T Lymphocyte Activation, Differentiation and Death
Organizer(s): Laurie H. Glimcher, Gerald R. Crabtree and Harvey I. CantorDate: January 16 - 22, 2002
Location: Keystone Resort, Keystone, CO, USA
There have been substantial advances in molecular and cellular biology that have provided new insight into the biochemical and genetic basis of lymphocyte recognition, activation and expression of distinct functional phenotypes. It has now become evident that for both T and B cells, stimuli delivered through their receptors can result in either clonal expansion or apoptosis. In the case of T cells, clonal expansion of helper cells is accompanied by differentiation into two major functional subsets which regulate the immune response. The pathways between the membrane and the nucleus and their molecular components are an area of very active investigation. This meeting will draw together scientists working on diverse aspects of this problem, including receptor ligand interactions, intracellular pathways that transmit receptor mediated signals and the effect of such signal transduction pathways on gene regulation. The implications and applicability of these processes for human disease will be considered as well. The aim of this meeting is to integrate the information from these various experimental approaches into a new synthesis and molecular explanation of T cell activation, differentiation and death.
Discounted Abstract Deadline: October 1 2001
Discounted Registration Deadline: November 16 2001
We gratefully acknowledge additional support for this conference from: