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Web Desc
The Molecular and Integrative Basis for Toxic Responses
joint with Emerging Genomic Biomarkers: Impact on Drug Discovery and Clinical Practice
Organizer(s): Roger G. Ulrich and Robert A. Roth
Date: May 07 - 11, 2006
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Sponsored by ICOS Corporation
Summary of Meeting:
Drug toxicity continues to be an important human health problem and a major economic issue for the pharmaceutical industry, since it results in many failed candidates and drug recalls. It is widely recognized that knowledge of toxic mechanisms can aid in the design of safer drugs, and recent advances in molecular and genomic biology hold promise for increasing such mechanistic understanding. Determining untoward effects of drug exposure on cellular signaling pathways that result in altered RNA transcription, protein expression and activity along with the consequent impact on cell and tissue function has become an intense focus in toxicological research. This conference will bring together key scientists to discuss important organ targets for drug toxicity, emphasizing pathways and mediators of cell and tissue injury and the contribution of environmental and genetic factors that determine individual susceptibility.
Scholarship Deadline: January 5 2006
Discounted Abstract Deadline: January 5 2006
Abstract Deadline: March 17 2006
Discounted Registration Deadline: March 17 2006
We gratefully acknowledge additional support for this conference from:
ICOS CorporationNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Environmental Health Sciences (NIEHS)
Grant No. 1R13 ES014763-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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