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Web Desc
Jaks, Stats and Immunity
Organizer(s): Thomas A.F. Decker, Christian W. Schindler and David E. Levy
Date: January 05 - 10, 2007
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Sponsored by Pharmacopeia
Summary of Meeting:
The JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathways play an important role in a wide variety of biological processes. Most cytokines and many growth factors exert their biological functions via JAK/STAT signaling. The significance of JAK/STAT signaling is further underscored by the fact that aberrant JAK/STAT signaling is associated with human diseases such as immune disorders and tumorigenesis. Tyrosine phosphorylation of JAKs and STATs is a well established activator in these pathways, but STAT activity is also modulated by serine phosphorylation and, possibly, by methylation and acetylation as well. The identities and roles of the additional signal transduction pathways that might contribute to these modifications and other regulatory interactions are the subject of much current investigation. This meeting will focus on the following key aspects of current research in JAK/STAT signaling, particularly with regard to its role in immune function: recent advances in understanding the regulation of JAK activity, STAT nuclear translocation, the role of non-tyrosine- phosphorylated STATS, and negative regulation of the pathway; dissection and analysis of pathways that interact with JAKS and STATS in immune responses; links between the JAK/STAT pathway and innate immune receptors (e.g. Toll-like receptors) through type I interferon synthesis which, in turn, suggest critical roles of JAK/STAT target genes in the regulation of innate and adaptive immune response; and the role of JAK/STAT pathways in cancer will also play an important role.
Scholarship Deadline: September 13 2006
Discounted Abstract Deadline: September 13 2006
Abstract Deadline: October 9 2006
Discounted Registration Deadline: November 6 2006
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Educational donation provided by AmgenPharmacopeia
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI071686-01
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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