Hormonal Regulation of Tumorigenesis
Organizer(s): Nancy L. Weigel, Suzanne A. Fuqua and Donald TindallDate: February 20 - 25, 2005
Location: Hyatt Regency Monterey, Monterey, CA, USA
Steroid hormones are key factors in the development and growth of tumors in hormone dependent tissues including breast and prostate. These cancers are not only two of the most prevalent cancers, but are also second only to lung cancer in deaths from cancer. Thus, there is a great deal of interest in developing methods to block the actions/production of the steroids. The actions of the steroids are mediated by steroid hormone receptors, members of the nuclear receptor family of ligand-activated transcription factors. However, recent and ongoing studies have shown that the type and magnitude of the activities of the receptors is dependent upon the cohort of coactivators, corepressors, and activity of cell signaling pathways in the cell; these factors and their interaction with receptors are potential therapeutic targets. In both breast and prostate cancer, hormone ablation, or anti-hormone therapies are commonly used. However, tumors become resistant to these treatments. Although, it was initially assumed that these tumors had bypassed the requirements for the steroid receptors, there is exciting new data coming from a number of labs indicating that these tumors remain receptor-dependent and that alterations in receptor expression, coregulator expression and/or cell signaling permit the receptors to continue to function. Thus, there is evidence that androgen receptor is activated in tumors that have become resistant to androgen ablation and that some tamoxifen resistant tumors retain estrogen receptor dependence. Consequently, the contribution of steroid receptor action in hormonally regulated tumors is greater than initially realized and raises a new set of questions regarding how to block the receptor activity. The goal of this meeting is to bring together experts in steroid hormone action with experts in hormonal effects in tumorigenesis to address the important questions of the mechanisms by which the hormones and their receptors induce growth of tumors and how these processes can be blocked.
Discounted Abstract Deadline: October 20 2004
Discounted Registration Deadline: December 20 2004
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Wyeth Research Labs