Cardiac Development and Congenital Heart Disease
joint with Molecular Biology of Cardiac Disease
Organizer(s): Deepak Srivastava and Nadia A. RosenthalDate: March 07 - 12, 2004
Location: Keystone Resort, Keystone, CO, USA
Congenital heart disease (CHD) is the most common birth defect and the leading non-infectious killer of children in the first year of life. CHD represents abnormalities of heart formation in utero. Recent advances in understanding the molecular bases for heart formation and the recognition of cross-species conservation of regulatory pathways make a Keystone Symposium on this topic timely. The prospect of combining the advances in cardiogenesis with a theme of congenital heart defects offers an opportunity to focus basic science on efforts to understand and prevent heart disease in children. In addition, basic mechanisms of cardiogenesis may be applied to efforts of tissue engineering to construct new valves, vessels or other specific cardiac structures as multi-disciplinary fields mature. Although there are some other conferences that address overlapping issues, the most similar is the Weinstein Cardiovascular Development Conference. A Keystone Symposium on this topic will greatly enhance the focus on heart development and related disease and would allow the leaders in the field to congregate at one meeting. This will provide a unique opportunity for trainees to interact with senior investigators and should spur future collaborations between investigators. Upon completion of this conference, participants should be able to: - Understand the embryologic and molecular underpinnings of heart formation as they relate to congenital heart defects, which is the leading non-infectious cause of death in the first year of life. - Appreciate advances in understanding genetic mutations that lead to defects of heart development in humans with particular attention to mechanisms of gene function. - Explore signaling and transcriptional pathways that guide early cardiac specification and later steps of cardiac morphogenesis in a region-specific manner. - Understand the contribution of cardiac neural crest cells to the heart and the genes responsible for proper cardiac migration and differentiation of this unique lineage of cells. - Stimulate new avenues of research to address the molecular basis of cell movement during critical migration steps essential for remodeling of the developing heart. - Stimulate new avenues of research to incorporate advances in cardiac development into new knowledge regarding the etiology and prevention of congenital heart disease in children.
Discounted Abstract Deadline: November 24 2003
Discounted Registration Deadline: January 7 2004
We gratefully acknowledge additional support for this conference from: