Conformational Diseases of the Secretory Pathway
Organizer(s): Randal J. Kaufman and Tom A. RapoportDate: March 01 - 06, 2003
Location: Sagebrush Inn & Suites, Taos, NM, USA
In eukaryotes, nascent unfolded polypeptides achieve conformational maturation in the endoplasmic reticulum prior to cell surface expression or secretion. Particular mutations in the primary amino acid sequence can hinder the attainment of native protein structure, causing protein folding and quality control systems in the early secretory pathway to participate in the molecular pathogenesis of those human diseases where there is selective degradation or accumulation of a structurally-alerted gene product. The conference will focus on recent experimental findings that have begun to more fully dissect the complexity and diversity of these systems. The objectives are to stimulate a multi-disciplinary understanding of how specific covalent modifications and molecular chaperones facilitate protein folding, elucidate the repertoire of conformation-based monitoring and disposal systems, and define the complexity of cellular responses to the accumulation of aberrant molecules. An outcome will be the design of pharmacological strategies to enhance the intracellular transport of potentially salvageable molecules.
Discounted Abstract Deadline: November 1 2002
Discounted Registration Deadline: January 3 2003
We gratefully acknowledge additional support for this conference from:
Affinity BioReagents, Inc.