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Web Desc
Mast Cells in Physiology, Host Defense and Disease: Beyond IgE
Organizer(s): Melissa A. Brown, K. Frank Austen and Stephen J. Galli
Date: February 28 - March 04, 2004
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
Mast cells are critical effector cells in acute allergic reactions. In this setting, mast cell activation by antigen-dependent cross-linking of high affinity receptors for IgE (FcepsilonRI) induces the release of preformed molecules (such as histamine), as well as the synthesis and release of cytokines, chemokines, growth factors, leukotrienes and prostaglandins. However, mast cell functions can also be elicited by immune complexes, complement products, neuropeptides, cytokines and ligands of toll-like receptors. Accordingly, the proven or potential functions of mast cells include diverse, IgE-independent roles in host defense and disease (including autoimmune or cardiovascular disorders) as well as in physiological processes, such as regulation of epithelial barrier function and modulation of nerve function. This conference will assess what is currently known about the roles of mast cells and will consider how our understanding can be advanced by the application of new technologies and approaches to analyze and manipulate mast cell function.
Discounted Abstract Deadline: October 28 2003
Discounted Registration Deadline: December 29 2003
We gratefully acknowledge additional support for this conference from:
GlaxoSmithKline Research & Development, Ltd.
UCB Reseach/ UCB Pharma
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI058260-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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