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Web Desc
Proteolytic Enzymes as Therapeutic Targets
Organizer(s): Robert L. Heinrikson and Jan Potempa
Date: February 03 - 08, 2002
Location: Keystone Resort, Keystone, CO, USA
Sponsored in part by The Director's Sponsor Fund
Summary of Meeting:
Proteolytic enzymes play roles in almost every biological system, and they have proven to be important therapeutic targets for drug development. Inhibitors of angiotensin converting enzyme (ACE) represent a major success in benefiting sufferers of hypertension. HIV-protease inhibitors have literally changed the duration and quality of life of AIDS patients. Discoveries of new proteases continue unabated, and it remains a problem of how to develop inhibitors of these enzymes as drugs. Currently, the proteases involved in liberating the toxic Abeta peptide that accumulates in Alzheimer's Disease represent a topic of intense interest. Cysteinyl proteases such as caspases and virally encoded enzymes are also current targets with inhibitors entering clinical trials. This meeting will update, and facilitate scientific exchanges among investigators working on a spectrum of proteases that have been shown to participate in biological pathways relevant to human disease.
Discounted Abstract Deadline: November 2 2001
Discounted Registration Deadline: December 3 2001
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1 R13 AG20281-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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