Golgi Apparatus and Secretory Pathway of Eukaryotic Cells
joint with Traffic Control: Rab GTPases in Vesicular Transport
Organizer(s): L. Andrew Staehelin, Benjamin Glick and Kathryn E. HowellDate: January 20 - 25, 2004
Location: Beaver Run Resort, Breckenridge, CO, USA
The Golgi apparatus plays a central role in the biosynthesis, post-translational modification, and sorting and packaging of secretory molecules. The principal biosynthetic functions of this organelle include the assembly of proteoglycans and polysaccharides for the extracellular matrix or cell wall, the processing of the oligosaccharide side chains of soluble and membrane-associated glycoproteins, and the synthesis and processing of membrane lipids. The trafficking functions of the Golgi include the transport of cargo molecules from their sites of synthesis to their final destinations. Finally, the sorting and packaging functions involve the incorporation of various cargo molecules into different types of transport carriers for delivery to other organelles, as well as the internal recycling of resident Golgi molecules. In contrast to these well-defined functions, the structural and dynamic properties of the Golgi apparatus have remained controversial. At the center of this controversy is the fact that the Golgi apparatus continually exchanges components with other organelles, including the ER, endosomes, lysosomes/vacuoles, and the plasma membrane. A further complication is that Golgi architecture differs between organisms, can change during the cell cycle, and can vary in a tissue- and developmental stage-specific manner. The resulting diversity of experimental data has continued to fuel debate about how cargo molecules move through the Golgi, how the different cisternal elements maintain their identities despite the constant flux of components, and how and where cargo molecules are sorted and packaged into transport carriers. The central goal of this symposium is to bring together a broad group of researchers interested in the secretory pathway, with an emphasis on events that occur during transport to, through, and from the Golgi apparatus. Speakers include not only researchers studying yeast and mammalian cells but also a representative group of plant researchers. This meeting addresses biosynthetic functions of the Golgi in addition to the more frequently addressed cell biological functions. In retrospect, it is now obvious that the 1998 Golgi Centennial Meeting in Pavia, Italy was instrumental in promoting the paradigm shift from the vesicular transport model to the cisternal progression/maturation model of Golgi trafficking. The central challenge for this meeting will be to identify the current frontiers in secretory pathway research, and to stimulate new avenues of investigation by integrating insights from a wide range of experimental systems.
Discounted Abstract Deadline: September 22 2003
Discounted Registration Deadline: November 20 2003