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Web Desc
Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies
joint with Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases)
Organizer(s): Scott R. Barnum, Iain L. Campbell and Pedro R. Lowenstein
Date: January 11 - 15, 2005
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Sanofi-Aventis Pharmaceuticals, Inc. and The Director's Fund
Summary of Meeting:
Knowledge of the immunologic and inflammatory mechanisms contributing to acute and chronic central nervous system (CNS) diseases has increased dramatically in recent years. Inflammatory mediators and cellular processes once thought to be restricted to peripheral immune responses are now known to be central to the pathogenesis of many important CNS diseases, such as multiple sclerosis, Alzheimer's disease, stroke, HIV-dementia and others. Immune cell recruitment and regulation in the brain are known to be molded by the CNS environment where cells such as the microglia and astrocytes elaborate a variety of potent regulatory mediators. The mediators include an expanding array of cytokines, chemokines, proteases, as well as, complement proteins and reactive oxygen species. Determining the role of these mediators in CNS disease has been advanced considerably by the development of transgenic and knockout animal models. These animal models have, in many cases, provided unexpected results, thus broadening our understanding of inflammatory mechanisms in the CNS. This meeting will address recent advances in basic mechanisms, model approaches and novel therapies in immunologic and inflammatory diseases of the CNS and promote the interaction of basic and clinical researchers from diverse fields representing academia and industry.
Discounted Abstract Deadline: September 17 2004
Discounted Registration Deadline: November 11 2004
We gratefully acknowledge additional support for this conference from:
AlzheimerSanofi US
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Educational grant from Lilly USA, LLC
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13-NS050910-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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