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Web Desc
Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies
joint with Obesity: Molecular Physiology and Genetics of the Control of Body Weight
Organizer(s): Morris J. Birnbaum and Helena Edlund
Date: January 27 - February 02, 2005
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Biovitrum AB, Cell Press and Sanofi-Aventis Pharmaceuticals, Inc.
Summary of Meeting:
One of the major threats to modern health throughout the world is the current epidemic of obesity and diabetes mellitus. Obesity is generally regarded as a prerequisite for the development of diabetes in most individuals, and yet the precise relationship between these two diseases remains obscure. Work in the laboratories of many of the leading investigators in the world has begun to integrate aspects of obesity and fat cell biology into studies of insulin action and secretion, and the need for communication between scientists expert in diabetes and obesity more crucial than ever. Fortunately, recent advances in the genetic manipulation of mice have allowed rational investigation into the basic genetic and molecular mechanisms of metabolic regulation in both a cellular and organismal context. These research efforts by both basic and clinical scientists have successfully utilized the technologies of mouse genetics, experimental model systems, genomics, and proteomics as well as the traditional tools of physiology and molecular and cell biology to yield exciting new insights into this disease. Particularly novel findings relate to the interface between insulin signaling and membrane trafficking; beta cell development and apoptosis; adipocyte signaling to brain, beta cells, liver and muscle; and the role of cytokines in insulin resistance. The goal of the conference (held jointly with the Molecular Control of Adipogenesis and Obesity conference organized by Rudy Leibel) will be to bring together scientists working in several intersecting areas of the field, e.g., the application of new technologies to diabetes; stem cell and developmental biology; regulated membrane trafficking; integration of metabolism and gene expression; and therapeutics. One recurrent theme of the conference will be the constant interplay and mutual benefit of investigations based in tissue culture and broken cell systems with those in mouse and other non-mammalian model organisms. Half of the sessions will be held jointly with the concurrent meeting on adipogenesis in order to optimize the information flow between researchers in the fields of the related syndromes of diabetes and obesity. Among the broad themes to be considered will be 1) how molecular process govern and coordinate metabolic pathways among tissues, 3) the relationship between specialized metabolic regulation and such generalized processes as proliferation, differentiation, apoptosis growth, and 3) molecular determinants in the neuronal control of appetite and metabolism.
Discounted Abstract Deadline: September 27 2004
Discounted Registration Deadline: November 29 2004
We gratefully acknowledge additional support for this conference from:
Biovitrum AB
Celera
Cell PressJDRFSanofi US
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Roche Palo Alto
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13-DK070451-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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