Structural Genomics: From Gene Sequence to Function
joint with Frontiers of Structural Biology
Organizer(s): Gaetano T. Montelione, Barry Honig and Wayne A. HendricksonDate: January 05 - 11, 2002
Location: Beaver Run Resort, Breckenridge, CO, USA
Structural Genomics represents a new area at the interface between structural biology and genomic sciences. The various genome sequencing projects provide new opportunities and challenges to the field of structural biology, as many synergies exist between the information provided by the expanding database of linear sequences and three-dimensional structures of proteins. The goals of structural genomics include: (1) Coverage of sequence space in terms of protein structure by determination of a representative three-dimensional (3D) structure from each of 10,000 - 30,000 sequence clusters and homology modeling of all the corresponding proteins; (2) Analysis of the 3D structures of all the proteins coded by entire genomes; and (3) Structure-based Functional Genomics in which the biochemical functions of proteins are identified using clues provided by 3D structure analysis. The field of Structural Genomics is driven by developments in the areas of bioinformatics, molecular biology and protein production, X-ray crystallography, NMR spectroscopy, and homology modeling. Major challenges involve developing a sound scientific basis for target selection, high throughput protein production and crystallization, rapid X-ray crystallographic and NMR data collection, automated methods for generating 3D structures from these data, organization of these data into databases, and retrospective analysis of the data to develop broad understanding of protein evolution and structure / function relationships. Structural Genomics provides a new paradigm for structural biology and pharmaceutical development. This Keystone meeting will bring together key players in the international community to: (1) assess the feasibility and value of high throughput structure determination as a key component of an International Structural Genomics Initiative, (2) assess the scientific validity of various target selection strategies, and (3) foster international cooperation in this nascent field.
Discounted Abstract Deadline: September 17 2001
Discounted Registration Deadline: November 5 2001