B Cell Development, Function and Disease
Organizer(s): Harinder Singh, Mark J. Shlomchik and Riccardo Dalla-FaveraDate: March 28 - April 03, 2005
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
The defining feature of B lymphocyte development is the combinatorial recombination of antigen receptor gene segments which results in the generation of a vast repertoire of clonogenic B cells. Each naïve B cell expresses a unique antigen receptor comprised of an antibody molecule associated with signal transduction components. Signaling through the B cell receptor is required for B cell survival, activation in response to antigen and the induction of tolerance. B cell activation in germinal centers is accompanied by somatic hypermutation and isotype switch recombination of immunoglobulin (Ig) genes. The former process is used to select for higher affinity antibodies in an immune response and the latter to generate antibodies with different effector functions. Aberrant B cell activation can result in autoimmune disease or lymphomagenesis. Considerable progress has been recently achieved in several areas including (i) regulation of early B cell development from a lymphoid progenitor, (ii) mechanisms underlying somatic hypermutation and class switching of Ig genes, (iii) signalling functions of the B cell receptor, (iv) analysis of B cell subsets, (v) establishment and functioning of germinal centers (vi) control of plasma cell differentiation and (vii) mechanisms underlying autoimmunity. The meeting represents the continuation of a longstanding forum that uniquely focuses on both murine and human B cell biology so as to promote the analysis of B cell diseases and the generation of new therapeutic approaches. It brings together leading as well as young investigators.
Discounted Abstract Deadline: November 29 2004
Discounted Registration Deadline: January 28 2005
We gratefully acknowledge additional support for this conference from:
GlaxoSmithKline Research & Development, Ltd.