HIV Pathogenesis: Recent Advances in the Biology and Pathogenesis of Primate Lentiviruses
joint with HIV-1 Protection and Control by Vaccination
Organizer(s): Mario Stevenson, Bryan R. Cullen, Beatrice H. Hahn and Ronald C. DesrosiersDate: April 05 - 11, 2002
Location: Keystone Resort, Keystone, CO, USA
Steady advances are being made in understanding the functions of viral regulatory genes in virus replication and pathogenecity. However, there has been relatively little advance in attempting to exploit such regulatory proteins as antiviral targets. One goal of the meting would be to stimulate discussion on what regulatory protein functions could be exploited for antiviral strategies. Several emerging studies suggest that HIV-1 replication may persist in the host despite suppression of virus replication to below detectable limits by current plasma-based viral RNA assays. Thus, highly active antiretroviral therapy in its current form appears to be incapable of eradicating these reservoirs. The task ahead is to identify the nature of the persistent reservoir and to develop alternate strategies to more effectively control virus replication. In an attempt to establish the underlying basis for lymphocyte depletion in HIV-1 infection, investigators are taking various approaches to evaluate various aspects of the hematopoietic function, lymphocyte maturation, lymphocyte turnover and compartmentalization. These approaches are providing a more complete understanding of how primate lentiviruses affect lymphocyte depletion. In addition, these studies are providing important information on the processes that regulate hematopoiesis and lymphocyte function in humans. This information is critical to immune-based strategies to restore immune function in immunocompromised HIV-1 infected individuals. We believe that the meeting format will provide a unique opportunity for scientists with interests in AIDS immunology, virology and pathogenesis to be appraised of and to discuss the most exciting research developments and major problems in AIDS research. Such a forum does not exist outside of the National AIDS and Human Retrovirus meeting, however, the small size of the Keystone Symposium allows the intimacy in which scientific ideas can be exchanged and such an intimacy is not provided by the National AIDS meeting.
Discounted Abstract Deadline: December 13 2001
Discounted Registration Deadline: February 5 2002