Web Desc
Innate Immunity: Mechanisms and Modulation - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Kate A. Fitzgerald, Arturo Zychlinsky and Kate Schroder
Date: April 12 - 15, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by AstraZeneca, Cell Research, Genentech, Inc. and Merck & Co., Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
The innate immune system is the first line of response to pathogens and tissue injury. Specialized cells have evolved mechanisms to detect microbial and distress signals and translate these into effector mechanisms that fight infections, amplify inflammation, initiate acquired immunity and eventually resolve. Although the innate immune response is usually associated with infectious disease, it has been implicated in a broad range of diseases, including cancer, autoimmunity, degenerative and vascular diseases. This conference provides multidisciplinary perspectives on innate immunity, from fundamental science to clinical aspects of disease, as well as therapeutic approaches to immune modulation. The conference program will focus on recent advances in this rapidly developing field. Presentations will provide new insights into mechanisms of microbial and distress sensing and the effector mechanisms of innate immune cells including macrophages, neutrophils, dendritic cells and innate lymphoid cells. The program will also highlight new approaches to understanding protective and pathogenic innate immune function, and emerging therapeutic opportunities for targeting these mechanisms in disease.
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaChinese Society for Cell Biology, (Cell Research)Genentech, Inc.Merck & Co., Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, April 12 | 6:00AM - 6:40AM
Welcome and Keynote Address (6am Denver/Mountain Time Start)

Speaker 1 of 2
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Monday, April 12 | 6:00AM - 6:40AM
Welcome and Keynote Address (6am Denver/Mountain Time Start)

Speaker 2 of 2
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Structural Insights into Innate Immune Receptors and Signaling

Monday, April 12 | 6:40AM - 8:25AM
Nucleic Acid Sensing (6:40am Denver/Mountain Time Start)

Speaker 1 of 5
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne, Switzerland
DNA Sensing Pathways

Monday, April 12 | 6:40AM - 8:25AM
Nucleic Acid Sensing (6:40am Denver/Mountain Time Start)

Speaker 2 of 5
Scott Pesiridis, GlaxoSmithKline, USA
Therapeutic Modulation of the STING Pathway

Monday, April 12 | 6:40AM - 8:25AM
Nucleic Acid Sensing (6:40am Denver/Mountain Time Start)

Speaker 3 of 5
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammation by Nucleic Acid Binding Proteins and Non-Coding RNAs

Monday, April 12 | 6:40AM - 8:25AM
Nucleic Acid Sensing (6:40am Denver/Mountain Time Start)

Speaker 4 of 5
* Olivia Majer, MPI for Infection Biology, Germany
Short Talk: Cellular Mechanisms of Self Versus Non-Self Discrimination by Nucleic Acid-Sensing Toll-Like Receptors

Monday, April 12 | 6:40AM - 8:25AM
Nucleic Acid Sensing (6:40am Denver/Mountain Time Start)

Speaker 5 of 5
Tuo Li, UT Southwestern Medical Center, USA
Short Talk: How cGAS Is Regulated during Mitosis

Monday, April 12 | 8:45AM - 10:00AM
Innate Immunity Gone Awry (8:45am Denver/Mountain Time Start
)


Speaker 1 of 5
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Monday, April 12 | 8:45AM - 10:00AM
Innate Immunity Gone Awry (8:45am Denver/Mountain Time Start
)


Speaker 2 of 5
* Clare E. Bryant, University of Cambridge, UK

Monday, April 12 | 8:45AM - 10:00AM
Innate Immunity Gone Awry (8:45am Denver/Mountain Time Start
)


Speaker 3 of 5
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Targeting the PANoptosome for the Treatment of Inflammatory and Infectious Diseases

Monday, April 12 | 8:45AM - 10:00AM
Innate Immunity Gone Awry (8:45am Denver/Mountain Time Start
)


Speaker 4 of 5
Mariana J. Kaplan, NIAMS, National Institutes of Health, USA
Neutrophil Dysregulation in Systemic Autoimmunity

Monday, April 12 | 8:45AM - 10:00AM
Innate Immunity Gone Awry (8:45am Denver/Mountain Time Start
)


Speaker 5 of 5
Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA
Genetic Basis of Autoinflammatory Diseases

Monday, April 12 | 11:00AM - 12:00PM
Career Roundtable (11am Denver/Mountain Time Start)

Speaker 1 of 3
Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Monday, April 12 | 11:00AM - 12:00PM
Career Roundtable (11am Denver/Mountain Time Start)

Speaker 2 of 3
Barbara Rehermann, NIDDK, National Institutes of Health, USA

Monday, April 12 | 11:00AM - 12:00PM
Career Roundtable (11am Denver/Mountain Time Start)

Speaker 3 of 3
Scott Pesiridis, GlaxoSmithKline, USA

Monday, April 12 | 12:30PM - 2:00PM
Poster Session 1 (12:30pm Denver/Mountain Time Start)


Tuesday, April 13 | 6:00AM - 8:40AM
Immunometabolism (6am Denver/Mountain Time Start)

Speaker 1 of 8
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Repurposed for Cytokines

Tuesday, April 13 | 6:00AM - 8:40AM
Immunometabolism (6am Denver/Mountain Time Start)

Speaker 2 of 8
Tiffany Horng, ShanghaiTech University, China
Metabolic Regulation of Macrophage Biology

Tuesday, April 13 | 6:00AM - 8:40AM
Immunometabolism (6am Denver/Mountain Time Start)

Speaker 3 of 8
* Kathryn J. Moore, New York University Medical Center, USA
Macrophage Function in Metabolic Diseases

Tuesday, April 13 | 6:00AM - 8:40AM
Immunometabolism (6am Denver/Mountain Time Start)

Speaker 4 of 8
Barbara Rehermann, NIDDK, National Institutes of Health, USA
Impact of Gut Microbiota on Inflammation and Immunity

Tuesday, April 13 | 6:00AM - 8:40AM
Immunometabolism (6am Denver/Mountain Time Start)

Speaker 5 of 8
* Jennifer Dowling, Royal College of Surgeons in Ireland, Ireland
Short Talk: Mitochondrial Arginase-2 Is Essential for IL-10 Metabolic Reprogramming of Inflammatory Macrophages

Tuesday, April 13 | 6:00AM - 8:40AM
Immunometabolism (6am Denver/Mountain Time Start)

Speaker 6 of 8
Andrew Olive, Michigan State University, USA
Short Talk: Mitochondrial Respiration Contributes to the Interferon Gamma Response in Antigen Presenting Cells

Tuesday, April 13 | 6:00AM - 8:40AM
Immunometabolism (6am Denver/Mountain Time Start)

Speaker 7 of 8
Tsan Sam Xiao, Case Western Reserve University, USA
Short Talk: How to Stoke a Fiery Death: Recognition of Gasdermins by Proteases

Tuesday, April 13 | 6:00AM - 8:40AM
Immunometabolism (6am Denver/Mountain Time Start)

Speaker 8 of 8
Gili Rosenberg, Weizmann Institute of Science, Israel
Short Talk: Host Succinate Is an Activation Signal for Salmonella Virulence during Intracellular Infection

Tuesday, April 13 | 9:05AM - 9:55AM
Inflammatory Cell Death (9:05am Denver/Mountain Time Start)

Speaker 1 of 3
* Lucy G. Thorne, University College London, UK

Tuesday, April 13 | 9:05AM - 9:55AM
Inflammatory Cell Death (9:05am Denver/Mountain Time Start)

Speaker 2 of 3
* Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
NETosis

Tuesday, April 13 | 9:05AM - 9:55AM
Inflammatory Cell Death (9:05am Denver/Mountain Time Start)

Speaker 3 of 3
Vishva M. Dixit, Genentech, Inc., USA
Pores in Membranes

Tuesday, April 13 | 11:30AM - 12:30PM
Meet the Editors (11:30am Denver/Mountain Time Start)

Speaker 1 of 5
Karin Dumstrei, EMBO, Germany

Tuesday, April 13 | 11:30AM - 12:30PM
Meet the Editors (11:30am Denver/Mountain Time Start)

Speaker 2 of 5
Kirsty Minton, Nature Publishing Group, UK

Tuesday, April 13 | 11:30AM - 12:30PM
Meet the Editors (11:30am Denver/Mountain Time Start)

Speaker 3 of 5
Gaia Trincucci, Journal of Experimental Medicine, USA

Tuesday, April 13 | 11:30AM - 12:30PM
Meet the Editors (11:30am Denver/Mountain Time Start)

Speaker 4 of 5
Salvatore Fabbiano, Cell Press, USA

Tuesday, April 13 | 11:30AM - 12:30PM
Meet the Editors (11:30am Denver/Mountain Time Start)

Speaker 5 of 5
Marianne Clemence, PLOS ONE, USA

Wednesday, April 14 | 6:00AM - 8:25AM
Epigenetics and Gene Regulation (6am Denver/Mountain Time St
art)


Speaker 1 of 6
Gioacchino Natoli, Humanitas University, Italy
Chromatin Modifications as Readouts of Protein Kinase Activation and Inhibition

Wednesday, April 14 | 6:00AM - 8:25AM
Epigenetics and Gene Regulation (6am Denver/Mountain Time St
art)


Speaker 2 of 6
* Susan B. Carpenter, University of California, Santa Cruz, USA
Regulation of Inflammation by Long Non-Coding RNAs

Wednesday, April 14 | 6:00AM - 8:25AM
Epigenetics and Gene Regulation (6am Denver/Mountain Time St
art)


Speaker 3 of 6
* Kate L. Jeffrey, Harvard Medical School, USA
IBD Due to Loss-of-Function Mutations in a Chromatin Reader

Wednesday, April 14 | 6:00AM - 8:25AM
Epigenetics and Gene Regulation (6am Denver/Mountain Time St
art)


Speaker 4 of 6
Zaida G. Ramirez Ortiz, University of Massachusetts Medical School, USA
Short Talk: SCARF1-Induced Efferocytosis Plays an Immunomodulatory Role in Humans

Wednesday, April 14 | 6:00AM - 8:25AM
Epigenetics and Gene Regulation (6am Denver/Mountain Time St
art)


Speaker 5 of 6
Lucy G. Thorne, University College London, UK
Short Talk: SARS-CoV-2 B.1.1.7 Triggers a Less Potent Innate Immune Response than First Wave Isolates

Wednesday, April 14 | 6:00AM - 8:25AM
Epigenetics and Gene Regulation (6am Denver/Mountain Time St
art)


Speaker 6 of 6
Yuval Itan, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Identifying Mutations and Genes Underlying Severe COVID-19 in Exome Biobanks of Diverse Human Populations

Wednesday, April 14 | 8:45AM - 10:00AM
Innate Immune Defense Against Infection (8:45am Denver/Mount
ain Time Start)


Speaker 1 of 4
* Megan H. Orzalli, University of Massachusetts Medical School, USA

Wednesday, April 14 | 8:45AM - 10:00AM
Innate Immune Defense Against Infection (8:45am Denver/Mount
ain Time Start)


Speaker 2 of 4
Rotem Sorek, Weizmann Institute of Science, Israel
[NOT AVAILABLE ON DEMAND] Origin of Innate Immune Systems in Bacterial Defense against Phage

Wednesday, April 14 | 8:45AM - 10:00AM
Innate Immune Defense Against Infection (8:45am Denver/Mount
ain Time Start)


Speaker 3 of 4
* Stacy M. Horner, Duke University Medical Center, USA
Regulation of Anti-Viral Defense through RNA Methylation

Wednesday, April 14 | 8:45AM - 10:00AM
Innate Immune Defense Against Infection (8:45am Denver/Mount
ain Time Start)


Speaker 4 of 4
Venizelos Papayannopoulos, Francis Crick Institute, UK
The Dark Side of Histones

Wednesday, April 14 | 12:30PM - 2:00PM
Poster Session 2 (12:30pm Denver/Mountain Time Start)


Thursday, April 15 | 6:00AM - 8:30AM
Inflammasomes (6am Denver/Mountain Time Start)

Speaker 1 of 8
Veit Hornung, Ludwig-Maximilians-University Munich, Germany
Innate Immune Responses in Human Myeloid Cells

Thursday, April 15 | 6:00AM - 8:30AM
Inflammasomes (6am Denver/Mountain Time Start)

Speaker 2 of 8
* Kate Schroder, University of Queensland, Australia
Inflammasomes: From Fundamental Biology to New Therapeutics

Thursday, April 15 | 6:00AM - 8:30AM
Inflammasomes (6am Denver/Mountain Time Start)

Speaker 3 of 8
Clare E. Bryant, University of Cambridge, UK
Inflammasomes and Anti-Bacterial Defense

Thursday, April 15 | 6:00AM - 8:30AM
Inflammasomes (6am Denver/Mountain Time Start)

Speaker 4 of 8
Liang Shan, Washington University in St. Louis, USA
Short Talk: Mechanism of CARD8 Inflammasome Activation by HIV-1 Protease

Thursday, April 15 | 6:00AM - 8:30AM
Inflammasomes (6am Denver/Mountain Time Start)

Speaker 5 of 8
Dania Zhivaki, Boston Children's Hospital, USA
Short Talk: Inflammasomes within Hyperactive Dendritic Cells Stimulate Durable Anti-Tumor Immunity

Thursday, April 15 | 6:00AM - 8:30AM
Inflammasomes (6am Denver/Mountain Time Start)

Speaker 6 of 8
Pascal Devant, Harvard Medical School/Boston Children's Hospital, USA
Short Talk: Evolution-Inspired Redesign of the LPS Receptor Caspase-4 into an Interleukin-1 Converting Enzyme

Thursday, April 15 | 6:00AM - 8:30AM
Inflammasomes (6am Denver/Mountain Time Start)

Speaker 7 of 8
Louis Robert Hollingsworth, Boston Children's/Harvard University, USA
Short Talk: DPP9 Sequesters the NLRP1 C-Terminus to Repress Inflammasome Activation

Thursday, April 15 | 6:00AM - 8:30AM
Inflammasomes (6am Denver/Mountain Time Start)

Speaker 8 of 8
* Ioannis Kienes, University of Hohenheim, Germany
Short Talk: DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation

Thursday, April 15 | 8:50AM - 9:40AM
Innate Cells at Barrier Surfaces (8:50am Denver/Mountain Tim
e Start)


Speaker 1 of 5
* Andrew Olive, Michigan State University, USA

Thursday, April 15 | 8:50AM - 9:40AM
Innate Cells at Barrier Surfaces (8:50am Denver/Mountain Tim
e Start)


Speaker 2 of 5
* Kate Schroder, University of Queensland, Australia

Thursday, April 15 | 8:50AM - 9:40AM
Innate Cells at Barrier Surfaces (8:50am Denver/Mountain Tim
e Start)


Speaker 3 of 5
Xuetao Cao, Nankai University and Chinese Academy of Medical Sciences, China
Immune Gene Regulation: From Basic Mechanisms to Clinical Implications

Thursday, April 15 | 8:50AM - 9:40AM
Innate Cells at Barrier Surfaces (8:50am Denver/Mountain Tim
e Start)


Speaker 4 of 5
Gregory F. Sonnenberg, Weill Cornell Medicine, USA
[NOT AVAILABLE ON DEMAND] Immune Regulation of Intestinal Health

Thursday, April 15 | 8:50AM - 9:40AM
Innate Cells at Barrier Surfaces (8:50am Denver/Mountain Tim
e Start)


Speaker 5 of 5
Megan H. Orzalli, University of Massachusetts Medical School, USA
Innate Immunity in the Skin

Thursday, April 15 | 9:40AM - 9:50AM
Closing Remarks (9:40am Denver/Mountain Time Start)


Thursday, April 15 | 10:00AM - 11:00AM
Networking Lounge (10am Denver/Mountain Time Start)


*Session Chair.