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Sunday, January 23 | 4:00PM - 8:00PM
Registration
Arrival and Registration
Room: Colorado Ballroom Foyer


Sunday, January 23 | 6:00PM - 8:00PM
Welcome Mixer

Room: Colorado Ballroom Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 24 | 7:00AM - 8:00AM
Breakfast

Room: Summit Gallery


Monday, January 24 | 8:00AM - 9:00AM
Keynote Address
Welcome and Keynote Address
Room: Colorado Ballroom


Monday, January 24 | 9:00AM - 11:00AM
Plenary AM
When, How and Who Does Mtb Infect?
Room: Colorado Ballroom


Robin Wood, University of Cape Town, South Africa
TB Control and the Air We Breathe

Coffee Break

Richard F. Silver, Case Western Reserve University School of Medicine, USA
Infection and Immunity in the Lung


Lalita Ramakrishnan, University of Cambridge, UK
Latent TB: Does it Exist and if so what is It?

Rein Houben, LSHTM, UK
Short Talk: Quantifying the Thresholds and Pathways Following Mtb Infection

Hanif Esmail, University College London, UK
Short Talk: A 5-year Follow-up Study of Subclinical TB Identified by FDG-PET/CT in Asymptomatic, HIV Uninfected Household Contacts of Drug-resistant TB

† Nadege Nziza, Ragon Institute, USA
Short Talk: Discriminatory Antibody Footprints Across Active and Latent Tuberculosis

Monday, January 24 | 11:00AM - 5:00PM
On Own for Lunch



Monday, January 24 | 11:00AM - 1:00PM
Poster Setup

Room: Breckenridge Ballroom


Monday, January 24 | 1:00PM - 10:00PM
Poster Viewing

Room: Breckenridge Ballroom


Monday, January 24 | 2:30PM - 4:30PM
Workshop
Workshop 1: Novel Approaches to TB Therapy
Room: Colorado Ballroom


* Alan Sher, NIAID, National Institutes of Health, USA

Monique Theriault, Cornell University, USA
Metabolic Crosstalk and its Impacts on M. Tuberculosis Pathogenesis and Drug Discovery

Sadiya Parveen, Johns Hopkins School of Medicine, USA
A Novel Glutamine Metabolism Antagonist Inhibits Mtb Proliferation in Mice by a Mechanism Involving Immune Cell Metabolic Reprogramming

Conor Grant, Trinity College Dublin, Ireland
Tuberculosis Infection Reduces Macrophage Expression of Vitamin A Metabolism and Transport Genes

† Kathryn Rahlwes, UT Southwestern ME, USA
The Role of Deubiquitinating Enzymes during Mycobacterium Tuberculosis Infection of Macrophages

Harim Won, Harvard T.H. Chan School of Public Health, USA
Targeted Protein Self-degradation as a Novel Therapeutic Strategy for Tuberculosis

Jennie Ruelas Castillo, Johns Hopkins School of Medicine, USA
The Heme Oxygenase-1 Metalloporphyrin Inhibitor Stannsoporfin Enhances the Activity of a Novel Regimen for Multidrug-Resistant Tuberculosis in a Murine Model

Arnaud Machelart, Pasteur Institut of Lille, France
Intrinsic Antibacterial Activity of Beta-cyclodextrins Potentiates their Effect as Drug Nanocarriers Against Tuberculosis

Vivek V. Thacker, École Polytechnique Fédérale de Lausanne, Switzerland
Microphysiological Systems as New Infection Models for Tuberculosis

Monday, January 24 | 4:30PM - 5:00PM
Coffee Available

Room: Colorado Ballroom Foyer


Monday, January 24 | 5:00PM - 7:00PM
Plenary PM
TB Lessons from Co-Morbidities and Susceptible Hosts
Room: Colorado Ballroom


Lele Rangaka, University College London, UK
How HIV Co-Infection Changed our Perspective on TB

Blanca I. Restrepo, University of Texas HSC Houston, Brownsville Campus, USA
TB-Diabetes in Adults vs Elderly: Unexpected Interactions

Joseph Keane, Trinity College Dublin, Ireland
Cytokines Blockers and Tuberculosis Susceptibility

Brendan K. Podell, Colorado State University, USA
Short Talk: The Impact of Vitamin A Deficiency on Tuberculosis Progression

Annie Mayer Bridwell, Washington University School of Medicine, USA
Short Talk: Altered Diabetic Neutrophil Function as a Driver of Increased Susceptibility to M. Tuberculosis

Monday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites

Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, January 24 | 7:30PM - 10:00PM
Posters
Poster Session 1
Room: Breckenridge Ballroom


Tuesday, January 25 | 7:00AM - 8:00AM
Breakfast

Room: Summit Gallery


Tuesday, January 25 | 8:00AM - 11:00AM
Plenary AM
Breakthroughs in TB Chemotherapy, Drug Resistance and Assessing Therapeutic Outcome

Room: Colorado Ballroom


Clifton E. Barry III, NIAID, National Institutes of Health, USA
Clinical Trials, from the British Medical Research Council to PreDictTB

Valerie Mizrahi, University of Cape Town, South Africa
Opportunities and Challenges in Early-Stage TB Drug Discovery: Targeting DNA Replication as a Case Study

Coffee Break

David Barros, GlaxoSmithKline, Spain
Current Clinical Candidates for TB Treatment

Veronique Anne Dartois, Hackensack Meridian Health, USA
Re-Imagining Tuberculosis Pharmacology

Francesca Tomasi, Harvard T. H. Chan School of Public Health, USA
Short Talk: Peptidyl tRNA Hydrolase is Required to Maintain Pools of Charged tRNA in Mycobacterium tuberculosis

Divya Tiwari, Queen Mary University of London, UK
Short Talk: Characterizing Antimicrobial and Immunomodulatory Effects of Inhibiting M. Tuberculosis Biotin Protein Ligase

Gregory H. Babunovic, Harvard T.H. Chan School of Public Health, USA
Short Talk: Carrots and Consumption - How Retinoic Acid Elicits Macrophage Control of Mycobacterium tuberculosis

Tuesday, January 25 | 11:00AM - 5:00PM
On Own for Lunch



Tuesday, January 25 | 11:00AM - 1:00PM
Poster Setup

Room: Breckenridge Ballroom


Tuesday, January 25 | 1:00PM - 10:00PM
Poster Viewing

Room: Breckenridge Ballroom


Tuesday, January 25 | 2:30PM - 4:30PM
Workshop
Workshop 2: Young Investigator Workshop
Room: Colorado Ballroom


Stephen M. Carpenter, Case Western Reserve University, USA
Human Memory CD4+ T cells that Directly Recognize Macrophages Infected with Mycobacterium Tuberculosis are a Distinct and Smaller Subset of those that are Antigen-specific

Munyaradzi Nyasha Musvosvi, University of Cape Town, South Africa
Distinct Specificities in the aß T cell Response to Mycobacterium Tuberculosis Infection: Control Versus Disease Progression

Tyler D. Bold, University of Minnesota, USA
Human Immunology at the Site of HIV-Associated Tuberculosis Meningitis Infection Reveals Interferon Signatures Associated with Impaired Bacterial Control

Riti Sharan, Texas Biomedical Research Institute, USA
Impact of Timing of Antiretroviral Therapy on LTBI Reactivation in TB/SIV Co-Infection Model

Alissa C. Rothchild, University of Massachusetts Amherst, USA
Vaccination Modulates Early Innate Responses by Alveolar Macrophages to Mycobacterium Tuberculosis

† Mark R. Cronan, Max Planck Institute for Infection Biology, Germany
A New Role for Type 2 Immunity in Tuberculosis Pathogenesis

Sladjana Prisic, University of Hawaii at Manoa, USA
Two-in-one: Zinc Limitation Triggers Formation of a Distinct Subpopulation of Mycobacterium tuberculosis

Shuyi Ma, University of Washington, USA
Network-centric Functional Dissection of Ser/Thr Kinase Regulation in Mycobacterium Tuberculosis

Tuesday, January 25 | 4:30PM - 5:00PM
Coffee Available

Room: Colorado Ballroom Foyer


Tuesday, January 25 | 5:00PM - 7:00PM
Plenary PM
The Host-Pathogen Interaction: An Emerging Focus on Immunometabolism

Room: Colorado Ballroom


Shabaana A. Khader, Washington University School of Medicine, USA
Role of Immunometabolism in MDR TB

David G. Russell, Cornell University, USA
The Causes and Consequences of Macrophage Diversity in Tuberculosis in Vivo.

Adrie J. C. Steyn, Africa Health Research Institute & UAB, South Africa
Metabolic Mechanisms and Clinical Phenotypes

Eduardo Pinheiro Amaral, NIAID, National Institutes of Health, USA
Short Talk: GPX4/BACH1 Axis Regulates Necrotic Cell Death and Host Resistance in Mycobacterium Tuberculosis Infection in vivo by Modulating both Glutathione and Iron Metabolism

Pallavi Chandra, Washington University School of Medicine, USA
Short Talk: Macrophage Global Metabolomics Identifies Cholestenone as a Mycobacterium Tuberculosis-host Co-metabolite Present in Human Tuberculosis Infection

Tuesday, January 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites

Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, January 25 | 7:30PM - 10:00PM
Posters
Poster Session 2
Room: Breckenridge Ballroom


Wednesday, January 26 | 7:00AM - 8:00AM
Breakfast

Room: Summit Gallery


Wednesday, January 26 | 8:00AM - 10:30AM
Plenary AM
Recent Advances in Understanding Immune Correlates of Protection

Room: Colorado Ballroom


Elisa Nemes, University of Cape Town, South Africa
Immune Correlates of Protection in Human BCG and M72:ASO1E Trials

Frank Verreck, Biomedical Primate Research Center, Netherlands
Mucosal revaccination after intradermal BCG prevents TB disease in rhesus macaques

Coffee Break

Anne O'Garra, Francis Crick Institute, UK
Cross-Host Species Immune Correlates

Rosemary V. Swanson, Washington University in St. Louis, USA
Short Talk: Antigen-Specific B Cells Direct T Follicular-like Helper Cells into Lymphoid Follicles to Mediate Mycobacterium Tuberculosis Control

Ben Gern, Seattle Children's Research Institute, USA
Short Talk: Dissecting the Immune Regulation of Tuberculosis Granuloma Structure

† Taylor Foreman, National Institutes of Health, USA
Short Talk: Rapid Depletion of CD4 T Cells in Tuberculosis Granulomas Following SIV Co-infection

Wednesday, January 26 | 10:30AM - 11:00AM
Plenary AM
Special Lecture
Room: Colorado Ballroom


Sara Suliman, University of California, San Francisco, USA
Opportunities and Challenges in TB Research from a Young Investigator's Perspective

Wednesday, January 26 | 11:00AM - 5:00PM
On Own for Lunch



Wednesday, January 26 | 11:00AM - 1:00PM
Poster Setup

Room: Breckenridge Ballroom


Wednesday, January 26 | 1:00PM - 10:00PM
Poster Viewing

Room: Breckenridge Ballroom


Wednesday, January 26 | 2:30PM - 4:30PM
Workshop
Workshop 3: Vaccination and Immune Correlates
Room: Colorado Ballroom


Fergal Duffy, Seattle Children's Research Institute, USA
A Mouse-Derived Transcriptional Signature of Mtb Containment Predicts Human Outcomes

Dylan Sheerin, WEHI, Australia
Relationship of Blood Transcriptomic Signatures to Radiographic and Microbiologic Phenotype in a Cohort of Asymptomatic Tuberculosis Household Contacts

Michaela Reichmann, University of Southampton, UK
Investigating Tuberculosis Pathogenesis through Integrated Transcriptomic Analysis of Human Granulomas and a Biomimetic Model

† Allison Nicole Bucsan, NIH, USA
IV-BCG Dose Ranging Study in Non-human Primates to Investigate Correlates of Vaccine-Mediated Protection against Tuberculosis

Joshua M. Peters, Massachusetts Institute of Technology, USA
Intravenous BCG Protection is Associated with Primed Cell Circuits Activated upon Secondary Challenge

Maphe Mthembu, Africa Health Research Institute, South Africa
Discrepancy Between Mtb-specific IFN? and Mtb-specific IgG Responses in HIV+ People with Low CD4 Counts

Kievershen Nargan, Africa Health Research institute, South Africa
RNAscope and Immunohistochemistry Reveals Bacilli Previously Undetected in Human Pulmonary TB Tissue Samples

† Marjorie Nakibuule, MRC/UVRI and LSHTM, Uganda
B Cell Frequency in the Lungs of Active TB Patients with HIV. A TB Postmortem Study

Wednesday, January 26 | 4:30PM - 5:00PM
Coffee Available

Room: Colorado Ballroom Foyer


Wednesday, January 26 | 5:00PM - 7:00PM
Plenary PM
Moving TB Vaccine Research Forward in the Next 50 Years: New Perspectives and Opportunities

Room: Colorado Ballroom


Thomas J. Scriba, University of Cape Town, South Africa
Overview: Recent Advances in Clinical Vaccine Development

Iman Satti, Oxford University, UK
Aerosol Vaccination and Human Challenge Models

Maziar Divangahi, McGill University, Canada
Immune Mechanism in TB vs Respiratory Virus Infection: Learning from Each Other

Rocky Lai, University of Massachusetts Medial School, USA
Short Talk: Vaccine-mediated Protection in Genetically Diverse Collaborative Cross - A model for pre-clinical vaccine testing

Wednesday, January 26 | 6:30PM - 7:15PM
Keynote Address
Closing Keynote Address
Room: Colorado Ballroom


Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
The Future of TB Research and Control in an Age of Viral Pandemics

Wednesday, January 26 | 7:15PM - 7:30PM
Plenary
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Colorado Ballroom


Wednesday, January 26 | 7:30PM - 8:30PM
Social Hour with Lite Bites

Room: Breckenridge Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 26 | 8:00PM - 10:00PM
Posters
Poster Session 3
Room: Breckenridge Ballroom


Thursday, January 27 | 8:29AM - 8:29AM
Departure



*Session Chair
†Invited, not yet responded.

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