siRNAs and miRNAs
Organizer(s): Thomas Tuschl and Victor AmbrosDate: April 14 - 19, 2004
Location: Keystone Resort, Keystone, CO, USA
Short double-stranded RNA molecules are important sequence-specific posttranscriptional regulators of gene expression. Two classes of such RNA molecules have been identified: small interfering RNAs (siRNAs) and microRNAs (miRNAs). While siRNAs are generally complementary to mRNAs and mediate mRNA degradation, most miRNAs are only partially complementary and are believed to act predominantly as translational regulators. siRNAs and microRNA-like siRNA precursors have become important tools for studying gene function in mammalian cells and organisms. miRNAs represent an extensive class of evolutionary conserved noncoding RNAs of about 22 nucleotide in length that are thought to regulate gene expression in metazoans. The first miRNAs to be identified were the products of the lin-4 and let-7 genes of Caenorhabditis elegans. The miRNA and RNAi pathways are fundamentally related as members of the Dicer and the Argonaute protein families are involved in both of these RNA-mediated silencing processes. The aim of this meeting is to report on progress in understanding the molecular mechanisms underlying siRNA/miRNA function, as well as the technological adaptation of these cellular mechanisms to genome-wide analysis of gene function in mammalian systems and as therapeutic agents.
Discounted Abstract Deadline: December 16 2003
Discounted Registration Deadline: February 17 2004