Molecular Aspects of Transmissible Spongiform Encephalopathies (Prion Diseases)
Organizer(s): Byron Caughey, Charles Weissmann, Suzette Priola and Bruce ChesebroDate: April 02 - 06, 2003
Location: Beaver Run Resort, Breckenridge, CO, USA
The epidemic of bovine spongiform encephalopathy and its spread into humans has led to a marked expansion of research on the molecular bases of transmissible spongiform encephalopathies (TSE) or prion diseases. Studies with transgenic and prion protein (PrP)-knockout mice have established that PrP is critical in TSE transmission and pathogenesis. Much has been learned about the normal structure and folding options of recombinant PrP molecules and the interactions and interconversions between normal and TSE-associated PrP isoforms. Functional studies have suggested possible normal and disease associated roles for PrP. However, the essential nature of the infectious agent, the structure of TSE-associated PrP isoforms, and the mechanism(s) by which they cause disease are not yet clear. Furthermore, practical therapies and ante-mortem diagnostic tests are sorely lacking. This symposium will attempt to summarize the state of the field and to consider solutions to the problems posed by these enigmatic diseases.
Discounted Abstract Deadline: December 3 2002
Discounted Registration Deadline: February 3 2003
We gratefully acknowledge additional support for this conference from: