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Web Desc
Survival and Death in Immune Tolerance and Homeostasis
joint with Cellular Senescence and Cell Death
Organizer(s): Pamela S. Ohashi, Michael J. Lenardo and Richard Siegel
Date: March 03 - 09, 2005
Location: Keystone Resort, Keystone, CO, USA
Supported by The Director's Fund
Summary of Meeting:
Balancing lymphocyte survival and death is key for generating the lymphocyte repertoire. Maintaining lymphocyte homeostasis is critical for appropriate responses to pathogens and immunological memory. Understanding the mechanisms that control lymphocyte survival or apoptosis are likely to provide valuable insights into autoimmune disease and lymphoid malignancy where the normal molecular check points fail. Multiple interactions that maintain homeostasis of the lymphocyte repertoire have been defined, but the intracellular molecular pathways that regulate survival remain elusive. Unexpected complexities are emerging where apoptotic molecules have been shown to play contradictory roles in lymphocyte proliferation. This meeting will highlight novel and exciting contributions to the field of lymphocyte tolerance and homeostasis. It will combine studies of basic mechanisms, defined molecules and in vivo biology to give a current picture of how lymphocyte lifespan and death is regulated. Diseases resulting from altered lymphocyte homeostasis and possible therapeutic targets will also be discussed. From this unique combination of perspectives, we hope to stimulate collaborations and new ideas to solve these key issues in lymphocyte biology.
Discounted Abstract Deadline: November 3 2004
Discounted Registration Deadline: January 3 2005
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13-AI063787-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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