RNAi for Target Validation and as a Therapeutic
joint with MicroRNAs and siRNAs: Biological Functions and Mechanisms
Organizer(s): John M. Maraganore and Stephen H. FriendDate: January 28 - February 02, 2007
Location: Keystone Resort, Keystone, CO, USA
RNA Interference (RNAi) remains a promising new approach for gene silencing both in the context of post-genomic research on target validation and for potential therapeutic applications. As a tool for target validation, synthetic and DNA-based RNAi strategies have been applied in both academia and industry, with significant recent advances in understanding selection of siRNA sequences, optimization for potency and specificity, mechanisms for activation of innate immunity, and vector-based methods for whole-genome siRNA libraries. Several applications of these technologies will be presented. As a therapeutic strategy, synthetic and DNA-based RNAi strategies have advanced to pre-clinical animal models and early clinical testing. These approaches have explored multiple strategies to address the delivery hurdle, and include both local and systemic administration opportunities. The goals of the meeting are to discuss the latest advances in RNAi technology as both a research tool and therapeutic strategy.
Scholarship Deadline: September 28 2006
Discounted Abstract Deadline: September 28 2006
Abstract Deadline: October 27 2006
Discounted Registration Deadline: November 28 2006
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Isis Pharmaceuticals, Inc.
Thermo Fisher Scientific, Inc.