Regulation of Cellular Responses by Lipid Mediators
Organizer(s): Philip W. Majerus and Stephen M. PrescottDate: February 01 - 06, 2002
Location: Sagebrush Inn & Suites, Taos, NM, USA
This symposium will consider intracellular lipid messengers that evoke cell responses following activation by agonists. We will emphasize how these messengers interact with other signaling pathways. For example activation of phosphatidylinositol signaling to yield inositol phosphates and DAG interact with many cellular effector molecules including those with FYVE and PH domains. For example PDK-I, AKT, p70S6K, GSK-3 and a number of guanine nucleotide exchange factors. Receptors also activate PI kinases and phosphatases and the functions of many of the products of these reactions have recently been shown to have signaling roles. InsP5 and InsP6 have recently been shown to be required for mRNA export and some transcription reactions in yeast. The tumor suppressor gene PTEN is an inositol phosphatase as is SopB a Salmonella virulence factor that is essential for pathogenesis. Additional defects in these lipid-signaling pathways are associated with diseases including an inositol phosphatase in LOWE syndrome and a PLC in drosophila NORPA which cause blindness. Other signals are initiated by PLA-2 and PLD. These sessions will emphasize downstream events such as the targets for phosphatidic acid and the mechanisms whereby COX-2 products are tumorigenic (e.g., their role in activating PPARs and their alteration of NFkB and p53-dependent transcription).
Discounted Abstract Deadline: October 1 2001
Discounted Registration Deadline: November 30 2001