Web Desc
Autophagy: Mechanisms and Disease - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Patricia Boya, Felix Randow and Masaaki Komatsu
Date: October 05 - 08, 2020
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Sponsored by Astellas Pharma Inc., AstraZeneca and Cell Research
For important information on the coronavirus, please click here
Summary of Meeting:
Autophagy is an intracellular pathway for degradation that allows for the recycling of cellular components inside lysosomes to sustain tissue homeostasis. Countless effort has been devoted to help unravel the molecular mechanisms that regulate this pathway, but many questions remain unresolved. Therefore, this conference program gathers an interdisciplinary group of scientists to address the current and future challenges in the field such as discussions on the existence of non-canonical forms of the pathway and how selectivity is achieved. This conference also addresses the minimal requirements to generate functional autophagosomes and the molecular bases of autophagy regulation. One of the major themes of this conference is a session which reviews how model systems such as plants, worms and mice help to unravel the physiological roles of this essential pathway and why this research can also be applied to find new therapies for human diseases. For example, while it is now clear that many human pathologies have alterations in autophagy, how scientists could potentially manipulate the pathway in vivo is a major challenge that will be addressed at this conference. Finally, this conference provides a unique frame to display the current research and future challenges of the field during physiological and pathological conditions.
Global Health Travel Award Deadline: September 22 2020
Scholarship Deadline: September 22 2020
Abstract Deadline: September 14 2020
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Astellas Pharma Inc.AstraZenecaCell Research
We gratefully acknowledge additional support for this conference from:
Novus Biologicals
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA254442-01
Funding for this conference was made possible (in part) by 1R13CA254442-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, October 05 | 6:00AM - 6:35AM
Welcoming Remarks and Keynote Address: Beth Levine Lecture (
6am Denver/Mountain Time Start)

Speaker 2 of 2
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Autophagy, Mitochondria and Disease

Monday, October 05 | 6:00AM - 6:35AM
Welcoming Remarks and Keynote Address: Beth Levine Lecture (
6am Denver/Mountain Time Start)

Speaker 1 of 2
* Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain

Monday, October 05 | 6:35AM - 7:45AM
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain
Time Start)


Speaker 8 of 8
Salwa Sebti, University of Texas Southwestern Medical Center, USA
Short Talk: Role of Autophagy and Beclin 1 in Aging

Monday, October 05 | 6:35AM - 7:45AM
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain
Time Start)


Speaker 7 of 8
Yang Liu, University of Texas Southwestern Medical Center, USA
Short Talk: Crosstalk between TLR9 and Beclin 1 in Muscle

Monday, October 05 | 6:35AM - 7:45AM
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain
Time Start)


Speaker 6 of 8
Xiaonan Dong, University of Texas Southwestern Medical Center, USA
Short Talk: Role of Sorting Nexins in Virophagy

Monday, October 05 | 6:35AM - 7:45AM
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain
Time Start)


Speaker 5 of 8
Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship

Monday, October 05 | 6:35AM - 7:45AM
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain
Time Start)


Speaker 4 of 8
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship

Monday, October 05 | 6:35AM - 7:45AM
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain
Time Start)


Speaker 3 of 8
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Beth Levine: A Legacy of Science, Collaboration, Community and Mentorship

Monday, October 05 | 6:35AM - 7:45AM
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain
Time Start)


Speaker 2 of 8
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Monday, October 05 | 6:35AM - 7:45AM
Mini Symposium to Honor Beth Levine (6:35am Denver/Mountain
Time Start)


Speaker 1 of 8
* Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain

Monday, October 05 | 7:45AM - 8:00AM
Break (7:45am Denver/Mountain Time Start)


Monday, October 05 | 8:00AM - 10:00AM
New Insights into the Molecular Regulation of Autophagy (8am
Denver/Mountain Time Start)


Speaker 2 of 7
David C. Rubinsztein, Cambridge Institute for Medical Research, UK
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy

Monday, October 05 | 8:00AM - 10:00AM
New Insights into the Molecular Regulation of Autophagy (8am
Denver/Mountain Time Start)


Speaker 1 of 7
* Felix Randow, Medical Research Council, UK

Monday, October 05 | 8:00AM - 10:00AM
New Insights into the Molecular Regulation of Autophagy (8am
Denver/Mountain Time Start)


Speaker 3 of 7
* Fulvio Reggiori, University Medical Centre Groningen, Netherlands
Molecular Regulation of Autophagosome Formation

Monday, October 05 | 8:00AM - 10:00AM
New Insights into the Molecular Regulation of Autophagy (8am
Denver/Mountain Time Start)


Speaker 4 of 7
Noboru Mizushima, University of Tokyo, Japan
Molecular Mechanism of Large-Scale Organelle Degradation in the Lens

Monday, October 05 | 8:00AM - 10:00AM
New Insights into the Molecular Regulation of Autophagy (8am
Denver/Mountain Time Start)


Speaker 5 of 7
Olatz Pampliega, Achucarro Basque Center for Neuroscience, Spain
Short Talk: Amyloid beta Modulates Neuronal Autophagy through the Primary Cilium

Monday, October 05 | 8:00AM - 10:00AM
New Insights into the Molecular Regulation of Autophagy (8am
Denver/Mountain Time Start)


Speaker 6 of 7
Chunmei Chang, University of California, Berkeley, USA
Short Talk: Reconstituting Cargo Triggered LC3 Lipidation in Autophagy

Monday, October 05 | 8:00AM - 10:00AM
New Insights into the Molecular Regulation of Autophagy (8am
Denver/Mountain Time Start)


Speaker 7 of 7
Thomas J. Mercer, Francis Crick Institute, UK
Short Talk: Examining the Regulation of Autophagy via Identification and Characterisation of ULK Kinase Substrates

Monday, October 05 | 11:00AM - 1:00PM
Poster Session 1 (11am Denver/Mountain Time Start)


Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 1 of 11
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Chaperone Mediated Autophagy

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 2 of 11
* Richard J. Youle, NINDS, National Institutes of Health, USA
Mitophagy

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 3 of 11
* Anne Simonsen, University of Oslo, Norway
Regulation of Autophagy by Lipid-Binding Proteins

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 4 of 11
Martin McMahon, University of Utah School of Medicine, USA
Combined Targeting of RAS Signaling Plus Autophagy as a Future Treatment Strategy for Cancer

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)



Coffee Break

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 6 of 11
Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain
New Links between Autophagy and Developmental Cell Death

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 7 of 11
Jennifer Martinez, NIEHS, National Institutes of Health, USA
Non-Canonical Autophagy Mediates Immunotolerant Mechanisms

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 8 of 11
Andrea KH Stavoe, University of Texas Health Science Center at Houston, USA
Short Talk: Aging Represses Autophagosome Biogenesis but not Autophagosome Transport or Maturation in Neurons

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 9 of 11
Caroline Mauvezin, IDIBELL, Spain
Short Talk: Autophagy and Lysosomal Degradation Ensure Accurate Chromosomal Segregation to Prevent Genomic Instability

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 10 of 11
Chris Shoemaker, Dartmouth College, USA
Short Talk: Receptor-Mediated Clustering of FIP200 Bypasses the Role of LC3 Lipidation in Autophagy

Tuesday, October 06 | 6:00AM - 10:00AM
Selective and Non-Canonical Autophagy (6am Denver/Mountain T
ime Start)


Speaker 11 of 11
Yasuhiro Yamamoto, University of Tokyo, Japan
Short Talk: Selective Autophagy of NEK9 Regulates Primary Cilia Formation

Tuesday, October 06 | 11:00AM - 12:00PM
Meet the Editors (11am Denver/Mountain Time Start)

Speaker 1 of 4
Sadaf Shadan, Nature, UK

Tuesday, October 06 | 11:00AM - 12:00PM
Meet the Editors (11am Denver/Mountain Time Start)

Speaker 2 of 4
Stella M. Hurtley, Science, UK

Tuesday, October 06 | 11:00AM - 12:00PM
Meet the Editors (11am Denver/Mountain Time Start)

Speaker 3 of 4
Elisabetta Argenzio, EMBO Journal, Germany

Tuesday, October 06 | 11:00AM - 12:00PM
Meet the Editors (11am Denver/Mountain Time Start)

Speaker 4 of 4
Petra Gross, Journal of Cell Science, UK

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 1 of 10
Ivan Dikic, Goethe University Medical School, Germany
ER-Phagy

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 2 of 10
* Alicia Melendez, Queens College - CUNY, USA
Autophagy in Germline Development

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 3 of 10
Rosa Puertollano, NHLBI, National Institutes of Health, USA
Emerging New Roles of Lysosomes in Cellular Response to Stress

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 4 of 10
Felix Randow, Medical Research Council, UK
Autophagy and Bacterial Infection

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)



Coffee Break

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 6 of 10
Tassula Proikas-Cezanne, University of Tuebingen, Germany
Regulation of WIPI Beta-Propeller Function in Autophagy

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 7 of 10
* Masaaki Komatsu, Juntendo University School of Medicine, Japan
ER-phagy Mediated by the Ufm1-System

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 8 of 10
Carmine Settembre, Telethon Foundation, Italy
Short Talk: Selective Autophagy of the Endoplasmic Reticulum (ER-phagy): From Cellular Functions to Signalling Regulation

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 9 of 10
Paul J. Wrighton, Brigham and Women's Hospital, USA
Short Talk: Live and Quantitative Imaging Reveals in vivo Dynamics and Molecular Basis of Physiological-Stress Induced Mitophagy

Wednesday, October 07 | 6:00AM - 10:00AM
Autophagy and Organelle Crosstalk (6am Denver/Mountain Time
Start)


Speaker 10 of 10
Thanh N. Nguyen, Monash University, Australia
Short Talk: Atg4 Family Proteins Drive Phagophore Growth Independently of the LC3/GABARAP Lipidation System

Wednesday, October 07 | 10:00AM - 12:00PM
Poster Session 2 (10am Denver/Mountain Time Start)


Wednesday, October 07 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 1 of 3
Jennifer Martinez, NIEHS, National Institutes of Health, USA

Wednesday, October 07 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 2 of 3
Alicia Melendez, Queens College - CUNY, USA

Wednesday, October 07 | 12:00PM - 1:00PM
Career Roundtable (12pm Denver/Mountain Time Start)

Speaker 3 of 3
Leon O. Murphy, Casma Therapeutics, USA

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 1 of 12
* Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 2 of 12
Guido Kroemer, Cordeliers Research Center, France
Autophagy and Obesity

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 3 of 12
Anna Katharina Simon, University of Oxford, UK
Cell-Extrinsic Role of Autophagy in Inflammation

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 4 of 12
Hong Zhang, Chinese Academy of Sciences, China
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Regulate Autophagy Activity

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 5 of 12
* Martin Graef, Max Planck Institute for Biology of Aging, Germany
Autophagy and Cellular Aging

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)



Coffee Break

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 7 of 12
Leon O. Murphy, Casma Therapeutics, USA
New Mechanistic Insight into the Regulation of TFEB at the Lysosome

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 8 of 12
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
New Therapies for Infectious Diseases

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 9 of 12
Aditya Murthy, Genentech, Inc., USA
Short Talk: Multiplexed Proteomics in Macrophages Uncovers Novel Roles of Autophagy in Anti-Microbial Immunity

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 10 of 12
Yasin Dagdas, Gregor Mendel Institute, Austria
Short Talk: A Cross-Kingdom Conserved ER-Phagy Receptor Maintains Endoplasmic Reticulum Homeostasis during Stress

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 11 of 12
Yanxiang (Jessie) Guo, Rutgers University, USA
Short Talk: Autophagy Compensates for Lkb1 Loss to Maintain Adult Mice Homeostasis and Survival

Thursday, October 08 | 6:00AM - 10:00AM
Autophagy and Disease, New Therapeutic Opportunities (6am De
nver/Mountain Time Start)


Speaker 12 of 12
Nicolas Dupont, INSERM U1151 Université de Paris, France
Short Talk: The Primary Cilium and Lipophagy Translate Mechanical Forces to Direct Metabolic Adaptation of Kidney Epithelial Cells

Thursday, October 08 | 10:00AM - 10:10AM
Closing Remarks (Organizers) (10am Denver/Mountain Time Star
t)


*Session Chair.