Roles of TGF-ß in Disease Pathogenesis: Novel Therapeutic Strategies Organizer(s): Anita B. Roberts, Michael B. Sporn and John M. McPherson Date: March 28 - April 02, 2005
Location: Keystone Resort, Keystone, CO, USAElucidation of the signal transduction pathways of TGF-ß has heralded an exciting new era enabling insights into molecular mechanisms of this multifunctional molecule in both normal adult physiology and disease pathogenesis, including especially wound healing, fibrosis, carcinogenesis and immune cell dysfunction. Characterization of the receptor kinases and identification of the Smad signaling pathway has identified new molecular targets and led to development of novel inhibitors of the pathway. Increased understanding of the biochemistry of TGF-ß itself has also enabled development of anti-ligand approaches. Our goal for this conference is to bring together researchers focused on the basic biochemistry of TGF-ß and on the use of animal models to elucidate its roles in disease pathogenesis and researchers from Biotech/Pharma who are developing new drugs based on the TGF-ß pathway to both enhance our insights into mechanisms of action of TGF-ß and provide novel therapeutic approaches for clinical treatment of disease. Discounted Abstract Deadline: November 29 2004 Discounted Registration Deadline: January 28 2005 We gratefully acknowledge additional support for this conference from:   We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Antisense Pharma GmbH
Educational grant from Lilly USA, LLC
Genentech, Inc.
Genzyme Corporation
GlaxoSmithKline
Janssen Pharmaceuticals, Inc.
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