Web Desc
Synthetic Biology: At the Crossroads of Genetic Engineering and Human Therapeutics - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Jose M. Lora and Timothy K. Lu
Date: May 03 - 04, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Sponsored by Synthego
For important information on the coronavirus, please click here
Summary of Meeting:
Synthetic Biology tools and principles have matured tremendously over the last decade and have reached extraordinary levels of sophistication, both in eukaryotic and prokaryotic systems. Synthetic biology as a therapeutic modality is starting to enter multiple clinical studies and has the potential to have a significant impact on medicine across a wide range of diseases (e.g., metabolic, immune-mediated, cancer, and neurologic diseases). This Keystone Symposia conference will delve into the field of synthetic biology with a special emphasis on its applications to medicine. While there are conferences that capture synthetic biology in only a few talks mixed in among other various topics, there is a paucity of conferences focused on synthetic biology as drugs to treat disease. However, due to the rapid pace of fundamental scientific advances along with an expanding number of biotechnology companies and emerging clinical studies with synthetic biology at their core, this conference will be highly relevant for a wide audience of scientists both from academia and industry. In addition, other meetings in this field have a highly technology-driven focus on synthetic biology techniques with relatively little attention given to biological and medical context. Ultimately, this Keystone Symposia conference should inspire researchers from diverse backgrounds to discuss synthetic biology via many new angles.
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Synthego
We gratefully acknowledge additional support for this conference from:
DCVC Bio
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Grant No. 1R13EB029305-01
Funding for this conference was made possible (in part) by 1R13EB029305 - 01 from the National Institute of Biomedical Imaging and Bioengineering. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, May 03 | 8:00AM - 8:40AM
Welcome and Keynote Address (8am Denver/Mountain Time Start)

Speaker 1 of 3
* Jose M. Lora, Intergalactic Therapeutics, USA

Monday, May 03 | 8:00AM - 8:40AM
Welcome and Keynote Address (8am Denver/Mountain Time Start)

Speaker 2 of 3
* Joshua N. Leonard, Northwestern University, USA

Monday, May 03 | 8:00AM - 8:40AM
Welcome and Keynote Address (8am Denver/Mountain Time Start)

Speaker 3 of 3
Martin Fussenegger, ETH Zürich, Switzerland
[NOT AVAILABLE ON DEMAND] Cell-Based Therapies of the Future

Monday, May 03 | 8:40AM - 11:00AM
Engineering Life with Synthetic Biology Tools and Principles
(8:40am Denver/Mountain Time Start)


Speaker 1 of 7
* Joshua N. Leonard, Northwestern University, USA
Advancing the Frontiers of Design-Driven Engineering for Programmable Cell-Based Therapies

Monday, May 03 | 8:40AM - 11:00AM
Engineering Life with Synthetic Biology Tools and Principles
(8:40am Denver/Mountain Time Start)


Speaker 2 of 7
Timothy K. Lu, Massachusetts Institute of Technology, USA
Engineered Gene Circuits for Diagnostics and Therapeutics

Monday, May 03 | 8:40AM - 11:00AM
Engineering Life with Synthetic Biology Tools and Principles
(8:40am Denver/Mountain Time Start)



Coffee Break

Monday, May 03 | 8:40AM - 11:00AM
Engineering Life with Synthetic Biology Tools and Principles
(8:40am Denver/Mountain Time Start)


Speaker 4 of 7
Jeff Hasty, University of California, San Diego, USA
[NOT AVAILABLE ON DEMAND] Modulating Bacterial Populations with Synthetic Biology

Monday, May 03 | 8:40AM - 11:00AM
Engineering Life with Synthetic Biology Tools and Principles
(8:40am Denver/Mountain Time Start)


Speaker 5 of 7
Yvonne Y. Chen, University of California, Los Angeles, USA
[NOT AVAILABLE ON DEMAND] Synthetic Biology in Immunotherapy

Monday, May 03 | 8:40AM - 11:00AM
Engineering Life with Synthetic Biology Tools and Principles
(8:40am Denver/Mountain Time Start)


Speaker 6 of 7
* Zhen Xie, Tsinghua University, China
Oncolytic Adenovirus Programmed by Synthetic Gene Circuit for Cancer Immunotherapy

Monday, May 03 | 8:40AM - 11:00AM
Engineering Life with Synthetic Biology Tools and Principles
(8:40am Denver/Mountain Time Start)


Speaker 7 of 7
Matthew Chang, National University of Singapore, Singapore
Reprogramming Microbes to Rewire Host-Microbiome Interactions

Monday, May 03 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 1 of 3
Roger Geiger, Institute for Research in Biomedicine, Switzerland

Monday, May 03 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 2 of 3
Virginia W. Cornish, Columbia University, USA

Monday, May 03 | 12:30PM - 1:30PM
Career Roundtable (12:30pm Denver/Mountain Time Start)

Speaker 3 of 3
David Hava, Synlogic, Inc., USA

Monday, May 03 | 1:30PM - 3:00PM
Poster Session (1:30pm Denver/Mountain Time Start)


Monday, May 03 | 3:00PM - 6:00PM
Bioengineering Cells and Viruses in Disease (3pm Denver/Moun
tain Time Start)


Speaker 1 of 8
Luis Ángel Fernández, National Center of Biotechnology - CSIC, Spain
Engineering E. coli for the Targeted Injections of Proteins into Tumor Cells

Monday, May 03 | 3:00PM - 6:00PM
Bioengineering Cells and Viruses in Disease (3pm Denver/Moun
tain Time Start)


Speaker 2 of 8
Jose M. Lora, Intergalactic Therapeutics, USA
Synthetic Immunotherapy with Engineered Bacteria

Monday, May 03 | 3:00PM - 6:00PM
Bioengineering Cells and Viruses in Disease (3pm Denver/Moun
tain Time Start)


Speaker 3 of 8
Howard L. Kaufman, Massachusetts General Hospital, USA
New Strategies for Improving the Therapeutic Potential of Oncolytic Viruses in Cancer and Other Diseases

Monday, May 03 | 3:00PM - 6:00PM
Bioengineering Cells and Viruses in Disease (3pm Denver/Moun
tain Time Start)


Speaker 4 of 8
* Francisco J. Quintana, Harvard Medical School and the Broad Institute of MIT and Harvard, USA
Engineering Bacteria and Yeast for the Control of Inflammation

Monday, May 03 | 3:00PM - 6:00PM
Bioengineering Cells and Viruses in Disease (3pm Denver/Moun
tain Time Start)



Coffee Break

Monday, May 03 | 3:00PM - 6:00PM
Bioengineering Cells and Viruses in Disease (3pm Denver/Moun
tain Time Start)


Speaker 6 of 8
Roger Geiger, Institute for Research in Biomedicine, Switzerland
Metabolic Modulation of the Tumor Microenvironment with Synthetic Biology

Monday, May 03 | 3:00PM - 6:00PM
Bioengineering Cells and Viruses in Disease (3pm Denver/Moun
tain Time Start)


Speaker 7 of 8
Cammie Lesser, Massachusetts General Hospital, USA
Leveraging Bacterial Secretion Systems to Develop Therapeutic Designer Probiotics

Monday, May 03 | 3:00PM - 6:00PM
Bioengineering Cells and Viruses in Disease (3pm Denver/Moun
tain Time Start)


Speaker 8 of 8
* Jason Paul Lynch, Massachusetts General Hospital, USA
Short Talk: Development of Designer Probiotics for the Treatment of Inflammatory Bowel Disease


Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)


Speaker 1 of 9
* Jose M. Lora, Intergalactic Therapeutics, USA

Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)


Speaker 2 of 9
David Hava, Synlogic, Inc., USA
Targeting Metabolic Diseases with Synthetic Biotic Medicines

Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)


Speaker 3 of 9
Virginia W. Cornish, Columbia University, USA
Expanding the Synthetic Capabilities of Yeast

Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)


Speaker 4 of 9
Gary K. Lee, Senti Biosciences, USA
Precise Targeting of Acute Myeloid Leukemia with OR / NOT Logic-Gated Gene Circuits in CAR-NK Cells

Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)



Coffee Break

Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)


Speaker 6 of 9
* Breanna DiAndreth, A2 Biotherapeutics, Inc., USA
Short Talk: Engineered T Cells Directed at Tumors with Defined Allelic Loss

Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)


Speaker 7 of 9
Michael Fero, TeselaGen Biotechnology, USA
Short Talk: Machine Learning Models for Predictive Bioengineering

Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)


Speaker 8 of 9
Rajkamal Srivastava, Saha Institute of Nuclear Physics, HBNI, India, India
Short Talk: Engineering Reversible Logic Based Synthetic Gene Circuits in Living Bacteria and Its Potential Application in Therapeutic Delivery to Human Cancer Cells

Tuesday, May 04 | 8:00AM - 11:00AM
Synthetic Biology: Industry Perspective (8am Denver/Mountain
Time Start)


Speaker 9 of 9
Tim Joseph Chris De Coster, Leiden University Medical Center, Netherlands
Short Talk: Anti-Arrhythmic Ion Channel Engineering Enables Self-Restoration of Cardiac Rhythm: Towards Synthetic Biomedicine in Cardiology

Tuesday, May 04 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 1 of 3
Kusumika Mukherjee, Cell Press, USA

Tuesday, May 04 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 2 of 3
George Inglis, Communications Biology, Nature, USA

Tuesday, May 04 | 12:30PM - 1:30PM
Meet the Editors (12:30pm Denver/Mountain Time Start)

Speaker 3 of 3
Maria Polychronidou, EMBO, Germany

Tuesday, May 04 | 1:30PM - 3:00PM
Networking Lounge (1:30pm Denver/Mountain Time Start)


Tuesday, May 04 | 3:00PM - 5:50PM
Next Generation Synthetic Biology (3pm Denver/Mountain Time
Start)


Speaker 1 of 8
Kole T. Roybal, University of California, San Francisco, USA
Enhancing Engineered Immune Cell Therapies with Synthetic Biology

Tuesday, May 04 | 3:00PM - 5:50PM
Next Generation Synthetic Biology (3pm Denver/Mountain Time
Start)


Speaker 2 of 8
* Owen J. L. Rackham, Duke-NUS, Singapore
Using Data-Driven Approaches to Develop Engineered Cell Therapies

Tuesday, May 04 | 3:00PM - 5:50PM
Next Generation Synthetic Biology (3pm Denver/Mountain Time
Start)


Speaker 3 of 8
* Samira Kiani, University of Pittsburgh School of Medicine, USA
CRISPR-Based Genetic Circuits: Immunomodulation as a Tool to Address Safety and Developing Therapeutics

Tuesday, May 04 | 3:00PM - 5:50PM
Next Generation Synthetic Biology (3pm Denver/Mountain Time
Start)



Coffee Break

Tuesday, May 04 | 3:00PM - 5:50PM
Next Generation Synthetic Biology (3pm Denver/Mountain Time
Start)


Speaker 5 of 8
Iowis Zhu, University of California, San Francisco, USA
Short Talk: Next Generation Receptors for the Enhanced Control of Cellular Immunotherapy

Tuesday, May 04 | 3:00PM - 5:50PM
Next Generation Synthetic Biology (3pm Denver/Mountain Time
Start)


Speaker 6 of 8
Rogelio A. Hernandez-Lopez, University of California San Francisco, USA
Short Talk: T Cell Circuits that Sense Antigen Density with Ultrasensitive Threshold

Tuesday, May 04 | 3:00PM - 5:50PM
Next Generation Synthetic Biology (3pm Denver/Mountain Time
Start)


Speaker 7 of 8
* Tingxi (Tim) Guo, Massachusetts Institute of Technology, USA
Short Talk: Sense-and-Respond Payload Delivery using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation

Tuesday, May 04 | 3:00PM - 5:50PM
Next Generation Synthetic Biology (3pm Denver/Mountain Time
Start)


Speaker 8 of 8
William C.W. Chen, Massachusetts Institute of Technology, USA
Short Talk: Highly Programmable Synthetic Transcription System for Precision Control of Gene Expression and Functional Phenotype in Mammalian Cells

Tuesday, May 04 | 5:50PM - 6:00PM
Closing Remarks (5:50pm Denver/Mountain Time Start)


*Session Chair.