einstein College of Medicine, USA
Short Talk: SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Thursday, April 22 | 3:00PM - 6:00PM
Hematologic Malignancies (3pm Denver/Mountain Time Start)

Speaker 7 of 8
Jing Fang, University of South Carolina, USA
Short Talk: Dissect the Function of GPR68 in Acute Myeloid Leukemia and Hematopoietic Stem Cells

Thursday, April 22 | 3:00PM - 6:00PM
Hematologic Malignancies (3pm Denver/Mountain Time Start)

Speaker 8 of 8
Amitava Sengupta, Indian Institute of Chemical Biology, India
Short Talk: Polybromo SWI/SNF Integrates Chromatin Remodeling & BMP/TGF-ß Signaling to Determine Mesenchymal Stromal Osteolineage Commitment and Hematopoiesis

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 1 of 9
* Ravi Majeti, Stanford University, USA
Reprogramming B-ALL into APCs for Cancer Vaccination

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 2 of 9
Kate Yen, Auron Therapeutics, USA
Differentiation Therapy in AML

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 3 of 9
* Catriona H.M. Jamieson, University of California, San Diego, USA
Innate Immune Deaminases Fuel Pre-Leukemia Stem Cell Malignant Transformation

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 4 of 9
Melvin Edward Thomas III, St. Jude Children's Research Hospital, USA
Short Talk: Germline Mutations in SAMD9 and SAMD9L Impair Hematopoietic Cell Function

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 5 of 9
Panagiotis Ntziachristos, Northwestern University, USA
Short Talk: Characterizing Mechanisms Controlling Aberrant Spliceosome Levels and Its Impact on Therapy Response in Acute Lymphoblastic Leukemia

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 6 of 9
Elvin Wagenblast, University Health Network, Princess Margaret Cancer Centre, Canada
Short Talk: Mapping the Cellular Origin and Developmental Context of Myeloid Leukemia in Down Syndrome

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 7 of 9
Liping Li, Johns Hopkins University, USA
Short Talk: High Mobility Group A1 Chromatin Remodeling Proteins Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce GATA2 and Cell Cycle Progression

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 8 of 9
Shailaja Hegde, University of Cincinnati, USA
Short Talk: Cell Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1a

Friday, April 23 | 8:00AM - 11:00AM
Hematologic Malignancies: Biology and Therapy (8am Denver/Mo
untain Time Start)


Speaker 9 of 9
Michael E. Lawler, Thomas Jefferson University, USA
Short Talk: Interrogation of TLR2 Inflammatory Signaling in AML

Friday, April 23 | 1:30PM - 3:00PM
Networking Lounge (1:30pm Denver/Mountain Time Start)


Friday, April 23 | 3:00PM - 5:50PM
Transcription and Epigenetics (3pm Denver/Mountain Time Star
t)


Speaker 1 of 7
* Atsushi Iwama, University of Tokyo, Japan
Chromatin Accessibility in MDS Stem and Progenitor Cells

Friday, April 23 | 3:00PM - 5:50PM
Transcription and Epigenetics (3pm Denver/Mountain Time Star
t)


Speaker 2 of 7
Patricia Ernst, University of Colorado Anschutz Medical Center, USA
MLL1 Levels and Activity Influence Hematopoietic Development

Friday, April 23 | 3:00PM - 5:50PM
Transcription and Epigenetics (3pm Denver/Mountain Time Star
t)


Speaker 3 of 7
Hanna K.A. Mikkola, University of California, Los Angeles, USA
Mechanisms Regulating Human Hematopoietic Stem Cell Specification and Self-Renewal

Friday, April 23 | 3:00PM - 5:50PM
Transcription and Epigenetics (3pm Denver/Mountain Time Star
t)


Speaker 4 of 7
* Margaret A. Goodell, Baylor College of Medicine, USA
Clonal Competition Among Hematopoietic Stem Cells

Friday, April 23 | 3:00PM - 5:50PM
Transcription and Epigenetics (3pm Denver/Mountain Time Star
t)


Speaker 5 of 7
Vikram R. Paralkar, University of Pennsylvania, USA
Short Talk: An Atlas of Hematopoietic Transcription Factor Binding to Ribosomal DNA Reveals a Role for CEBPA in Regulation of rRNA Transcription

Friday, April 23 | 3:00PM - 5:50PM
Transcription and Epigenetics (3pm Denver/Mountain Time Star
t)


Speaker 6 of 7
Maxim Pimkin, Dana Farber Cancer Institute, USA
Short Talk: A Combinatorial Transcriptional Mechanism of Immune Escape in AML

Friday, April 23 | 3:00PM - 5:50PM
Transcription and Epigenetics (3pm Denver/Mountain Time Star
t)


Speaker 7 of 7
Xiaotian Zhang, University of Michigan, USA
Short Talk: 3D Genomics Analysis in Acute Myeloid Leukemia Reveals the Activation of the Homeobox Genes Driven Leukemic-Specific 3D Network

Friday, April 23 | 5:50PM - 6:00PM
Closing Remarks (5:50pm Denver/Mountain Time Start)


*Session Chair.