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Wednesday, March 28 | 3:00PM - 7:30PM
Registration
Room: Van Horne Foyer


Wednesday, March 28 | 6:30PM - 7:30PM
Refreshments
Room: Van Horne Foyer


Wednesday, March 28 | 7:30PM - 9:30PM
Keynote Address
Room: Van Horne AB

Speaker 1 of 2
David Baltimore, California Institute of Technology, USA
Engineering Immunity to Cancer and other Diseases

Wednesday, March 28 | 7:30PM - 9:30PM
Keynote Address
Room: Van Horne AB

Speaker 2 of 2
Luigi M. Naldini, San Raffaele Telethon Institute, Italy
Novel Approaches to Regulate Transgene Expression and Enhance the Efficacy and Safety of Gene Therapy

Thursday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Alberta, New Brunswick, Cascade, Conservatory


Thursday, March 29 | 8:00AM - 9:00AM
Morning Lecture
Room: Van Horne AB

Speaker 1 of 1
Steven A. Rosenberg, NCI, National Institutes of Health, USA
Current Immunotherapies Based on Lymphodepletion and Adoptive Cell Transfer

Thursday, March 29 | 9:00AM - 9:20AM
Coffee Break
Room: Van Horne Foyer


Thursday, March 29 | 9:20AM - 11:15AM
Adoptive Immunotherapy
Room: Van Horne AB

Speaker 1 of 3
Malcolm K. Brenner, Baylor College of Medicine, USA
Adoptive Immunotherapy of EBV-Associated Malignancies with EBV-Specific Cytotoxic T-Cell Lines

Thursday, March 29 | 9:20AM - 11:15AM
Adoptive Immunotherapy
Room: Van Horne AB

Speaker 2 of 3
Philip D. Greenberg, University of Washington, USA
Engineering T Cells for Adoptive Transfer

Thursday, March 29 | 9:20AM - 11:15AM
Adoptive Immunotherapy
Room: Van Horne AB

Speaker 3 of 3
* James P. Allison, University of Texas MD Anderson Cancer Center, USA
Immune Checkpoint Blockade in Cancer Therapy

Thursday, March 29 | 11:15AM - 1:00PM
Poster Setup
Room: Alberta, New Brunswick, Cascade, Conservatory


Thursday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta, New Brunswick, Cascade, Conservatory


Thursday, March 29 | 2:00PM - 3:30PM
Editor's Forum
Room: Van Horne AB

Speaker 1 of 3
* Linda J. Miller, American Association for Cancer Research, USA
Scientific Journals, Plagiarism and Fraud

Thursday, March 29 | 2:00PM - 3:30PM
Editor's Forum
Room: Van Horne AB

Speaker 2 of 3
Juan Carlos Lopez, Haystack Science, USA
Challenges in Producing (and Publishing) Translational Research

Thursday, March 29 | 2:00PM - 3:30PM
Editor's Forum
Room: Van Horne AB

Speaker 3 of 3
Heather L. Van Epps, Journal of Experimental Medicine, USA
1896: Experimental Medicine Then and Now

Thursday, March 29 | 3:30PM - 4:30PM
Special Lecture
Room: Van Horne AB

Speaker 1 of 1
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Regulatory T Cell Function is Mediated by the Novel Inhibitory Cytokine Interleukin-34

Thursday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 29 | 5:00PM - 7:00PM
Programing of T Cells and Differentiation
Room: Van Horne AB

Speaker 1 of 3
Carl H. June, University of Pennsylvania, USA
Adoptive Immunotherapy: New Ways to Skin the Cat?

Thursday, March 29 | 5:00PM - 7:00PM
Programing of T Cells and Differentiation
Room: Van Horne AB

Speaker 2 of 3
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Understanding the Generation and Function of Memory T Cell Subsets

Thursday, March 29 | 5:00PM - 7:00PM
Programing of T Cells and Differentiation
Room: Van Horne AB

Speaker 3 of 3
* Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA
Programmed Tolerance of CD8+ T Cells by B Cell APC

Thursday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta, New Brunswick, Cascade, Conservatory


Thursday, March 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Alberta, New Brunswick, Cascade, Conservatory


Friday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: Alberta, New Brunswick, Cascade, Conservatory


Friday, March 30 | 8:00AM - 9:00AM
Morning Lecture
Room: Van Horne AB

Speaker 1 of 1
Nicholas P. Restifo, Lyell, USA
The Future of Adoptive Immunotherapy

Friday, March 30 | 9:00AM - 9:20AM
Coffee Break
Room: Van Horne Foyer


Friday, March 30 | 9:20AM - 11:30AM
Lymphodepletion
Room: Van Horne AB

Speaker 1 of 4
* Charles D. Surh, La Jolla Institute for Allergy and Immunology, USA
Potentials of T Cell Homeostatic Cytokines

Friday, March 30 | 9:20AM - 11:30AM
Lymphodepletion
Room: Van Horne AB

Speaker 2 of 4
Yang Liu, University of Michigan, Ann Arbor, USA
Short Talk: CD24 Controls T Cell Homeostasis and Cancer Resistance

Friday, March 30 | 9:20AM - 11:30AM
Lymphodepletion
Room: Van Horne AB

Speaker 3 of 4
Hyam I. Levitsky, Century Therapeutics, USA
In vivo Depletion of Immune Regulatory Factors

Friday, March 30 | 9:20AM - 11:30AM
Lymphodepletion
Room: Van Horne AB

Speaker 4 of 4
Stanley R. Riddell, Fred Hutchinson Cancer Research Center, University of Washington, USA
Establishing T Cell Memory by Adoptive Transfer of T Cell Clones

Friday, March 30 | 11:30AM - 1:00PM
Poster Setup
Room: Alberta, New Brunswick, Cascade, Conservatory


Friday, March 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta, New Brunswick, Cascade, Conservatory


Friday, March 30 | 2:00PM - 2:30PM
Special Lecture
Room: Van Horne A/B

Speaker 1 of 1
Robert H. Wiltrout, NCI, National Institutes of Health, USA
Immunotherapy of Cancer by IL12-based Cytokine Combinations

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2A
Room: Van Horne A/B

Speaker 1 of 5
Phillip K. Darcy, Peter MacCallum Cancer Centre, Australia
Investigation of the Role of Gene-Modified CD4+ T Cell Subsets for Cancer Immunotherapy

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2A
Room: Van Horne A/B

Speaker 2 of 5
Wolfgang Uckert, Humboldt-University, Germany
Enhanced Functional Expression of T Cell Receptors by Genetic Modification and Vector Optimization

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2A
Room: Van Horne A/B

Speaker 3 of 5
Jacob Schachter, Sheba Medical Center, Israel
Adoptive Immunotherapy

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2A
Room: Van Horne A/B

Speaker 4 of 5
Antoni Ribas, University of California, Los Angeles, USA
PET Imaging of Adoptive Transfer Immunotherapy

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2A
Room: Van Horne A/B

Speaker 5 of 5
* Michael H. Kershaw, Peter MacCallum Cancer Center, Australia
Targeting a Carbohydrate Antigen using T Cells Modified with a Humanized Chimeric Receptor Gene

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2B
Room: Van Horne C

Speaker 1 of 6
Mary Jo Turk, Dartmouth Hitchcock Medical Center, USA
The Induction of T Cell Memory in the Absence of Tregs after Surgical Excision

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2B
Room: Van Horne C

Speaker 2 of 6
Shimon Slavin, International Center for Cell Therapy & Cancer Immunotherapy, Israel
Cell-Mediated Immunotherapy of Hematological Malignancies and Metastatic Solid Tumors

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2B
Room: Van Horne C

Speaker 3 of 6
Weiping Zou, University of Michigan, USA
Tregs, Th17 and their regulation in the tumor microenvironment

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2B
Room: Van Horne C

Speaker 4 of 6
Sjoerd H. van der Burg, Leiden University Medical Center, Netherlands
Human Tumor-Specific Regulatory T-Cells in Therapeutic Vaccination Strategies

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2B
Room: Van Horne C

Speaker 5 of 6
Jill E. Slansky, University of Colorado Health Sciences Center, USA
Relating TCR-Peptide-MHC Affinity to Immunogenicity

Friday, March 30 | 2:30PM - 4:30PM
Workshop 2B
Room: Van Horne C

Speaker 6 of 6
* Karin U. Jooss, Gritstone Oncology, USA
GM-CSF Transduced Cancer Cell Immunotherapies in Combination with Anti-CTLA4: Of Mice and Men

Friday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Friday, March 30 | 5:00PM - 7:00PM
Triggering Self Recognition
Room: Van Horne AB

Speaker 1 of 4
Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Cytokines are critical regulators of anti-tumor immunity

Friday, March 30 | 5:00PM - 7:00PM
Triggering Self Recognition
Room: Van Horne AB

Speaker 2 of 4
Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
Short Talk: The Hybrid Nature of Altered Self: Structural Basis for MHC Class II-Restricted TCR Recognition of a Mutant Tumor Antigen

Friday, March 30 | 5:00PM - 7:00PM
Triggering Self Recognition
Room: Van Horne AB

Speaker 3 of 4
Elizabeth M. Jaffee, Johns Hopkins University, USA
Tipping the Immune System Balance in Favor of Effective Anti-Cancer Therapy

Friday, March 30 | 5:00PM - 7:00PM
Triggering Self Recognition
Room: Van Horne AB

Speaker 4 of 4
* Linda A. Sherman, The Scripps Research Institute, USA
Immune Tolerance to Persistent Antigens and Dealing with the Consequences for Tumor Immunotherapy

Friday, March 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta, New Brunswick, Cascade, Conservatory


Friday, March 30 | 7:30PM - 10:00PM
Poster Session 2
Room: Alberta, New Brunswick, Cascade, Conservatory


Saturday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: Alberta, New Brunswick, Cascade, Conservatory


Saturday, March 31 | 8:00AM - 11:00AM
Dendritic Cells
Room: Van Horne AB

Speaker 1 of 5
* A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA
Understanding the Interplay of the Human Immune System with Cancer in Humanized Mice

Saturday, March 31 | 8:00AM - 11:00AM
Dendritic Cells
Room: Van Horne AB

Speaker 2 of 5
Lieping Chen, Yale University, USA
Co-Stimulatory and Co-Inhibitory Receptor-Ligand Pairs

Saturday, March 31 | 8:00AM - 11:00AM
Dendritic Cells
Room: Van Horne AB

Speaker 3 of 5
Vincenzo Cerundolo, University of Oxford, UK
Harnessing NKT cells in cancer vaccination strategies

Saturday, March 31 | 8:00AM - 11:00AM
Dendritic Cells
Room: Van Horne AB

Speaker 4 of 5
Andrew L. Mellor, Georgia Regents University, USA
Immunoregulatory Plasmacytoid Dendritic Cells Expressing Indoleamine 2,3 Dioxygenase (IDO)

Saturday, March 31 | 8:00AM - 11:00AM
Dendritic Cells
Room: Van Horne AB

Speaker 5 of 5
Patrick Hwu, University of Texas MD Anderson Cancer Center, USA
Short Talk: Use of Activated Plasmacytoid Dendritic Cells to Induce
Antitumor Immunity


Saturday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Saturday, March 31 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta, New Brunswick, Cascade, Conservatory


Saturday, March 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta, New Brunswick, Cascade, Conservatory


Saturday, March 31 | 2:00PM - 2:30PM
Special Lecture
Room: Van Horne AB

Speaker 1 of 1
Vincenzo Bronte, University of Verona, Italy
Myeloid Suppressor Cells in Cancer

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3A
Room: Van Horne A/B

Speaker 1 of 5
Franck Housseau, Johns Hopkins School of Medicine, USA
Interferon-Producing Killer Dendritic Cells

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3A
Room: Van Horne A/B

Speaker 2 of 5
Naoto Hirano, Princess Margaret Cancer Centre, Canada
IL-21 Mediated Expansion of Antigen-Speciific CD8+ T Cells

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3A
Room: Van Horne A/B

Speaker 3 of 5
Diana F. Hausman, Zymeworks, USA
Clinical Studies of IL-21 in the Immunotherapy of Cancer

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3A
Room: Van Horne A/B

Speaker 4 of 5
Reno Debets, Erasmus MC Cancer Institute, Netherlands
IL-21 Promotes Naieve T Cell Phenotype and Antigen-Specific Functions in TCR-Transduced T Cells

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3A
Room: Van Horne A/B

Speaker 5 of 5
* Gosse J. Adema, University Medical Center, NCMLS Nijmegen, Netherlands
The Impact of Toll-Like Receptors on Regulatory T Cells

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3B
Room: Van Horne C

Speaker 1 of 6
Peter P. Lee, Stanford University School of Medicine, USA
Downregulation of Interferon-Signaling Pathways in Lymphocytes from Metastatic Melanoma Patients

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3B
Room: Van Horne C

Speaker 2 of 6
Paul R. Walker, Geneva University Hospital, Switzerland
Functional Differentiation of CD8 T Cells during the Effector Phase of Brain Tumor Immunity

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3B
Room: Van Horne C

Speaker 3 of 6
Nathalie Rufer, Swiss Institute for Experimental Cancer Research, Switzerland
In vivo Clonal Distribution and Longevity of Functional Human Tumor Antigen Specific T Cells

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3B
Room: Van Horne C

Speaker 4 of 6
* George Coukos, University Hospital of Lausanne - CHUV, Switzerland
Regulation of T Cell Trafficking by Tumor Endothelium: Implications for Immunotherapy

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3B
Room: Van Horne C

Speaker 5 of 6
Mikael J. Pittet, Massachusetts General Hospital, USA
Noninvasive in vivo Assessment of CTL Delivery at the Tumor Site

Saturday, March 31 | 2:30PM - 4:30PM
Workshop 3B
Room: Van Horne C

Speaker 6 of 6
Michelle Krogsgaard, New York University School of Medicine, USA
Imaging Sensitivity of T-Cell Recognition of Melanoma Antigens

Saturday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Saturday, March 31 | 5:00PM - 7:00PM
Visualizing T Cell Target Cell Interactions in Real-Time
Room: Van Horne AB

Speaker 1 of 4
* Mark M. Davis, Stanford University School of Medicine, USA
T Cell Recognition

Saturday, March 31 | 5:00PM - 7:00PM
Visualizing T Cell Target Cell Interactions in Real-Time
Room: Van Horne AB

Speaker 2 of 4
Andrey S. Shaw, Genentech, Inc., USA
Antigen Recognition and Immunological Synapse Formation

Saturday, March 31 | 5:00PM - 7:00PM
Visualizing T Cell Target Cell Interactions in Real-Time
Room: Van Horne AB

Speaker 3 of 4
Alex Y.C. Huang, Case Western Reserve University School of Medicine, USA
Short Talk: Chemokine Guidance of Cellular Cooperation During Primary Adaptive Immune Response

Saturday, March 31 | 5:00PM - 7:00PM
Visualizing T Cell Target Cell Interactions in Real-Time
Room: Van Horne AB

Speaker 4 of 4
Rajat Varma, Xencor Inc., USA
Short Talk: A Dynamic View of the Immunological Synapse

Saturday, March 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta, New Brunswick, Cascade, Conservatory


Saturday, March 31 | 7:30PM - 10:00PM
Poster Session 3
Room: Alberta, New Brunswick, Cascade, Conservatory


Sunday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Alberta, New Brunswick, Cascade, Conservatory


Sunday, April 01 | 8:00AM - 9:00AM
Concluding Keynote Address
Room: Van Horne AB

Speaker 1 of 1
Rafi Ahmed, Emory University School of Medicine, USA
Inducing Functional Immune Responses or CD8 T Cell Memory

Sunday, April 01 | 9:00AM - 9:20AM
Coffee Break
Room: Van Horne Foyer


Sunday, April 01 | 9:20AM - 11:30AM
Genetically Engineering Cells for Adoptive Immunotherapy
Room: Van Horne AB

Speaker 1 of 4
Ton N. Schumacher, Netherlands Cancer Institute, Netherlands
Prospects and Limitations of T Cell Receptor Gene Therapy

Sunday, April 01 | 9:20AM - 11:30AM
Genetically Engineering Cells for Adoptive Immunotherapy
Room: Van Horne AB

Speaker 2 of 4
Ken-ichi Hanada, National Cancer Institute, National Institutes of Health, USA
Short Talk: Genetic Engineering of T Cells for the Recognition of Renal Cell Tumors

Sunday, April 01 | 9:20AM - 11:30AM
Genetically Engineering Cells for Adoptive Immunotherapy
Room: Van Horne AB

Speaker 3 of 4
Juan Carlos Zúñiga-Pflücker, Sunnybrook Research Institute, Canada
From Stem Cells to T-Cells in vitro, a Toolkit for Cellular Immunotherapy

Sunday, April 01 | 9:20AM - 11:30AM
Genetically Engineering Cells for Adoptive Immunotherapy
Room: Van Horne AB

Speaker 4 of 4
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Cancer Immunotherapy via Manipulation of T Cell Activation and Tumor Microenvironment

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4A
Room: Van Horne A/B

Speaker 1 of 5
* Lili Yang, California Institute of Technology, USA
Gene Modification of Hematopoietic Stem Cells

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4A
Room: Van Horne A/B

Speaker 2 of 5
Linda Liu, Maxcyte Corp, USA
Genetically Engineering Cells at Industrial Scale for Immunotherapy

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4A
Room: Van Horne A/B

Speaker 3 of 5
Hans J. Stauss, Royal Free College, UK
Exploiting T Cell Receptor Genes for Cancer Immunotherapy

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4A
Room: Van Horne A/B

Speaker 4 of 5
Michel Sadelain, Memorial Sloan Kettering Cancer Center, USA
Novel Genetic Strategies to Enhance T Cell Function

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4A
Room: Van Horne A/B

Speaker 5 of 5
Cyrille J. Cohen, Bar-Ilan University, Israel
Genetically Engineering Human T Cell Receptor Structure

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4B
Room: Van Horne C

Speaker 1 of 7
* Thomas Gajewski, University of Chicago, USA
T Cell Anergy as a Mechanism of Immune Escape

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4B
Room: Van Horne C

Speaker 2 of 7
Charles G. Drake, Columbia University, USA
STAT3 is required for Il-17 and Il-23 in the Tumor Microenvironment

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4B
Room: Van Horne C

Speaker 3 of 7
Pawel Kalinski, University of Pittsburgh, USA
Reciprocal Impact of Effector and Memory CD8+ T Cells on the Effectiveness of Cancer Vaccines

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4B
Room: Van Horne C

Speaker 4 of 7
Mark Selby, Bristol Myers-Squibb, USA
Combination of CTLA-4 and PD-1 Blockade Induces Potent Anti-Tumor Responses

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4B
Room: Van Horne C

Speaker 5 of 7
Martin L. Ashdown, ImmunAid P/L, Australia
Breaking a Deadly Cycle: Succesful Timed Treg Lymphodepletion in Cancer - Is it Already Happening Accidentally in the Oncology Clinic with Standard Drugs?

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4B
Room: Van Horne C

Speaker 6 of 7
Wilfred A. Jefferies, University of British Columbia, Canada
Epigenetic Control of the Immune Escape Mechanisms in Malignant Carcinomas

Sunday, April 01 | 2:00PM - 4:30PM
Workshop 4B
Room: Van Horne C

Speaker 7 of 7
Annette Paschen, University Hospital Essen, Germany
Generation of the Melan-A/MART-1 CTL Epitope - How Cellular Proteases Reduce the Specific T Cell Stimulatory Capacity of Melanoma

Sunday, April 01 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Sunday, April 01 | 5:00PM - 7:00PM
Future Work for the Clinic
Room: Van Horne AB

Speaker 1 of 3
Rienk Offringa, Genentech Inc., USA
The Potential and Pitfalls of Targeting Cancer through Self-Antigens

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