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Web Desc
Roles of TGF-ß in Disease Pathogenesis: Novel Therapeutic Strategies
Organizer(s): Anita B. Roberts, Michael B. Sporn and John M. McPherson
Date: March 28 - April 02, 2005
Location: Keystone Resort, Keystone, CO, USA
Supported by The Director's Fund
Summary of Meeting:
Elucidation of the signal transduction pathways of TGF-ß has heralded an exciting new era enabling insights into molecular mechanisms of this multifunctional molecule in both normal adult physiology and disease pathogenesis, including especially wound healing, fibrosis, carcinogenesis and immune cell dysfunction. Characterization of the receptor kinases and identification of the Smad signaling pathway has identified new molecular targets and led to development of novel inhibitors of the pathway. Increased understanding of the biochemistry of TGF-ß itself has also enabled development of anti-ligand approaches. Our goal for this conference is to bring together researchers focused on the basic biochemistry of TGF-ß and on the use of animal models to elucidate its roles in disease pathogenesis and researchers from Biotech/Pharma who are developing new drugs based on the TGF-ß pathway to both enhance our insights into mechanisms of action of TGF-ß and provide novel therapeutic approaches for clinical treatment of disease.
Discounted Abstract Deadline: November 29 2004
Discounted Registration Deadline: January 28 2005
We gratefully acknowledge additional support for this conference from:
Genzyme CorporationNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Antisense Pharma GmbH

Educational grant from Lilly USA, LLC

Genentech, Inc.

Genzyme Corporation

GlaxoSmithKline

Janssen Pharmaceuticals, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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