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Web Desc
Molecular Mechanisms of Fibrosis: From Bench to Bedside
Organizer(s): Thomas A. Wynn, W. Michael Gallatin and Mark Lupher, Jr.
Date: March 11 - 15, 2007
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored by ICOS Corporation
Summary of Meeting:
Tissue fibrosis or scarring is a leading cause of morbidity and mortality worldwide. Current health statistics suggest that almost 45% of all deaths in the western world are attributed to some type of chronic fibrotic disease. Fibrosis affects nearly all tissues and organ systems. Diseases in which fibrosis is a major cause of morbidity and mortality include the interstitial lung diseases, liver cirrhosis, kidney disease, heart disease, systemic sclerosis, among others. Fibrotic tissue remodeling can also influence cancer metastasis and accelerate chronic graft rejection in transplant recipients. Current treatments for fibrotic disorders target the inflammatory cascade, but they have been largely unsuccessful, primarily because the mechanisms that are involved in fibrogenesis are believed to be distinct from those involved in inflammation. Because mechanistic studies are difficult to carry out in humans, numerous experimental models have been developed over the past few years to dissect the immunological and molecular mechanisms of fibrosis. The first of new therapies based on these models is just beginning to approach clinical testing. The goal of this meeting is to bring together academic researchers, clinicians, and members of the pharmaceutical industry to discuss the most recent advances in the field and to identify common mechanistic themes of tissue fibrogenesis in various tissue systems. By bringing together a diverse group of researchers, the meeting will provide a more integrated perspective from basic disease mechanisms through to the more pragmatic challenges of clinical trial design in chronic progressive disease. Some of the topics that will be discussed include: extracellular matrix remodeling in fibrosis and cancer; the role of bone marrow in epithelial-mesenchymal transitions; experimental models of fibrosis; pulmonary, cardiac, liver, and kidney fibrosis; systemic sclerosis (scleroderma); as well as recent clinical developments with experimental anti-fibrotic drugs. This meeting will feature plenary talks from key investigators in the field and will also include workshops and poster sessions.
Scholarship Deadline: November 13 2006
Discounted Abstract Deadline: November 13 2006
Abstract Deadline: December 12 2006
Discounted Registration Deadline: January 11 2007
We gratefully acknowledge additional support for this conference from:
ICOS Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genzyme Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL087522-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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