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Saturday, February 11 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Saturday, February 11 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Saturday, February 11 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 1
Thomas A. Steitz, Howard Hughes Medical Institute, Yale University, USA
Motion in RNA and DNA Enzymes

Sunday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Sunday, February 12 | 8:00AM - 11:00AM
Topology and Polymerases
Room: Chamisa Ballroom 1

Speaker 1 of 5
* James M. Berger, Johns Hopkins University School of Medicine, USA
Structural Mechanisms for Initiating DNA Replication in Bacteria

Sunday, February 12 | 8:00AM - 11:00AM
Topology and Polymerases
Room: Chamisa Ballroom 1

Speaker 2 of 5
Smita S. Patel, UMDNJ-RW Johnson Medical School, USA
Dynamics of DNA Replication Catalyzed by Helicase and Polymerase

Sunday, February 12 | 8:00AM - 11:00AM
Topology and Polymerases
Room: Chamisa Ballroom 1

Speaker 3 of 5
Eric C. Greene, Columbia University, USA
Short Talk: Visualizing One-Dimensional Diffusion of Proteins on DNA

Sunday, February 12 | 8:00AM - 11:00AM
Topology and Polymerases
Room: Chamisa Ballroom 1

Speaker 4 of 5
Stephen C. Kowalczykowski, University of California, Davis, USA
Single-Molecule Visualization of Protein-DNA Interactions

Sunday, February 12 | 8:00AM - 11:00AM
Topology and Polymerases
Room: Chamisa Ballroom 1

Speaker 5 of 5
Tania A. Baker, Massachusetts Institute of Technology, USA
Controlling Recombination and Repair: Activation, Remodeling and Destruction

Sunday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Sunday, February 12 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Sunday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Sunday, February 12 | 2:30PM - 4:30PM
Workshop 1: Mechanisms
Room: Chamisa Ballroom 1

Speaker 1 of 8
* Smita S. Patel, UMDNJ-RW Johnson Medical School, USA

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 1: Mechanisms
Room: Chamisa Ballroom 1

Speaker 2 of 8
Steven Kazmirski, AstraZeneca, USA
Out-of-Plane Motions in Open Sliding Clamps: Molecular Dynamics Simulations of Eukaryotic and Archaeal PCNA

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 1: Mechanisms
Room: Chamisa Ballroom 1

Speaker 3 of 8
Kristina M. Herbert, Yale University, USA
Transcriptional Pauses by RNA Polymerase are Mediated by a Common Intermediate

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 1: Mechanisms
Room: Chamisa Ballroom 1

Speaker 4 of 8
Joshua Lev Adelman, University of California, Berkeley, USA
The Mechanochemistry of Transcription Termination Factor Rho

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 1: Mechanisms
Room: Chamisa Ballroom 1

Speaker 5 of 8
Colin G. Wu, Washington University School of Medicine, USA
Kinetic Mechanism of DNA Unwinding by E. coli RecBC Helicase

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 1: Mechanisms
Room: Chamisa Ballroom 1

Speaker 6 of 8
Amy Kathleen McClendon, University of Cincinnati, USA
Recognition of DNA Supercoil Geometry by Human Type II Topoisomerases

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 1: Mechanisms
Room: Chamisa Ballroom 1

Speaker 7 of 8
Scott W. Nelson, Pennsylvania State University, USA
Uncoupling of the T4 Phage Replisome upon Encountering an Abasic Lesion in the Leading Strand DNA Template

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 1: Mechanisms
Room: Chamisa Ballroom 1

Speaker 8 of 8
Katharina Schlacher, MD Anderson Cancer Center, USA
DNA Polymerase V and RecA Protein, a Minimal Mutasome

Sunday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Sunday, February 12 | 5:00PM - 7:00PM
Polymerases 1
Room: Chamisa Ballroom 1

Speaker 1 of 3
* Stephen J. Benkovic, Pennsylvania State University, USA
Studies on the T4 Replisome

Sunday, February 12 | 5:00PM - 7:00PM
Polymerases 1
Room: Chamisa Ballroom 1

Speaker 2 of 3
Seth A. Darst, Rockefeller University, USA
Structural Basis for Transcription Repair Coupling in Bacteria

Sunday, February 12 | 5:00PM - 7:00PM
Polymerases 1
Room: Chamisa Ballroom 1

Speaker 3 of 3
Robert C. Landick, University of Wisconsin-Madison, USA
Regulatory Dynamics in the RNA Polymerase Active Site

Sunday, February 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Sunday, February 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Monday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Monday, February 13 | 8:00AM - 11:00AM
Complex Systems
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Myron F. Goodman, University of Southern California, USA
Roles of DNA Polymerase V and RecA Protein in SOS Damage-Induced Mutation

Monday, February 13 | 8:00AM - 11:00AM
Complex Systems
Room: Chamisa Ballroom 1

Speaker 2 of 5
Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
The Mechanisms of Replication Fork Restart

Monday, February 13 | 8:00AM - 11:00AM
Complex Systems
Room: Chamisa Ballroom 1

Speaker 3 of 5
Stephen C. West, Francis Crick Institute, UK
Short Talk: A Role for Pol eta in Double-Strand Break Repair by Homologous Recombination

Monday, February 13 | 8:00AM - 11:00AM
Complex Systems
Room: Chamisa Ballroom 1

Speaker 4 of 5
Nicholas E. Dixon, University of Wollongong, Australia
A Molecular Mousetrap Determines Polarity of Replication Fork Arrest by Tus-Ter Sites in E. coli

Monday, February 13 | 8:00AM - 11:00AM
Complex Systems
Room: Chamisa Ballroom 1

Speaker 5 of 5
Piero R. Bianco, University at Buffalo, State University of New York, USA
Short Talk: Single Molecule Studies of the Role of Rad54 Protein in the Synapsis Stage of Homologous Recombination

Monday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Monday, February 13 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Monday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Monday, February 13 | 2:30PM - 4:30PM
Workshop 2: Complex Systems
Room: Chamisa Ballroom 1

Speaker 1 of 8
* Stephen C. West, Francis Crick Institute, UK

Monday, February 13 | 2:30PM - 4:30PM
Workshop 2: Complex Systems
Room: Chamisa Ballroom 1

Speaker 2 of 8
Alice P. Telesnitsky, University of Michigan, USA
RT Template Switching is an HIV-1 Fidelity Mechanism

Monday, February 13 | 2:30PM - 4:30PM
Workshop 2: Complex Systems
Room: Chamisa Ballroom 1

Speaker 3 of 8
Dieudonne Ndjonka, Ohio State University, USA
Crystal Structure of a Cleavage-Active Conformation of Phage Lambda Repressor

Monday, February 13 | 2:30PM - 4:30PM
Workshop 2: Complex Systems
Room: Chamisa Ballroom 1

Speaker 4 of 8
Fred Dyda, NIDDK, National Institutes of Health, USA
Structure, DNA Recognition and Active Site Assembly of a New Class of DNA Transposase

Monday, February 13 | 2:30PM - 4:30PM
Workshop 2: Complex Systems
Room: Chamisa Ballroom 1

Speaker 5 of 8
Desirazu N. Rao, Indian Institute of Science, India
Unidirectional Translocation and Interaction with DNA end for Cleavage
by Type III Restriction Enzymes


Monday, February 13 | 2:30PM - 4:30PM
Workshop 2: Complex Systems
Room: Chamisa Ballroom 1

Speaker 6 of 8
Julia C. Drees, USA
Inhibition of RecA Protein Function by the RdgC Protein from Escherichia coli

Monday, February 13 | 2:30PM - 4:30PM
Workshop 2: Complex Systems
Room: Chamisa Ballroom 1

Speaker 7 of 8
Aliaa Abdelhakim, Massachusetts Institute of Technology, USA
Auto-Tethering of the AAA+ Unfoldase ClpX to the Mu Transpososome Guides Remodeling of the Stable Protein Complex

Monday, February 13 | 2:30PM - 4:30PM
Workshop 2: Complex Systems
Room: Chamisa Ballroom 1

Speaker 8 of 8
Min Li, NIDDK, National Institutes of Health, USA
Reconstitution of Efficient Concerted Integration by HIV Integrase: Reaction Pathway and Critical Intermediates

Monday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Monday, February 13 | 5:00PM - 7:00PM
Complex RNA Systems in RNA Metabolism
Room: Chamisa Ballroom 1

Speaker 1 of 3
* Rachel Green, Johns Hopkins University School of Medicine, USA
Molecular Dissection of Ribosome Function in Two Active Sites

Monday, February 13 | 5:00PM - 7:00PM
Complex RNA Systems in RNA Metabolism
Room: Chamisa Ballroom 1

Speaker 2 of 3
Anna Marie Pyle, Yale University, USA
The HCV NS3 Helicase/Translocase: Activities and Biophysical Properties of a Tunable Motor

Monday, February 13 | 5:00PM - 7:00PM
Complex RNA Systems in RNA Metabolism
Room: Chamisa Ballroom 1

Speaker 3 of 3
Sidney R. Kushner, University of Georgia, USA
Initiation of mRNA Decay in Escherichia coli Involves at Least Six Distinct Endoribonucleases

Monday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Monday, February 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Tuesday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Tuesday, February 14 | 8:00AM - 11:00AM
Regulation and More Polymerases
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Joan W. Conaway, Stowers Institute for Medical Research, USA
Regulation of RNA Polymerase II Transcription

Tuesday, February 14 | 8:00AM - 11:00AM
Regulation and More Polymerases
Room: Chamisa Ballroom 1

Speaker 2 of 5
Irina Artsimovitch, Ohio State University, USA
Short Talk: Regulation of Transcription through the Secondary Channel

Tuesday, February 14 | 8:00AM - 11:00AM
Regulation and More Polymerases
Room: Chamisa Ballroom 1

Speaker 3 of 5
Michael M. Cox, University of Wisconsin-Madison, USA
Regulation of Recombinase Function in Bacteria

Tuesday, February 14 | 8:00AM - 11:00AM
Regulation and More Polymerases
Room: Chamisa Ballroom 1

Speaker 4 of 5
Carol W. Greider, Johns Hopkins University School of Medicine, USA
Telomeres and Telomerase in Stem Cells and Cancer

Tuesday, February 14 | 8:00AM - 11:00AM
Regulation and More Polymerases
Room: Chamisa Ballroom 1

Speaker 5 of 5
Michael E. O'Donnell, Rockefeller University, USA
The Mechanics of Lagging Strand DNA Synthesis

Tuesday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Tuesday, February 14 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Tuesday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 1 of 9
* Sidney R. Kushner, University of Georgia, USA

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 2 of 9
Allyn J. Schoeffler, Genentech, USA
Structure-Function Relationships in Bacterial Type IIA Topoisomerases

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 3 of 9
Olga N. Umanskaya, Russian Academy of Sciences, Russia
DNA-Topoisomerase II Can Induce but not Accomplish Illegitimate Recombination

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 4 of 9
Phuong T. Pham, University of Southern Califonria, USA
Processive Aid-catalyzed Cytosine Deamination on ssDNA Simulates Somatic Hypermutation

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 5 of 9
Shelley L. Lusetti, New Mexico State University, USA
The RecF Protein Antagonizes RecX Function via Direct Interaction

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 6 of 9
Katrin Karbstein, University of California, Berkeley, USA
An Essential GTPase Promotes Assembly of Pre-Ribosomal RNA Processing Complexes

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 7 of 9
Anoop Cheeran, Center for DNA Fingerprinting and Diagnostics, India
E.coli RNA Polymerase Mutations Impaired for H-19B N Specific Transcription Antitermination: Implications for the Mechanism of Transcription Antitermination

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 8 of 9
Dmitry Temiakov, Thomas Jefferson University, USA
Structural Basis of Transcription Inhibition by Antibiotic Streptolydigin

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 3: New Enzymes
Room: Chamisa Ballroom 1

Speaker 9 of 9
Marcin Nowotny, NIDDK, National Institutes of Health, USA
Crystal Structures of RNase H Complexed with RNA•DNA Hybrid Substrate

Tuesday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Tuesday, February 14 | 5:00PM - 7:00PM
Polymerases II
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Tom E. Ellenberger, Washington University School of Medicine, USA

Tuesday, February 14 | 5:00PM - 7:00PM
Polymerases II
Room: Chamisa Ballroom 1

Speaker 2 of 4
Peter M. Burgers, Washington University School of Medicine, USA
The Role of Ubiquitinated PCNA in Coordinating Translesion DNA Synthesis

Tuesday, February 14 | 5:00PM - 7:00PM
Polymerases II
Room: Chamisa Ballroom 1

Speaker 3 of 4
Richard H. Ebright, Rutgers University, USA
Small-Molecule Inhibitors of Bacterial RNA Polymerase: Tagetitoxin, Lipiarmycin, Myxopyronin

Tuesday, February 14 | 5:00PM - 7:00PM
Polymerases II
Room: Chamisa Ballroom 1

Speaker 4 of 4
Dmitri G. Vassylyev, University of Alabama at Birmingham, USA
Structural Studies of Prokaryotic RNA Polymerases and Transcription Regulation

Tuesday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Tuesday, February 14 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Wednesday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, February 15 | 8:00AM - 11:15AM
Catalysis and Processing Enzymes
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Daniel Herschlag, Stanford University, USA
Dissecting Ribozyme Mechanisms: Lessons Learned about RNA and Catalysis

Wednesday, February 15 | 8:00AM - 11:15AM
Catalysis and Processing Enzymes
Room: Chamisa Ballroom 1

Speaker 2 of 5
Tom E. Ellenberger, Washington University School of Medicine, USA
Short Talk: TelK Puts an End to Chromosomes

Wednesday, February 15 | 8:00AM - 11:15AM
Catalysis and Processing Enzymes
Room: Chamisa Ballroom 1

Speaker 3 of 5
Steven M. Block, Stanford University, USA
Breaking the Nanometer Barrier in Single-Molecule Studies

Wednesday, February 15 | 8:00AM - 11:15AM
Catalysis and Processing Enzymes
Room: Chamisa Ballroom 1

Speaker 4 of 5
Timothy M. Lohman, Washington University School of Medicine, USA
Mechanisms of DNA Unwinding and Translocation by SF-1 DNA Helicases

Wednesday, February 15 | 8:00AM - 11:15AM
Catalysis and Processing Enzymes
Room: Chamisa Ballroom 1

Speaker 5 of 5
Linda B. Bloom, University of Florida, USA
Short Talk: Dynamics of Loading the Escherichia coli Sliding Clamp

Wednesday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, February 15 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, February 15 | 5:00PM - 7:00PM
Processing Enzymes
Room: Chamisa Ballroom 1

Speaker 1 of 3
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Structural basis for RNA processing by Dicer

Wednesday, February 15 | 5:00PM - 7:00PM
Processing Enzymes
Room: Chamisa Ballroom 1

Speaker 2 of 3
James L. Keck, University of Wisconsin Medical School, USA
Structural and Cellular Mechanisms of Bacterial RecQ DNA Helicases

Wednesday, February 15 | 5:00PM - 7:00PM
Processing Enzymes
Room: Chamisa Ballroom 1

Speaker 3 of 3
Stewart H. Shuman, Memorial Sloan-Kettering Institute, USA
Mechanism of DNA Nonhomologous End Joining in Bacteria

Wednesday, February 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, February 15 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Wednesday, February 15 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Thursday, February 16 | 10:26AM - 10:26AM
Departure


*Session Chair.

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