Web Desc
RNA Editing and Modifications: From Biology to Therapy - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Jin Billy Li, Stacy M. Horner and Michaela Frye
Date: September 30 - October 02, 2020
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Sponsored by AstraZeneca and Moderna
For important information on the coronavirus, please click here
Summary of Meeting:
The biochemical modifications made to RNA after transcription, called the epitranscriptome, play a critical role in life. The development of new technologies has transformed the field in recent years. Our understanding of the reason for and regulation of RNA editing and modifications, as well as their roles in human infection and disease is deepening and therapeutic applications are emerging. This conference will bring together leading experts in RNA editing and modifications, technology development, and medicine to present and discuss cutting edge research. We anticipate that participants of this conference will benefit from learning the cutting edge of the rapidly advancing field and help move the field forward by creating collaboration opportunities.
Global Health Travel Award Deadline: October 2 2020
Scholarship Deadline: September 22 2020
Abstract Deadline: September 9 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZeneca
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA254455-01
Funding for this conference was made possible (in part) by 1R13CA254455-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, September 30 | 8:00AM - 8:45AM
Welcoming Remarks (Organizers) and Keynote Address (8am Denv
er/Mountain Time Start)

Speaker 2 of 2
Chuan He, University of Chicago, USA
Reversible RNA Methylation in Gene Expression Regulation

Wednesday, September 30 | 8:00AM - 8:45AM
Welcoming Remarks (Organizers) and Keynote Address (8am Denv
er/Mountain Time Start)

Speaker 1 of 2
* Stacy M. Horner, Duke University Medical Center, USA

Wednesday, September 30 | 8:45AM - 11:00AM
Dynamic Regulation of the Epitranscriptome (8:45am Denver/Mo
untain Time Start)


Speaker 6 of 6
* Polly Chen, National University of Singapore, Singapore
Short Talk: Dynamic Regulation of A-to-I RNA Editing by RNA Helicases

Wednesday, September 30 | 8:45AM - 11:00AM
Dynamic Regulation of the Epitranscriptome (8:45am Denver/Mo
untain Time Start)


Speaker 5 of 6
Marisa Almeida Pereira, iBiMED-Institute of Biomedicine, Portugal
Short Talk: Lack of m5U Modification in tRNAs Induces the Formation of tRNA-Derived Fragments

Wednesday, September 30 | 8:45AM - 11:00AM
Dynamic Regulation of the Epitranscriptome (8:45am Denver/Mo
untain Time Start)


Speaker 4 of 6
Jin Billy Li, Stanford University, USA
ADAR1 RNA Editing and Innate Immunity

Wednesday, September 30 | 8:45AM - 11:00AM
Dynamic Regulation of the Epitranscriptome (8:45am Denver/Mo
untain Time Start)



Coffee Break

Wednesday, September 30 | 8:45AM - 11:00AM
Dynamic Regulation of the Epitranscriptome (8:45am Denver/Mo
untain Time Start)


Speaker 2 of 6
Aldema Sas-Chen, Weizmann Institute of Science, Israel
Short Talk: Dynamic RNA Acetylation as a Mechanism for RNA Thermostabilization

Wednesday, September 30 | 8:45AM - 11:00AM
Dynamic Regulation of the Epitranscriptome (8:45am Denver/Mo
untain Time Start)


Speaker 1 of 6
* Blerta Xhemalce, University of Texas, Austin, USA
Targeting RNA Methylation in Cancer

Wednesday, September 30 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 3 of 3
Chuan He, University of Chicago, USA

Wednesday, September 30 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 2 of 3
Lynn Abell, Agios Pharmaceuticals, USA

Wednesday, September 30 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 1 of 3
Kate Meyer, Duke University, USA

Wednesday, September 30 | 1:00PM - 4:00PM
'Self' vs 'Non-Self' RNA Pattern Recognition (1pm Denver/Mou
ntain Time Start)


Speaker 7 of 7
Reshma Kurup, Indiana University, USA
Short Talk: ADAR3 Alters the MAVS/NF-kappaB Signaling Pathway in Glioblastoma

Wednesday, September 30 | 1:00PM - 4:00PM
'Self' vs 'Non-Self' RNA Pattern Recognition (1pm Denver/Mou
ntain Time Start)


Speaker 6 of 7
Grace Chen, Yale University School of Medicine, USA
Circular RNA Immunity

Wednesday, September 30 | 1:00PM - 4:00PM
'Self' vs 'Non-Self' RNA Pattern Recognition (1pm Denver/Mou
ntain Time Start)


Speaker 5 of 7
* Noam Stern-Ginossar, Weizmann Institute of Science, Israel
m6A and Innate Immunity

Wednesday, September 30 | 1:00PM - 4:00PM
'Self' vs 'Non-Self' RNA Pattern Recognition (1pm Denver/Mou
ntain Time Start)



Coffee Break

Wednesday, September 30 | 1:00PM - 4:00PM
'Self' vs 'Non-Self' RNA Pattern Recognition (1pm Denver/Mou
ntain Time Start)


Speaker 3 of 7
Michael A. Tartell, Harvard University, USA
Short Talk: Cap-Proximal N6-Methylation Protects Viral mRNA against Interferon beta Pretreatment

Wednesday, September 30 | 1:00PM - 4:00PM
'Self' vs 'Non-Self' RNA Pattern Recognition (1pm Denver/Mou
ntain Time Start)


Speaker 2 of 7
* Carl Walkley, St Vincent's Institute, Australia
The in vivo Functions of A-to-I Editing

Wednesday, September 30 | 1:00PM - 4:00PM
'Self' vs 'Non-Self' RNA Pattern Recognition (1pm Denver/Mou
ntain Time Start)


Speaker 1 of 7
Stacy M. Horner, Duke University Medical Center, USA
RNA Methylation in Viral Infection

Thursday, October 01 | 8:00AM - 11:00AM
Functions and Mechanism (8am Denver/Mountain Time Start)

Speaker 2 of 7
Kazuko Nishikura, Wistar Institute, USA
ADAR RNA Editing and Genome Stability

Thursday, October 01 | 8:00AM - 11:00AM
Functions and Mechanism (8am Denver/Mountain Time Start)

Speaker 1 of 7
* Yunsun Nam, University of Texas Southwestern Medical Center, USA
Structural Basis for Substrate Specificity of RNA Methyltransferases

Thursday, October 01 | 8:00AM - 11:00AM
Functions and Mechanism (8am Denver/Mountain Time Start)

Speaker 3 of 7
Bei Liu, Duke University, USA
Short Talk: Syn-Anti Isomerization of the m6A Methylamino Group as a Molecular Timer that Slows Nucleic Acid Annealing and Conformational Transitions

Thursday, October 01 | 8:00AM - 11:00AM
Functions and Mechanism (8am Denver/Mountain Time Start)


Coffee Break

Thursday, October 01 | 8:00AM - 11:00AM
Functions and Mechanism (8am Denver/Mountain Time Start)

Speaker 5 of 7
Kate Meyer, Duke University, USA
Uncovering m6A and Its Role in RNA Regulation

Thursday, October 01 | 8:00AM - 11:00AM
Functions and Mechanism (8am Denver/Mountain Time Start)

Speaker 6 of 7
* Peter Beal, University of California, Davis, USA
ADAR Structure and Substrate Recognition

Thursday, October 01 | 8:00AM - 11:00AM
Functions and Mechanism (8am Denver/Mountain Time Start)

Speaker 7 of 7
Kayla Shumate, Vanderbilt University, USA
Short Talk: CAPS1 RNA Editing Selectivity Mediates Dopamine Neurotransmission in the Dorsal Striatum

Thursday, October 01 | 11:00AM - 1:00PM
Poster Session 1 (11am Denver/Mountain Time Start)


Thursday, October 01 | 1:00PM - 4:00PM
Understanding and Exploiting Epitranscriptome in Cancer (1pm
Denver/Mountain Time Start)


Speaker 1 of 7
Eli Eisenberg, Tel Aviv University, Israel
Human Recoding Sites: Profile, Evolution, Adaptation

Thursday, October 01 | 1:00PM - 4:00PM
Understanding and Exploiting Epitranscriptome in Cancer (1pm
Denver/Mountain Time Start)


Speaker 2 of 7
* Jianjun Chen, Beckman Research Institute of City of Hope, USA
m6A in Cancer

Thursday, October 01 | 1:00PM - 4:00PM
Understanding and Exploiting Epitranscriptome in Cancer (1pm
Denver/Mountain Time Start)


Speaker 3 of 7
Anna-Maria Herzner, Genentech, Inc., USA
Short Talk: Dual Protection from Endogenous dsRNA-Induced Type-I IFN Responses by ADAR and hnRNPC

Thursday, October 01 | 1:00PM - 4:00PM
Understanding and Exploiting Epitranscriptome in Cancer (1pm
Denver/Mountain Time Start)



Coffee Break

Thursday, October 01 | 1:00PM - 4:00PM
Understanding and Exploiting Epitranscriptome in Cancer (1pm
Denver/Mountain Time Start)


Speaker 5 of 7
* F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, Germany
RNA Deamination in Immunity and Cancer

Thursday, October 01 | 1:00PM - 4:00PM
Understanding and Exploiting Epitranscriptome in Cancer (1pm
Denver/Mountain Time Start)


Speaker 6 of 7
Michael G. Kharas, Memorial Sloan Kettering Cancer Center, USA
RNA Methylation and the Control of Cell Fate in the Blood

Thursday, October 01 | 1:00PM - 4:00PM
Understanding and Exploiting Epitranscriptome in Cancer (1pm
Denver/Mountain Time Start)


Speaker 7 of 7
Dhwani Rupani, MD Anderson Cancer Center, USA
Short Talk: Loss of Adar1 in Pancreatic Acinar Cells Leads to Apoptosis and Inflammation

Friday, October 02 | 8:00AM - 11:00AM
Transcriptome Engineering and Technology Development (8am De
nver/Mountain Time Start)


Speaker 5 of 7
* Eva Maria Novoa Pardo, Centre for Genomic Regulation, Spain
Quantitative Profiling of Pseudouridine Modification Dynamics Using Native RNA Nanopore Sequencing

Friday, October 02 | 8:00AM - 11:00AM
Transcriptome Engineering and Technology Development (8am De
nver/Mountain Time Start)


Speaker 6 of 7
Omar Abudayyeh, Massachusetts Institute of Technology, USA
Harnessing Novel CRISPR Systems for Programmable RNA Editing

Friday, October 02 | 8:00AM - 11:00AM
Transcriptome Engineering and Technology Development (8am De
nver/Mountain Time Start)


Speaker 7 of 7
Supuni Thalalla Gamage, National Cancer Institute, USA
Short Talk: Chemistry to Discover and Decode RNA Acetylation

Friday, October 02 | 8:00AM - 11:00AM
Transcriptome Engineering and Technology Development (8am De
nver/Mountain Time Start)



Coffee Break

Friday, October 02 | 8:00AM - 11:00AM
Transcriptome Engineering and Technology Development (8am De
nver/Mountain Time Start)


Speaker 3 of 7
Meng How Tan, Nanyang Technology University, Singapore
Short Talk: Development of an Efficient and Specific Platform for Programmable RNA Base Editing

Friday, October 02 | 8:00AM - 11:00AM
Transcriptome Engineering and Technology Development (8am De
nver/Mountain Time Start)


Speaker 2 of 7
Yi-Tao Yu, University of Rochester Medical Center, USA
Pseudouridine-Mediated Stop Codon Read Through

Friday, October 02 | 8:00AM - 11:00AM
Transcriptome Engineering and Technology Development (8am De
nver/Mountain Time Start)


Speaker 1 of 7
Thorsten Stafforst, Universität Tübingen, Germany
Harnessing ADAR Activity for Site-Directed RNA Editing

Friday, October 02 | 11:00AM - 1:00PM
Poster Session 2 (11am Denver/Mountain Time Start)


Friday, October 02 | 1:00PM - 3:55PM
The Role of Epitranscriptome in Development and Stem Cell (1
pm Denver/Mountain Time Start)


Speaker 1 of 8
Michaela Frye, Deutsches Krebsforschungszentrum, Germany
m5C RNA Methylation

Friday, October 02 | 1:00PM - 3:55PM
The Role of Epitranscriptome in Development and Stem Cell (1
pm Denver/Mountain Time Start)


Speaker 2 of 8
Guifeng Wei, University of Oxford, UK
Short Talk: Acute depletion of METTL3 Identifies a Role for N6-Methyladenosine in Alternative Intron/Exon Inclusion in the Nascent Transcriptome

Friday, October 02 | 1:00PM - 3:55PM
The Role of Epitranscriptome in Development and Stem Cell (1
pm Denver/Mountain Time Start)


Speaker 3 of 8
* Kamil R. Kranc, Barts Cancer Institute, Queen Mary University of London, UK
Targeting m6A mRNA Readers in Blood Malignancies

Friday, October 02 | 1:00PM - 3:55PM
The Role of Epitranscriptome in Development and Stem Cell (1
pm Denver/Mountain Time Start)



Coffee Break

Friday, October 02 | 1:00PM - 3:55PM
The Role of Epitranscriptome in Development and Stem Cell (1
pm Denver/Mountain Time Start)


Speaker 5 of 8
Brian C. Capell, University of Pennsylvania, USA
Short Talk: Dynamic Epitranscriptomic Regulation of Self-Renewing Epithelia via METTL3-Mediated m6A

Friday, October 02 | 1:00PM - 3:55PM
The Role of Epitranscriptome in Development and Stem Cell (1
pm Denver/Mountain Time Start)


Speaker 6 of 8
* Alexey Ruzov, University of Nottingham, UK
The Role of m6A in R-Loop Regulation

Friday, October 02 | 1:00PM - 3:55PM
The Role of Epitranscriptome in Development and Stem Cell (1
pm Denver/Mountain Time Start)


Speaker 7 of 8
Diana Guallar, Universidade de Santiago de Compostela, Spain
Short Talk: ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress

Friday, October 02 | 1:00PM - 3:55PM
The Role of Epitranscriptome in Development and Stem Cell (1
pm Denver/Mountain Time Start)


Speaker 8 of 8
Michael McMillan, University of Michigan, USA
Short Talk: Intersection between RNA Methylation and TDP43-Mediated Toxicity in ALS

Friday, October 02 | 3:55PM - 4:00PM
Closing Remarks

Speaker 1 of 1
Michaela Frye, Deutsches Krebsforschungszentrum, Germany

*Session Chair.