Web Desc
Myeloid Cells and Innate Immunity in Solid Tumors - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Judith A. Varner, Lisa M. Coussens and Dmitry I. Gabrilovich
Date: September 21 - 23, 2020
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Sponsored by AbbVie Inc., AstraZeneca, and Gilead Sciences, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
The field of cancer immunology is moving at a rapid pace, with discoveries based on T cell biology and T cell targeted therapeutics eliciting real clinical successes and excitement about the future of cancer care. However, as only twenty percent of patients respond to T cell targeted therapeutics, further work must be done to harness the power of immunology in cancer care. Recent research has shown that myeloid cells create major roadblocks to cancer eradication by promoting immune suppression, angiogenesis and resistance to immune therapy. Advances in the science of these diverse cell types, roles and mechanisms governing myeloid cells in cancer, along with the recent developments of myeloid cell targeted therapeutics, has generated significant interest in the academic and pharmaceutical communities. Conferences that gather experts to focus discussion exclusively on roles of myeloid cells and innate immunity in cancer will help to move our understanding of cancer immune suppression and the field of cancer immune therapy forward. The objectives of this proposed conference are to present the latest developments in our understanding of the origins and contributions of various myeloid cell subsets to tumor growth and metastasis. Additionally, this conference will challenge paradigms about macrophage and granulocyte origins in tumors, about links between metabolism and function, and about mechanisms by which myeloid cells control immunity. The conference will also feature the latest clinical studies of myeloid cell targeted therapeutics in cancer which will stimulate new ideas, collaborations and advance development of new cancer immune therapeutics.
Global Health Travel Award Deadline: August 24 2020
Scholarship Deadline: August 24 2020
Abstract Deadline: September 3 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.AstraZenecaGilead Sciences, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA254451-01
Funding for this conference was made possible (in part) by 1R13CA254451-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, September 21 | 8:00AM - 8:30AM
Opening Remarks and Keynote Address (8am Denver/Mountain Tim
e Start)

Speaker 1 of 2
* Judith A. Varner, University of California, San Diego, USA

Monday, September 21 | 8:00AM - 8:30AM
Opening Remarks and Keynote Address (8am Denver/Mountain Tim
e Start)

Speaker 2 of 2
Robert H. Vonderheide, University of Pennsylvania, USA
CD40 as a Gateway Pathway in the Tumor Microenvironment

Monday, September 21 | 8:30AM - 11:00AM
Ontogeny of Myeloid Cells in Cancer (8:30am Denver/Mountain
Time Start)


Speaker 1 of 7
Miriam Merad, Mount Sinai School of Medicine, USA
Identification of a Dendritic Cells Immunoregulatory Program that Dampens Tumor Specific Immunity

Monday, September 21 | 8:30AM - 11:00AM
Ontogeny of Myeloid Cells in Cancer (8:30am Denver/Mountain
Time Start)


Speaker 2 of 7
* Judith A. Varner, University of California, San Diego, USA
Mechanisms Governing Accumulation of Macrophages in Cancer

Monday, September 21 | 8:30AM - 11:00AM
Ontogeny of Myeloid Cells in Cancer (8:30am Denver/Mountain
Time Start)



Coffee Break

Monday, September 21 | 8:30AM - 11:00AM
Ontogeny of Myeloid Cells in Cancer (8:30am Denver/Mountain
Time Start)


Speaker 4 of 7
David G. DeNardo, Washington University Medical School, USA
Origins of Macrophages in Pancreatic Cancer

Monday, September 21 | 8:30AM - 11:00AM
Ontogeny of Myeloid Cells in Cancer (8:30am Denver/Mountain
Time Start)


Speaker 5 of 7
* Dmitry I. Gabrilovich, AstraZeneca, USA
Monocyte-Like Precursors of Granulocytes in Cancer

Monday, September 21 | 8:30AM - 11:00AM
Ontogeny of Myeloid Cells in Cancer (8:30am Denver/Mountain
Time Start)


Speaker 6 of 7
Chang Su, Duke University, USA
Short Talk: Dissecting the Role of MerTK Signaling in Promoting Alternatively Activated Macrophages Polarization

Monday, September 21 | 8:30AM - 11:00AM
Ontogeny of Myeloid Cells in Cancer (8:30am Denver/Mountain
Time Start)


Speaker 7 of 7
Danielle N. Huggins, University of Minnesota, USA
Short Talk: Single Cell Sequencing Identifies Novel Metastasis-Associated Macrophage Subsets in the Lung

Monday, September 21 | 1:30PM - 3:00PM
Poster Session (1:30pm Denver/Mountain Time Start)


Monday, September 21 | 3:00PM - 6:00PM
Epigenetics, Metabolism and Metastasis of Myeloid Cells in C
ancer (3pm Denver/Mountain Time Start)


Speaker 1 of 8
Gwendalyn J. Randolph, Washington University, USA
Serous Cavity Macrophages and Ovarian Cancer in the Peritoneum-Studies in Mice

Monday, September 21 | 3:00PM - 6:00PM
Epigenetics, Metabolism and Metastasis of Myeloid Cells in C
ancer (3pm Denver/Mountain Time Start)


Speaker 2 of 8
* Catherine Hedrick, La Jolla Institute for Immunology, USA
Myeloid Cells in Modulating Cancer Metastasis

Monday, September 21 | 3:00PM - 6:00PM
Epigenetics, Metabolism and Metastasis of Myeloid Cells in C
ancer (3pm Denver/Mountain Time Start)


Speaker 3 of 8
* Weiping Zou, University of Michigan, USA
Impact of Autophagy on Tumor-Associated Macrophages and Cancer Metastasis

Monday, September 21 | 3:00PM - 6:00PM
Epigenetics, Metabolism and Metastasis of Myeloid Cells in C
ancer (3pm Denver/Mountain Time Start)



Coffee Break

Monday, September 21 | 3:00PM - 6:00PM
Epigenetics, Metabolism and Metastasis of Myeloid Cells in C
ancer (3pm Denver/Mountain Time Start)


Speaker 5 of 8
Diana Hargreaves, The Salk Institute for Biological Studies, USA
Epigenetic Control of Myeloid Cells in Cancer

Monday, September 21 | 3:00PM - 6:00PM
Epigenetics, Metabolism and Metastasis of Myeloid Cells in C
ancer (3pm Denver/Mountain Time Start)


Speaker 6 of 8
Florent Ginhoux, Singapore Immunology Network, Singapore
Macrophage and Dendritic Cell Biology: From Development to Functions

Monday, September 21 | 3:00PM - 6:00PM
Epigenetics, Metabolism and Metastasis of Myeloid Cells in C
ancer (3pm Denver/Mountain Time Start)


Speaker 7 of 8
Ferdinando Pucci, Oregon Health & Science University, USA
Short Talk: Tumor-Immune Communication via Extracellular Vesicles: A Lymph Node Macrophage Link

Monday, September 21 | 3:00PM - 6:00PM
Epigenetics, Metabolism and Metastasis of Myeloid Cells in C
ancer (3pm Denver/Mountain Time Start)


Speaker 8 of 8
Rachel Cederberg, BC Cancer Research Centre, Canada
Short Talk: Eosinophils Inhibit Pulmonary Metastasis and Directly Kill Tumor Cells

Tuesday, September 22 | 8:00AM - 11:00AM
Immune Suppression and Metastasis Mediated by Myeloid Cells
(8am Denver/Mountain Time Start)


Speaker 1 of 8
* Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Re-tuning the Tumor Microenvironment to Promote Immunotherapy

Tuesday, September 22 | 8:00AM - 11:00AM
Immune Suppression and Metastasis Mediated by Myeloid Cells
(8am Denver/Mountain Time Start)


Speaker 2 of 8
Jo A. Van Ginderachter, VIB-Vrije Universiteit Brussel, Belgium
Transcriptional Profiling of Glioblastoma-Associated Myeloid Cells across Species and Disease Stage Reveals Macrophage Competition and Functional Specialization

Tuesday, September 22 | 8:00AM - 11:00AM
Immune Suppression and Metastasis Mediated by Myeloid Cells
(8am Denver/Mountain Time Start)


Speaker 3 of 8
* Vincenzo Bronte, University of Verona, Italy
DAB2-Expressing TAMs Promote Cancer Cell Invasion

Tuesday, September 22 | 8:00AM - 11:00AM
Immune Suppression and Metastasis Mediated by Myeloid Cells
(8am Denver/Mountain Time Start)



Coffee Break

Tuesday, September 22 | 8:00AM - 11:00AM
Immune Suppression and Metastasis Mediated by Myeloid Cells
(8am Denver/Mountain Time Start)


Speaker 5 of 8
Antonio Sica, University of Eastern Piedmont, Italy
Metabolic Regulation of Myeloid Derived Suppressor Cells in Cancer

Tuesday, September 22 | 8:00AM - 11:00AM
Immune Suppression and Metastasis Mediated by Myeloid Cells
(8am Denver/Mountain Time Start)


Speaker 6 of 8
Michael C. Schmid, University of Liverpool, UK
Myeloid Cells in Pancreatic Cancer Metastasis

Tuesday, September 22 | 8:00AM - 11:00AM
Immune Suppression and Metastasis Mediated by Myeloid Cells
(8am Denver/Mountain Time Start)


Speaker 7 of 8
Pierre Close, University of Liege, Belgium
Short Talk: Wobble tRNA Modification and Translation Reprogramming in the Tumour Microenvironment during Breast Cancer Development

Tuesday, September 22 | 8:00AM - 11:00AM
Immune Suppression and Metastasis Mediated by Myeloid Cells
(8am Denver/Mountain Time Start)


Speaker 8 of 8
Hafsa Munir, University of Cambridge, UK
Short Talk: Amyloid ß Secreted by the Tumor Microenvironment Drives Neutrophil Extracellular Traps Production to Support Tumor Progression

Tuesday, September 22 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 1 of 3
Simon T. Barry, AstraZeneca, UK

Tuesday, September 22 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 2 of 3
Claudia Jakubzick, Dartmouth College, USA

Tuesday, September 22 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 3 of 3
Rosandra Natasha Kaplan, NCI, National Institutes of Health, USA

Tuesday, September 22 | 1:30PM - 3:00PM
Poster Session (1:30pm Denver/Mountain Time Start)


Tuesday, September 22 | 3:00PM - 6:00PM
Promotion of Tumor Progression by Myeloid Cells (3pm Denver/
Mountain Time Start)


Speaker 1 of 8
* Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Activating a Collaborative Innate-Adaptive Immune Response to Control Metastasis

Tuesday, September 22 | 3:00PM - 6:00PM
Promotion of Tumor Progression by Myeloid Cells (3pm Denver/
Mountain Time Start)


Speaker 2 of 8
Minna Roh-Johnson, University of Utah, USA
Horizontal Transfer of Macrophage Mitochondria in Cancer

Tuesday, September 22 | 3:00PM - 6:00PM
Promotion of Tumor Progression by Myeloid Cells (3pm Denver/
Mountain Time Start)


Speaker 3 of 8
Claudia Jakubzick, Dartmouth College, USA
Rediscovering the Role of B Cells in Cancer Immune Surveillance

Tuesday, September 22 | 3:00PM - 6:00PM
Promotion of Tumor Progression by Myeloid Cells (3pm Denver/
Mountain Time Start)



Coffee Break

Tuesday, September 22 | 3:00PM - 6:00PM
Promotion of Tumor Progression by Myeloid Cells (3pm Denver/
Mountain Time Start)


Speaker 5 of 8
Shruti Naik, New York University, USA
Eavesdropping on the Conversation between Immune and Epithelial Stem Cells during Tissue Repair

Tuesday, September 22 | 3:00PM - 6:00PM
Promotion of Tumor Progression by Myeloid Cells (3pm Denver/
Mountain Time Start)


Speaker 6 of 8
* Rosandra Natasha Kaplan, NCI, National Institutes of Health, USA
Myeloid Cells as Regulators of Immune Suppression in the Pre-Metastatic Niche and Myeloid Based Approaches to Rebalance the Dysregulated Niche

Tuesday, September 22 | 3:00PM - 6:00PM
Promotion of Tumor Progression by Myeloid Cells (3pm Denver/
Mountain Time Start)


Speaker 7 of 8
Mingjian Fei, Genentech, USA
Short Talk: Blocking Dying Tumor Cell Clearance Enhances Antitumor Immune Response

Tuesday, September 22 | 3:00PM - 6:00PM
Promotion of Tumor Progression by Myeloid Cells (3pm Denver/
Mountain Time Start)


Speaker 8 of 8
Ziyan Zoe Xu, The Salk Institute, USA
Short Talk: Lipid Metabolism Controls Macrophage Functional Reprogramming in Tumor Microenvironment

Wednesday, September 23 | 8:00AM - 11:00AM
Targeting Myeloid Cells in Cancer Therapy I (8am Denver/Moun
tain Time Start)


Speaker 1 of 8
* Lisa M. Coussens, Oregon Health & Science University, USA
Therapeutic Targeting of Macrophages: Lessons Learned from Mouse Models and Their Translation to the Clinic

Wednesday, September 23 | 8:00AM - 11:00AM
Targeting Myeloid Cells in Cancer Therapy I (8am Denver/Moun
tain Time Start)


Speaker 2 of 8
Limin Shang, Light Chain Bioscience, Switzerland
CD47 Targeting in Cancer Therapy

Wednesday, September 23 | 8:00AM - 11:00AM
Targeting Myeloid Cells in Cancer Therapy I (8am Denver/Moun
tain Time Start)


Speaker 3 of 8
* Simon T. Barry, AstraZeneca, UK
Therapeutic Targeting of Macrophages and Neutrophils

Wednesday, September 23 | 8:00AM - 11:00AM
Targeting Myeloid Cells in Cancer Therapy I (8am Denver/Moun
tain Time Start)



Coffee Break

Wednesday, September 23 | 8:00AM - 11:00AM
Targeting Myeloid Cells in Cancer Therapy I (8am Denver/Moun
tain Time Start)


Speaker 5 of 8
Nagy A. Habib, Imperial College London and MiNA Therapeutics, UK
MTL - CEBPA - Next Generation Immunotherapy Targeting Myeloid Cell Differentiation

Wednesday, September 23 | 8:00AM - 11:00AM
Targeting Myeloid Cells in Cancer Therapy I (8am Denver/Moun
tain Time Start)


Speaker 6 of 8
Sven Brandau, University Hospital Essen, Germany
Short Talk: Unravelling the Identity and Function of MDSC in Human Cancer Patients

Wednesday, September 23 | 8:00AM - 11:00AM
Targeting Myeloid Cells in Cancer Therapy I (8am Denver/Moun
tain Time Start)


Speaker 7 of 8
Yolanda Calle, University of Roehampton, UK
Short Talk: Therapeutic Drugs Promote Differentiation of AML Blasts to a Mixed M1/M2 and Migratory Phenotype Resistant to Treatment Facilitated by the Bone Marrow Microenvironment.

Wednesday, September 23 | 8:00AM - 11:00AM
Targeting Myeloid Cells in Cancer Therapy I (8am Denver/Moun
tain Time Start)


Speaker 8 of 8
Natalie Horvat, European Molecular Biological Laboratories, Germany
Short Talk: Polarization of TAMs by Iron Nanoparticles as an Adjuvant Lung Cancer Therapy

Wednesday, September 23 | 1:30PM - 3:00PM
Poster Session (1:30pm Denver/Mountain Time Start)


Wednesday, September 23 | 3:00PM - 5:45PM
Targeting Myeloid Cells in Cancer Therapy II (3pm Denver/Mou
ntain Time Start)


Speaker 1 of 8
Brenda C. O'Connell, Infinity Pharmaceuticals, Inc, USA
Targeting PI3K-gamma with IPI-549, a Tumor Macrophage-Reprogramming Small Molecule, in Patients with Advanced Solid Tumors

Wednesday, September 23 | 3:00PM - 5:45PM
Targeting Myeloid Cells in Cancer Therapy II (3pm Denver/Mou
ntain Time Start)


Speaker 2 of 8
* Jennifer Guerriero, Dana-Farber Cancer Institute, USA
Differentiating Macrophages are Regulated by PARP Inhibitors and can be Harnessed to Overcome PARP-Inhibitor Resistance in BRCA-Associated Triple-Negative Breast Cancer

Wednesday, September 23 | 3:00PM - 5:45PM
Targeting Myeloid Cells in Cancer Therapy II (3pm Denver/Mou
ntain Time Start)


Speaker 3 of 8
* David A. Cheresh, University of California, San Diego, USA
Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression

Wednesday, September 23 | 3:00PM - 5:45PM
Targeting Myeloid Cells in Cancer Therapy II (3pm Denver/Mou
ntain Time Start)



Coffee Break

Wednesday, September 23 | 3:00PM - 5:45PM
Targeting Myeloid Cells in Cancer Therapy II (3pm Denver/Mou
ntain Time Start)


Speaker 5 of 8
Caroline Bonnans, Immune-Onc Therapeutics, USA
Short Talk: Antagonistic Antibodies Targeting LAIR1 Promote Inflammatory Phenotypes in Myeloid Cells and Activate Lymphocytes

Wednesday, September 23 | 3:00PM - 5:45PM
Targeting Myeloid Cells in Cancer Therapy II (3pm Denver/Mou
ntain Time Start)


Speaker 6 of 8
Shadi Swaidani, Cleveland Clinic Foundation, USA
Short Talk: Elevated Systemic Myeloid-Derived Suppressor Cells and Interleukin 8 Correlate with Increased Incidence of Venous Thromboembolism in Cancer Patients Receiving Immune-Checkpoint Inhibitors

Wednesday, September 23 | 3:00PM - 5:45PM
Targeting Myeloid Cells in Cancer Therapy II (3pm Denver/Mou
ntain Time Start)


Speaker 7 of 8
Mehdi Chaib, University of Tennessee Health Science Center, USA
Short Talk: PKC Delta Activation Restricts Innate Immune Suppression and Promotes antigen Presentation in Triple Negative Breast Cancer

Wednesday, September 23 | 3:00PM - 5:45PM
Targeting Myeloid Cells in Cancer Therapy II (3pm Denver/Mou
ntain Time Start)


Speaker 8 of 8
Jihong Bae, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Extracellular Vesicles Derived from a Commensal Bacteria Enhance Anticancer Immunity by Modulating Tumor Infiltrating Immune Cells

Wednesday, September 23 | 5:45PM - 6:00PM
Closing Remarks (Organizers) (5:45pm Denver/Mountain Time St
art)