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Sunday, January 23 | 4:00PM - 8:00PM
Registration
Arrival and Registration
Room: British/Columbia Foyer


Sunday, January 23 | 6:00PM - 8:00PM
Welcome Mixer

Room: British/Columbia Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 24 | 7:00AM - 8:00AM
Breakfast

Room: Pacific Ballroom


Monday, January 24 | 8:00AM - 9:00AM
Keynote Address
Welcome and Keynote Address
Room: British Ballroom


Ivan Dikic, Goethe University Medical School, Germany
Phosphoribosyl-Dependent Ubiquitination and Pathogenesis

Monday, January 24 | 9:00AM - 11:15AM
Plenary AM
Regulating Nuclear Function with Ubiquitin
Room: British Ballroom


Niels Mailand, University of Copenhagen, Denmark
Ubiquitin-Dependent Signaling in the DNA Damage Response

Coffee Break

Jo R. Morris, University of Birmingham, UK
SUMOylation in the DNA Double-Strand Break Response

Lori A. Passmore, MRC Laboratory of Molecular Biology, UK
Monoubiquitination in DNA Crosslink Repair

Tom Deegan, University of Edinburgh, UK
Short Talk: A Conserved Mechanism for Regulating Replisome Ubiquitylation and Disassembly in Eukaryotes

Stefan Muller, Goethe University Frankfurt, Germany
Short Talk: Safeguarding Proteome and Genome Integrity by Sumo-ubiquitin Networks

Imke Leonie Lemmer, LMU Munich, Germany
Short Talk: Nfe2l1 Shapes the Muscle Ubiquitome to Regulate Fiber Type and Metabolic Fitness

Monday, January 24 | 9:00AM - 11:15AM
Plenary AM
Proteolysis Targeting Chimeras (PROTACs)
This session is from Targeted Protein Degradation
Room: Columbia Ballroom


Alessio Ciulli, University of Dundee, School of Life Sciences, UK
Structural Chemical Biology and Insights into PROTAC Mechanism of Action

Coffee Break

Nathanael Gray, Stanford University, USA
Targeting Kinases Via Protein Degradation

Shaomeng Wang, University of Michigan, USA
Targeting Transcriptional Factor STAT3 and Other STAT Proteins by PROTAC

Short Talk(s) Chosen from Abstracts


Monday, January 24 | 11:15AM - 5:00PM
On Own for Lunch



Monday, January 24 | 11:15AM - 1:00PM
Poster Setup

Room: Pacific Ballroom


Monday, January 24 | 1:00PM - 10:00PM
Poster Viewing

Room: Pacific Ballroom


Monday, January 24 | 4:30PM - 5:00PM
Coffee Available

Room: British/Columbia Foyer


Monday, January 24 | 5:00PM - 7:00PM
Plenary PM (JT)
Mechanisms of Protein Ubiquitylation and Degradation (Joint)
Room: British/Columbia Ballroom


Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Cullin-RING E3 Ligation Mechanisms

Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Zinc Finger Degrome

Kylie J. Walters, NCI, National Institutes of Health, USA
Outskirts of the Proteasome: Substrate Receptors and Beyond

Weaam Ibrahim Mohamed, Institute of Biochemistry, Switzerland
Short Talk: Regulation of RING E3 Ubiquitin Ligases by Oligomerization: What do we Learn from CRL4(DCAF1) and the hGID Complexes?

Monday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites

Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, January 24 | 7:30PM - 10:00PM
Posters
Poster Session 1
Room: Pacific Ballroom


Tuesday, January 25 | 7:00AM - 8:00AM
Breakfast

Room: Pacific Ballroom


Tuesday, January 25 | 7:30AM - 8:00AM
Poster Setup

Room: Pacific Ballroom


Tuesday, January 25 | 8:00AM - 7:00PM
Poster Viewing

Room: Pacific Ballroom


Tuesday, January 25 | 8:00AM - 11:00AM
Plenary AM (JT)
Strategies for Therapeutic Targeting of the Ubiquitin Proteasome System (Joint)

Room: British/Columbia Ballroom


Mikko Taipale, University of Toronto, Canada
Functional Genomics by Induced Proximity

Eva d'Hennezel, Novartis Institutes of Biomedical Research, USA
Strategies for Therapeutic Targeting of the UPS

Simone Bonazzi, Novartis Institutes of Biomedical Research, USA
Strategies for Therapeutic Targeting of the UPS (cont)

Coffee Break

Sara Buhrlage, Dana-Farber Cancer Institute, USA
Approaches to Identify New DUB Inhibitors

Ingrid E. Wertz, Bristol Myers Squibb, USA
Identification, Development, and Characterization of Inhibitors for Deubiquitinating Enzymes

Mandeep Kaur Mann, University of Toronto, Canada
Short Talk: Discovery of First-in-class USP5 Inhibitors

Tuesday, January 25 | 11:00AM - 12:30PM
Lunch

Room: Pacific Ballroom


Tuesday, January 25 | 12:00PM - 2:30PM
Posters
Poster Session 2
Room: Pacific Ballroom


Tuesday, January 25 | 2:30PM - 4:30PM
Workshop
Workshop
Room: British Ballroom


Thang V. Nguyen, University of Missouri, School of Medicine, USA
USP15 Antagonizes CRL4CRBN-mediated Ubiquitylation of Glutamine Synthetase and Neo-substrates

Darren M. O'Hara, Almac Discovery, UK
Discovery of a Novel USP19 Inhibitor with Muscle Sparing Activity in vivo

† Jason Qichen Tang, University of Toronto, Canada
Expanding the Druggable Space for USPs by Targeting Accessory Domains

Sammy Villa, University of California, USA
The OTUD6 Deubiquitinase Associates with 40S Ribosomes to Regulate Translation and Responses to Stressors in Drosophila

Jonathan W. Bushman, Harvard Medical School, USA
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors

Alexa Nadine Wilson, Dalhousie University, Canada
Stressed Out: How a Herpesvirus E3 Ubiquitin Ligase Targets the Cellular Stress Response

Ivan Mwebaza, Case Western Reserve University, USA
Mycobacterium Tuberculosis Derived Mannosylated Lipoarabinomannan
Upregulates E3 Ligases that Mediate Degradation of Proximal TCR Signaling Kinases in Human CD4+ T Cells Leading to Suboptimal Activation


† Rashmi Agrata, National Centre for Biological Sciences, TIFR, India
UBC13 Deamidation by Shigella Flexneri Disrupts its Interactions with TRAF6 (RING E3) to Impair Ubiquitination

Tuesday, January 25 | 4:30PM - 5:00PM
Coffee Available

Room: British/Columbia Foyer


Tuesday, January 25 | 5:00PM - 7:00PM
Plenary PM
Ubiquitin-Dependent Quality Control Mechanisms
Room: British Ballroom


Sonya Neal, University of California, San Diego, USA
The Role of Rhomboid Pseudoprotease Dfm1 in ERADicating Misfolded Membrane Proteins

Eric J. Bennett, University of California, San Diego, USA
Ribosome Associated Quality Control Mechanisms

Susan Shao, Harvard Medical School, USA
Mechanisms of Ribosome-Associated Protein Degradation

Miguel A. Prado, Harvard Medical School, USA
Short Talk: Global Remodeling of the Proteome in Terminal Differentiation

Olivia Rissland, University of Colorado School of Medicine, USA
Short Talk: Clearance of Maternal Proteins during Early Embryogenesis

Tuesday, January 25 | 5:00PM - 7:00PM
Plenary PM
Novel Approaches to Protein Degradation/Homeostasis for Therapeutics
This session is from Targeted Protein Degradation

Room: Columbia Ballroom


Speaker to be Announced

Eric S. Fischer, Dana-Farber Cancer Institute, USA
How Structural Biology will Transform Targeted Protein Degradation?

Speaker to be Announced

Short Talk(s) Chosen from Abstracts


Tuesday, January 25 | 7:00PM - 7:00PM
On Own for Dinner



Wednesday, January 26 | 7:00AM - 8:00AM
Breakfast

Room: Pacific Ballroom


Wednesday, January 26 | 8:00AM - 11:00AM
Plenary AM
New Paradigms in Protein Ubiquitylation
Room: British Ballroom


Emily Troemel, University of California, San Diego, USA
Ubiquitin Signaling within the Intracellular Pathogen Response Pathway

Heran Darwin, New York University School of Medicine, USA
Proteasomal Regulation of Mycobacterial Virulence

Coffee Break

Katerina Artavanis-Tsakonas, University of Cambridge, UK
How Parasites Interfere with and Manipulate the Host Ubiquitin-Proteasome System

Satpal Virdee, University of Dundee, UK
Non-lysine Ubiquitination and Deubiquitination

Joshua L. Andersen, Brigham Young University, USA
Short Talk: TNK1 is a Ubiquitin-sensing Kinase that can be Targeted to Block Tumor Growth

Vincent Chu, Harvard Medical School, USA
Short Talk: Selective Destabilization of Polypeptides Synthesized from NMD-targeted Transcripts

Luis Gerardo Villa-Diaz, Oakland University, USA
Short Talk: Enhanced Ubiquitin Pathway Regulation in Human Pluripotent Stem Cells Cultured in Microgravity Conditions

Wednesday, January 26 | 8:00AM - 11:00AM
Plenary AM
Novel Approaches to the Development and Discovery of Molecular Glues
This session is from Targeted Protein Degradation

Room: Columbia Ballroom


Anita K. Gandhi, Bristol-Myers Squibb, USA
Emerging CELMoDs in Hematological Malignancies

Daniel K. Nomura, University of California, Berkeley, USA
Reimagining Druggability using Chemoproteomic Platforms

Coffee Break

Georg E. Winter, CeMM Research Center for Molecular Medicine, Austria
Chemical Genomics Approaches to Targeted Protein Degradation

Ekaterina Vinogradova, Rockefeller University, USA
Covalent Small-Molecule Protein Degraders

Short Talk(s) Chosen from Abstracts


Wednesday, January 26 | 11:00AM - 5:00PM
On Own for Lunch



Wednesday, January 26 | 4:30PM - 5:00PM
Coffee Available

Room: British/Columbia Foyer


Wednesday, January 26 | 5:00PM - 6:45PM
Plenary PM
Ubiquitin System Dysregulation in Disease
Room: British Ballroom


J. Wade Harper, Harvard Medical School, USA
Systematic Analysis of Ubiquitin System Dysfunction in Mitochondrial Disorders

James A. Olzmann, University of California, Berkeley, USA
Lipid Droplet Proteome Dynamics and lipotoxicity

Michael Rape, University of California, Berkeley, USA
The Role of Heterotypic Ubiquitin Chains in Protein Quality Control

Achim Werner, NIDCR, National Institutes of Health, USA
Short Talk: Ubiquitin-dependent Restriction of CDC42 Signaling Specifies Embryonic Patterning

Wednesday, January 26 | 5:00PM - 6:45PM
Plenary PM
Methodologies and Technologies for the Investigation of Protein Degradation
This session is from Targeted Protein Degradation

Room: Columbia Ballroom


Steven P. Gygi, Harvard Medical School, USA
Reimagining Fragment Based Multiplexed Chemical Proteomics for Cell Based Screening of Large Electrophile Libraries

Rajesh Chopra, Apple Tree Partners, USA
Phenotypic Screens for Identifying Modulators of E3 Ligase Function

Hsueh-Chi S. Yen, Academia Sinica, Taiwan
C-Terminal End-Directed Protein Elimination by
CRL2 Ubiquitin Ligases


Short Talk(s) Chosen from Abstracts


Wednesday, January 26 | 6:45PM - 7:00PM
Plenary
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: British Ballroom


Wednesday, January 26 | 6:45PM - 7:00PM
Plenary
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from Targeted Protein Degradation
Room: Columbia Ballroom


Wednesday, January 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites

Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 26 | 8:00PM - 9:00PM
Cash Bar

Room: Pacific Ballroom


Thursday, January 27 | 10:29AM - 10:29AM
Departure



*Session Chair
†Invited, not yet responded.

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