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Web Desc
Cellular Senescence and Cell Death
joint with Survival and Death in Immune Tolerance and Homeostasis
Organizer(s): Douglas R. Green, Scott W. Lowe and Jacqueline A. Lees
Date: March 03 - 09, 2005
Location: Keystone Resort, Keystone, CO, USA
Supported by The Director's Fund
Summary of Meeting:
When we consider the enormous number of cells that proliferate in an individual over the course of a lifetime, cancer is a remarkably rare occurrence. Two major and general checks on carcinogenesis are the processes of cellular senescence and apoptosis. Although these appear to be fundamentally different in their final outcome, both processes have a number of similarities. The elucidation of nature and mechanisms of these similarities are a major goal of this meeting. Both apoptosis and senescence are irreversible after a point of no return, and function as anti-tumor mechanisms that can be disrupted as part of oncogenesis. Many of the upstream inducers and regulators are common to both, and stressors that trigger apoptosis in one cell type will induce senescence in another. These include telomere malfunction, oncogene activation, and DNA damage. The regulation of senescence and apoptosis are affected by common signaling pathways, including p53, PI3-kinase and AKT, stress-induced kinase pathways, and nuclear factor-kappaB. In addition to roles in checking cancer, or perhaps as a consequence of these roles, apoptosis and senescence contribute to aging. The goal of this meeting is to bring together experts in apoptosis, senescence, and oncogenic transformation in order to explore the similarities and differences in these processes. The interconnections between these biological events and the overlapping principles that emerge represent an emerging field in biology and biomedical research.
Discounted Abstract Deadline: November 3 2004
Discounted Registration Deadline: January 3 2005
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.EMD Biosciences, Inc.Genentech, Inc.IDUN Pharmaceuticals, Inc.
Merck Research Laboratories
Novartis Institutes for BioMedical ResearchPioneer Hi-Bred a DuPont business
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Maxim Pharmaceuticals, Inc.

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13-CA112922-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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